Effects of antisense oligonucleotide-mediated depletion of Tumor Necrosis Factor (TNF) receptor 1-associated death domain protein on TNF-induced gene expression

Molecular Pharmacology

Volumn 66, Issue 3, 2004, Pages 572-579

  Siwkowski, Andrew M ^a   Madge, Lisa A ^b   Koo, Seongjoon ^a   McMillan, Erin L ^a   Monia, Brett P ^a   Pober, Jordan S ^b   Baker, Brenda F ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ANTISENSE OLIGONUCLEOTIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; ISIS 100720; ISIS 110731; ISIS 110732; ISIS 25290; ISIS 25291; MESSENGER RNA; PHOSPHOTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1 ASSOCIATED DEATH DOMAIN PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UMBILICAL VEIN;

CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGONUCLEOTIDES, ANTISENSE; PROTEINS; RECEPTORS, TUMOR NECROSIS FACTOR; TNF RECEPTOR-ASSOCIATED FACTOR 1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 4944255289     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Baud V and Karin M (2001) Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol 11:372-377.
2. Bennett CF (1999) Antisense oligonucleotides therapeutics. Exp Opin Invest Drugs 8:237-253S.
3. Beutler BA (1999) The role of TNF in health and disease. J Rheumatol 26(Suppl 57):16-21.
4. Cantarella G, Lempereur L, Presta M, Ribatti D, Lombardo G, Lazarovici P, Zappala G, Pafumi C, and Bernardini R (2002) Nerve growth factor-endothelial cell interaction leads to angiogenesis in vitro and in vivo. FASEB J 16:1307-1309.
5. Cheng N and Chen J (2001) Tumor necrosis factor-α induction of endothelial ephrin A1 expression is mediated by a p38 MAPK- and SAPK/JNK-dependent but nuclear factor-κB-independent mechanism. J Biol Chem 276:13771-13777.
6. Chinnaiyan AM, O'Rourke K, Yu GL, Lyons RH, Garg M, Duan DR, Xing L, Gentz R, Ni J, and Dixit VM (1996) Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science (Wash DC) 274:990-992.
7. Cook PD (1998) Second generation antisense oligonucleotides: 2′-modifications. Ann Reports Med Chem 33:313-325.
8. Dunn C, Wiltshire C, MacLaren A, and Gillespie DAF (2002) Molecular mechanisms and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor. Cell Signal 14:585-593.
9. Eisen MB, Spellman PT, Brown PO, and Botstein D (1998) Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95:14863-14868.
10. Eliopoulos AG, Blake SMS, Floettmann JE, Rowe M, and Young LS (1999) Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2. J Virol 73:1023-1035.
11. El Yazidi-Belkoura I, Adriaenssens E, Dolle L, Descamps S, and Hondermarck H (2003) Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells. J Biol Chem 278:16952-16956.
12. Hsu H, Huang J, Shu H-B, Baichwal V, and Goeddel DV (1996b) TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4:387-396.
13. Hsu H, Shu H-B, Pan M-G, and Goeddel DV (1996a) TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84:299-308.
14. Hsu H, Xiong J, and Goeddel DV (1995) The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81:495-504.
15. Introna M, Mantovani A (1997) Early activation signals in endothelial cells. Stimulation by cytokines. Arterioscler Thromb Vasc Biol 17:423-428.
16. Izumi KM, Cahir McFarland ED, Ting AT, Riley EA, Seed B, and Kieff ED (1999) The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation. Mol Cell Biol 19:5759-5767.
17. Jiang Y, Woronicz JD, Liu W, and Goeddel DV (1999) Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science (Wash DC) 283:543-546.
18. Koller E, Gaarde WA, and Monia BP (2000) Elucidating cell signaling mechanisms using antisense technology. Trends Pharmacol Sci 21:142-148.
19. Lopez-Cabrera M, Munoz E, Blazquez MV, Ursa MA, Santis AG, and Sanchez-Madrid F (1995) Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of the its tumor necrosis factor-α-responsive elements. J Boil Chem 270:21545-21551.
20. MacEwan DJ (2002) TNF receptor subtype signalling: Differences and cellular consequences. Cell Signal 14:477-492.
21. Madge LA and Pober JS (2000) A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFκB in human endothelial cells. J Biol Chem 275:15458-15465.
22. Madge LA and Pober JS (2001) TNF signaling in vascular endothelial cells. Exp Mol Pathol 70:317-325.
23. McFarlane SM, Pashmi G, Connell MC, Littlejohn AF, Tucker SJ, Vandenabeele P, and MacEwan DJ (2002) Differential activation of nuclear factor-kB by tumour necrosis factor receptor subtypes. TNFR1 predominates whereas TNFR2 activates transcription poorly. FEBS Lett 515:119-126.
24. McKay RA, Miraglia LJ, Cummins LL, Owens SR, Sasmor H, and Dean NM (1999) Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-α expression. J Biol Chem 274:1715-1722.
25. O'Neill LA and Greene C (1998) Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects and plants. J Leukoc Biol 63:650-657.
26. Pahl HL (1999) Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18:6853-6866.
27. Paleolog EW, Delasalle SJ, Buurman WA, and Feldman M (1994) Functional activities of receptors for tumor necrosis factor-α on human vascular endothelial cells. Blood 84:2578-2590.
28. Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, and Dixit VM (1998) Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett 431:351-356.
29. Park A and Baichwal VR (1996) Systematic mutational analysis of the death domain of the tumor necrosis factor receptor 1-associated protein TRADD. J Biol Chem 271:9858-9862.
30. Sanghvi YS, Andrade M, Deshmukh RR, Holmberg L, Scozzari A, and Cole DL (1999) Chem synthesis and purification of phosphorothioate antisense oligonucleotides, in Manual of Antisense Methodology (Hartmann G and Endres S eds), pp. 3-23, Kluwer Academic, Boston.
31. Schmid RM and Adler G (2000) NF-κB/Rel/IkB: implications in gastrointestinal diseases. Gastroenterology 118:1208-1228.
32. Shaulian E and Karin M (2001) AP-1 in cell proliferation and survival. Oncogene 20:2390-2400.
33. Slowik MR, De Luca LG, Fiers W, and Pober JS (1993) Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration. Am J Pathol 143:1724-1730.
34. Wajant H, Henkler F, and Scheurich P (2001) The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. Cellular Signal 13:389-400.
35. Wang Q, Ji Y, Wang X, and Evers BM (2000) Isolation and molecular characterization of the 5′-upstream region of the human TRAIL gene. Biochem Biophys Res Commun 276:466-471.
36. Winer J, Jung CKS, Shackel I, and Williams PM (1999) Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem 270:41-49.
37. Wu H, Lima WF, and Crooke ST (1999) Properties of cloned and expressed human RNase H1. J Biol Chem 274:28270-28278.
38. Xu XS, Vanderziel C, Bennett CF, and Monia BP (1998) A role for c-Raf kinase and Ha-Ras in cytokine-mediated induction of cell adhesion molecules. J Biol Chem 273:33230-33238.
39. Zhang H, Cook J, Nickel J, Yu R, Stecker K, Myers K, and Dean NM (2000) Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis. Nat Biotechnol 18:862-867.
40. Zhao B, Stavchansky SA, Bowden RA, and Bowman PD (2003) Effect of interleukin-1β and tumor necrosis factor-α on gene expression in human endothelial cells. Am J Physiol 284:C1577-83.