Zebrafish as a model of human hematologic disorders

Current Opinion in Hematology

Volumn 11, Issue 4, 2004, Pages 255-261

  Shafizadeh, Ebrahim ^a   Paw, Barry H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Hematopoietic disorders; Morpholinos; Transgenic zebrafish; Zebrafish

Indexed keywords

HEME;

ANEMIA; BIOSYNTHESIS; BLOOD DISEASE; CELL DIFFERENTIATION; CELL LINE; CELL SPECIFICITY; CELL TRANSPLANTATION; CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE 2; CONGENITAL ERYTHROPOIETIC PORPHYRIA; ERYTHROCYTE FRAGILITY; ERYTHROID CELL; ERYTHROPOIESIS; GENE FUNCTION; GENE IDENTIFICATION; GENE INACTIVATION; GENE MUTATION; GENE TARGETING; GENETIC ANALYSIS; GENETIC MODEL; HEMATOLOGIC DISEASE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; HEMOCHROMATOSIS; HEMOLYTIC ANEMIA; HEPATIC PORPHYRIA; HEREDITARY ELLIPTOCYTOSIS; HEREDITARY SPHEROCYTOSIS; HUMAN; IRON DEFICIENCY ANEMIA; KNOCKOUT GENE; MICROCYTIC ANEMIA; MUTATIONAL ANALYSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SIDEROBLASTIC ANEMIA; THROMBOCYTOPENIA; TRANSCRIPTION REGULATION; TRANSGENIC ANIMAL; X CHROMOSOME LINKED DISORDER; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; EMBRYO, NONMAMMALIAN; ERYTHROPOIESIS; HEMATOLOGIC DISEASES; HEMATOPOIETIC SYSTEM; HUMANS; MUTATION; ZEBRAFISH;

EID: 4344605205     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.moh.0000138686.15806.71     Document Type: Review

References (70)

1. Ackermann GE, Paw BH: Zebrafish: a genetic model for vertebrate organogenesis and human disorders. Front Biosci 2003, 8:d1227-d1253.
2. Penberthy WT, Shafizadeh E, Lin S: The zebrafish as a model for human disease. Front Biosci 2002, 7:d1439-d1453.
3. Paw BH, Zon LI: Zebrafish: a genetic approach in studying hematopoiesis. Curr Opin Hematol 2000, 7:79-84.
4. Berman J, Hsu K, Look AT: Zebrafish as a model organism for blood diseases. Br J Haematol 2003, 123:568-576.
5. North TE, Zon LI: Modeling human hematopoietic and cardiovascular diseases in zebrafish. Dev Dyn 2003, 228:568-583.
6. Orkin SH: Hematopoiesis: how does it happen? Curr Opin Cell Biol 1995, 7:870-877.
7. Galloway JL, Zon LI: Ontogeny of hematopoiesis: examining the emergence of hematopoietic cells in the vertebrate embryo. Curr Top Dev Biol 2003, 53:139-158.
8. Amatruda JF, Zon LI: Dissecting hematopoiesis and disease using the zebrafish. Dev Biol 1999, 216:1-15.
9. Al-Adhami MA KY: Ontogenesis of haematopoietic sites in brachydanio rerio. Dev Growth Differ 1977, 19:171-179.
10. Willett CE, Cortes A, Zuasti A, Zapata AG: Early hematopoiesis and developing lymphoid organs in the zebrafish. Dev Dyn 1999, 214:323-336.
11. Brownlie A, Hersey C, Oates AC, et al.: Characterization of embryonic globin genes of the zebrafish. Dev Biol 2003, 255:48-61. This comprehensive work illustrates the process of globin switching in zebrafish and describes characterization of zinfendal mutant as a potential model of thalassemia.
12. Bennett CM, Kanki JP, Rhodes J, et al.: Myelopoiesis in the zebrafish, Danio rerio. Blood 2001, 98:643-651.
13. Hsu K, Kanki JP, Look AT: Zebrafish myelopoiesis and blood cell development. Curr Opin Hematol 2001, 8:245-251.
14. Lieschke GJ, Oates AC, Crowhurst MO, et al.: Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish. Blood 2001, 98:3087-3096.
15. Jagadeeswaran P, Sheehan JP, Craig FE, Troyer D: Identification and characterization of zebrafish thrombocytes. Br J Haematol 1999, 107:731-738.
16. Ransom DG, Haffter P, Odenthal J, et al.: Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development 1996, 123:311-319.
17. Weinstein BM, Schier AF, Abdelilah S, et al.: Hematopoietic mutations in the zebrafish. Development 1996, 123:303-309.
18. Discher DE: New insights into erythrocyte membrane organization and microelasticity. Curr Opin Hematol 2000, 7:117-122.
19. Tse WT, Lux SE: Red blood cell membrane disorders. Br J Haematol 1999, 104:2-13.
20. Liao EC, Paw BH, Peters LL, et al.: Hereditary spherocytosis in zebrafish riesling illustrates evolution of erythroid beta-spectrin structure, and function in red cell morphogenesis and membrane stability. Development 2000, 127:5123-5132.
21. Shafizadeh E, Paw BH, Foott H, et al.: Characterization of zebrafish merlot/chablis as non-mammalian vertebrate models for severe congenital anemia due to protein 4.1 deficiency. Development 2002, 129:4359-4370.
22. Bloom ML, Kaysser TM, Birkenmeier CS, Barker JE: The murine mutation jaundiced is caused by replacement of an arginine with a stop codon in the mRNA encoding the ninth repeat of beta-spectrin. Proc Natl Acad Sci USA 1994, 91:10099-10103.
23. Paw BH, Davidson AJ, Zhou Y, et al.: Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet 2003, 34:59-64. This work describes positional cloning of retsina mutant and illustrates a novel evolutionary conserved function of band 3 protein in cytokinesis.
24. Ponka P: Cell biology of heme. Am J Med Sci 1999, 318:241-256.
25. Brownlie A, Donovan A, Pratt SJ, et al.: Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nat Genet 1998, 20:244-250.
26. Yamamoto M, Nakajima O: Animal models for X-linked sideroblastic anemia. Int J Hematol 2000, 72:157-164.
27. Wang H, Long Q, Marty SD, et al.: A zebrafish model for hepatoerythropoietic porphyria. Nat Genet 1998, 20:239-243.
28. Childs S, Weinstein BM, Mohideen MA, et al.: Zebrafish dracula encodes ferrochelatase and its mutation provides a model for erythropoietic protoporphyria. Curr Biol 2000, 10:1001-1004.
29. Ponka P: Hereditary causes of disturbed iron homeostasis in the central nervous system. Ann N Y Acad Sci 2004, 1012:267-281. This article is an excellent review that describes iron pathway and the genetic cause of several iron overloading disorder confined to the brain.
30. Hentze MW, Muckenthaler MU, Andrews NC: Balancing acts: molecular control of mammalian iron metabolism. Cell 2004, 117:285-297. This paper is a comprehensive review on cellular and systemic iron homeostasis.
31. Sun G, Gargus JJ, Ta DT, Vickery LE: Identification of a novel candidate gene in the iron-sulfur pathway implicated in ataxia-susceptibility: human gene encoding HscB, a J-type co-chaperone. J Hum Genet 2003, 48:415-419.
32. Chung J, Wessling-Resnick M: Molecular mechanisms and regulation of iron transport. Crit Rev Clin Lab Sci 2003, 40:151-182.
33. Andrews NC: Animal models of hereditary iron transport disorders. Adv Exp Med Biol 2002, 509:1-17.
34. Donovan A, Brownlie A, Zhou Y, et al.: Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 2000, 403:776-781.
35. Gordeuk VR, Caleffi A, Corradini E, et al.: Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene. Blood Cells Mol Dis 2003, 31:299-304.
36. Montosi G, Donovan A, Totaro A, et al.: Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. J Clin Invest 2001, 108:619-623.
37. Donovan A, Brownlie A, Dorschner MO, et al.: The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Blood 2002, 100:4655-4659.
38. Fleming MD, Trenor CC III, Su MA, et al.: Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 1997, 16:383-386.
39. Gunshin H, Mackenzie B, Berger UV, et al.: Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997, 388:482-488.
40. Lyons SE, Lawson ND, Lei L, et al.: A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes. Proc Natl Acad Sci USA 2002, 99:5454-5459.
41. Pevny L, Simon MC, Robertson E, et al.: Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 1991, 349:257-260.
42. Ohneda K, Yamamoto M: Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage. Acta Haematol 2002, 108:237-245.
43. Fujiwara Y, Chang AN, Williams AM, Orkin SH: Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood 2004, 103:583-585.
44. Thompson MA, Ransom DG, Pratt SJ, et al.: The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Dev Biol 1998, 197:248-269.
45. Liao W, Bisgrove BW, Sawyer H, et al.: The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation. Development 1997, 124:381-389.
46. Stainier DY, Weinstein BM, Detrich HW III, et al.: Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages. Development 1995, 121:3141-3150.
47. Parker L, Stainier DY: Cell-autonomous and non-autonomous requirements for the zebrafish gene cloche in hematopoiesis. Development 1999, 126:2643-2651.
48. Long Q, Huang H, Shafizadeh E, et al.: Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish. Nat Cell Biol 2000, 2:549-552.
49. Langenau DM, Traver D, Ferrando AA, et al.: Myc-induced T cell leukemia in transgenic zebrafish. Science 2003, 299:887-890. This elegant work illustrates the power of transgenic techniques in zebrafish and highlights the conservation of hematopoietic system among higher vertebrates.
50. Nasevicius A, Ekker SC: Effective targeted gene 'knockdown' in zebrafish. Nat Genet 2000, 26:216-220.
51. Day K, Krishnegowda N, Jagadeeswaran P: Knockdown of prothrombin in zebrafish. Blood Cells Mol Dis 2004, 32:191-198.
52. Liu TX, Howlett NG, Deng M, et al.: Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell 2003, 5:903-914. This article illustrates the efficacy of morpholino oligomers and describes a novel model of human Fanconi anemia.
53. D'Andrea AD, Grompe M: The Fanconi anaemia/BRCA pathway. Nat Rev Cancer 2003, 3:23-34.
54. Taniguchi T, Dandrea AD: Molecular pathogenesis of fanconi anemia. Int J Hematol 2002, 75:123-128.
55. Gregory RC, Taniguchi T, D'Andrea AD: Regulation of the Fanconi anemia pathway by monoubiquitination. Semin Cancer Biol 2003, 13:77-82.
56. Traver D, Paw BH, Poss KD, et al.: Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol 2003, 4:1238-1246. This is a pioneer work describing flow cytometric analysis of zebrafish hematopoietic cells.
57. Traver D, Winzeler A, Stern HM, et al.: Biological effects of lethal irradiation and rescue by hematopoietic cell transplantation in zebrafish. Blood 2004, (in Press)
58. Peterson RT, Link BA, Dowling JE, Schreiber SL: Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc Natl Acad Sci USA 2000, 97:12965-12969.
59. Peterson RT, Shaw SY, Peterson TA, et al.: Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol 2004, 22:595-599.
60. Stern HM, Zon LI: Cancer genetics and drug discovery in the zebrafish. Nat Rev Cancer 2003, 3:533-539.
61. Langenau DM, Ferrando AA, Traver D, et al.: In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci USA 2004, 101:7369-7374.
62. Trede NS, Langenau DM, Traver D, et al.: The use of zebrafish to understand immunity. Immunity 2004, 20:367-379. This paper presents a comprehensive review of new technologies and advances as related to zebrafish and immunological research.
63. Traver D, Herbomel P, Patton EE, et al.: The zebrafish as a model organism to study development of the immune system. Adv Immunol 2003, 81:253-330.
64. Herbomel P, Thisse B, Thisse C: Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process. Dev Biol 2001, 238:274-288.
65. Jagadeeswaran P, Gregory M, Johnson S, Thankavel B: Haemostatic screening and identification of zebrafish mutants with coagulation pathway defects: an approach to identifying novel haemostatic genes in man. Br J Haematol 2000, 110:946-956.
66. Long Q, Meng A, Wang H, et al.: GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development 1997, 124:4105-4111.
67. Hsu K, Traver D, Kutok JL, et al.: The pu.1 promoter drives myeloid gene expression in zebrafish. Blood 2004.
68. Ward AC, McPhee DO, Condron MM, et al.: The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish. Blood 2003, 102:3238-3240.
69. Jessen JR, Willett CE, Lin S: Artificial chromosome transgenesis reveals long-distance negative regulation of rag1 in zebrafish. Nat Genet 1999, 23:15-16.
70. Lin HF, Paw BH, Gregory M, et al.: Production and characterization of transgenic zebrafish (Danio rario) with fluorescent thrombocytes and thrombocyte precursors. Blood 2001.