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Volumn 3, Issue 10, 2008, Pages

A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; PROTEIN BNIP3; PROTEIN P53; TELOMERASE REVERSE TRANSCRIPTASE; ANTISENSE OLIGONUCLEOTIDE; HYBRID PROTEIN; TELOMERASE;

EID: 54849434623     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003364     Document Type: Article
Times cited : (45)

References (111)
  • 1
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn EH (2001) Switching and signaling at the telomere. Cell 106: 661-673.
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 2
    • 0033152429 scopus 로고    scopus 로고
    • Telomerase and the maintenance of chromosome ends
    • Bryan TM, Cech TR (1999) Telomerase and the maintenance of chromosome ends. Curr Opin Cell Biol 11: 318-324.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 318-324
    • Bryan, T.M.1    Cech, T.R.2
  • 3
    • 0034606226 scopus 로고    scopus 로고
    • Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals
    • Goytisolo FA, Samper E, Martin-Caballero J, Finnon P, Herrera E, et al. (2000) Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J Exp Med 192: 1625-1636.
    • (2000) J Exp Med , vol.192 , pp. 1625-1636
    • Goytisolo, F.A.1    Samper, E.2    Martin-Caballero, J.3    Finnon, P.4    Herrera, E.5
  • 4
    • 0033822365 scopus 로고    scopus 로고
    • Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
    • Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, et al. (2000) Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet 26: 85-88.
    • (2000) Nat Genet , vol.26 , pp. 85-88
    • Wong, K.K.1    Chang, S.2    Weiler, S.R.3    Ganesan, S.4    Chaudhuri, J.5
  • 5
    • 20444371017 scopus 로고    scopus 로고
    • The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
    • Masutomi K, Possemato R, Wong JM, Currier JL, Tothova Z, et al. (2005) The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci U S A 102: 8222-8227.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 8222-8227
    • Masutomi, K.1    Possemato, R.2    Wong, J.M.3    Currier, J.L.4    Tothova, Z.5
  • 8
    • 0032699279 scopus 로고    scopus 로고
    • Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants
    • Friedman KL, Cech TR (1999) Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes Dev 13: 2863-2874.
    • (1999) Genes Dev , vol.13 , pp. 2863-2874
    • Friedman, K.L.1    Cech, T.R.2
  • 9
    • 0033948026 scopus 로고    scopus 로고
    • Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase
    • Xia J, Peng Y, Mian IS, Lue NF (2000) Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase. Mol Cell Biol 20: 5196-5207.
    • (2000) Mol Cell Biol , vol.20 , pp. 5196-5207
    • Xia, J.1    Peng, Y.2    Mian, I.S.3    Lue, N.F.4
  • 10
    • 0034964393 scopus 로고    scopus 로고
    • Analysis of telomerase processivity: Mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance
    • Peng Y, Mian IS, Lue NF (2001) Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance. Mol Cell 7: 1201-1211.
    • (2001) Mol Cell , vol.7 , pp. 1201-1211
    • Peng, Y.1    Mian, I.S.2    Lue, N.F.3
  • 11
    • 0033790120 scopus 로고    scopus 로고
    • Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding
    • Beattie TL, Zhou W, Robinson MO, Harrington L (2000) Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol Biol Cell 11: 3329-3340.
    • (2000) Mol Biol Cell , vol.11 , pp. 3329-3340
    • Beattie, T.L.1    Zhou, W.2    Robinson, M.O.3    Harrington, L.4
  • 12
    • 0035137710 scopus 로고    scopus 로고
    • Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions
    • Bachand F, Autexier C (2001) Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions. Mol Cell Biol 21: 1888-1897.
    • (2001) Mol Cell Biol , vol.21 , pp. 1888-1897
    • Bachand, F.1    Autexier, C.2
  • 13
    • 0035144580 scopus 로고    scopus 로고
    • RNA binding domain of telomerase reverse transcriptase
    • Lai CK, Mitchell JR, Collins K (2001) RNA binding domain of telomerase reverse transcriptase. Mol Cell Biol 21: 990-1000.
    • (2001) Mol Cell Biol , vol.21 , pp. 990-1000
    • Lai, C.K.1    Mitchell, J.R.2    Collins, K.3
  • 14
    • 0034775749 scopus 로고    scopus 로고
    • N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo
    • Armbruster BN, Banik SS, Guo C, Smith AC, Counter CM (2001) N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. Mol Cell Biol 21: 7775-7786.
    • (2001) Mol Cell Biol , vol.21 , pp. 7775-7786
    • Armbruster, B.N.1    Banik, S.S.2    Guo, C.3    Smith, A.C.4    Counter, C.M.5
  • 15
    • 0033636319 scopus 로고    scopus 로고
    • Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase
    • Bryan TM, Goodrich KJ, Cech TR (2000) Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Mol Cell 6: 493-499.
    • (2000) Mol Cell , vol.6 , pp. 493-499
    • Bryan, T.M.1    Goodrich, K.J.2    Cech, T.R.3
  • 16
    • 0030248792 scopus 로고    scopus 로고
    • Telomerase activity in hematopoietic cells is associated with self-renewal potential
    • Morrison SJ, Prowse KR, Ho P, Weissman IL (1996) Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5: 207-216.
    • (1996) Immunity , vol.5 , pp. 207-216
    • Morrison, S.J.1    Prowse, K.R.2    Ho, P.3    Weissman, I.L.4
  • 18
    • 0037148326 scopus 로고    scopus 로고
    • Clinical utility of telomerase in cancer
    • Hiyama E, Hiyama K (2002) Clinical utility of telomerase in cancer. Oncogene 21: 643-649.
    • (2002) Oncogene , vol.21 , pp. 643-649
    • Hiyama, E.1    Hiyama, K.2
  • 19
    • 5444247905 scopus 로고    scopus 로고
    • Does the reservoir for self-renewal stem from the ends?
    • Harrington L (2004) Does the reservoir for self-renewal stem from the ends? Oncogene 23: 7283-7289.
    • (2004) Oncogene , vol.23 , pp. 7283-7289
    • Harrington, L.1
  • 20
    • 0029040101 scopus 로고
    • Developmental and tissue-specific regulation of mouse telomerase and telomere length
    • Prowse KR, Greider CW (1995) Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci U S A 92: 4818-4822.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 21
    • 0032440892 scopus 로고    scopus 로고
    • Telomerase expression in chickens: Constitutive activity in somatic tissues and down-regulation in culture
    • Venkatesan RN, Price C (1998) Telomerase expression in chickens: constitutive activity in somatic tissues and down-regulation in culture. Proc Natl Acad Sci U S A 95: 14763-14768.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 14763-14768
    • Venkatesan, R.N.1    Price, C.2
  • 23
    • 0038349343 scopus 로고    scopus 로고
    • The zebrafish as a vertebrate model of functional aging and very gradual senescence
    • Kishi S, Uchiyama J, Baughman AM, Goto T, Lin MC, et al. (2003) The zebrafish as a vertebrate model of functional aging and very gradual senescence. Exp Gerontol 38: 777-786.
    • (2003) Exp Gerontol , vol.38 , pp. 777-786
    • Kishi, S.1    Uchiyama, J.2    Baughman, A.M.3    Goto, T.4    Lin, M.C.5
  • 24
    • 0037986212 scopus 로고    scopus 로고
    • Telomerase activity is widespread in adult somatic tissues of Xenopus
    • Bousman S, Schneider G, Shampay J (2003) Telomerase activity is widespread in adult somatic tissues of Xenopus. J Exp Zoolog B Mol Dev Evol 295: 82-86.
    • (2003) J Exp Zoolog B Mol Dev E , vol.295 , pp. 82-86
    • Bousman, S.1    Schneider, G.2    Shampay, J.3
  • 25
    • 0035355340 scopus 로고    scopus 로고
    • Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
    • Gonzalez-Suarez E, Samper E, Ramirez A, Flores JM, Martin-Caballero J, et al. (2001) Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. Embo J 20: 2619-2630.
    • (2001) Embo J , vol.20 , pp. 2619-2630
    • Gonzalez-Suarez, E.1    Samper, E.2    Ramirez, A.3    Flores, J.M.4    Martin-Caballero, J.5
  • 26
    • 0030070054 scopus 로고    scopus 로고
    • Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
    • Blasco MA, Rizen M, Greider CW, Hanahan D (1996) Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nat Genet 12: 200-204.
    • (1996) Nat Genet , vol.12 , pp. 200-204
    • Blasco, M.A.1    Rizen, M.2    Greider, C.W.3    Hanahan, D.4
  • 27
    • 23844540299 scopus 로고    scopus 로고
    • Effects of telomerase and telomere length on epidermal stem cell behavior
    • Flores I, Cayuela ML, Blasco MA (2005) Effects of telomerase and telomere length on epidermal stem cell behavior. Science 309: 1253-1256.
    • (2005) Science , vol.309 , pp. 1253-1256
    • Flores, I.1    Cayuela, M.L.2    Blasco, M.A.3
  • 28
    • 0043026840 scopus 로고    scopus 로고
    • Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells
    • Satyanarayana A, Wiemann SU, Buer J, Lauber J, Dittmar KE, et al. (2003) Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells. Embo J 22: 4003-4013.
    • (2003) Embo J , vol.22 , pp. 4003-4013
    • Satyanarayana, A.1    Wiemann, S.U.2    Buer, J.3    Lauber, J.4    Dittmar, K.E.5
  • 29
    • 23944516520 scopus 로고    scopus 로고
    • Conditional telomerase induction causes proliferation of hair follicle stem cells
    • Sarin KY, Cheung P, Gilison D, Lee E, Tennen RI, et al. (2005) Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 436: 1048-1052.
    • (2005) Nature , vol.436 , pp. 1048-1052
    • Sarin, K.Y.1    Cheung, P.2    Gilison, D.3    Lee, E.4    Tennen, R.I.5
  • 30
    • 0033525558 scopus 로고    scopus 로고
    • Longevity, stress response, and cancer in aging telomerase-deficient mice
    • Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, et al. (1999) Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96: 701-712.
    • (1999) Cell , vol.96 , pp. 701-712
    • Rudolph, K.L.1    Chang, S.2    Lee, H.W.3    Blasco, M.4    Gottlieb, G.J.5
  • 31
    • 38349138949 scopus 로고    scopus 로고
    • Structure and function of the smallest vertebrate telomerase RNA from teleost fish
    • Xie M, Mosig A, Qi X, Li Y, Stadler PF, et al. (2008) Structure and function of the smallest vertebrate telomerase RNA from teleost fish. J Biol Chem 283: 2049-2059.
    • (2008) J Biol Chem , vol.283 , pp. 2049-2059
    • Xie, M.1    Mosig, A.2    Qi, X.3    Li, Y.4    Stadler, P.F.5
  • 32
    • 46649083790 scopus 로고    scopus 로고
    • The teleost Oryzias latipes shows telomere shortening with age despite considerable telomerase activity throughout life
    • Hatakeyama H, Nakamura K, Izumiyama-Shimomura N, Ishii A, Tsuchida S, et al. (2008) The teleost Oryzias latipes shows telomere shortening with age despite considerable telomerase activity throughout life. Mech Ageing Dev 129: 550-557.
    • (2008) Mech Ageing Dev , vol.129 , pp. 550-557
    • Hatakeyama, H.1    Nakamura, K.2    Izumiyama-Shimomura, N.3    Ishii, A.4    Tsuchida, S.5
  • 33
    • 33749189650 scopus 로고    scopus 로고
    • Hypoxia induces telomerase reverse transcriptase (TERT) gene expression in non-tumor fish tissues in vivo: The marine medaka (Oryzias melastigma) model
    • Yu RM, Chen EX, Kong RY, Ng PK, Mok HO, et al. (2006) Hypoxia induces telomerase reverse transcriptase (TERT) gene expression in non-tumor fish tissues in vivo: the marine medaka (Oryzias melastigma) model. BMC Mol Biol 7: 27.
    • (2006) BMC Mol Biol , vol.7 , pp. 27
    • Yu, R.M.1    Chen, E.X.2    Kong, R.Y.3    Ng, P.K.4    Mok, H.O.5
  • 34
    • 46149101976 scopus 로고    scopus 로고
    • Identification of zebrafish LPTS: A gene with similarities to human LPTS/PinX1 that inhibits telomerase activity
    • Sun C, Wu Z, Jia F, Wang Y, Li T, et al. (2008) Identification of zebrafish LPTS: a gene with similarities to human LPTS/PinX1 that inhibits telomerase activity. Gene 420: 90-98.
    • (2008) Gene , vol.420 , pp. 90-98
    • Sun, C.1    Wu, Z.2    Jia, F.3    Wang, Y.4    Li, T.5
  • 35
    • 0036137878 scopus 로고    scopus 로고
    • Telomere shortening and cell fates in mouse models of neoplasia
    • Artandi SE (2002) Telomere shortening and cell fates in mouse models of neoplasia. Trends Mol Med 8: 44-47.
    • (2002) Trends Mol Med , vol.8 , pp. 44-47
    • Artandi, S.E.1
  • 37
    • 0037224923 scopus 로고    scopus 로고
    • Telomere-based crisis: Functional differences between telomerase activation and ALT in tumor progression
    • Chang S, Khoo CM, Naylor ML, Maser RS, DePinho RA (2003) Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev 17: 88-100.
    • (2003) Genes Dev , vol.17 , pp. 88-100
    • Chang, S.1    Khoo, C.M.2    Naylor, M.L.3    Maser, R.S.4    DePinho, R.A.5
  • 39
    • 33644511376 scopus 로고    scopus 로고
    • Telomerase: Not just for the elongation of telomeres
    • Calado RT, Chen J (2006) Telomerase: not just for the elongation of telomeres. Bioessays 28: 109-112.
    • (2006) Bioessays , vol.28 , pp. 109-112
    • Calado, R.T.1    Chen, J.2
  • 40
    • 38949156672 scopus 로고    scopus 로고
    • TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program
    • Choi J, Southworth LK, Sarin KY, Venteicher AS, Ma W, et al. (2008) TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet 4: e10.
    • (2008) PLoS Genet , vol.4
    • Choi, J.1    Southworth, L.K.2    Sarin, K.Y.3    Venteicher, A.S.4    Ma, W.5
  • 41
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, et al. (1997) Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25-34.
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1    Lee, H.W.2    Hande, M.P.3    Samper, E.4    Lansdorp, P.M.5
  • 42
    • 17144420804 scopus 로고    scopus 로고
    • Mice with bad ends: Mouse models for the study of telomeres and telomerase in cancer and aging
    • Blasco MA (2005) Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging. Embo J 24: 1095-1103.
    • (2005) Embo J , vol.24 , pp. 1095-1103
    • Blasco, M.A.1
  • 43
    • 1942437469 scopus 로고    scopus 로고
    • Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice
    • Erdmann N, Liu Y, Harrington L (2004) Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proc Natl Acad Sci U S A 101: 6080-6085.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 6080-6085
    • Erdmann, N.1    Liu, Y.2    Harrington, L.3
  • 44
    • 6544263270 scopus 로고    scopus 로고
    • Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice
    • Yuan X, Ishibashi S, Hatakeyama S, Saito M, Nakayama J, et al. (1999) Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice. Genes Cells 4: 563-572.
    • (1999) Genes Cells , vol.4 , pp. 563-572
    • Yuan, X.1    Ishibashi, S.2    Hatakeyama, S.3    Saito, M.4    Nakayama, J.5
  • 45
    • 17844373798 scopus 로고    scopus 로고
    • The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo
    • Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, et al. (2000) The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol 10: 1459-1462.
    • (2000) Curr Biol , vol.10 , pp. 1459-1462
    • Liu, Y.1    Snow, B.E.2    Hande, M.P.3    Yeung, D.4    Erdmann, N.J.5
  • 46
    • 0037133668 scopus 로고    scopus 로고
    • Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert
    • Liu Y, Kha H, Ungrin M, Robinson MO, Harrington L (2002) Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert. Proc Natl Acad Sci U S A 99: 3597-3602.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 3597-3602
    • Liu, Y.1    Kha, H.2    Ungrin, M.3    Robinson, M.O.4    Harrington, L.5
  • 47
    • 3543010768 scopus 로고    scopus 로고
    • Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo
    • Chiang YJ, Hemann MT, Hathcock KS, Tessarollo L, Feigenbaum L, et al. (2004) Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. Mol Cell Biol 24: 7024-7031.
    • (2004) Mol Cell Biol , vol.24 , pp. 7024-7031
    • Chiang, Y.J.1    Hemann, M.T.2    Hathcock, K.S.3    Tessarollo, L.4    Feigenbaum, L.5
  • 48
    • 22944488871 scopus 로고    scopus 로고
    • Telomeres and human disease: Ageing, cancer and beyond
    • Blasco MA (2005) Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet 6: 611-622.
    • (2005) Nat Rev Genet , vol.6 , pp. 611-622
    • Blasco, M.A.1
  • 49
    • 15944422499 scopus 로고    scopus 로고
    • Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia
    • Yamaguchi H, Calado RT, Ly H, Kajigaya S, Baerlocher GM, et al. (2005) Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med 352: 1413-1424.
    • (2005) N Engl J Med , vol.352 , pp. 1413-1424
    • Yamaguchi, H.1    Calado, R.T.2    Ly, H.3    Kajigaya, S.4    Baerlocher, G.M.5
  • 50
    • 28944455294 scopus 로고    scopus 로고
    • Short telomeres, even in the presence of telomerase, limit tissue renewal capacity
    • Hao LY, Armanios M, Strong MA, Karim B, Feldser DM, et al. (2005) Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. Cell 123: 1121-1131.
    • (2005) Cell , vol.123 , pp. 1121-1131
    • Hao, L.Y.1    Armanios, M.2    Strong, M.A.3    Karim, B.4    Feldser, D.M.5
  • 52
    • 9244224093 scopus 로고    scopus 로고
    • Hematopoietic gene expression profile in zebrafish kidney marrow
    • Song HD, Sun XJ, Deng M, Zhang GW, Zhou Y, et al. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proc Natl Acad Sci U S A 101: 16240-16245.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 16240-16245
    • Song, H.D.1    Sun, X.J.2    Deng, M.3    Zhang, G.W.4    Zhou, Y.5
  • 53
    • 24044480341 scopus 로고    scopus 로고
    • Transcriptional regulation of hematopoietic stem cell development in zebrafish
    • Hsia N, Zon LI (2005) Transcriptional regulation of hematopoietic stem cell development in zebrafish. Exp Hematol 33: 1007-1014.
    • (2005) Exp Hematol , vol.33 , pp. 1007-1014
    • Hsia, N.1    Zon, L.I.2
  • 54
    • 0032760851 scopus 로고    scopus 로고
    • Dissecting hematopoiesis and disease using the zebrafish
    • Amatruda JF, Zon LI (1999) Dissecting hematopoiesis and disease using the zebrafish. Dev Biol 216: 1-15.
    • (1999) Dev Biol , vol.216 , pp. 1-15
    • Amatruda, J.F.1    Zon, L.I.2
  • 55
    • 4344605205 scopus 로고    scopus 로고
    • Zebrafish as a model of human hematologic disorders
    • Shafizadeh E, Paw BH (2004) Zebrafish as a model of human hematologic disorders. Curr Opin Hematol 11: 255-261.
    • (2004) Curr Opin Hematol , vol.11 , pp. 255-261
    • Shafizadeh, E.1    Paw, B.H.2
  • 56
    • 18244401639 scopus 로고    scopus 로고
    • Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodysplastic syndrome
    • Craven SE, French D, Ye W, de Sauvage F, Rosenthal A (2005) Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodysplastic syndrome. Blood 105: 3528-3534.
    • (2005) Blood , vol.105 , pp. 3528-3534
    • Craven, S.E.1    French, D.2    Ye, W.3    de Sauvage, F.4    Rosenthal, A.5
  • 57
    • 22044431919 scopus 로고    scopus 로고
    • Role of telomerase in hematopoietic stem cells
    • Lansdorp PM (2005) Role of telomerase in hematopoietic stem cells. Ann N Y Acad Sci 1044: 220-227.
    • (2005) Ann N Y Acad Sci , vol.1044 , pp. 220-227
    • Lansdorp, P.M.1
  • 58
  • 59
    • 0033153424 scopus 로고    scopus 로고
    • Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
    • Herrera E, Samper E, Martin-Caballero J, Flores JM, Lee HW, et al. (1999) Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. Embo J 18: 2950-2960.
    • (1999) Embo J , vol.18 , pp. 2950-2960
    • Herrera, E.1    Samper, E.2    Martin-Caballero, J.3    Flores, J.M.4    Lee, H.W.5
  • 60
    • 0037413726 scopus 로고    scopus 로고
    • Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation
    • Leri A, Franco S, Zacheo A, Barlucchi L, Chimenti S, et al. (2003) Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation. Embo J 22: 131-139.
    • (2003) Embo J , vol.22 , pp. 131-139
    • Leri, A.1    Franco, S.2    Zacheo, A.3    Barlucchi, L.4    Chimenti, S.5
  • 61
    • 11144263631 scopus 로고    scopus 로고
    • Zebrafish scl functions independently in hematopoietic and endothelial development
    • Dooley KA, Davidson AJ, Zon LI (2005) Zebrafish scl functions independently in hematopoietic and endothelial development. Dev Biol 277: 522-536.
    • (2005) Dev Biol , vol.277 , pp. 522-536
    • Dooley, K.A.1    Davidson, A.J.2    Zon, L.I.3
  • 62
    • 14644394305 scopus 로고    scopus 로고
    • Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos
    • Gering M, Patient R (2005) Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. Dev Cell 8: 389-400.
    • (2005) Dev Cell , vol.8 , pp. 389-400
    • Gering, M.1    Patient, R.2
  • 63
    • 25844493155 scopus 로고    scopus 로고
    • Hematopoietic stem cell fate is established by the Notch-Runx pathway
    • Burns CE, Traver D, Mayhall E, Shepard JL, Zon LI (2005) Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev 19: 2331-2342.
    • (2005) Genes Dev , vol.19 , pp. 2331-2342
    • Burns, C.E.1    Traver, D.2    Mayhall, E.3    Shepard, J.L.4    Zon, L.I.5
  • 64
    • 0032861322 scopus 로고    scopus 로고
    • Ontogeny and behaviour of early macrophages in the zebrafish embryo
    • Herbomel P, Thisse B, Thisse C (1999) Ontogeny and behaviour of early macrophages in the zebrafish embryo. Development 126: 3735-3745.
    • (1999) Development , vol.126 , pp. 3735-3745
    • Herbomel, P.1    Thisse, B.2    Thisse, C.3
  • 65
    • 28444462501 scopus 로고    scopus 로고
    • Analysis of thrombocyte development in CD41-GFP transgenic zebrafish
    • Lin HF, Traver D, Zhu H, Dooley K, Paw BH, et al. (2005) Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood 106: 3803-3810.
    • (2005) Blood , vol.106 , pp. 3803-3810
    • Lin, H.F.1    Traver, D.2    Zhu, H.3    Dooley, K.4    Paw, B.H.5
  • 66
    • 33845448620 scopus 로고    scopus 로고
    • Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development
    • Murayama E, Kissa K, Zapata A, Mordelet E, Briolat V, et al. (2006) Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development. Immunity 25: 963-975.
    • (2006) Immunity , vol.25 , pp. 963-975
    • Murayama, E.1    Kissa, K.2    Zapata, A.3    Mordelet, E.4    Briolat, V.5
  • 67
    • 34250883337 scopus 로고    scopus 로고
    • Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
    • North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, et al. (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 447: 1007-1011.
    • (2007) Nature , vol.447 , pp. 1007-1011
    • North, T.E.1    Goessling, W.2    Walkley, C.R.3    Lengerke, C.4    Kopani, K.R.5
  • 68
    • 49449098431 scopus 로고    scopus 로고
    • CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis
    • Bertrand JY, Kim AD, Teng S, Traver D (2008) CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Development 135: 1853-1862.
    • (2008) Development , vol.135 , pp. 1853-1862
    • Bertrand, J.Y.1    Kim, A.D.2    Teng, S.3    Traver, D.4
  • 69
    • 0030728460 scopus 로고    scopus 로고
    • GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene
    • Long Q, Meng A, Wang H, Jessen JR, Farrell MJ, et al. (1997) GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development 124: 4105-4111.
    • (1997) Development , vol.124 , pp. 4105-4111
    • Long, Q.1    Meng, A.2    Wang, H.3    Jessen, J.R.4    Farrell, M.J.5
  • 70
    • 27744547091 scopus 로고    scopus 로고
    • Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
    • Wu WS, Heinrichs S, Xu D, Garrison SP, Zambetti GP, et al. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123: 641-653.
    • (2005) Cell , vol.123 , pp. 641-653
    • Wu, W.S.1    Heinrichs, S.2    Xu, D.3    Garrison, S.P.4    Zambetti, G.P.5
  • 71
    • 0027283604 scopus 로고
    • Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents
    • Lotem J, Sachs L (1993) Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood 82: 1092-1096.
    • (1993) Blood , vol.82 , pp. 1092-1096
    • Lotem, J.1    Sachs, L.2
  • 73
    • 0347413714 scopus 로고    scopus 로고
    • Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis
    • Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, et al. (2003) Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell 5: 903-914.
    • (2003) Dev Cell , vol.5 , pp. 903-914
    • Liu, T.X.1    Howlett, N.G.2    Deng, M.3    Langenau, D.M.4    Hsu, K.5
  • 74
    • 0028222955 scopus 로고
    • Bcl-2 blocks p53-dependent apoptosis
    • Chiou SK, Rao L, White E (1994) Bcl-2 blocks p53-dependent apoptosis. Mol Cell Biol 14: 2556-2563.
    • (1994) Mol Cell Biol , vol.14 , pp. 2556-2563
    • Chiou, S.K.1    Rao, L.2    White, E.3
  • 75
    • 0034958237 scopus 로고    scopus 로고
    • p53-dependent apoptosis pathways
    • Shen Y, White E (2001) p53-dependent apoptosis pathways. Adv Cancer Res 82: 55-84.
    • (2001) Adv Cancer Res , vol.82 , pp. 55-84
    • Shen, Y.1    White, E.2
  • 76
    • 0032828652 scopus 로고    scopus 로고
    • Inhibition of telomerase limits the growth of human cancer cells
    • Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, et al. (1999) Inhibition of telomerase limits the growth of human cancer cells. Nat Med 5: 1164-1170.
    • (1999) Nat Med , vol.5 , pp. 1164-1170
    • Hahn, W.C.1    Stewart, S.A.2    Brooks, M.W.3    York, S.G.4    Eaton, E.5
  • 77
    • 0036150238 scopus 로고    scopus 로고
    • Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit
    • Moriarty TJ, Huard S, Dupuis S, Autexier C (2002) Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. Mol Cell Biol 22: 1253-1265.
    • (2002) Mol Cell Biol , vol.22 , pp. 1253-1265
    • Moriarty, T.J.1    Huard, S.2    Dupuis, S.3    Autexier, C.4
  • 78
    • 0033568462 scopus 로고    scopus 로고
    • Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
    • Zhang X, Mar V, Zhou W, Harrington L, Robinson MO (1999) Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev 13: 2388-2399.
    • (1999) Genes Dev , vol.13 , pp. 2388-2399
    • Zhang, X.1    Mar, V.2    Zhou, W.3    Harrington, L.4    Robinson, M.O.5
  • 79
    • 0031466610 scopus 로고    scopus 로고
    • Genetics of erythropoiesis: Induced mutations in mice and zebrafish
    • Orkin SH, Zon LI (1997) Genetics of erythropoiesis: induced mutations in mice and zebrafish. Annu Rev Genet 31: 33-60.
    • (1997) Annu Rev Genet , vol.31 , pp. 33-60
    • Orkin, S.H.1    Zon, L.I.2
  • 80
    • 0032524043 scopus 로고    scopus 로고
    • The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis
    • Thompson MA, Ransom DG, Pratt SJ, MacLennan H, Kieran MW, et al. (1998) The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Dev Biol 197: 248-269.
    • (1998) Dev Biol , vol.197 , pp. 248-269
    • Thompson, M.A.1    Ransom, D.G.2    Pratt, S.J.3    MacLennan, H.4    Kieran, M.W.5
  • 81
    • 0036337052 scopus 로고    scopus 로고
    • Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis
    • Kalev-Zylinska ML, Horsfield JA, Flores MV, Postlethwait JH, Vitas MR, et al. (2002) Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis. Development 129: 2015-2030.
    • (2002) Development , vol.129 , pp. 2015-2030
    • Kalev-Zylinska, M.L.1    Horsfield, J.A.2    Flores, M.V.3    Postlethwait, J.H.4    Vitas, M.R.5
  • 82
    • 0025029030 scopus 로고
    • Hypervariable ultra-long telomeres in mice
    • Kipling D, Cooke HJ (1990) Hypervariable ultra-long telomeres in mice. Nature 347: 400-402.
    • (1990) Nature , vol.347 , pp. 400-402
    • Kipling, D.1    Cooke, H.J.2
  • 83
    • 0024362809 scopus 로고
    • Human telomeres contain at least three types of G-rich repeat distributed non-randomly
    • Allshire RC, Dempster M, Hastie ND (1989) Human telomeres contain at least three types of G-rich repeat distributed non-randomly. Nucleic Acids Res 17: 4611-4627.
    • (1989) Nucleic Acids Res , vol.17 , pp. 4611-4627
    • Allshire, R.C.1    Dempster, M.2    Hastie, N.D.3
  • 85
    • 10244222239 scopus 로고    scopus 로고
    • Heterozygous telomerase RNA mutations found in dyskeratosis congenita and aplastic anemia reduce telomerase activity via haploinsufficiency
    • Marrone A, Stevens D, Vulliamy T, Dokal I, Mason PJ (2004) Heterozygous telomerase RNA mutations found in dyskeratosis congenita and aplastic anemia reduce telomerase activity via haploinsufficiency. Blood 104: 3936-3942.
    • (2004) Blood , vol.104 , pp. 3936-3942
    • Marrone, A.1    Stevens, D.2    Vulliamy, T.3    Dokal, I.4    Mason, P.J.5
  • 86
    • 0037480961 scopus 로고    scopus 로고
    • Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
    • Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL (2003) Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 102: 517-520.
    • (2003) Blood , vol.102 , pp. 517-520
    • Allsopp, R.C.1    Morin, G.B.2    DePinho, R.3    Harley, C.B.4    Weissman, I.L.5
  • 87
    • 16444384725 scopus 로고    scopus 로고
    • Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage
    • Armstrong L, Saretzki G, Peters H, Wappler I, Evans J, et al. (2005) Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage. Stem Cells 23: 516-529.
    • (2005) Stem Cells , vol.23 , pp. 516-529
    • Armstrong, L.1    Saretzki, G.2    Peters, H.3    Wappler, I.4    Evans, J.5
  • 88
    • 5444247906 scopus 로고    scopus 로고
    • The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis
    • Davidson AJ, Zon LI (2004) The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis. Oncogene 23: 7233-7246.
    • (2004) Oncogene , vol.23 , pp. 7233-7246
    • Davidson, A.J.1    Zon, L.I.2
  • 91
    • 26944495173 scopus 로고    scopus 로고
    • MicroRNA function in animal development
    • Wienholds E, Plasterk RH (2005) MicroRNA function in animal development. FEBS Lett 579: 5911-5922.
    • (2005) FEBS Lett , vol.579 , pp. 5911-5922
    • Wienholds, E.1    Plasterk, R.H.2
  • 92
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • Chen CZ, Li L, Lodish HF, Bartel DP (2004) MicroRNAs modulate hematopoietic lineage differentiation. Science 303: 83-86.
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 93
    • 28344438648 scopus 로고    scopus 로고
    • A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis
    • Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis ML, et al. (2005) A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell 123: 819-831.
    • (2005) Cell , vol.123 , pp. 819-831
    • Fazi, F.1    Rosa, A.2    Fatica, A.3    Gelmetti, V.4    De Marchis, M.L.5
  • 95
    • 0037161961 scopus 로고    scopus 로고
    • Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway
    • Xiang H, Wang J, Mao Y, Liu M, Reddy VN, et al. (2002) Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway. Oncogene 21: 3784-3791.
    • (2002) Oncogene , vol.21 , pp. 3784-3791
    • Xiang, H.1    Wang, J.2    Mao, Y.3    Liu, M.4    Reddy, V.N.5
  • 97
    • 0037326054 scopus 로고    scopus 로고
    • Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae
    • Smith CD, Smith DL, DeRisi JL, Blackburn EH (2003) Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae. Mol Biol Cell 14: 556-570.
    • (2003) Mol Biol Cell , vol.14 , pp. 556-570
    • Smith, C.D.1    Smith, D.L.2    DeRisi, J.L.3    Blackburn, E.H.4
  • 98
    • 0037387730 scopus 로고    scopus 로고
    • Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4A/pRb
    • Veitonmaki N, Fuxe J, Hultdin M, Roos G, Pettersson RF, et al. (2003) Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4A/pRb. Faseb J 17: 764-766.
    • (2003) Faseb J , vol.17 , pp. 764-766
    • Veitonmaki, N.1    Fuxe, J.2    Hultdin, M.3    Roos, G.4    Pettersson, R.F.5
  • 99
    • 0038504020 scopus 로고    scopus 로고
    • Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I
    • Young JI, Sedivy JM, Smith JR (2003) Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I. J Biol Chem 278: 19904-19908.
    • (2003) J Biol Chem , vol.278 , pp. 19904-19908
    • Young, J.I.1    Sedivy, J.M.2    Smith, J.R.3
  • 100
    • 33746190649 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase regulates the expression of a key cell cycle regulator, cyclin D1
    • Jagadeesh S, Banerjee PP (2006) Telomerase reverse transcriptase regulates the expression of a key cell cycle regulator, cyclin D1. Biochem Biophys Res Commun 347: 774-780.
    • (2006) Biochem Biophys Res Commun , vol.347 , pp. 774-780
    • Jagadeesh, S.1    Banerjee, P.P.2
  • 101
    • 33947424355 scopus 로고    scopus 로고
    • Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafish
    • Tsai SB, Tucci V, Uchiyama J, Fabian NJ, Lin MC, et al. (2007) Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafish. Aging Cell 6: 209-224.
    • (2007) Aging Cell , vol.6 , pp. 209-224
    • Tsai, S.B.1    Tucci, V.2    Uchiyama, J.3    Fabian, N.J.4    Lin, M.C.5
  • 102
    • 50849120727 scopus 로고    scopus 로고
    • Kishi S, Bayliss PE, Uchiyama J, Koshimizu E, Qi J, et al. (2008) The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet 4: e1000152.
    • Kishi S, Bayliss PE, Uchiyama J, Koshimizu E, Qi J, et al. (2008) The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet 4: e1000152.
  • 105
    • 0036898541 scopus 로고    scopus 로고
    • Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling
    • Langheinrich U, Hennen E, Stott G, Vacun G (2002) Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling. Curr Biol 12: 2023-2028.
    • (2002) Curr Biol , vol.12 , pp. 2023-2028
    • Langheinrich, U.1    Hennen, E.2    Stott, G.3    Vacun, G.4
  • 106
    • 0030737882 scopus 로고    scopus 로고
    • Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats
    • Zijlmans JM, Martens UM, Poon SS, Raap AK, Tanke HJ, et al. (1997) Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci U S A 94: 7423-7428.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 7423-7428
    • Zijlmans, J.M.1    Martens, U.M.2    Poon, S.S.3    Raap, A.K.4    Tanke, H.J.5
  • 107
    • 34447622529 scopus 로고    scopus 로고
    • Measurements of telomere length on individual chromosomes by image cytometry
    • Poon SS, Lansdorp PM (2001) Measurements of telomere length on individual chromosomes by image cytometry. Methods Cell Biol 64: 69-96.
    • (2001) Methods Cell Biol , vol.64 , pp. 69-96
    • Poon, S.S.1    Lansdorp, P.M.2
  • 108
    • 31544466516 scopus 로고    scopus 로고
    • Human telomeres have different overhang sizes at leading versus lagging strands
    • Chai W, Du Q, Shay JW, Wright WE (2006) Human telomeres have different overhang sizes at leading versus lagging strands. Mol Cell 21: 427-435.
    • (2006) Mol Cell , vol.21 , pp. 427-435
    • Chai, W.1    Du, Q.2    Shay, J.W.3    Wright, W.E.4
  • 109
    • 12644292903 scopus 로고    scopus 로고
    • Characterization of zebrafish mutants with defects in embryonic hematopoiesis
    • Ransom DG, Haffter P, Odenthal J, Brownlie A, Vogelsang E, et al. (1996) Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development 123: 311-319.
    • (1996) Development , vol.123 , pp. 311-319
    • Ransom, D.G.1    Haffter, P.2    Odenthal, J.3    Brownlie, A.4    Vogelsang, E.5
  • 110
    • 0031735118 scopus 로고    scopus 로고
    • Positional cloning of the zebrafish sauternes gene: A model for congenital sideroblastic anaemia
    • Brownlie A, Donovan A, Pratt SJ, Paw BH, Oates AC, et al. (1998) Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nat Genet 20: 244-250.
    • (1998) Nat Genet , vol.20 , pp. 244-250
    • Brownlie, A.1    Donovan, A.2    Pratt, S.J.3    Paw, B.H.4    Oates, A.C.5


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