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Volumn 10, Issue 5, 2008, Pages 405-412

Regulatory T cells in rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; INTERLEUKIN 7; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; INTERLEUKIN 17;

EID: 55949101372     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-008-0065-y     Document Type: Review
Times cited : (9)

References (84)
  • 1
    • 0014792798 scopus 로고
    • Cell interactions in the induction of tolerance: The role of thymic lymphocytes
    • Gershon RK, Kondo K: Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology 1970, 18: 723-737.
    • (1970) Immunology , vol.18 , pp. 723-737
    • Gershon, R.K.1    Kondo, K.2
  • 2
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, et al.: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995, 155: 1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3
  • 3
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • Asano M, Toda M, Sakaguchi N, Sakaguchi S: Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996, 184: 387-396.
    • (1996) J Exp Med , vol.184 , pp. 387-396
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 4
    • 0033136302 scopus 로고    scopus 로고
    • Thymus and autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
    • Itoh M, Takahashi T, Sakaguchi N, et al.: Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999, 162: 5317-5326.
    • (1999) J Immunol , vol.162 , pp. 5317-5326
    • Itoh, M.1    Takahashi, T.2    Sakaguchi, N.3
  • 5
    • 0033064551 scopus 로고    scopus 로고
    • Post-thymectomy autoimmune gastritis: Fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells
    • Suri-Payer E, Amar A, McHugh R, et al.: Post-thymectomy autoimmune gastritis: Fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells. Eur J Immunol 1999, 29: 669-677.
    • (1999) Eur J Immunol , vol.29 , pp. 669-677
    • Suri-Payer, E.1    Amar, A.2    McHugh, R.3
  • 6
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle H, Holtschke T, Huenig T, et al.: Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 1991, 352: 621-624.
    • (1991) Nature , vol.352 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Huenig, T.3
  • 7
    • 15444374646 scopus 로고    scopus 로고
    • Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    • Setoguchi R, Hori S, Takahashi T, Sakaguchi S: Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 2005, 201: 723-735.
    • (2005) J Exp Med , vol.201 , pp. 723-735
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3    Sakaguchi, S.4
  • 8
    • 0342632839 scopus 로고    scopus 로고
    • Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo
    • Suzuki H, Zhou YW, Kato M, et al.: Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo. J Exp Med 1999, 190: 1561-1572.
    • (1999) J Exp Med , vol.190 , pp. 1561-1572
    • Suzuki, H.1    Zhou, Y.W.2    Kato, M.3
  • 9
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    • Malek TR, Yu A, Vincek V, et al.: CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2002, 17: 167-178.
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3
  • 10
    • 0031647622 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
    • Takahashi T, Kuniyasu Y, Toda M, et al.: Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998, 10: 1969-1980.
    • (1998) Int Immunol , vol.10 , pp. 1969-1980
    • Takahashi, T.1    Kuniyasu, Y.2    Toda, M.3
  • 11
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • Thornton AM, Shevach EM: CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998, 188: 287-296.
    • (1998) J Exp Med , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 12
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow ME, Jeffery, E, Hjerrild, KA, et al.: Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001, 27: 68-73.
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.2    Hjerrild, K.A.3
  • 13
    • 0034526617 scopus 로고    scopus 로고
    • JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome
    • Chatila TA, Blaeser F, Ho N, et al.: JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest 2000, 106: R75-R81.
    • (2000) J Clin Invest , vol.106
    • Chatila, T.A.1    Blaeser, F.2    Ho, N.3
  • 14
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S: Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 15
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY: Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003, 4: 330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 16
    • 8344275995 scopus 로고    scopus 로고
    • Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
    • Yagi H, Nomura T, Nakamura K, et al.: Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol 2004, 16: 1643-1656.
    • (2004) Int Immunol , vol.16 , pp. 1643-1656
    • Yagi, H.1    Nomura, T.2    Nakamura, K.3
  • 17
    • 19344374571 scopus 로고    scopus 로고
    • HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells
    • Oswald-Richter K, Grill SM, Shariat N, et al.: HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. PLoS Biol 2004, 2: 955-966.
    • (2004) PLoS Biol , vol.2 , pp. 955-966
    • Oswald-Richter, K.1    Grill, S.M.2    Shariat, N.3
  • 18
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor Foxp3
    • Fontenot J, Rasmussen J, Williams L, et al.: Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 2005, 22: 329-341.
    • (2005) Immunity , vol.22 , pp. 329-341
    • Fontenot, J.1    Rasmussen, J.2    Williams, L.3
  • 19
    • 16844362608 scopus 로고    scopus 로고
    • Mechanisms of suppression by suppressor T cells
    • von Boehmer H: Mechanisms of suppression by suppressor T cells. Nat Immunol 2005, 6: 338-344.
    • (2005) Nat Immunol , vol.6 , pp. 338-344
    • von Boehmer, H.1
  • 20
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
    • Williams LM, Rudensky AY: Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 2007, 8: 277-284.
    • (2007) Nat Immunol , vol.8 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 21
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Zheng Y, Josefowicz SZ, Kas A, et al.: Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 2007, 445: 936-940.
    • (2007) Nature , vol.445 , pp. 936-940
    • Zheng, Y.1    Josefowicz, S.Z.2    Kas, A.3
  • 22
    • 33847242598 scopus 로고    scopus 로고
    • Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    • Marson A, Kretschmer K, Frampton GM, et al.: Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 2007, 445: 931-935.
    • (2007) Nature , vol.445 , pp. 931-935
    • Marson, A.1    Kretschmer, K.2    Frampton, G.M.3
  • 23
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • Wu Y, Borde M, Heissmeyer V, et al.: FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006, 126: 375-387.
    • (2006) Cell , vol.126 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3
  • 24
    • 34247215187 scopus 로고    scopus 로고
    • Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
    • Ono M, Yaguchi H, Ohkura N, et al.: Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 2007, 446: 685-689.
    • (2007) Nature , vol.446 , pp. 685-689
    • Ono, M.1    Yaguchi, H.2    Ohkura, N.3
  • 25
    • 34548680545 scopus 로고    scopus 로고
    • Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells
    • Pacholczyk R, Kern J, Singh N, et al.: Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Immunity 2007, 27: 493-504.
    • (2007) Immunity , vol.27 , pp. 493-504
    • Pacholczyk, R.1    Kern, J.2    Singh, N.3
  • 26
    • 0037108485 scopus 로고    scopus 로고
    • Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25-precursors
    • Zheng SG, Gray JD, Ohtsuka K, et al.: Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25-precursors. J Immunol 2002, 169: 4183-4189.
    • (2002) J Immunol , vol.169 , pp. 4183-4189
    • Zheng, S.G.1    Gray, J.D.2    Ohtsuka, K.3
  • 27
    • 33846923124 scopus 로고    scopus 로고
    • IL-2 is essential for TGF-beta to convert naive CD4+CD25-cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells
    • Zheng SG, Wang J, Wang P, et al.: IL-2 is essential for TGF-beta to convert naive CD4+CD25-cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol 2007, 178: 2018-2027.
    • (2007) J Immunol , vol.178 , pp. 2018-2027
    • Zheng, S.G.1    Wang, J.2    Wang, P.3
  • 28
    • 2542420993 scopus 로고    scopus 로고
    • In vivo instruction of suppressor commitment in naive T cells
    • Apostolou I, von Boehmer H: In vivo instruction of suppressor commitment in naive T cells. J Exp Med 2004, 199: 1401-1408.
    • (2004) J Exp Med , vol.199 , pp. 1401-1408
    • Apostolou, I.1    von Boehmer, H.2
  • 29
    • 29244435493 scopus 로고    scopus 로고
    • Inducing and expanding regulatory T cell populations by foreign antigen
    • Kretschmer K, Apostolou I, Hawiger D, et al.: Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 2005, 6: 1219-1227.
    • (2005) Nat Immunol , vol.6 , pp. 1219-1227
    • Kretschmer, K.1    Apostolou, I.2    Hawiger, D.3
  • 30
    • 4043052238 scopus 로고    scopus 로고
    • Regulatory T cells and mechanisms of immune system control
    • O'Garra A, Vieira P: Regulatory T cells and mechanisms of immune system control. Nat Med 2004, 10: 801-805.
    • (2004) Nat Med , vol.10 , pp. 801-805
    • O'Garra, A.1    Vieira, P.2
  • 31
    • 2442450433 scopus 로고    scopus 로고
    • IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
    • Vieira PL, Christensen JR, Minaee S, et al.: IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J Immunol 2004, 172: 5986-5993.
    • (2004) J Immunol , vol.172 , pp. 5986-5993
    • Vieira, P.L.1    Christensen, J.R.2    Minaee, S.3
  • 32
    • 1242345130 scopus 로고    scopus 로고
    • Antigen-specific regulatory T cells-their induction and role in infection
    • Mills KH, McGuirk P: Antigen-specific regulatory T cells-their induction and role in infection. Semin Immunol 2004, 16: 107-117.
    • (2004) Semin Immunol , vol.16 , pp. 107-117
    • Mills, K.H.1    McGuirk, P.2
  • 33
    • 0347895101 scopus 로고    scopus 로고
    • Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
    • Kemper C, Chan AC, Green JM, et al.: Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 2003, 421: 388-392.
    • (2003) Nature , vol.421 , pp. 388-392
    • Kemper, C.1    Chan, A.C.2    Green, J.M.3
  • 34
    • 10744226674 scopus 로고    scopus 로고
    • Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes
    • Cosmi L, Liotta F, Lazzeri E, et al.: Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. Blood 2003, 102: 4107-4114.
    • (2003) Blood , vol.102 , pp. 4107-4114
    • Cosmi, L.1    Liotta, F.2    Lazzeri, E.3
  • 35
    • 8644249136 scopus 로고    scopus 로고
    • Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis
    • Rifa'i M, Kawamoto Y, Nakashima I, Suzuki H: Essential roles of CD8+ CD122+ regulatory T cells in the maintenance of T cell homeostasis. J Exp Med 2004, 200: 1123-1134.
    • (2004) J Exp Med , vol.200 , pp. 1123-1134
    • Rifa'i, M.1    Kawamoto, Y.2    Nakashima, I.3    Suzuki, H.4
  • 36
    • 28244441236 scopus 로고    scopus 로고
    • Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells
    • Endharti AT, Rifa'I M, Shi Z, et al.: Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells. J Immunol 2005, 175: 7093-7097.
    • (2005) J Immunol , vol.175 , pp. 7093-7097
    • Endharti, A.T.1    Rifa'I, M.2    Shi, Z.3
  • 37
    • 18644366689 scopus 로고    scopus 로고
    • License to heal: Bidirectional interaction of antigen-specific regulatory T cells and tolerogenic APC
    • Vlad G, CorBesini R, Suciu-Foca N: License to heal: bidirectional interaction of antigen-specific regulatory T cells and tolerogenic APC. J Immunol 2005, 174: 5907-5914.
    • (2005) J Immunol , vol.174 , pp. 5907-5914
    • Vlad, G.1    Cortesini, R.2    Suciu-Foca, N.3
  • 38
    • 20144388310 scopus 로고    scopus 로고
    • Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8-double-negative regulatory T cells
    • Fischer K, Voelkl S, Heymann J, et al.: Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8-double-negative regulatory T cells. Blood 2005, 105: 2828-2835.
    • (2005) Blood , vol.105 , pp. 2828-2835
    • Fischer, K.1    Voelkl, S.2    Heymann, J.3
  • 39
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • Bluestone JA, Abbas AK: Natural versus adaptive regulatory T cells. Nat Rev Immunol 2003, 3: 253-257.
    • (2003) Nat Rev Immunol , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 40
    • 3142708571 scopus 로고    scopus 로고
    • Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
    • Paust S, Lu L, McCarty N, Cantor H: Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci U S A 2004, 101: 10398-10403.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10398-10403
    • Paust, S.1    Lu, L.2    McCarty, N.3    Cantor, H.4
  • 41
    • 5044220930 scopus 로고    scopus 로고
    • IDO expression by dendritic cells: Tolerance and tryptophan catabolism
    • Mellor AL, Munn DH: IDO expreTsion by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004, 4: 762-774.
    • (2004) Nat Rev Immunol , vol.4 , pp. 762-774
    • Mellor, A.L.1    Munn, D.H.2
  • 42
    • 45549090382 scopus 로고    scopus 로고
    • Preferential costimulation by CD80 results in IL-10-dependent TGFbeta1(+)-adaptive regulatory T cell generation
    • Perez N, Karumuthil-Melethil S, Li R, et al.: Preferential costimulation by CD80 results in IL-10-dependent TGFbeta1(+)-adaptive regulatory T cell generation. J Immunol 2008, 180: 6566-6576.
    • (2008) J Immunol , vol.180 , pp. 6566-6576
    • Perez, N.1    Karumuthil-Melethil, S.2    Li, R.3
  • 43
    • 44449110691 scopus 로고    scopus 로고
    • Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II
    • Liang B, Workman C, Lee J, et al.: Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J Immunol 2008, 180: 5916-5926.
    • (2008) J Immunol , vol.180 , pp. 5916-5926
    • Liang, B.1    Workman, C.2    Lee, J.3
  • 44
    • 5644302161 scopus 로고    scopus 로고
    • Human T regulatory cells can use the perforin pathway to cause autologous target cell death
    • Grossman WJ, Verbsky JW, Barchet W, et al.: Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 2004, 21: 589-601.
    • (2004) Immunity , vol.21 , pp. 589-601
    • Grossman, W.J.1    Verbsky, J.W.2    Barchet, W.3
  • 45
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • Deaglio S, Dwyer KM, Gao W, et al.: Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 2007, 204: 1257-1265.
    • (2007) J Exp Med , vol.204 , pp. 1257-1265
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3
  • 46
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison LW, Workman CJ, Kuo TT, et al.: The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007, 450: 566-569.
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3
  • 48
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare C, Medzhitov R: Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003, 299: 1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 49
    • 42949162462 scopus 로고    scopus 로고
    • Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators
    • van Mierlo GJ, Scherer HU, Hameetman M: Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators. J Immunol 2008, 180: 2747-2751.
    • (2008) J Immunol , vol.180 , pp. 2747-2751
    • van Mierlo, G.J.1    Scherer, H.U.2    Hameetman, M.3
  • 50
    • 33845910939 scopus 로고    scopus 로고
    • Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease
    • Lohr J, Knoechel B, Wang JJ, et al.: Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J Exp Med 2006, 203: 2785-2791.
    • (2006) J Exp Med , vol.203 , pp. 2785-2791
    • Lohr, J.1    Knoechel, B.2    Wang, J.J.3
  • 51
    • 0038666539 scopus 로고    scopus 로고
    • CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis
    • Morgan ME, Sutmuller RP, Witteveen HJ, et al.: CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum 2003, 48: 1452-1460.
    • (2003) Arthritis Rheum , vol.48 , pp. 1452-1460
    • Morgan, M.E.1    Sutmuller, R.P.2    Witteveen, H.J.3
  • 52
    • 22244448391 scopus 로고    scopus 로고
    • Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells
    • Morgan ME, Flierman R, van Duivenvoorde LM, et al.: Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells. Arthritis Rheum 2005, 52: 2212-2221.
    • (2005) Arthritis Rheum , vol.52 , pp. 2212-2221
    • Morgan, M.E.1    Flierman, R.2    van Duivenvoorde, L.M.3
  • 53
    • 20144370643 scopus 로고    scopus 로고
    • The role of regulatory T cells in antigen-induced arthritis: Aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells
    • Frey O, Petrow PK, Gajda M, et al.: The role of regulatory T cells in antigen-induced arthritis: Aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells. Arthritis Res Ther 2005, 7: R291-R301.
    • (2005) Arthritis Res Ther , vol.7
    • Frey, O.1    Petrow, P.K.2    Gajda, M.3
  • 54
    • 33847021422 scopus 로고    scopus 로고
    • Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis
    • Nguyen LT, Jacobs J, Mathis D, Benoist C: Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis. Arthritis Rheum 2007, 56: 509-520.
    • (2007) Arthritis Rheum , vol.56 , pp. 509-520
    • Nguyen, L.T.1    Jacobs, J.2    Mathis, D.3    Benoist, C.4
  • 55
    • 37149026641 scopus 로고    scopus 로고
    • Treg cells suppress osteoclast formation: A new link between the immune system and bone
    • Zaiss MM, Axmann R, Zwerina J, et al.: Treg cells suppress osteoclast formation: A new link between the immune system and bone. Arthritis Rheum 2007, 56: 4104-4112.
    • (2007) Arthritis Rheum , vol.56 , pp. 4104-4112
    • Zaiss, M.M.1    Axmann, R.2    Zwerina, J.3
  • 56
    • 30144433577 scopus 로고    scopus 로고
    • Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: An important factor in pathogenesis, counter-regulated by endogenous IFN-gamma
    • Kelchtermans H, De Klerck B, Mitera T, et al.: Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: An important factor in pathogenesis, counter-regulated by endogenous IFN-gamma. Arthritis Res Ther 2005, 7: R402-R415.
    • (2005) Arthritis Res Ther , vol.7
    • Kelchtermans, H.1    De Klerck, B.2    Mitera, T.3
  • 57
    • 34848858303 scopus 로고    scopus 로고
    • Enhanced efficacy of regulatory T cell transfer against increasing resistance, by elevated Foxp3 expression induced in arthritic murine hosts
    • Ohata J, Miura T, Johnson TA, et al.: Enhanced efficacy of regulatory T cell transfer against increasing resistance, by elevated Foxp3 expression induced in arthritic murine hosts. Arthritis Rheum 2007, 56: 2947-2956.
    • (2007) Arthritis Rheum , vol.56 , pp. 2947-2956
    • Ohata, J.1    Miura, T.2    Johnson, T.A.3
  • 58
    • 33947168299 scopus 로고    scopus 로고
    • Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis
    • van Amelsfort JM, van Roon JA, Noordegraaf M, et al.: Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis. Arthritis Rheum 2007, 56: 732-742.
    • (2007) Arthritis Rheum , vol.56 , pp. 732-742
    • van Amelsfort, J.M.1    van Roon, J.A.2    Noordegraaf, M.3
  • 59
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    • Ehrenstein MR, Evans JG, Singh A, et al.: Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 2004, 200: 277-285.
    • (2004) J Exp Med , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3
  • 60
    • 15244361536 scopus 로고    scopus 로고
    • CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease
    • Cao D, van Vollenhoven R, Klareskog L, et al.: CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther 2004, 6: R335-R346.
    • (2004) Arthritis Res Ther , vol.6
    • Cao, D.1    van Vollenhoven, R.2    Klareskog, L.3
  • 61
    • 17644384896 scopus 로고    scopus 로고
    • CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
    • Möttönen M, Heikkinen J, Mustonen L, et al.: CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol 2005, 140: 360-367.
    • (2005) Clin Exp Immunol , vol.140 , pp. 360-367
    • Möttönen, M.1    Heikkinen, J.2    Mustonen, L.3
  • 62
    • 33747605602 scopus 로고    scopus 로고
    • Early rheumatoid arthritis is associated with a deficit in the CD4+CD25 high regulatory T cell population in peripheral blood
    • Lawson CA, Brown AK, Bejarano V, et al.: Early rheumatoid arthritis is associated with a deficit in the CD4+CD25 high regulatory T cell population in peripheral blood. Rheumatology (Oxford) 2006, 45: 1210-1217.
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 1210-1217
    • Lawson, C.A.1    Brown, A.K.2    Bejarano, V.3
  • 63
    • 4444300314 scopus 로고    scopus 로고
    • CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    • van Amelsfort JM, Jacobs KM, Bijlsma JW, et al.: CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum 2004, 50: 2775-2785.
    • (2004) Arthritis Rheum , vol.50 , pp. 2775-2785
    • van Amelsfort, J.M.1    Jacobs, K.M.2    Bijlsma, J.W.3
  • 64
    • 26244456364 scopus 로고    scopus 로고
    • The presence of cytokine-suppressive CD4+CD25+ T cells in the peripheral blood and synovial fluid of patients with rheumatoid arthritis
    • Liu MF, Wang CR, Fung LL, et al.: The presence of cytokine-suppressive CD4+CD25+ T cells in the peripheral blood and synovial fluid of patients with rheumatoid arthritis. Scand J Immunol 2005, 62: 312-317.
    • (2005) Scand J Immunol , vol.62 , pp. 312-317
    • Liu, M.F.1    Wang, C.R.2    Fung, L.L.3
  • 65
    • 34548148643 scopus 로고    scopus 로고
    • Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis
    • Behrens F, Himsel A, Rehart S, et al.: Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis. Ann Rheum Dis, 2007, 66: 1151-1156.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1151-1156
    • Behrens, F.1    Himsel, A.2    Rehart, S.3
  • 66
    • 0037261145 scopus 로고    scopus 로고
    • Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis
    • Cao D, Malmström V, Baecher-Allan C, et al.: Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol 2003, 33: 215-223.
    • (2003) Eur J Immunol , vol.33 , pp. 215-223
    • Cao, D.1    Malmström, V.2    Baecher-Allan, C.3
  • 67
    • 37349019689 scopus 로고    scopus 로고
    • Accumulation of FoxP3-expressing CD4+CD25+ T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis
    • Jiao Z, Wang W, Jia R, et al.: Accumulation of FoxP3-expressing CD4+CD25+ T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis. Scand J Rheumatol 2007, 36: 428-433.
    • (2007) Scand J Rheumatol , vol.36 , pp. 428-433
    • Jiao, Z.1    Wang, W.2    Jia, R.3
  • 68
    • 33745522182 scopus 로고    scopus 로고
    • FOXP3 identifies regulatory CD25bright CD4+ T cells in rheumatic joints
    • Cao D, Böjesson O, Larsson P, et al.: FOXP3 identifies regulatory CD25bright CD4+ T cells in rheumatic joints. Scand J Immunol 2006, 63: 444-452.
    • (2006) Scand J Immunol , vol.63 , pp. 444-452
    • Cao, D.1    Börjesson, O.2    Larsson, P.3
  • 69
    • 33646370647 scopus 로고    scopus 로고
    • TNF downmodulates the function of human CD4+CD25hi T-regulatory cells
    • Valencia X, Stephens G, Goldbach-Mansky R, et al.: TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood 2006, 108: 253-261.
    • (2006) Blood , vol.108 , pp. 253-261
    • Valencia, X.1    Stephens, G.2    Goldbach-Mansky, R.3
  • 70
    • 33845955906 scopus 로고    scopus 로고
    • alpha1beta1 Integrin+ and regulatory Foxp3+ T cells constitute two functionally distinct human CD4+ T cell subsets oppositely modulated by TNFalpha blockade
    • Goldstein I, Ben-Horin S, Koltakov A, et al.: Alpha1beta1 Integrin+ and regulatory Foxp3+ T cells constitute two functionally distinct human CD4+ T cell subsets oppositely modulated by TNFalpha blockade. J Immunol 2007, 178: 201-210.
    • (2007) J Immunol , vol.178 , pp. 201-210
    • Goldstein, I.1    Ben-Horin, S.2    Koltakov, A.3
  • 71
    • 33846446041 scopus 로고    scopus 로고
    • Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta
    • Nadkarni S, Mauri C, Ehrenstein MR: Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. J Exp Med 2007, 204: 33-39.
    • (2007) J Exp Med , vol.204 , pp. 33-39
    • Nadkarni, S.1    Mauri, C.2    Ehrenstein, M.R.3
  • 72
    • 33646392755 scopus 로고    scopus 로고
    • Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
    • Bresson D, Togher L, Rodrigo E, et al.: Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest 2006, 116: 1371-1381.
    • (2006) J Clin Invest , vol.116 , pp. 1371-1381
    • Bresson, D.1    Togher, L.2    Rodrigo, E.3
  • 73
    • 40449141393 scopus 로고    scopus 로고
    • TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis
    • Deepe GS Jr, Gibbons RS: TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. J Immunol 2008, 180: 1088-1097.
    • (2008) J Immunol , vol.180 , pp. 1088-1097
    • Deepe Jr., G.S.1    Gibbons, R.S.2
  • 74
    • 40749155409 scopus 로고    scopus 로고
    • Autoantigen-specific IL-10-transduced T cells suppress chronic arthritis by promoting the endogenous regulatory IL-10 response
    • Guichelaar T, ten Brink CB, van Kooten PJ, et al.: Autoantigen-specific IL-10-transduced T cells suppress chronic arthritis by promoting the endogenous regulatory IL-10 response. J Immunol 2008, 180: 1373-1381.
    • (2008) J Immunol , vol.180 , pp. 1373-1381
    • Guichelaar, T.1    ten Brink, C.B.2    van Kooten, P.J.3
  • 75
    • 0141733605 scopus 로고    scopus 로고
    • Collagen-induced arthritis is exacerbated in IL-10-deficient mice
    • Finnegan A, Kaplan CD, Cao Y, et al.: Collagen-induced arthritis is exacerbated in IL-10-deficient mice. Arthritis Res Ther 2003, 5: R18-R24.
    • (2003) Arthritis Res Ther , vol.5
    • Finnegan, A.1    Kaplan, C.D.2    Cao, Y.3
  • 76
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy MJ, Bak-Jensen KS, Chen Y, et al.: TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 2007, 8: 1390-1397.
    • (2007) Nat Immunol , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1    Bak-Jensen, K.S.2    Chen, Y.3
  • 77
    • 0034040902 scopus 로고    scopus 로고
    • Reduced expression of the regulatory CD4+ T cell subset is related to Th1/Th2 balance and disease severity in rheumatoid arthritis
    • Yudoh K, Matsuno H, Nakazawa F, et al.: Reduced expression of the regulatory CD4+ T cell subset is related to Th1/Th2 balance and disease severity in rheumatoid arthritis. Arthritis Rheum 2000, 43: 617-627.
    • (2000) Arthritis Rheum , vol.43 , pp. 617-627
    • Yudoh, K.1    Matsuno, H.2    Nakazawa, F.3
  • 78
    • 0028226993 scopus 로고
    • Immunoregulatory role of interleukin 10 in rheumatoid arthritis
    • Katsikis PD, Chu CQ, Brennan FM, et al.: Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med 1994, 179: 1517-1527.
    • (1994) J Exp Med , vol.179 , pp. 1517-1527
    • Katsikis, P.D.1    Chu, C.Q.2    Brennan, F.M.3
  • 79
    • 0028813787 scopus 로고
    • Elevated interleukin-10 levels in patients with rheumatoid arthritis
    • Cush JJ, Splawski JB, Thomas R, et al.: Elevated interleukin-10 levels in patients with rheumatoid arthritis. Arthritis Rheum 1995, 38: 96-104.
    • (1995) Arthritis Rheum , vol.38 , pp. 96-104
    • Cush, J.J.1    Splawski, J.B.2    Thomas, R.3
  • 80
    • 10344229958 scopus 로고    scopus 로고
    • Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis
    • van Bilsen JH, van Dongen H, Lard LR, et al.: Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis. Proc Natl Acad Sci U S A 2004, 101: 17180-17185.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 17180-17185
    • van Bilsen, J.H.1    van Dongen, H.2    Lard, L.R.3
  • 81
    • 33846196712 scopus 로고    scopus 로고
    • IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes
    • Peluso I, Fantini MC, Fina D, et al.: IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes. J Immunol 2007, 178: 732-739.
    • (2007) J Immunol , vol.178 , pp. 732-739
    • Peluso, I.1    Fantini, M.C.2    Fina, D.3
  • 82
    • 33749552196 scopus 로고    scopus 로고
    • Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis
    • Li J, Shen W, Kong K, Liu Z: Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis. Scand J Immunol 2006, 64: 515-522.
    • (2006) Scand J Immunol , vol.64 , pp. 515-522
    • Li, J.1    Shen, W.2    Kong, K.3    Liu, Z.4
  • 83
    • 0346969978 scopus 로고    scopus 로고
    • Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25-T cells
    • Walker MR, Kasprowicz DJ, Gersuk VH, et al.: Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25-T cells. J Clin Invest 2003, 112: 1437-1443.
    • (2003) J Clin Invest , vol.112 , pp. 1437-1443
    • Walker, M.R.1    Kasprowicz, D.J.2    Gersuk, V.H.3
  • 84
    • 34547214205 scopus 로고    scopus 로고
    • Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
    • Roncarolo MG, Battaglia M: Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nat Rev Immunol 2007, 7: 585-598.
    • (2007) Nat Rev Immunol , vol.7 , pp. 585-598
    • Roncarolo, M.G.1    Battaglia, M.2


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