Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease

Atherosclerosis

Volumn 181, Issue 2, 2005, Pages 305-310

  Steiner, Sabine ^a   Niessner, Alexander ^a   Ziegler, Sophie ^a   Richter, Bernhard ^a   Seidinger, Daniela ^a   Pleiner, Johannes ^a   Penka, Martina ^b   Wolzt, Michael ^a   Huber, Kurt ^b   Wojta, Johann ^a   Minar, Erich ^a   Kopp, Christoph W ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Cardiology and Emergency Medicine   (Austria)

Author keywords

Endothelial progenitor cells; Erythropoietin; Exercise; Vascular endothelial growth factor; Vascular function

Indexed keywords

ANGIOGENESIS MODULATOR; CD133 ANTIGEN; CD34 ANTIGEN; ERYTHROPOIETIN; NITRIC OXIDE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ADULT; ANGIOGENESIS; ARTICLE; BRACHIAL ARTERY; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ENDOTHELIUM CELL; FEMALE; FLOW CYTOMETRY; HUMAN; MALE; MEDICAL DOCUMENTATION; MUSCLE TRAINING; PERIPHERAL BLOOD STEM CELL; PHYSICAL STRESS; PRIORITY JOURNAL; RUNNING;

ADULT; CORONARY ARTERIOSCLEROSIS; ENDOTHELIUM, VASCULAR; ERYTHROPOIETIN; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; NEOVASCULARIZATION, PHYSIOLOGIC; NITRATES; NITRIC OXIDE; NITRITES; PHYSICAL ENDURANCE; RISK FACTORS; STEM CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASODILATION;

EID: 22544478168     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2005.01.006     Document Type: Article

References (24)

1. T. Asahara, H. Masuda, and T. Takahashi Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization Circ Res 85 1999 221 228
2. F.M. Rauscher, P.J. Goldschmidt-Clermont, and B.H. Davis Aging, progenitor cell exhaustion, and atherosclerosis Circulation 108 2003 457 463
3. M. Peichev, A.J. Naiyer, and D. Pereira Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors Blood 95 2000 952 958
4. U.M. Gehling, S. Ergun, and U. Schumacher In vitro differentiation of endothelial cells from AC133-positive progenitor cells Blood 95 2000 3106 3112
5. T. Asahara, T. Murohara, and A. Sullivan Isolation of putative progenitor endothelial cells for angiogenesis Science 275 1997 964 967
6. M. Vasa, S. Fichtlscherer, and A. Aicher Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease Circ Res 89 2001 E1 E7
7. J.M. Hill, G. Zalos, and J.P. Halcox Circulating endothelial progenitor cells, vascular function, and cardiovascular risk N Engl J Med 348 2003 593 600
8. S. Dimmeler, A. Aicher, and M. Vasa HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway J Clin Invest 108 2001 391 397
9. C. Heeschen, A. Aicher, and R. Lehmann Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization Blood 102 2003 1340 1346
10. U. Laufs, N. Werner, and A. Link Physical training increases endothelial progenitor cell, inhibits neointima formation, and enhances angiogenesis Circulation 109 2004 220 226
11. J. Rehmann, J. Li, and L. Parvathaneni Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells J Am Coll Cardiol 43 2004 2314 2318
12. T. Gustafsson, A. Puntschart, L. Kaijser, E. Jansson, and C.J. Sundberg Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle Am J Physiol 276 1999 H679 H685
13. L. Hoffner, J.J. Nielsen, H. Langberg, and Y. Hellsten Exercise but not prostanoids enhance levels of vascular endothelial growth factor and other proliferative agents in human skeletal muscle interstitium J Physiol 550 2003 217 225
14. Y.O. Schumacher, J. Temme, D. Bueltermann, A. Schmid, and A. Berg The influence of exercise on serum markers of altered erythropoiesis and the indirect detection models of recombinant human erythropoietin abuse in athletes Haematologica 88 2003 712 714
15. G.F. Fletcher, G.J. Balady, and E.A. Amsterdam Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association Circulation 104 2001 1694 1740
16. J. Karvonen, and T. Vuorimaa Heart rate and exercise intensity during sports activities. Practical application Sports Med 5 1988 303 311
17. G. Fuchsjager-Mayrl, J. Pleiner, and G.F. Wiesinger Exercise training improves vascular endothelial function in patients with type 1 diabetes Diab Care 25 2002 1795 1801
18. S. Mochizuki, E. Toyota, and O. Hiramatsu Effect of dietary control on plasma nitrate level and estimation of basal systemic nitric oxide production rate in humans Heart Vessels 15 2000 274 279
19. R.J. Shephard, and G.J. Balady Exercise as cardiovascular therapy Circulation 99 1999 963 972
20. S.N. Blair, J.B. Kampert, and H.W. Kohl 3rd Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women JAMA 276 1996 205 210
21. D.J. Green, J.H. Walsh, and A.J. Maiorana Exercise-induced improvement in endothelial dysfunction is not mediated by changes in Cv risk factors: a pooled analysis of diverse patients populations Am J Physiol Heart Circ Physiol 285 2003 2679 2687
22. R. Hambrecht, V. Adams, and S. Erbs Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase Circulation 107 2003 3152 3158
23. A. Aicher, C. Heeschen, and C. Mildner-Rihm Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells Nat Med 9 2003 1370 3176
24. V. Adams, K. Lenk, and A. Linke Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia Arterioscler Thromb Vasc Biol 24 2004 684 690