-
1
-
-
3242882820
-
PI3-kinase related kinases: 'big' players in stress-induced signaling pathways
-
Abraham, R. T. (2004). PI3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair 3, 883-887.
-
(2004)
DNA Repair
, vol.3
, pp. 883-887
-
-
Abraham, R.T.1
-
2
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham, R. T. (2001). Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177-2196.
-
(2001)
Genes Dev
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
3
-
-
0029993122
-
Alteration of cell cycle-dependent histone phosphorylations by okadaic acid. Induction of mitosis-specific H3 phosphorylation and chromatin condensation in mammalian interphase cells
-
Ajiro, K., Yoda, K., Utsumi, K., and Nishikawa, Y. (1996). Alteration of cell cycle-dependent histone phosphorylations by okadaic acid. Induction of mitosis-specific H3 phosphorylation and chromatin condensation in mammalian interphase cells. J. Biol. Chem. 271, 13, 197-13201.
-
(1996)
J. Biol. Chem
, vol.271
, Issue.13
, pp. 197-13201
-
-
Ajiro, K.1
Yoda, K.2
Utsumi, K.3
Nishikawa, Y.4
-
4
-
-
33745763425
-
Regulation of mitotic entry by microcephalin and its overlap with ATR signalling
-
Alderton, G. K., Galbiati, L., Griffith, E., Surinya, K. H., Neitzel, H., Jackson, A. P., Jeggo, P. A., and O'Driscoll, M. (2006). Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nat. Cell Biol. 8, 725-733.
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 725-733
-
-
Alderton, G.K.1
Galbiati, L.2
Griffith, E.3
Surinya, K.H.4
Neitzel, H.5
Jackson, A.P.6
Jeggo, P.A.7
O'Driscoll, M.8
-
5
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist, C. J. and Kastan, M. B. (2003). DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
6
-
-
0035869118
-
Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells
-
Balajee, A. S. and Geard, C. R. (2001). Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells. Nucleic Acids Res. 29, 1341-1351.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 1341-1351
-
-
Balajee, A.S.1
Geard, C.R.2
-
7
-
-
5044220936
-
Checking on DNA damage in S phase
-
Bartek, J., Lukas, C., and Lukas, J. (2004). Checking on DNA damage in S phase. Nat. Rev. Mol. Cell Biol. 5, 792-804.
-
(2004)
Nat. Rev. Mol. Cell Biol
, vol.5
, pp. 792-804
-
-
Bartek, J.1
Lukas, C.2
Lukas, J.3
-
8
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
Bartkova, J. et al. (2006). Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444, 633-637.
-
(2006)
Nature
, vol.444
, pp. 633-637
-
-
Bartkova, J.1
-
9
-
-
33745186920
-
Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells
-
Biton, S., Dar, I., Mittelman, L., Pereg, Y., Barzilai, A., and Shiloh, Y. (2006). Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells. J. Biol. Chem. 281, 17482-17491.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 17482-17491
-
-
Biton, S.1
Dar, I.2
Mittelman, L.3
Pereg, Y.4
Barzilai, A.5
Shiloh, Y.6
-
10
-
-
0035163108
-
DNA repair and mutagenesis in Werner syndrome
-
Bohr, V. A., Souza, P. N., Nyaga, S. G., Dianov, G., Kraemer, K., Seidman, M. M., and Brosh, R. M., Jr. (2001). DNA repair and mutagenesis in Werner syndrome. Environ. Mol. Mutagen. 38, 227-234.
-
(2001)
Environ. Mol. Mutagen
, vol.38
, pp. 227-234
-
-
Bohr, V.A.1
Souza, P.N.2
Nyaga, S.G.3
Dianov, G.4
Kraemer, K.5
Seidman, M.M.6
Brosh Jr., R.M.7
-
11
-
-
9744284973
-
ATM is required for the cellular response to thymidine induced replication fork stress
-
Bolderson, E., Scorah, J., Helleday, T., Smythe, C., and Meuth, M. (2004). ATM is required for the cellular response to thymidine induced replication fork stress. Hum. Mol. Genet. 13, 2937-2945.
-
(2004)
Hum. Mol. Genet
, vol.13
, pp. 2937-2945
-
-
Bolderson, E.1
Scorah, J.2
Helleday, T.3
Smythe, C.4
Meuth, M.5
-
12
-
-
0040436076
-
Functional and physical interaction between WRN helicase and human replication protein A
-
Brosh, R. M., Jr., Orren, D. K., Nehlin, J. O., Ravn, P. H., Kenny, M. K., Machwe, A., and Bohr, V. A. (1999). Functional and physical interaction between WRN helicase and human replication protein A. J. Biol. Chem. 274, 18341-18350.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 18341-18350
-
-
Brosh Jr., R.M.1
Orren, D.K.2
Nehlin, J.O.3
Ravn, P.H.4
Kenny, M.K.5
Machwe, A.6
Bohr, V.A.7
-
13
-
-
33645532464
-
Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
-
Bryant, H. E., and Helleday, T. (2006). Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Res. 34, 1685-1691.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 1685-1691
-
-
Bryant, H.E.1
Helleday, T.2
-
14
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., and Helleday, T. (2005). Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434, 913-917.
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
Parker, K.M.4
Flower, D.5
Lopez, E.6
Kyle, S.7
Meuth, M.8
Curtin, N.J.9
Helleday, T.10
-
15
-
-
33646937737
-
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links
-
Cheng, W. H., Kusumoto, R., Opresko, P. L., Sui, X., Huang, S., Nicolette, M. L., Paull, T. T., Campisi, J., Seidman, M., and Bohr, V. A. (2006). Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res. 34, 2751-2760.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 2751-2760
-
-
Cheng, W.H.1
Kusumoto, R.2
Opresko, P.L.3
Sui, X.4
Huang, S.5
Nicolette, M.L.6
Paull, T.T.7
Campisi, J.8
Seidman, M.9
Bohr, V.A.10
-
16
-
-
14244255612
-
Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1
-
Cheng, W. H., Sakamoto, S., Fox, J. T., Komatsu, K., Carney, J., and Bohr, V. A. (2005). Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1. FEBS Lett. 579, 1350-1356.
-
(2005)
FEBS Lett
, vol.579
, pp. 1350-1356
-
-
Cheng, W.H.1
Sakamoto, S.2
Fox, J.T.3
Komatsu, K.4
Carney, J.5
Bohr, V.A.6
-
17
-
-
2442660468
-
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1
-
Cheng, W. H., von Kobbe, C., Opresko, P. L., Arthur, L. M., Komatsu, K., Seidman, M. M., Carney, J. P., and Bohr, V. A. (2004). Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. J. Biol. Chem. 279, 21169-21176.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 21169-21176
-
-
Cheng, W.H.1
von Kobbe, C.2
Opresko, P.L.3
Arthur, L.M.4
Komatsu, K.5
Seidman, M.M.6
Carney, J.P.7
Bohr, V.A.8
-
18
-
-
0041690966
-
Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution
-
Cheng, W. H., von Kobbe, C., Opresko, P. L., Fields, K. M., Ren, J., Kufe, D., and Bohr, V. A. (2003). Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Mol. Cell. Biol. 23, 6385-6395.
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 6385-6395
-
-
Cheng, W.H.1
von Kobbe, C.2
Opresko, P.L.3
Fields, K.M.4
Ren, J.5
Kufe, D.6
Bohr, V.A.7
-
19
-
-
3242876404
-
Ataxia-telangiectasia, an evolving phenotype
-
Chun, H. H. and Gatti, R. A. (2004). Ataxia-telangiectasia, an evolving phenotype. DNA Repair 3, 1187-1196.
-
(2004)
DNA Repair
, vol.3
, pp. 1187-1196
-
-
Chun, H.H.1
Gatti, R.A.2
-
20
-
-
0034231844
-
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest
-
Constantinou, A., Tarsounas, M., Karow, J. K., Brosh, R. M., Bohr, V. A., Hickson, I. D., and West, S. C. (2000). Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest. EMBO Rep. 1, 80-84.
-
(2000)
EMBO Rep
, vol.1
, pp. 80-84
-
-
Constantinou, A.1
Tarsounas, M.2
Karow, J.K.3
Brosh, R.M.4
Bohr, V.A.5
Hickson, I.D.6
West, S.C.7
-
21
-
-
10344256183
-
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity
-
Crabbe, L., Verdun, R. E., Haggblom, C. I., and Karlseder, J. (2004). Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306, 1951-1953.
-
(2004)
Science
, vol.306
, pp. 1951-1953
-
-
Crabbe, L.1
Verdun, R.E.2
Haggblom, C.I.3
Karlseder, J.4
-
22
-
-
33344464960
-
ATM regulates ATR chromatin loading in response to DNA double-strand breaks
-
Cuadrado, M., Martinez-Pastor, B., Murga, M., Toledo, L. I., Gutierrez-Martinez, P., Lopez, E., and Fernandez-Capetillo, O. (2006). ATM regulates ATR chromatin loading in response to DNA double-strand breaks. J. Exp. Med. 203, 297-303.
-
(2006)
J. Exp. Med
, vol.203
, pp. 297-303
-
-
Cuadrado, M.1
Martinez-Pastor, B.2
Murga, M.3
Toledo, L.I.4
Gutierrez-Martinez, P.5
Lopez, E.6
Fernandez-Capetillo, O.7
-
23
-
-
17144395509
-
ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation
-
Davalos, A. R., Kaminker, P., Hansen, R. K., and Campisi, J. (2004). ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation. Cell Cycle 3, 1579-1586.
-
(2004)
Cell Cycle
, vol.3
, pp. 1579-1586
-
-
Davalos, A.R.1
Kaminker, P.2
Hansen, R.K.3
Campisi, J.4
-
24
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer, H. et al.. (2005). Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917-921.
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
-
25
-
-
0033957793
-
The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci
-
Frei, C. and Gasser, S. M. (2000). The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci. Genes Dev. 14, 81-96.
-
(2000)
Genes Dev
, vol.14
, pp. 81-96
-
-
Frei, C.1
Gasser, S.M.2
-
26
-
-
0034125103
-
Role for ATM in DNA damage-induced phosphorylation of BRCA1
-
Gatei, M., Scott, S. P., Filippovitch, I., Soronika, N., Lavin, M. F., Weber, B., and Khanna, K. K. (2000). Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Res. 60, 3299-3304.
-
(2000)
Cancer Res
, vol.60
, pp. 3299-3304
-
-
Gatei, M.1
Scott, S.P.2
Filippovitch, I.3
Soronika, N.4
Lavin, M.F.5
Weber, B.6
Khanna, K.K.7
-
27
-
-
0038013782
-
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
-
Gatei, M. et al.. (2003). Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J. Biol. Chem. 278, 14806-14811.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 14806-14811
-
-
Gatei, M.1
-
28
-
-
0037468169
-
MDC1 is required for the intra-S-phase DNA damage checkpoint
-
Goldberg, M., Stucki, M., Falck, J., D'Amours, D., Rahman, D., Pappin, D., Bartek, J., and Jackson, S. P. (2003). MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 421, 952-956.
-
(2003)
Nature
, vol.421
, pp. 952-956
-
-
Goldberg, M.1
Stucki, M.2
Falck, J.3
D'Amours, D.4
Rahman, D.5
Pappin, D.6
Bartek, J.7
Jackson, S.P.8
-
29
-
-
0030751354
-
The Werner syndrome protein is a DNA helicase
-
Gray, M. D., Shen, J. C., Kamath-Loeb, A. S., Blank, A., Sopher, B. L., Martin, G. M., Oshima, J., and Loeb, L. A. (1997). The Werner syndrome protein is a DNA helicase. Nat. Genet. 17, 100-103.
-
(1997)
Nat. Genet
, vol.17
, pp. 100-103
-
-
Gray, M.D.1
Shen, J.C.2
Kamath-Loeb, A.S.3
Blank, A.4
Sopher, B.L.5
Martin, G.M.6
Oshima, J.7
Loeb, L.A.8
-
30
-
-
0031686571
-
The premature ageing syndrome protein, WRN, is a 3′ → 5′ exonuclease
-
Huang, S., Li, B., Gray, M. D., Oshima, J., Mian, I. S., and Campisi, J. (1998). The premature ageing syndrome protein, WRN, is a 3′ → 5′ exonuclease. Nat. Genet. 20, 114-116.
-
(1998)
Nat. Genet
, vol.20
, pp. 114-116
-
-
Huang, S.1
Li, B.2
Gray, M.D.3
Oshima, J.4
Mian, I.S.5
Campisi, J.6
-
31
-
-
9244252580
-
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
-
Huyen, Y., Zgheib, O., Ditullio, R. A., Jr., Gorgoulis, V. G., Zacharatos, P., Petty, T. J., Sheston, E. A., Mellert, H. S., Stavridi, E. S., and Halazonetis, T. D. (2004). Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432, 406-411.
-
(2004)
Nature
, vol.432
, pp. 406-411
-
-
Huyen, Y.1
Zgheib, O.2
Ditullio Jr., R.A.3
Gorgoulis, V.G.4
Zacharatos, P.5
Petty, T.J.6
Sheston, E.A.7
Mellert, H.S.8
Stavridi, E.S.9
Halazonetis, T.D.10
-
32
-
-
33744754369
-
Inhibition of DNA synthesis by ionizing radiation: A marker for an S-phase checkpoint
-
Jaspers, N. G., and Zdzienicka, M. Z. (2006). Inhibition of DNA synthesis by ionizing radiation: a marker for an S-phase checkpoint. Methods Mol. Biol. 314, 51-59.
-
(2006)
Methods Mol. Biol
, vol.314
, pp. 51-59
-
-
Jaspers, N.G.1
Zdzienicka, M.Z.2
-
33
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C., Lukas, J., and Jackson, S. P. (2006). ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 8, 37-45.
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.5
Lukas, J.6
Jackson, S.P.7
-
34
-
-
25144471062
-
Cellular dynamics and modulation of WRN protein is DNA damage specific
-
Karmakar, P., and Bohr, V. A. (2005). Cellular dynamics and modulation of WRN protein is DNA damage specific. Mech. Ageing Dev. 126, 1146-1158.
-
(2005)
Mech. Ageing Dev
, vol.126
, pp. 1146-1158
-
-
Karmakar, P.1
Bohr, V.A.2
-
35
-
-
0036500555
-
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
-
Kim, S. T., Xu, B., and Kastan, M. B. (2002). Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 16, 560-570.
-
(2002)
Genes Dev
, vol.16
, pp. 560-570
-
-
Kim, S.T.1
Xu, B.2
Kastan, M.B.3
-
36
-
-
2942687831
-
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
-
Kitagawa, R., Bakkenist, C. J., McKinnon, P. J., and Kastan, M. B. (2004). Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 18, 1423-1438.
-
(2004)
Genes Dev
, vol.18
, pp. 1423-1438
-
-
Kitagawa, R.1
Bakkenist, C.J.2
McKinnon, P.J.3
Kastan, M.B.4
-
37
-
-
33747614605
-
Involvement of novel autophosphorylation sites in ATM activation
-
Kozlov, S. V., Graham, M. E., Peng, C., Chen, P., Robinson, P. J., and Lavin, M. F. (2006). Involvement of novel autophosphorylation sites in ATM activation. EMBO J 25, 3504-3514.
-
(2006)
EMBO J
, vol.25
, pp. 3504-3514
-
-
Kozlov, S.V.1
Graham, M.E.2
Peng, C.3
Chen, P.4
Robinson, P.J.5
Lavin, M.F.6
-
38
-
-
33644905252
-
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks
-
Kruhlak, M. J., Celeste, A., Dellaire, G., Fernandez-Capetillo, O., Muller, W. G., McNally, J. G., Bazett-Jones, D. P., and Nussenzweig, A. (2006). Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J. Cell Biol. 172, 823-834.
-
(2006)
J. Cell Biol
, vol.172
, pp. 823-834
-
-
Kruhlak, M.J.1
Celeste, A.2
Dellaire, G.3
Fernandez-Capetillo, O.4
Muller, W.G.5
McNally, J.G.6
Bazett-Jones, D.P.7
Nussenzweig, A.8
-
39
-
-
27144551710
-
Accumulation of Werner protein at DNA double-strand breaks in human cells
-
Lan, L., Nakajima, S., Komatsu, K., Nussenzweig, A., Shimamoto, A., Oshima, J., and Yasui, A. (2005). Accumulation of Werner protein at DNA double-strand breaks in human cells. J. Cell Sci. 118, 4153-4162.
-
(2005)
J. Cell Sci
, vol.118
, pp. 4153-4162
-
-
Lan, L.1
Nakajima, S.2
Komatsu, K.3
Nussenzweig, A.4
Shimamoto, A.5
Oshima, J.6
Yasui, A.7
-
40
-
-
27644443332
-
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway
-
Laud, P. R., Multani, A. S., Bailey, S. M., Wu, L., Ma, J., Kingsley, C., Lebel, M., Pathak, S., DePinho, R. A., and Chang, S. (2005). Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev. 19, 2560-2570.
-
(2005)
Genes Dev
, vol.19
, pp. 2560-2570
-
-
Laud, P.R.1
Multani, A.S.2
Bailey, S.M.3
Wu, L.4
Ma, J.5
Kingsley, C.6
Lebel, M.7
Pathak, S.8
DePinho, R.A.9
Chang, S.10
-
41
-
-
0033621354
-
The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I
-
Lebel, M., Spillare, E. A., Harris, C. C., and Leder, P. (1999). The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J. Biol. Chem. 274, 37795-37799.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 37795-37799
-
-
Lebel, M.1
Spillare, E.A.2
Harris, C.C.3
Leder, P.4
-
42
-
-
17644409069
-
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
-
Lee, J. H. and Paull, T. T. (2005). ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308, 551-554.
-
(2005)
Science
, vol.308
, pp. 551-554
-
-
Lee, J.H.1
Paull, T.T.2
-
43
-
-
19944432787
-
Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase
-
Liberi, G., Maffioletti, G., Lucca, C., Chiolo, I., Baryshnikova, A., Cotta-Ramusino, C., Lopes, M., Pellicioli, A., Haber, J. E., and Foiani, M. (2005). Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes Dev. 19, 339-350.
-
(2005)
Genes Dev
, vol.19
, pp. 339-350
-
-
Liberi, G.1
Maffioletti, G.2
Lucca, C.3
Chiolo, I.4
Baryshnikova, A.5
Cotta-Ramusino, C.6
Lopes, M.7
Pellicioli, A.8
Haber, J.E.9
Foiani, M.10
-
44
-
-
30744465308
-
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
-
Lou, Z. et al.. (2006). MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol. Cell 21, 187-200.
-
(2006)
Mol. Cell
, vol.21
, pp. 187-200
-
-
Lou, Z.1
-
45
-
-
0036316015
-
Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells
-
Lundin, C., Erixon, K., Arnaudeau, C., Schultz, N., Jenssen, D., Meuth, M., and Helleday, T. (2002). Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells. Mol. Cell. Biol. 22, 5869-5878.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 5869-5878
-
-
Lundin, C.1
Erixon, K.2
Arnaudeau, C.3
Schultz, N.4
Jenssen, D.5
Meuth, M.6
Helleday, T.7
-
46
-
-
17344367023
-
Targeted gene knockout mediated by triple helix forming oligonucleotides
-
Majumdar, A. et al. (1998). Targeted gene knockout mediated by triple helix forming oligonucleotides. Nat. Genet. 20, 212-214.
-
(1998)
Nat. Genet
, vol.20
, pp. 212-214
-
-
Majumdar, A.1
-
47
-
-
2442531966
-
Junction of RecQ helicase biochemistry and human disease
-
Opresko, P. L., Cheng, W. H., and Bohr, V. A. (2004a). Junction of RecQ helicase biochemistry and human disease. J. Biol. Chem. 279, 18099-18102.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 18099-18102
-
-
Opresko, P.L.1
Cheng, W.H.2
Bohr, V.A.3
-
48
-
-
2942637828
-
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
-
Opresko, P. L., Otterlei, M., Graakjaer, J., Bruheim, P., Dawut, L., Kolvraa, S., May, A., Seidman, M. M., and Bohr, V. A. (2004b). The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol. Cell 14, 763-774.
-
(2004)
Mol. Cell
, vol.14
, pp. 763-774
-
-
Opresko, P.L.1
Otterlei, M.2
Graakjaer, J.3
Bruheim, P.4
Dawut, L.5
Kolvraa, S.6
May, A.7
Seidman, M.M.8
Bohr, V.A.9
-
49
-
-
1842576658
-
The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways
-
Pichierri, P., and Rosselli, F. (2004). The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. EMBO J. 23, 1178-1187.
-
(2004)
EMBO J
, vol.23
, pp. 1178-1187
-
-
Pichierri, P.1
Rosselli, F.2
-
50
-
-
0037435026
-
Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle
-
Pichierri, P., Rosselli, F., and Franchitto, A. (2003). Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle. Oncogene 22, 1491-1500.
-
(2003)
Oncogene
, vol.22
, pp. 1491-1500
-
-
Pichierri, P.1
Rosselli, F.2
Franchitto, A.3
-
51
-
-
10744233671
-
Repair of and checkpoint response to topoisomerase I-mediated DNA damage
-
Pommier, Y. et al. (2003). Repair of and checkpoint response to topoisomerase I-mediated DNA damage. Mutat. Res. 532, 173-203.
-
(2003)
Mutat. Res
, vol.532
, pp. 173-203
-
-
Pommier, Y.1
-
52
-
-
0036581178
-
Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: Implications for the disease phenotype
-
Poot, M., Gollahon, K. A., Emond, M. J., Silber, J. R., and Rabinovitch, P. S. (2002). Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype. FASEB J. 16, 757-758.
-
(2002)
FASEB J
, vol.16
, pp. 757-758
-
-
Poot, M.1
Gollahon, K.A.2
Emond, M.J.3
Silber, J.R.4
Rabinovitch, P.S.5
-
53
-
-
0026702210
-
Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
-
Poot, M., Hoehn, H., Runger, T. M., and Martin, G. M. (1992). Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp. Cell Res. 202, 267-273.
-
(1992)
Exp. Cell Res
, vol.202
, pp. 267-273
-
-
Poot, M.1
Hoehn, H.2
Runger, T.M.3
Martin, G.M.4
-
54
-
-
0035349905
-
Werner syndrome cells are sensitive to DNA cross-linking drugs
-
Poot, M., Yom, J. S., Whang, S. H., Kato, J. T., Gollahon, K. A., and Rabinovitch, P. S. (2001). Werner syndrome cells are sensitive to DNA cross-linking drugs. FASEB J. 15, 1224-1226.
-
(2001)
FASEB J
, vol.15
, pp. 1224-1226
-
-
Poot, M.1
Yom, J.S.2
Whang, S.H.3
Kato, J.T.4
Gollahon, K.A.5
Rabinovitch, P.S.6
-
55
-
-
0035871341
-
Loss of Werner syndrome protein function promotes aberrant mitotic recombination
-
Prince, P. R., Emond, M. J., and Monnat, R. J., Jr. (2001). Loss of Werner syndrome protein function promotes aberrant mitotic recombination. Genes Dev. 15, 933-938.
-
(2001)
Genes Dev
, vol.15
, pp. 933-938
-
-
Prince, P.R.1
Emond, M.J.2
Monnat Jr., R.J.3
-
56
-
-
0347624597
-
Repair kinetics of genomic interstrand DNA cross-links: Evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway
-
Rothfuss, A., and Grompe, M. (2004). Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. Mol. Cell. Biol. 24, 123-134.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 123-134
-
-
Rothfuss, A.1
Grompe, M.2
-
57
-
-
0036787870
-
Homologous recombination resolution defect in werner syndrome
-
Saintigny, Y., Makienko, K., Swanson, C., Emond, M. J., and Monnat, R. J., Jr. (2002). Homologous recombination resolution defect in werner syndrome. Mol. Cell. Biol. 22, 6971-6978.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 6971-6978
-
-
Saintigny, Y.1
Makienko, K.2
Swanson, C.3
Emond, M.J.4
Monnat Jr., R.J.5
-
58
-
-
23344444636
-
Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
-
Saleh-Gohari, N., Bryant, H. E., Schultz, N., Parker, K. M., Cassel, T. N., and Helleday, T. (2005). Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol. Cell. Biol. 25, 7158-7169.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 7158-7169
-
-
Saleh-Gohari, N.1
Bryant, H.E.2
Schultz, N.3
Parker, K.M.4
Cassel, T.N.5
Helleday, T.6
-
59
-
-
0034739853
-
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
-
Schultz, L. B., Chehab, N. H., Malikzay, A., and Halazonetis, T. D. (2000). p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J. Cell Biol. 151, 1381-1390.
-
(2000)
J. Cell Biol
, vol.151
, pp. 1381-1390
-
-
Schultz, L.B.1
Chehab, N.H.2
Malikzay, A.3
Halazonetis, T.D.4
-
60
-
-
3242670803
-
ATR and ATM regulate the timing of DNA replication origin firing
-
Shechter, D., Costanzo, V., and Gautier, J. (2004a). ATR and ATM regulate the timing of DNA replication origin firing. Nat. Cell Biol. 6, 648-655.
-
(2004)
Nat. Cell Biol
, vol.6
, pp. 648-655
-
-
Shechter, D.1
Costanzo, V.2
Gautier, J.3
-
61
-
-
3242708425
-
Regulation of DNA replication by ATR: Signaling in response to DNA intermediates
-
Shechter, D., Costanzo, V., and Gautier, J. (2004b). Regulation of DNA replication by ATR: signaling in response to DNA intermediates. DNA Repair 3, 901-908.
-
(2004)
DNA Repair
, vol.3
, pp. 901-908
-
-
Shechter, D.1
Costanzo, V.2
Gautier, J.3
-
62
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh, Y. (2003). ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3, 155-168.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
63
-
-
33745823159
-
The ATM-mediated DNA-damage response: Taking shape
-
Shiloh, Y. (2006). The ATM-mediated DNA-damage response: taking shape. Trends Biochem. Sci. 31, 402-410.
-
(2006)
Trends Biochem. Sci
, vol.31
, pp. 402-410
-
-
Shiloh, Y.1
-
64
-
-
0030994386
-
rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
-
Stewart, E., Chapman, C. R., Al-Khodairy, F., Carr, A. M., and Enoch, T. (1997). rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J. 16, 2682-2692.
-
(1997)
EMBO J
, vol.16
, pp. 2682-2692
-
-
Stewart, E.1
Chapman, C.R.2
Al-Khodairy, F.3
Carr, A.M.4
Enoch, T.5
-
65
-
-
33845715977
-
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
-
Stiff, T., Walker, S. A., Cerosaletti, K., Goodarzi, A. A., Petermann, E., Concannon, P., O'Driscoll, M., and Jeggo, P. A. (2006). ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J. 25, 5775-5782.
-
(2006)
EMBO J
, vol.25
, pp. 5775-5782
-
-
Stiff, T.1
Walker, S.A.2
Cerosaletti, K.3
Goodarzi, A.A.4
Petermann, E.5
Concannon, P.6
O'Driscoll, M.7
Jeggo, P.A.8
-
66
-
-
3242891189
-
The Mre11 complex and the metabolism of chromosome breaks: The importance of communicating and holding things together
-
Stracker, T. H., Theunissen, J. W., Morales, M., and Petrini, J. H. (2004). The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. DNA Repair 3, 845-854.
-
(2004)
DNA Repair
, vol.3
, pp. 845-854
-
-
Stracker, T.H.1
Theunissen, J.W.2
Morales, M.3
Petrini, J.H.4
-
67
-
-
0019979019
-
Altered frequency of initiation sites of DNA replication in Werner's syndrome cells
-
Takeuchi, F., Hanaoka, F., Goto, M., Akaoka, I., Hori, T., Yamada, M., and Miyamoto, T. (1982). Altered frequency of initiation sites of DNA replication in Werner's syndrome cells. Hum. Genet. 60, 365-368.
-
(1982)
Hum. Genet
, vol.60
, pp. 365-368
-
-
Takeuchi, F.1
Hanaoka, F.2
Goto, M.3
Akaoka, I.4
Hori, T.5
Yamada, M.6
Miyamoto, T.7
-
68
-
-
34447648735
-
Werner syndrome protein prevents DNA breaks upon chromatin structure alternation
-
Turaga, R., Massip, L., Chavez, A., Johnson, B., and Lebel, M. (2007). Werner syndrome protein prevents DNA breaks upon chromatin structure alternation. Aging Cell 6, 471-481.
-
(2007)
Aging Cell
, vol.6
, pp. 471-481
-
-
Turaga, R.1
Massip, L.2
Chavez, A.3
Johnson, B.4
Lebel, M.5
-
69
-
-
0037038362
-
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells
-
Tauchi, H. et al. (2002). Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature 420, 93-98.
-
(2002)
Nature
, vol.420
, pp. 93-98
-
-
Tauchi, H.1
-
70
-
-
33646122683
-
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks
-
Trenz, K., Smith, E., Smith, S., and Costanzo, V. (2006). ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J. 25, 1764-1774.
-
(2006)
EMBO J
, vol.25
, pp. 1764-1774
-
-
Trenz, K.1
Smith, E.2
Smith, S.3
Costanzo, V.4
-
71
-
-
0142136826
-
Requirement of the MRN complex for ATM activation by DNA damage
-
Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., and Shiloh, Y. (2003). Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 22, 5612-5621.
-
(2003)
EMBO J
, vol.22
, pp. 5612-5621
-
-
Uziel, T.1
Lerenthal, Y.2
Moyal, L.3
Andegeko, Y.4
Mittelman, L.5
Shiloh, Y.6
-
72
-
-
0347362703
-
Werner syndrome protein contains three structure-specific DNA binding domains
-
von Kobbe, C., Thoma, N. H., Czyzewski, B. K., Pavletich, N. P., and Bohr, V. A. (2003). Werner syndrome protein contains three structure-specific DNA binding domains. J. Biol. Chem. 278, 52997-53006.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 52997-53006
-
-
von Kobbe, C.1
Thoma, N.H.2
Czyzewski, B.K.3
Pavletich, N.P.4
Bohr, V.A.5
-
73
-
-
0035032649
-
Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation
-
Xu, B., Kim, S., and Kastan, M. B. (2001). Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol. Cell. Biol. 21, 3445-3450.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 3445-3450
-
-
Xu, B.1
Kim, S.2
Kastan, M.B.3
-
74
-
-
0031848284
-
Replication focus-forming activity 1 and the Werner syndrome gene product
-
Yan, H., Chen, C. Y., Kobayashi, R., and Newport, J. (1998). Replication focus-forming activity 1 and the Werner syndrome gene product. Nat. Genet. 19, 375-378.
-
(1998)
Nat. Genet
, vol.19
, pp. 375-378
-
-
Yan, H.1
Chen, C.Y.2
Kobayashi, R.3
Newport, J.4
-
75
-
-
0035851181
-
Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase
-
Yannone, S. M., Roy, S., Chan, D. W., Murphy, M. B., Huang, S., Campisi, J., and Chen, D. J. (2001). Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. J. Biol. Chem. 276, 38242-38248.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 38242-38248
-
-
Yannone, S.M.1
Roy, S.2
Chan, D.W.3
Murphy, M.B.4
Huang, S.5
Campisi, J.6
Chen, D.J.7
-
76
-
-
15844409553
-
Positional cloning of the Werner's syndrome gene
-
Yu, C. E. et al. (1996). Positional cloning of the Werner's syndrome gene. Science 272, 258-262.
-
(1996)
Science
, vol.272
, pp. 258-262
-
-
Yu, C.E.1
-
77
-
-
33746601439
-
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
-
Ziv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D. C., Lukas, J., Bekker-Jensen, S., Bartek, J., and Shiloh, Y. (2006). Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat. Cell Biol. 8, 870-876.
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 870-876
-
-
Ziv, Y.1
Bielopolski, D.2
Galanty, Y.3
Lukas, C.4
Taya, Y.5
Schultz, D.C.6
Lukas, J.7
Bekker-Jensen, S.8
Bartek, J.9
Shiloh, Y.10
|