Pursuing different 'TRADDes': TRADD signaling induced by TNF-receptor 1 and the Epstein-Barr virus oncoprotein LMP1

Biological Chemistry

Volumn 389, Issue 10, 2008, Pages 1261-1271

  Kieser, Arnd ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Apoptosis; Latent membrane protein 1 (LMP1); NF B; TNF receptor 1; TRADD; Transformation

Indexed keywords

CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; LATENT MEMBRANE PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; STAT PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN;

APOPTOSIS; B LYMPHOCYTE; BINDING SITE; CELL DEATH; CELL SURVIVAL; EPSTEIN BARR VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

CELL DEATH; HERPESVIRUS 4, HUMAN; HUMANS; PROTEIN KINASES; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN; VIRAL MATRIX PROTEINS;

HUMAN HERPESVIRUS 4;

EID: 54049086943     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2008.144     Document Type: Review

References (126)

1. Ahmad, R., Raina, D., Trivedi, V., Ren, J., Rajabi, H., Kharbanda, S., and Kufe, D. (2007). MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling. Nat. Cell Biol. 9, 1419-1427.
2. Arch, R.H., Gedrich, R.W., and Thompson, C.B. (1998). Tumor necrosis factor receptor-associated factors (TRAFs) - a family of adapter proteins that regulates life and death. Genes Dev. 12, 2821-2830.
3. Atkinson, P.G., Coope, H.J., Rowe, M., and Ley, S.C. (2003). Latent membrane protein 1 of Epstein-Barr virus stimulates processing of NF-κB 2 p100 to p52. J. Biol. Chem. 278, 51134-51142.
4. Baud, V. and Karin, M. (2001). Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 11, 372-377.
5. Bender, L.M., Morgan, M.J., Thomas, L.R., Liu, Z.G., and Thorburn, A. (2005). The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm. Cell Death Differ. 12, 473-481.
6. Bode, J.G., Brenndörfer, E.D., and Häussinger, D. (2008). HCV employs multiple strategies to subvert innate host antiviral response. Biol. Chem. 389, 1283-1298.
7. Cahir-McFarland, E.D., Izumi, K.M., and Mosialos, G. (1999). Epstein-Barr virus transformation: involvement of latent membrane protein 1-mediated activation of NF-κB. Oncogene 18, 6959-6964.
8. Cahir-McFarland, E.D., Carter, K., Rosenwald, A., Giltnane, J.M., Henrickson, S.E., Staudt, L.M., and Kieff, E. (2004). Role of NF-κB in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. J. Virol. 78, 4108-4119.
9. Cameron, J.E., Yin, Q., Fewell, C., Lacey, M., McBride, J., Wang, X., Lin, Z., Schaefer, B.C., and Flemington, E.K. (2008). Epstein-Barr virus latent membrane protein 1 induces cellular microRNA miR-146a, a modulator of lymphocyte signaling pathways. J. Virol. 82, 1946-1958.
10. Chan, F.K., Chun, H.J., Zheng, L., Siegel, R.M., Bui, K.L., and Lenardo, M.J. (2000). A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288, 2351-2354.
11. Chen, Z.J. (2005). Ubiquitin signalling in the NF-κB pathway. Nat. Cell Biol. 7, 758-765.
12. Dawson, C.W., Tramoutanis, G., Eliopoulos, A.G., and Young, L.S. (2003). Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling. J. Biol. Chem. 278, 3694-3704.
13. Dawson, C.W., Laverick, L., Morris, M.A., Tramoutanis, G., and Young, L.S. (2008). Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. J. Virol. 82, 3654-3664.
14. Deng, Y., Ren, X., Yang, L., Lin, Y., and Wu, X. (2003). A JNK-dependent pathway is required for TNFα-induced apoptosis. Cell 115, 61-70.
15. Devergne, O., Hatzivassiliou, E., Izumi, K.M., Kaye, K.M., Kleijnen, M.F., Kieff, E., and Mosialos, G. (1996). Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-κB activation. Mol. Cell. Biol. 16, 7098-7108.
16. Devin, A., Lin, Y., Yamaoka, S., Li, Z., Karin, M., and Liu, Z. (2001). The α and β subunits of IκB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. Mol. Cell. Biol. 21, 3986-3994.
17. Dirmeier, U., Neuhierl, B., Kilger, E., Reisbach, G., Sandberg, M.L., and Hammerschmidt, W. (2003). Latent membrane protein 1 is critical for efficient growth transformation of human B cells by Epstein-Barr virus. Cancer Res. 63, 2982-2989.
18. Ea, C.K., Deng, L., Xia, Z.P., Pineda, G., and Chen, Z.J. (2006). Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 22, 245-257.
19. Eliopoulos, A.G., Blake, S.M., Floettmann, J.E., Rowe, M., and Young, L.S. (1999a). Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2. J. Virol. 73, 1023-1035.
20. Eliopoulos, A.G., Gallagher, N.J., Blake, S.M., Dawson, C.W., and Young, L.S. (1999b). Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein 1 coregulates interleukin-6 and interleukin-8 production. J. Biol. Chem. 274, 16085-16096.
21. Eliopoulos, A.G., Caamano, J.H., Flavell, J., Reynolds, G.M., Murray, P.G., Poyet, J.L., and Young, L.S. (2003a). Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-κB2 to p52 via an IKKγ/ NEMO-independent signalling pathway. Oncogene 22, 7557-7569.
22. Eliopoulos, A.G., Waites, E.R., Blake, S.M., Davies, C., Murray, P., and Young, L.S. (2003b). TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 but not CD40. J. Virol. 77, 1316-1328.
23. Floettmann, J.E. and Rowe, M. (1997). Epstein-Barr virus latent membrane protein-1 (LMP1) C-terminus activation region 2 (CTAR2) maps to the far C-terminus and requires oligomerisation for NF-κB activation. Oncogene 15, 1851-1858.
24. Fotin-Mleczek, M., Henkler, F., Samel, D., Reichwein, M., Hausser, A., Parmryd, I., Scheurich, P., Schmid, J.A., and Wajant, H. (2002). Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8. J. Cell Sci. 115, 2757-2770.
25. Ghosh, S. and Karin, M. (2002). Missing pieces in the NF-κB puzzle. Cell 109 (Suppl.), S81-96.
26. Gires, O., Zimber-Strobl, U., Gonnella, R., Ueffing, M., Marschall, G., Zeidler, R., Pich, D., and Hammerschmidt, W. (1997). Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule. EMBO J. 16, 6131-6140.
27. Gires, O., Kohlhuber, F., Kilger, E., Baumann, M., Kieser, A., Kaiser, C., Zeidler, R., Scheffer, B., Ueffing, M., and Hammerschmidt, W. (1999). Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins. EMBO J. 18, 3064-3073.
28. Grimm, T., Schneider, S., Naschberger, E., Huber, J., Guenzi, E., Kieser, A., Reitmeir, P., Schulz, T.F., Morris, C.A., and Sturzl, M. (2005). EBV latent membrane protein-1 protects B cells from apoptosis by inhibition of BAX. Blood 105, 3263-3269.
29. Gururaja, T.L., Yung, S., Ding, R., Huang, J., Zhou, X., Mc-Laughlin, J., Daniel-Issakani, S., Singh, R., Cooper, R.D., Payan, D.G., et al. (2007). A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1. Chem. Biol. 14, 1105-1118.
30. Habelhah, H., Takahashi, S., Cho, S.G., Kadoya, T., Watanabe, T., and Ronai, Z. (2004). Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-κB. EMBO J. 23, 322-332.
31. Hacker, H. and Karin, M. (2006). Regulation and function of IKK and IKK-related kinases. Sci. STKE 2006, re13.
32. Hacker, H., Redecke, V., Blagoev, B., Kratchmarova, I., Hsu, L.C., Wang, G.G., Kamps, M.P., Raz, E., Wagner, H., Hacker, G., et al. (2006). Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439, 204-207.
33. Hatzivassiliou, E., Miller, W.E., Raab-Traub, N., Kieff, E., and Mosialos, G. (1998). A fusion of the EBV latent membrane protein-1 (LMP1) transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal growth factor receptor expression, nuclear factor-κB, and stress-activated protein kinase. J. Immunol. 160, 1116-1121.
34. He, Z., Xin, B., Yang, X., Chan, C., and Cao, L. (2000). Nuclear factor-κB activation is involved in LMP1-mediated transformation and tumorigenesis of rat-1 fibroblasts. Cancer Res. 60, 1845-1848.
35. Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J.L., Schneider, P., Seed, B., and Tschopp, J. (2000). Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat. Immunol. 1, 489-495.
36. Hsu, H., Xiong, J., and Goeddel, D.V. (1995). The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell 81, 495-504.
37. Hsu, H., Huang, J., Shu, H.B., Baichwal, V., and Goeddel, D.V. (1996a). TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4, 387-396.
38. Hsu, H., Shu, H.B., Pan, M.G., and Goeddel, D.V. (1996b). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84, 299-308.
39. Huen, D.S., Henderson, S.A., Croom-Carter, D., and Rowe, M. (1995). The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-κB and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain. Oncogene 10, 549-560.
40. Huye, L.E., Ning, S., Kelliher, M., and Pagano, J.S. (2007). Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination. Mol. Cell. Biol. 27, 2910-2918.
41. Ishida, T., Mizushima, S., Azuma, S., Kobayashi, N., Tojo, T., Suzuki, K., Aizawa, S., Watanabe, T., Mosialos, G., Kieff, E., et al. (1996). Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J. Biol. Chem. 271, 28745-28748.
42. Izumi, K.M. and Kieff, E.D. (1997). The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB. Proc. Natl. Acad. Sci. USA 94, 12592-12597.
43. Izumi, K.M., Kaye, K.M., and Kieff, E.D. (1997). The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation. Proc. Natl. Acad. Sci. USA 94, 1447-1452.
44. Izumi, K.M., Cahir-McFarland, E.D., Ting, A.T., Riley, E.A., Seed, B., and Kieff, E.D. (1999). The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-κB activation. Mol. Cell. Biol. 19, 5759-5767.
45. Jin, Z. and El-Deiry, W.S. (2006). Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis. Mol. Cell. Biol. 26, 8136-8148.
46. Karin, M. and Greten, F.R. (2005). NF-κB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5, 749-759.
47. Kaye, K.M., Izumi, K.M., and Kieff, E. (1993). Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proc. Natl. Acad. Sci. USA 90, 9150-9154.
48. Kaye, K.M., Izumi, K.M., Mosialos, G., and Kieff, E. (1995). The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues. J. Virol. 69, 675-683.
49. Kaye, K.M., Izumi, K.M., Li, H., Johannsen, E., Davidson, D., Longnecker, R., and Kieff, E. (1999). An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation. J. Virol. 73, 10525-10530.
50. Kelliher, M.A., Grimm, S., Ishida, Y., Kuo, F., Stanger, B.Z., and Leder, P. (1998). The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity 8, 297-303.
51. Kieser, A. (2007). Signal transduction by the Epstein-Barr virus oncogene latent membrane protein 1 (LMP1). Signal Transduction 7, 20-33.
52. Kieser, A., Kilger, E., Gires, O., Ueffing, M., Kolch, W., and Hammerschmidt, W. (1997). Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade. EMBO J. 16, 6478-6485.
53. Kieser, A., Kaiser, C., and Hammerschmidt, W. (1999). LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2. EMBO J. 18, 2511-2521.
54. Kilger, E., Kieser, A., Baumann, M., and Hammerschmidt, W. (1998). Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor. EMBO J. 17, 1700-1709.
55. Kim, Y.S., Morgan, M.J., Choksi, S., and Liu, Z.G. (2007). TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol. Cell 26, 675-687.
56. Krikos, A., Laherty, C.D., and Dixit, V.M. (1992). Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by κB elements. J. Biol. Chem. 267, 17971-17976.
57. Kulwichit, W., Edwards, R.H., Davenport, E.M., Baskar, J.F., Godfrey, V., and Raab-Traub, N. (1998). Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice. Proc. Natl. Acad. Sci. USA 95, 11963-11968.
58. Kutz, H., Reisbach, G., Schultheiss, U., and Kieser, A. (2008). The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein-Barr virus. Virology 371, 246-256.
59. Laherty, C.D., Hu, H.M., Opipari, A.W., Wang, F., and Dixit, V.M. (1992). The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor κB. J. Biol. Chem. 267, 24157-24160.
60. Lam, N. and Sugden, B. (2003). LMP1, a viral relative of the TNF receptor family, signals principally from intracellular compartments. EMBO J. 22, 3027-3038.
61. Lee, K.H., Feig, C., Tchikov, V., Schickel, R., Hallas, C., Schutze, S., Peter, M.E., and Chan, A.C. (2006). The role of receptor internalization in CD95 signaling. EMBO J. 25, 1009-1023.
62. Liebowitz, D., Wang, D., and Kieff, E. (1986). Orientation and patching of the latent infection membrane protein encoded by Epstein-Barr virus. J. Virol. 58, 233-237.
63. Lin, A. (2003). Activation of the JNK signaling pathway: breaking the brake on apoptosis. Bioessays 25, 17-24.
64. Lin, A. and Karin, M. (2003). NF-κB in cancer: a marked target. Semin. Cancer Biol. 13, 107-114.
65. Lin, Y., Devin, A., Rodriguez, Y., and Liu, Z.G. (1999). Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 13, 2514-2526.
66. Liu, Z.G., Hsu, H., Goeddel, D.V., and Karin, M. (1996). Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87, 565-576.
67. Locksley, R.M., Killeen, N., and Lenardo, M.J. (2001). The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104, 487-501.
68. Ludwig, S. and Planz, O. (2008). Influenza viruses and the NFκB pathway - towards a novel concept of antiviral therapy. Biol. Chem. 389, 1307-1312.
69. Luftig, M., Prinarakis, E., Yasui, T., Tsichritzis, T., Cahir-McFarland, E., Inoue, J., Nakano, H., Mak, T.W., Yeh, W.C., Li, X., et al. (2003). Epstein-Barr virus latent membrane protein 1 activation of NF-κB through IRAK1 and TRAF6. Proc. Natl. Acad. Sci. USA 100, 15595-15600.
70. Luftig, M., Yasui, T., Soni, V., Kang, M.S., Jacobson, N., Cahir-McFarland, E., Seed, B., and Kieff, E. (2004). Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKKα-dependent noncanonical NF-κB activation. Proc. Natl. Acad. Sci. USA 101, 141-146.
71. Maeda, S., Chang, L., Li, Z.W., Luo, J.L., Leffert, H., and Karin, M. (2003). IKKβ is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFα. Immunity 19, 725-737.
72. Mainou, B.A., Everly, D.N., and Raab-Traub, N. (2005). Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K. Oncogene 24, 6917-6924.
73. Mainou, B.A., Everly, D.N., and Raab-Traub, N. (2007). Unique signaling properties of CTAR1 in LMP1-mediated transformation. J. Virol. 81, 9680-9692.
74. Michallet, M.C., Meylan, E., Ermolaeva, M.A., Vazquez, J., Rebsamen, M., Curran, J., Poeck, H., Bscheider, M., Hartmann, G., Konig, M., et al. (2008). TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 28, 651-661.
75. Micheau, O. and Tschopp, J. (2003). Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181-190.
76. Mitchell, T. and Sugden, B. (1995). Stimulation of NF-κB-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus. J. Virol. 69, 2968-2976.
77. Morgan, M.J., Kim, Y.S., and Liu, Z.G. (2008). TNFα and reactive oxygen species in necrotic cell death. Cell Res. 18, 343-349.
78. Motsch, N., Pfuhl, T., Mrazek, J., Barth, S., and Grasser, F.A. (2007). Epstein-Barr Virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a. RNA Biol. 4, 131-137.
79. Niedobitek, G. (1999). The Epstein-Barr virus: a group 1 carcinogen? Virchow's Arch. 435, 79-86.
80. Nowak, M., Gaines, G.C., Rosenberg, J., Minter, R., Bahjat, F.R., Rectenwald, J., MacKay, S.L., Edwards, C.K. III, and Moldawer, L.L. (2000). LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-α and the TNF-p55 receptor. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278, R1202-1209.
81. Oganesyan, G., Saha, S.K., Guo, B., He, J.Q., Shahangian, A., Zarnegar, B., Perry, A., and Cheng, G. (2006). Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 439, 208-211.
82. Park, A. and Baichwal, V.R. (1996). Systematic mutational analysis of the death domain of the tumor necrosis factor receptor 1-associated protein TRADD. J. Biol. Chem. 271, 9858-9862.
83. Park, Y.C., Ye, H., Hsia, C., Segal, D., Rich, R.L., Liou, H.C., Myszka, D.G., and Wu, H. (2000). A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell 101, 777-787.
84. Pfeffer, K., Matsuyama, T., Kundig, T.M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P.S., Kronke, M., and Mak, T.W. (1993). Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73, 457-467.
85. Rastelli, J., Homig-Holzel, C., Seagal, J., Muller, W., Hermann, A.C., Rajewsky, K., and Zimber-Strobl, U. (2008). LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class switch recombination to IgG1. Blood 111, 1448-1455.
86. Saito, N., Courtois, G., Chiba, A., Yamamoto, N., Nitta, T., Hironaka, N., Rowe, M., and Yamaoka, S. (2003). Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-κB through distinct signaling pathways in fibroblast cell lines. J. Biol. Chem. 278, 46565-46575.
87. Sandberg, M., Hammerschmidt, W., and Sugden, B. (1997). Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3. J. Virol. 71, 4649-4656.
88. Sandu, C., Gavathiotis, E., Huang, T., Wegorzewska, I., and Werner, M.H. (2005). A mechanism for death receptor discrimination by death adaptors. J. Biol. Chem. 280, 31974-31980.
89. Sanz, L., Sanchez, P., Lallena, M.J., Diaz-Meco, M.T., and Moscat, J. (1999). The interaction of p62 with RIP links the atypical PKCs to NF-κB activation. EMBO J. 18, 3044-3053.
90. Schneider, F., Neugebauer, J., Griese, J., Liefold, N., Kutz, H., Briseno, C., and Kieser, A. (2008). The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity. PLoS Biol. 6, e8.
91. Schneider-Brachert, W., Tchikov, V., Neumeyer, J., Jakob, M., Winoto-Morbach, S., Held-Feindt, J., Heinrich, M., Merkel, O., Ehrenschwender, M., Adam, D., et al. (2004). Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 21, 415-428.
92. Schneider-Brachert, W., Tchikov, V., Merkel, O., Jakob, M., Hallas, C., Kruse, M.L., Groitl, P., Lehn, A., Hildt, E., Held-Feindt, J., et al. (2006). Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism. J. Clin. Invest. 116, 2901-2913.
93. Schultheiss, U., Puschner, S., Kremmer, E., Mak, T.W., Engelmann, H., Hammerschmidt, W., and Kieser, A. (2001). TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1. EMBO J. 20, 5678-5691.
94. Senftleben, U., Li, Z.W., Baud, V., and Karin, M. (2001). IKKβ is essential for protecting T cells from TNFα-induced apoptosis. Immunity 14, 217-230.
95. Siwkowski, A.M., Madge, L.A., Koo, S., McMillan, E.L., Monia, B.P., Pober, J.S., and Baker, B.F. (2004). Effects of antisense oligonucleotide- mediated depletion of tumor necrosis factor (TNF) receptor 1-associated death domain protein on TNF-induced gene expression. Mol. Pharmacol. 66, 572-579.
96. Song, Y.J., Jen, K.Y., Soni, V., Kieff, E., and Cahir-McFarland, E. (2006). IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-κB activation. Proc. Natl. Acad. Sci. USA 103, 2689-2694.
97. Soni, V., Yasui, T., Cahir-McFarland, E., and Kieff, E. (2006). LMP1 transmembrane domain 1-2 FWLY mediates intermolecular interactions with 3-6 to activate NF-κB. J. Virol. 80, 10787-10793.
98. Soni, V., Cahir-McFarland, E., and Kieff, E. (2007). LMP1 TRAF-ficking activates growth and survival pathways. Adv. Exp. Med. Biol. 597, 173-187.
99. Stanger, B.Z., Leder, P., Lee, T.H., Kim, E., and Seed, B. (1995). RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81, 513-523.
100. Stevenson, D., Charalambous, C., and Wilson, J.B. (2005). Epstein-Barr virus latent membrane protein 1 (CAO) up-regulates VEGF and TGFα concomitant with hyperlasia, with subsequent up-regulation of p16 and MMP9. Cancer Res. 65, 8826-8835.
101. Taganov, K.D., Boldin, M.P., Chang, K.J., and Baltimore, D. (2006). NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. USA 103, 12481-12486.
102. Tang, G., Minemoto, Y., Dibling, B., Purcell, N.H., Li, Z., Karin, M., and Lin, A. (2001). Inhibition of JNK activation through NF-κB target genes. Nature 414, 313-317.
103. Tartaglia, L.A., Rothe, M., Hu, Y.F., and Goeddel, D.V. (1993). Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor. Cell 73, 213-216.
104. Thorley-Lawson, D.A. (2001). Epstein-Barr virus: exploiting the immune system. Nat. Rev. Immunol. 1, 75-82.
105. Ting, A.T., Pimentel-Muinos, F.X., and Seed, B. (1996). RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/APO-1-initiated apoptosis. EMBO J. 15, 6189-6196.
106. Tsao, D.H., McDonagh, T., Telliez, J.B., Hsu, S., Malakian, K., Xu, G.Y., and Lin, L.L. (2000). Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway. Mol. Cell 5, 1051-1057.
107. Tsao, D.H., Hum, W.T., Hsu, S., Malakian, K., and Lin, L.L. (2007). The NMR structure of the TRADD death domain, a key protein in the TNF signaling pathway. J. Biomol. NMR 39, 337-342.
108. Varfolomeev, E.E. and Ashkenazi, A. (2004). Tumor necrosis factor: an apoptosis JuNKie? Cell 116, 491-497.
109. Vockerodt, M., Haier, B., Buttgereit, P., Tesch, H., and Kube, D. (2001). The Epstein-Barr virus latent membrane protein 1 induces interleukin-10 in Burkitt's lymphoma cells but not in Hodgkin's cells involving the p38/SAPK2 pathway. Virology 280, 183-198.
110. Vockerodt, M., Pinkert, D., Smola-Hess, S., Michels, A., Ransohoff, R.M., Tesch, H., and Kube, D. (2005). The Epstein-Barr virus oncoprotein latent membrane protein 1 induces expression of the chemokine IP-10: Importance of mRNA half-life regulation. Int. J. Cancer 114, 598-605.
111. Wajant, H., Pfizenmaier, K., and Scheurich, P. (2003). Tumor necrosis factor signaling. Cell Death Differ. 10, 45-65.
112. Wan, J., Sun, L., Mendoza, J.W., Chui, Y.L., Huang, D.P., Chen, Z.J., Suzuki, N., Suzuki, S., Yeh, W.C., Akira, S., et al. (2004). Elucidation of the c-Jun N-terminal kinase pathway mediated by Epstein-Barr virus-encoded latent membrane protein 1. Mol. Cell. Biol. 24, 192-199.
113. Wan, J., Zhang, W., Wu, L., Bai, T., Zhang, M., Lo, K.W., Chui, Y.L., Cui, Y., Tao, Q., Yamamoto, M., et al. (2006). BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway. Mol. Cell. Biol. 26, 448-456.
114. Wang, C., Deng, L., Hong, M., Akkaraju, G.R., Inoue, J., and Chen, Z.J. (2001). TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351.
115. Wang, D., Liebowitz, D., and Kieff, E. (1985). An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 43, 831-840.
116. Wicovsky, A., Muller, N., Daryab, N., Marienfeld, R., Kneitz, C., Kavuri, S., Leverkus, M., Baumann, B., andWajant, H. (2007). Sustained JNK activation in response to tumor necrosis factor is mediated by caspases in a cell type-specific manner. J. Biol. Chem. 282, 2174-2183.
117. Wolff, T., Zielecki, F., Abt, M., Voss, D., Semmler, I., and Matthaei, M. (2008). Sabotage of antiviral signaling and effectors by influenza viruses. Biol. Chem. 389, 1299-1305.
118. Wu, C.J., Conze, D.B., Li, T., Srinivasula, S.M., and Ashwell, J.D. (2006a). Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation. Nat. Cell Biol. 8, 398-406.
119. Wu, H. and Arron, J.R. (2003). TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Bioessays 25, 1096-1105.
120. Wu, L., Nakano, H., and Wu, Z. (2006b). The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-κB through TRAF6 and TAK1. J. Biol. Chem. 281, 2162-2169.
121. Xie, P., Hostager, B.S., and Bishop, G.A. (2004). Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes. J. Exp. Med. 199, 661-671.
122. Xin, B., He, Z., Yang, X., Chan, C.P., Ng, M.H., and Cao, L. (2001). TRADD domain of Epstein-Barr virus transforming protein LMP1 is essential for inducing immortalization and suppressing senescence of primary rodent fibroblasts. J. Virol. 75, 3010-3015.
123. Young, L.S. and Rickinson, A.B. (2004). Epstein-Barr virus: 40 years on. Nat. Rev. Cancer 4, 757-768.
124. Zhang, S.Q., Kovalenko, A., Cantarella, G., and Wallach, D. (2000). Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKγ) upon receptor stimulation. Immunity 12, 301-311.
125. Zheng, L., Bidere, N., Staudt, D., Cubre, A., Orenstein, J., Chan, F.K., and Lenardo, M. (2006). Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. Mol. Cell. Biol. 26, 3505-3513.
126. Zou, P., Kawada, J., Pesnicak, L., and Cohen, J.I. (2007). Bortezomib induces apoptosis of Epstein-Barr virus (EBV)-transformed B cells and prolongs survival of mice inoculated with EBV-transformed B cells. J. Virol. 81, 10029-10036.