Effect of endurance training on lipid metabolism in women: A potential role for PPARα in the metabolic response to training

American Journal of Physiology - Endocrinology and Metabolism

Volumn 279, Issue 2 42-2, 2000, Pages

  Horowitz, Jeffrey F ^a   Leone, Teresa C ^a   Feng, Weqing ^a   Kelly, Daniel P ^a   Klein, Samuel ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Exercise; Fatty acid; Intramuscular triglyceride; Lipolysis; Stable isotopes

Indexed keywords

ACTIN; ACYL COENZYME A DEHYDROGENASE; ADRENALIN; CITRATE SYNTHASE; FATTY ACID; INSULIN; LIPID; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; NORADRENALIN; OXYGEN; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; UNCLASSIFIED DRUG; VERY LONG CHAIN ACYL COENZYME A DEHYDROGENASE;

ADULT; CONTROLLED STUDY; CYCLING; ENDURANCE; FATTY ACID OXIDATION; FEMALE; GENE CONTROL; GENE EXPRESSION; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; LIPID METABOLISM; LIPOLYSIS; MUSCLE LEVEL; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REVIEW; SKELETAL MUSCLE; TRAINING;

EID: 0033851801     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2000.279.2.e348     Document Type: Review

References (40)

1. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)
2. Adrenergic regulation of lipolysis in situ at rest and during exercise
3. Muscle electrolytes in man
4. 'Western blotting': Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A
5. Activation of a novel metabolic gene regulatory pathway by chronic stimulation of skeletal muscle
6. Metabolic characteristics of fibre types in human skeletal muscle
7. Calculation of substrate oxidation rates in vivo from gaseous exchange
8. Effects of exercise intensity and training on lipid metabolism in young women
9. Induction of the peroxisome proliferator activated receptor by fenofibrate in rat liver
10. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression
11. Regional lipolytic responses to isoproterenol in women
12. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle
13. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences
14. Mitochondrial citric acid cycle and related enzymes: Adaptive response to exercise
15. Endurance exercise training does not alter lipolytic or adipose tissue blood flow sensitivity to epinephrine
16. Muscle triglyceride utilization during exercise: Effect of training
17. Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue
18. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
19. Skeletal muscle substrate utilization during submaximal exercise in man: Effect of endurance training
20. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
21. Blood flow through human adipose tissue determined with radioactive xenon
22. PPAR tissue distribution and interactions with other hormone-signaling pathways
23. A critical role for the peroxisome proliferator-activated receptor alpha (PPARα) in the cellular fasting response: The PPARalpha-null mouse as a model of fatty acid oxidation disorders
24. Effect of endurance training on plasma free fatty acid turnover and oxidation during exercise
25. Regional acetate kinetics and oxidation in human volunteers
26. Adaptation of muscle to exercise. Increase in levels of palmityl CoA synthetase, carnitine palmityltransferase, and palmityl CoA dehydrogenase and in the capacity to oxidize fatty acids
27. Exercise metabolism at different time intervals after a meal
28. Extraction of exogenous plasma trigiycerides by the working human forearm muscle in the fasting state
29. Absence of restricted diffusion in adipose tissue capillaries
30. Improved accuracy of stable isotope tracer: Tracee ratio measurements by gas chromotography/mass spectrometry
31. Effects of training duration on substrate turnover and oxidation during exercise
32. Metabolite levels in human skeletal muscle and adipose tissue studied with microdialysis at low perfusion flow
33. Modification and validation of a commercially available portable detector for measurement of adipose tissue blood flow
34. External and internal standards in the single isotope deriviative (radioenzymatic) assay of plasma norepinephrine and epinephrine in normal humans and patients with diabetes or chronic renal failure
35. A new correction factor for use in tracer estimations of plasma fatty acid oxidation
36. Influences of glucose loading and of injected insulin on hepatic glucose output
37. Dexamethasone and insulin demonstrate marked and opposite regulation of the steady-state mRNA level of the peroxisomal proliferator-activated receptor (PPAR) in hepatic cells. Hormonal modulation of fatty-acid-induced transcription
38. Mechanisms underlying regional differences in lipolysis in human adipose tissue
39. Solubility of krypton and xenon in blood-protein solutions, and tissue homogenates