TRADD domain of Epstein-Barr virus transforming protein LMP1 is essential for inducing immortalization and suppressing senescence of primary rodent fibroblasts

Journal of Virology

Volumn 75, Issue 6, 2001, Pages 3010-3015

  Xin, B ^a   He, Z ^a   Yang, X ^a   Chan, C P ^a   Ng, M H ^a   Cao, L ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LATENT MEMBRANE PROTEIN 1; TRANSCRIPTION FACTOR AP 1; TRANSFORMING PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL GROWTH; CELL IMMORTALIZATION; CONTROLLED STUDY; EPSTEIN BARR VIRUS; FIBROBLAST; LIFESPAN; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; RAT; SENESCENCE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; VIRUS CARCINOGENESIS; VIRUS RECOMBINANT;

ANIMALS; CELL AGING; CELL DIVISION; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA MUTATIONAL ANALYSIS; FIBROBLASTS; HERPESVIRUS 4, HUMAN; MICE; PROTEIN STRUCTURE, TERTIARY; PROTEINS; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 1; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS; VIRAL MATRIX PROTEINS;

EID: 0035123884     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.6.3010-3015.2001     Document Type: Article

References (41)

1. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
2. Mutations in the 1κBa gene in Hodgkin's disease suggest a tumour suppressor role for IκBα
3. Epstein-Barr virus transformation: Involvement of latent membrane protein 1-mediated activation of NF-κB
4. Replicative senescence: An old lives' tale?
5. A biomarker that identifies senescent human cells in cuhure and in aging skin in vivo
6. Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter
7. Activation of the c-Jun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1)
8. Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein 1 coregulates interleukin-6 and interleukin-8 production
9. Nucleotide sequence of an mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane protein
10. Latent membrane protein I of Epstein-Barr virus mimics a constitutively active receptor molecule
11. Replicative senescence: The human fibroblast comes of age
12. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1
13. The serial cultivation of human diploid cell stains
14. Nuclear factor-κB activation is involved in LMP1-mediated transformation and tumorigenesis of rat-1 fibroblasts
15. Rules to replicate by
16. 1-to-S-phase transition
17. The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-κB and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain
18. The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation
19. The Epstein-Barr virus oncogene product latent membrane protein I engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB
20. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
21. An Epstein-Barr virus that expresses only the first 231 LMPI amino acids efficiently initiates primary B-lymphocyte growth transformation
22. The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation: Fibroblast cocultivation complements a critical function within the terminal 155 residues
23. Epstein Barr virus and its replication
24. Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade
25. Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells
26. Differential regulation of the c-myc oncogene promoter by the NF-κB rel family of transcription factors
27. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
28. Stimulation of NF-κB-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus
29. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
30. Aberrant rel/nfkb genes and activity in human cancer
31. Epstein-Barr virus
32. Role of the INK4a locus in tumor suppression and cell mortality
33. Cancer cell cycles
34. Inhibitors of mammalian G1 cyclin-dependent kinases
35. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
36. Origins of G 1 arrest in senescent human fibroblasts
37. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms
38. Defective IκBα in Hodgkin cell lines with constitutively active NF-κB
39. INK4a expression
40. LMP1 of Epstein-Barr virus induces proliferation of primary mouse embryonic fibroblasts and cooperatively transforms the cells with a pl6-insensitive CDK4 oncogene
41. INK4a tumor suppressor versus other 1NK4 family members during mouse development and aging