PGC-1α Genotype Modifies the Association of Volitional Energy Expenditure with V̇O2max

Medicine and Science in Sports and Exercise

Volumn 35, Issue 12, 2003, Pages 1998-2004

  Franks, Paul W ^a   Barroso, Inês ^b   Luan, Jian'An ^a   Ekelund, Ulf ^a   Crowley, Vivion E F ^c   Brage, Søren ^a   Sandhu, Manjinder S ^a   Jakes, Rupert W ^a   Middelberg, Rita P S ^a   Harding, Anne Helen ^a   Schafer, Alan J ^b   O'Rahilly, Stephen ^c   Wareham, Nicholas J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Department of Life Sciences   (United States)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Fitness; Gene environment interaction; Physical activity; Polymorphism

Indexed keywords

GLYCINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; SERINE; UNCLASSIFIED DRUG; PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA COACTIVATOR-1; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ADAPTATION; ARTICLE; BIOGENESIS; CALIBRATION; CONTROLLED STUDY; DNA POLYMORPHISM; ENDURANCE; ENERGY EXPENDITURE; ERGOMETRY; EXERCISE; FEMALE; GENE ACTIVATION; GENE OVEREXPRESSION; HEART FUNCTION; HEART RATE; HEREDITY; HOMOZYGOTE; HUMAN; HUMAN EXPERIMENT; ISCHEMIC HEART DISEASE; LUNG FUNCTION; MALE; MORTALITY; NORMAL HUMAN; PHYSICAL ACTIVITY; TRAINING; ADULT; AGED; COMPARATIVE STUDY; ENERGY METABOLISM; FITNESS; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; MIDDLE AGED; OXYGEN CONSUMPTION; PHYSIOLOGY;

ADULT; AGED; ENERGY METABOLISM; EXERCISE; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; PHYSICAL FITNESS; POLYMORPHISM, GENETIC; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0345097647     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1249/01.MSS.0000099109.73351.81     Document Type: Article

References (37)

1. ANONYMOUS. Freely associating. Natl. Genet. 22:1-2, 1999.
2. BAAR, K., A. R. WENDE, T. E. JONES, et al. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J. 16:1879-1886, 2002.
3. BOOTH, F. W., and D. B. THOMASON. Molecular and cellular adaptation of muscle in response to exercise: perspectives of various models. Physiol. Rev. 71:541-585, 1991.
4. 2max response to exercise training: results from the HERITAGE Family Study. J. Appl. Physiol. 87:1003, 1999.
5. BOUCHARD, C., and T. RANKINEN. Individual differences in response to regular physical activity. Med. Sci. Sports Exerc. 33: S446-S451; discussion S452-S443, 2001.
6. CEESAY, S. M., A. M. PRENTICE, K. C. DAY, P. R. MURGATROYD, G. R. GOLDBERG, and W. SCOTT. The use of heart rate monitoring in the estimation of energy expenditure: a validation study using indirect whole-body calorimetry. Br. J. Nutr. 61:175-186, 1989.
7. CHEN, X., L. LEVINE, and P. Y. KWOK. Fluorescence polarization in homogeneous nucleic acid analysis. Genome Res. 9:492-498, 1999.
8. COLHOUN, H., and P. PRESCOTT-CLARKE (Eds.). Health Survey for England 1994. London: HMSO, 1996.
9. DUNN, A. L., B. H. MARCUS, J. B. KAMPERT, M. E. GARCIA, H. W. KOHL III, and S. N. BLAIR. Comparison of lifestyle and structured interventions to increase physical activity and cardiorespiratory fitness: a randomized trial. JAMA 281:327-334, 1999.
10. EK, J., G. ANDERSEN, S. A. URHAMMER, et al. Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. Diabetologia 44:2220-2226, 2001.
11. ELIA, M., and G. LIVESEY. Energy expenditure and fuel selection in biological systems: theory and practice of calculations based on indirect calorimetry and tracer methods. In: Metabolic Control of Eating, Energy Expenditure and the Bioenergetics of Obesity, A. P. Simopoulus (Ed.). Basel: Karger, 1992, pp. 68-131.
12. ESPARZA, J., C. Fox, I. T. HARPER, et al, Daily energy expenditure in Mexican and USA Pima Indians: low physical activity as a possible cause of obesity. Int. J. Obes. Relat. Memb. Disord. 24:55-59, 2000.
13. ESTERBAUER, H., H. OBERKOFLER, V. LINNEMAYR, et al. Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women. Diabetes 51:1281-1286, 2002.
14. GOLDBERG, G. R., A. M. PRENTICE, H. L. DAVIES, and P. R. MURGATROYD. Overnight and basal metabolic rates in men and women. Eur. J. Clin. Nutr. 42:137-144, 1988.
15. GOTO, M., S. TERADA, M. KATO, et al. cDNA cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats. Biochem. Biophys. Res. Commun. 274:350-354, 2000.
16. HALSALL, D. J., N. D. MARTENSZ, J. LUAN, P. MAISON, N. J. WAREHAM. A common apolipoprotein B signal peptide polymorphism modifies the relation between plasma non-esterified fatty acids and triglyceride concentration in men. Atherosclerosis 152:9-17, 2000.
17. HARA, K., K. TOBE, T. OKADA, et al. A genetic variation in the PGC-1 gene and insulin resistance. Diabetologia 45:740-743, 2002.
18. JAMSHIDI, Y., H. E. MONTGOMERY, H. W. HENSE, et al. Peroxisome proliferator-activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension. Circulation 105:950-955, 2002.
19. LACQUEMANT C., M. CHIKRI, P. BOUTIN, C. SAMSON, and P. FROGUEL. No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians. Diabetologia 45:602-603, 2002.
20. LIN, J., H. Wu, P. T. TARR, et al. Transcriptional co-activator PGC-1alpha drives the formation of slow-twitch muscle fibres. Nature 418:797-801, 2002.
21. LIVINGSTONE, M. B. E., A. M. PRENTICE, W. A. COWARD, et al. Simultaneous measurement of free-living energy expenditure by the doubly labeled water method and heart-rate monitoring. Am. J. Clin. Nutr. 52:59-65, 1990.
22. MEIRHAEGHE, A., J. LUAN, P. FRANKS, et al. The effect of the Gly16Arg polymorphism of the β(2)-adrenergic receptor gene on plasma free fatty acid levels is modulated by physical activity. J. Clin. Endocrinol. Metab. 86:5881-5887, 2001.
23. MULLER, Y. L., C. BOGARDUS, O. PEDERSEN, and L. BATER. A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. Diabetes 52:895-898, 2003.
24. OBERKOFLER, H., B. HOLZL, H. ESTERBAUER, et al. Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with hypertension in middle-aged men. Hypertension 41:368-372, 2003.
25. PUIGSERVER, P., Z. WU, C. W. PARK, R. GRAVES, M. WRIGHT, and B. M. SPIEGELMAN. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839, 1998.
26. SCHOFIELD W. N., C. SCHOFIELD, and W. P. T. JAMES. Predicting basal metabolic rates: new standards and review of previous work. Hum. Nutr. Clin. Nutr. 39C(Suppl.):5-41, 1985.
27. SPIEGELMAN, B. M., P. PUIGSERVER, and Z. Wu. Regulation of adipogenesis and energy balance by PPARgamma and PGC-1. Int. J. Obes. Relat. Metab. Disord. 24:S8-S10, 2000.
28. TERADA, S., M. GOTO, M. KATO, K. KAWANAKA, T. SHIMOKAWA, and I. TABATA. Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle. Biochem. Biophys. Res. Commun. 296:350-354, 2002.
29. THE SPORTS COUNCIL AND THE HEALTH EDUCATION AUTHORITY. Allied Dunbar National Fitness Survey. London: Health Education Authority, 1992.
30. WAREHAM, N. J., S. J. HENNINGS, C. D. BYRNE, C. N. HALES, A. M. PRENTICE, and N. E. DAY. A quantitative analysis of the relationship between habitual energy expenditure, fitness and the metabolic cardiovascular syndrome. Br. J. Nutr. 80:235-241, 1998.
31. WAREHAM, N. J., S. J. HENNINGS, A. M. PRENTICE, and N. E. DAY. Feasibility of heart rate monitoring to estimate total level and pattern of energy expenditure in a population-based epidemiological study. Br. J. Nutr. 78:889-900, 1997.
32. WEI, M., J. B. KAMPERT, C. E. BARLOW, et al. Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA 282:1547, 1999.
33. WEI, M., L. W. GIBBONS, T. L. MITCHELL, J. B. KAMPERT, C. D. LEE, and S. N. BLAIR. The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Ann. Intern. Med. 130:89-96, 1999.
34. WU, Z., P. PUIGSERVER, U. ANDERSSON, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98:115-124, 1999.
35. YOON, J. C., P. PUIGSERVER, G. CHEN, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413:131-138, 2001.
36. ZHANG, L., X. CUI, K. SCHMITT, R. HUBERT, W. NAVIDI, and N. ARNHEIM. Whole genome amplification from a single cell: implications for genetic analysis. Proc. Natl. Acad. Sci. USA 89:5847-5851, 1992.
37. ZHANG, Q., J. L. WRANA, and J. SODEK. Characterization of the promoter region of the porcine opn (osteopontin, secreted phosphoprotein 1) gene: identification of positive and negative regulatory elements and a "silent" second promoter. Eur. J. Biochem. 207:649-659, 1992.