The presence of cytokine-suppressive CD4+CD25+ T cells in the peripheral blood and synovial fluid of patients with rheumatoid arthritis

Scandinavian Journal of Immunology

Volumn 62, Issue 3, 2005, Pages 312-317

  Liu, M F ^a,b   Wang, C R ^a   Fung, L L ^a   Lin, L H ^a   Tsai, C N ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; AUTOIMMUNE DISEASE; BLOOD LEVEL; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; PATHOGENESIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; STATISTICAL SIGNIFICANCE; SYNOVIAL FLUID; SYNOVIAL FLUID LEVEL; SYNOVIUM; T LYMPHOCYTE;

ARTHRITIS, RHEUMATOID; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; HUMANS; IMMUNE TOLERANCE; MALE; RECEPTORS, INTERLEUKIN-2; SYNOVIAL FLUID;

EID: 26244456364     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2005.01656.x     Document Type: Article

References (33)

1. + regulatory T cells in autoimmunity and allergy. Curr Opin Immunol 2002;14:771-8.
2. Shevach EM. Regulatory T cells in autoimmunity. Annu Rev Immunol 2000;18:423-49.
3. Sakaguchi S, Sakaguchi N, Asano M et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-64.
4. Asano M, Toda M, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T-cell subpopulation. J Exp Med 1996;184:387-96.
5. + immunoregulatory T cells suppress polycolonal T-cell activation in vitro by inhibiting interlukin-2 production. J Exp Med 1998;188:287-96.
6. + naturally anergic and suppressive T cells. Int Immunol 1998;10:1969-80.
7. +CD45Rblow T cells: a population of T cells with immune regulatory activities. Eur J Immunol 1998;28:3453-47.
8. Nishizuka Y, Sakakura T. Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science 1969;166:753-5.
9. Kojima A, Tanaka-Kojima Y, Sakakura T et al. Prevention of postthymectomy autoimmune thyroidtis in mice. Lab Invest 1976;34:601-5.
10. Kojima A, Taguchi O, Nishizuka Y. Experimental production of possible autoimmune gastritis followed by macrocytic anemia in athymic nude mice. Lab Invest 1980;42:387-95.
11. Sakaguchi S, Takahashi T, Nishizuka Y. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocyte damage after adoptive transfer. J Exp Med 1982;156:1565-76.
12. Sakaguchi S, Takahasi T, Nishizuka Y. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J Exp Med 1982;156:1577-86.
13. + cells: a naturally occurring population of regulatory T cells. Blood 2001;98:2736-44.
14. + T Cells with regulatory properties from human blood. J Exp Med 2001;193:1303-1.
15. + regulatory cells in human peripheral blood. J Immunol 2001;167:1245-53.
16. + T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001;193:1285-94.
17. + thymocytes and peripheral T cells have immune suppressive activity. Eur J Immunol 2001;31:1247-54.
18. + T cells in patients with systemic lupus erythematosus. Scand J Immunol 2004;59:198-202.
19. + T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int Immunol 2000;12:1145-55.
20. Morgan ME, Sutmuller RPM, Witteveen HJ et al. CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum 2003;48:1452-60.
21. + T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol 2003;33:215-33.
22. Ehrenstein MR, Evans JG, Singh A et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF-α therapy. J Exp Med 2004;200:277-85.
23. Cao D, van Vollenhoven R, Klareskog L, Trollmo C, Malmstrom V. CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther 2004;6:R335-46.
24. Annacker O, Burlen-Defranoux O, Pimenta-Araujo R, Cumano A, Bandeira A. Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment. J Immunol 2000;164:3573-80.
25. Asseman C, Mauze S, Leach MW et al. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999;190:995-1004.
26. + T cells. J Exp Med 1996;183:2669-74.
27. Chen Y, Kuchroo VK, Inobe J et al. Regulatory T cell colonies induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994;265:1237-40.
28. + immunoregulatory cells. J Immunol 2001;167:1137-40.
29. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000;192:303-10.
30. Read S, Malmstrom V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD4+CD25+ regulatory cells that control intestinal role inflammation. J Exp Med 2000;192:295-302.
31. Feldman M, Brennan FM, Maini RN. Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 1996;43:28-38.
32. Moreland LW, Schiff MH, Baumgartner SW et al. Etanercept therapy in rheumatoid arthritis: a randomized controlled trial. Ann Intern Med 1999;130:478-86.
33. Bresnihan B, Alvaro-Garcia JM, Cobby M et al. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 1998;41:2196-204.