Effects of insulin resistance on substrate utilization during exercise in overweight women

Journal of Applied Physiology

Volumn 97, Issue 3, 2004, Pages 991-997

  Braun, Barry ^a   Sharoff, Carrie ^a   Chipkin, Stuart R ^b   Beaudoin, Francesca ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b BAYSTATE MEDICAL CENTER   (United States)

Author keywords

Carbohydrate metabolism; Contraction mediated glucose uptake; Glycogen; Stable isotope

Indexed keywords

GLYCOGEN;

ADULT; ARTICLE; BODY MASS; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; GLYCOGEN METABOLISM; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OXIDATION; PRIORITY JOURNAL;

ADULT; BLOOD GLUCOSE; CARBOHYDRATE METABOLISM; ENERGY METABOLISM; EXERCISE; FEMALE; GLYCOGEN; HUMANS; INSULIN; INSULIN RESISTANCE; MUSCLE, SKELETAL; OBESITY;

EID: 4344693088     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00231.2004     Document Type: Article

References (42)

1. Blaak EE and Saris WHM. Substrate oxidation, obesity and exercise training. Best Pract Res Clin Endocrinol Metab 16: 667-678, 2002.
2. Blaak EE, van Aggel-Leijssen DPC, Wagenmakers AJM, Saris WHM, and van Baak MA. Impaired oxidation of plasma-derived fatty acids in Type 2 diabetic subjects during moderate-intensity exercise. Diabetes 49: 2102-2107, 2000.
3. Braun B, Zimmermann MB, and Kretchmer N. Effects of exercise intensity on insulin sensitivity in women with NIDDM. J Appl Physiol 78: 300-306, 1995.
4. Bruce CR, Kriketos AD, and Hawley JA. Dissociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes. Diabetologia 47: 23-30, 2004.
5. Carey DG, Jenkins AB, Campbell LV, Freund J, and Chisholm DJ. Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes 45: 633-638, 1996.
6. Colberg SR, Hagberg JM, McCole SD, Zmuda JM, Thompson PD, and Kelley DE. Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise. J Appl Physiol 81: 2027-2033, 1996.
7. Colberg SR, Simoneau JA, Thaete FL, and Kelley DE. Skeletal muscle utilization of free fatty acids in women with visceral obesity. J Clin Invest 95: 1846-1853, 1995.
8. Dean D, Daugaard JR, Young ME, Saha A, Vavvas D, Asp S, Kiens B, Kim K, Witters L, Richters EA, and Ruderman N. Exercise diminishes the activity of acetyl-CoA in human muscle. Diabetes 49: 1295-1300, 2000.
9. DeFronzo RA, Bonadonna RC, and Ferrannini E. Pathogenesis of NIDDM: a balanced overview. Diabetes Care 15: 318-368, 1992.
10. D'Eon TM and Braun B. The role of estrogen and progesterone in regulating carbohydrate and fat utilization at rest and during exercise. J Womens Health Gend Based Med 11: 225-237, 2002.
11. Devlin JT, Hirshman MS, Horton ED, and Horton ES. Enhanced peripheral and splanchnic insulin sensitivity in NIDDM men after a single bout of exercise. Diabetes 36: 434-439, 1987.
12. Friedlander AL, Cassazza GA, Horning MA, Huie MJ, Piacentini MF, Trimmer JK, and Brooks GA. Training-induced alterations of carbohydrate metabolism in women: women respond differently from men. J Appl Physiol 85: 1175-1186, 1998.
13. Gan SK, Kriketos AD, Ellis BA, Thompson CH, Kraegen EW, and Chisholm DJ. Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese men. Diabetes Care 26: 1706-1713, 2003.
14. Geerling BJ, Alles MS, Murgatroyd PR, Goldberg GR, Harding M, and Prentice AM. Fatness in relation to substrate oxidation during exercise. Int J Obes Relat Metab Disord 18: 453-459, 1994.
15. Goodpaster BH, He J, Watkins S, and Kelley DE. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 86: 5755-5761, 2001.
16. Goodpaster BH, Thaete FL, Simoneau JA, and Kelly DE. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46: 1579-1585, 1997.
17. Goodpaster BH, Wolfe RR, and Kelley DE. Effects of obesity on substrate utilization during exercise. Obesity Res 10: 575-584, 2002.
18. Goodyear LJ and Kahn BB. Exercise, glucose transport, and insulin sensitivity. Annu Rev Med 49: 235-261, 1998.
19. Hayashi T, Wojtaszewski JF, and Goodyear LJ. Exercise regulation of glucose transport in skeletal muscle. Am J Physiol Endocrinol Metab 273: E1039-E1051, 1997.
20. Hegarty BD, Furier SM, Ye J, Cooney GJ, and Kraegen EW. The role of intramuscular lipid in insulin resistance. Acta Physiol Scand 178: 373-383, 2003.
21. Helge JW and Dela F. Effect of training on muscle triacylglycerol and structural lipids: a relation to insulin sensitivity? Diabetes 52: 1881-1887, 2003.
22. Ivy JL, Zderic TW, and Fogt DL. Prevention and treatment of non-insulin-dependent diabetes mellitus. Exerc Sport Sci Rev 31: 1-35, 1999.
23. Jeukendrup AE, Wagenmakers AJ, Stegen JH, Gijsen AP, Brouns F, and Saris WH. Carbohydrate ingestion can completely suppress endogenous glucose production during exercise. Am J Physiol Endocrinol Metab 276: E672-E683, 1999.
24. Kanaley JA, Cryer PE, and Jensen MD. Fatty acid kinetic response to exercise: effects of obesity, body fat distribution and energy-restricted diet. J Clin Invest 92: 255-261, 1993.
25. Kanaley JA, Weatherup-Dentes MM, Alvarado CR, and Whitehead G. Substrate oxidation during acute exercise and with exercise training in lean and obese women. Eur J Appl Physiol 85: 68-73, 2001.
26. Kelley DE and Goodpaster BH. Effects of physical activity on insulin action and glucose tolerance in obesity. Med Sci Sports Exerc 31: S619-S623, 1999.
27. Kelley DE and Goodpaster BH. Skeletal muscle triglyceride: an aspect of regional adiposity and insulin resistance. Diabetes Care 24: 933-941, 2001.
28. Kelley DE and Mandarino LJ. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49: 677-683, 2000.
29. Kennedy JW, Hirshman MF, Gervino EV, Ocel JV, Forse RA, Hoenig SJ, Aronson D, Goodyear LJ, and Horton ES. Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes. Diabetes 48: 1192-1197, 1999.
30. Levin K, Daa Scroeder H, Alford FP, and Beck-Nielsen H. Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with type II diabetes. Diabetologia 44: 824-833, 2001.
31. Matsuda M and DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22: 1462-1470, 1999.
32. Oakes ND, Bell KS, Furler SM, Chisholm DJ, and Kraegen EW. Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl co-A. Diabetes 46: 2022-2037, 1997.
33. Pan DA, Lillioja S, Kriketos AD, Milner MR, Bauer LA, Bogardus C, Jenkins AB, and Storlien LH. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46: 983-988, 1997.
34. Pasman WJ, Westerterp MS, and Saris WH. The effect of body weight changes and endurance training on 24 h substrate oxidation. Int J Obes Relat Metab Disord 23: 1223-1232, 1999.
35. Phillips DI, Caddy S, Ilic V, Fielding BA, Frayn KN, Borthwick AC, and Taylor R. Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in non-diabetic subjects. Metabolism 45: 947-950, 1996.
36. Phillips SM, Green HJ, Tarnopolsky MA, Heigenhauser GF, Hill RE, and Grant SM. Effect of training duration on substrate turnover and oxidation during exercise. J Appl Physiol 81: 2182-2191, 1996.
37. Sherman WM, Costill DL, Fink WJ, and Miller JM. Effect of exercise-diet manipulation on muscle glycogen and its subsequent utilization during performance. Int J Sports Med 1: 114-118, 1981.
38. Thorell A, Hirshman MF, Nygren J, Jorfeld L, Wojtaszewski JF, Dufresne SD, Horton ES, Ljungqvist O, and Goodyear LJ. Exercise and insulin cause GLUT4 translocation in human skeletal muscle. Am J Physiol Endocrinol Metab 277: E733-E741, 1999.
39. Van Aggel-Leijssen DP, Saris WH, Wagenmakers AJM, Senden J, and van Baak MA. Effect of exercise training at different intensities on fat metabolism in obese men. J Appl Physiol 92: 1300-1309, 2002.
40. Wade AJ, Marbut MM, and Round JM. Muscle fiber type and aetiology of obesity. Lancet 335: 805-808, 1990.
41. Wallberg-Henrickson H and Holloszy JO. Contractile activity increases glucose uptake in severely diabetic rats. J Appl Physiol 57: 1045-1049, 1984.
42. Wolfe RR. Radioactive and Stable Isotope Tracers in Metabolism. New York: Wiley-Liss, 1992, p. 283-316.