Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-κB

EMBO Journal

Volumn 23, Issue 2, 2004, Pages 322-332

  Habelhah, Hasem ^a   Takahashi, Shoichi ^a   Cho, Ssang Goo ^a   Kadoya, Takayuki ^a   Watanabe, Toshiki ^b   Ronai, Ze'ev ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

JNK; NF B; TNF ; TRAF2; Ubiquitin

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; ENZYME ACTIVATION; HELA CELL; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; BETA-CYCLODEXTRINS; CELL LINE; CELL MEMBRANE; CYCLODEXTRINS; CYTOSKELETON; ENZYME ACTIVATION; HUMANS; I-KAPPA B PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE MICRODOMAINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEINS; REED-STERNBERG CELLS; RNA INTERFERENCE; TNF RECEPTOR-ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

ANIMALIA; PHRAGMITES;

EID: 1542380581     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600044     Document Type: Article

References (32)

1. Arch RH, Gedrich RW, Thompson CB (2000) Translocation of TRAF proteins regulates apoptotic threshold of cells. Biochem Biophys Res Commun 272: 936-945
2. Arron JR, Pewzner-Jung Y, Walsh MC, Kobayashi T, Choi Y (2002) Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling. J Exp Med 196: 923-934
3. Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M (1999) Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev 13: 1297-1308
4. Bradley JR, Pober JS (2001) Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene 20: 6482-6491
5. Brink R, Lodish HF (1998) Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2-mediated NF-kappaB activation. J Biol Chem 273: 4129-4134
6. Cottin V, Doan JE, Riches DW (2002) Restricted localization of the TNF receptor CD12a to lipid rafts: a novel role for the death domain. J Immunol 168: 4095-4102
7. Dadgostar H, Cheng GH (2000) Membrane localization of TRAF3 enables JNK activation. J Biol Chem 275: 2539-2544
8. Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ (2000) Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103: 351-361
9. Fuchs SY, Ronai Z (1999) Ubiquitination and degradation of ATF2 are dimerization dependent. Mol Cell Biol 19: 3289-3298
10. Habelhah H, Frew IJ, Laine A, Janes PW, Relaix F, Sasson D, Bowtell DD, Ronai Z (2002) Stress-induced decrease in TRAF2 stability is mediated by Siah2. EMBO J 21: 5756-5765
11. Horie R, Watanabe T, Ito K, Morisita Y, Watanabe M, Ishida T, Higashihara M, Kadin M, Watanabe T (2002) Cytoplasmic aggregation of TRAF2 and TRAF5 protein in the Hodgkin-Reed-Sternberg cells. Am J Pathol 160: 1647-1654
12. Hostager BS, Catlett IM, Bishop GA (2000) Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling. J Biol Chem 275: 15392-15398
13. Hu HM, O'Rourke K, Boguski MS, Dixit VM (1994) A novel RING finger protein interacts with the cytoplasmic domain of CD40. J Biol Chem 269: 30069-30072
14. Ikonen E (2001) Role of lipid rafts in membrane transport. Curr Opion Cell Biol 13: 470-477
15. Joazeiro CA, Weissman AM (2000) RING finger proteins: mediators of ubiquitin ligase activity. Cell 102: 49-52
16. Ko YG, Lee JS, Kang YS, Ahn JH, Seo JS (1999) TNFα-mediated apoptosis is initiated in caveolae-like domains. J Immunol 162: 7217-7223
17. Kobayashi N, Kadono Y, Naito A, Matsumoto K, Yamamoto T, Tanaka S, Inoue J (2001) Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J 20 (6): 1271-1280
18. Leonardi A, Ellinger-Ziegelbauer H, Franzoso G, Brown K, Siebenlist U (2000) Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2. J Biol Chem 275: 271-278
19. Legler DF, Micheau O, Doucey MA, Tschopp J, Bron C (2003) Recruitment of TNF receptor 1 to lipid rafts is essential for TNFa-mediated NF-kB activation. Immunity 18: 655-664
20. Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J, Gu W (2002) Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 416: 648-653
21. Nakano H, Sakon S, Koseki H, Takemori T, Tada K, Matsumoto M, Munechika E, Sakai T, Shirasawa T, Akiba H, Kobata T, Santee SM, Ware CF, Rennert PD, Taniguchi M, Yagita H, Okumura K (1999) Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proc Natl Acad Sci USA 96: 9803-9808
22. Natoli G, Costanzo A, Ianni A, Templeton DJ, Woodgett JR, Balsano C, Levrero M (1997) Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway. Science 275: 200-203
23. Nishitoh H, Saito M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (1998) ASK1 is essential for JNK.SAPK activation by TRAF2. Mol Cell 2: 389-395
24. Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (1995) The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83: 1243-1252
25. Shi CS, Kehrl JH (2003) Tumor necrosis factor (TNF)-induced germinal center kinase related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). J Biol Chem 278: 15429-15434
26. Staudt LM (2000) The molecular and cellular origins of Hodgkin's disease. J Exp Med 191: 207-212
27. Tada K, Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak TW, Yagita H, Okumura K, Yeh WC, Nakao H (2001) Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-κB activation and protection from cell death. J Biol Chem 276: 36530-36534
28. Takayanagi H, Ogasawara K, Hida S, Chiba T, Murata S, Sato K, Takaoka A, Yokochi T, Oda H, Tanaka K, Nakamura K, Taniguchi T (2000) T-cell-mediated regulation of osteoclastogenesis by signaling cross-talk between RANKL and IFN-γ. Nature 408: 600-605
29. Takeuchi M, Rothe M, Goeddel DV (1996) Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. J Biol Chem 271: 19935-19942
30. Veldman RJ, Maestre N, Aduib OM, Medin JA, Salvayre T, Levade T (2001) A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: potential implications in tumour necrosis factor signaling. Biochem J 355: 859-868
31. Wang C, Deng L, Hong M, Akkaraju GR, Inoue J-I, Chen ZJ (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412: 346-351
32. Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC (2001) A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J Biol Chem 276: 24242-24252