-
1
-
-
0015383455
-
Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
-
Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26:239-257.
-
(1972)
Br J Cancer
, vol.26
, pp. 239-257
-
-
Kerr, J.F.1
Wyllie, A.H.2
Currie, A.R.3
-
3
-
-
0030947095
-
Programmed cell death in animal development
-
Jacobson MD, Weil M, Raff MC. Programmed cell death in animal development. Cell 1997;88:347-354.
-
(1997)
Cell
, vol.88
, pp. 347-354
-
-
Jacobson, M.D.1
Weil, M.2
Raff, M.C.3
-
4
-
-
0028943734
-
Apoptosis in the pathogenesis and treatment of disease
-
Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456-1462.
-
(1995)
Science
, vol.267
, pp. 1456-1462
-
-
Thompson, C.B.1
-
5
-
-
0032575714
-
Death receptors: Signaling and modulation
-
Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998;281:1305-1308.
-
(1998)
Science
, vol.281
, pp. 1305-1308
-
-
Ashkenazi, A.1
Dixit, V.M.2
-
6
-
-
0030931876
-
Cohen GM Caspases: The executioners of apoptosis
-
Cohen GM Caspases: the executioners of apoptosis. Biochem J 1997; 326:1-16.
-
(1997)
Biochem J
, vol.326
, pp. 1-16
-
-
-
7
-
-
0032575752
-
Mitochondria and apoptosis
-
Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281:1309-1312.
-
(1998)
Science
, vol.281
, pp. 1309-1312
-
-
Green, D.R.1
Reed, J.C.2
-
8
-
-
0032575750
-
Caspases: Enemies within
-
Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998; 281:1312-1316.
-
(1998)
Science
, vol.281
, pp. 1312-1316
-
-
Thornberry, N.A.1
Lazebnik, Y.2
-
10
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000;103:239-252.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
11
-
-
0035282334
-
Mammalian MAP kinase signalling cascades
-
Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001;410:37-40.
-
(2001)
Nature
, vol.410
, pp. 37-40
-
-
Chang, L.1
Karin, M.2
-
12
-
-
0036098552
-
AP-1 as a regulator of cell life and death
-
Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 2002;4:E131-E136.
-
(2002)
Nat Cell Biol
, vol.4
-
-
Shaulian, E.1
Karin, M.2
-
13
-
-
0027423418
-
Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
-
Hibi M, Lin A, Smeal T, Minden A, Karin M. Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993;7:2135-2148.
-
(1993)
Genes Dev
, vol.7
, pp. 2135-2148
-
-
Hibi, M.1
Lin, A.2
Smeal, T.3
Minden, A.4
Karin, M.5
-
14
-
-
0026004501
-
Phosphorylation of c-jun mediated by MAP kinases
-
Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR. Phosphorylation of c-jun mediated by MAP kinases. Nature 1991;353: 670-674.
-
(1991)
Nature
, vol.353
, pp. 670-674
-
-
Pulverer, B.J.1
Kyriakis, J.M.2
Avruch, J.3
Nikolakaki, E.4
Woodgett, J.R.5
-
15
-
-
0026635602
-
Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: Regulation by the N-terminal delta domain
-
Adler V, Franklin CC, Kraft AS. Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain. Proc Natl Acad Sci USA 1992;89:5341-5345.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 5341-5345
-
-
Adler, V.1
Franklin, C.C.2
Kraft, A.S.3
-
16
-
-
0025806587
-
Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain
-
Binetruy B, Smeal T, Karin M. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 1991;351: 122-127.
-
(1991)
Nature
, vol.351
, pp. 122-127
-
-
Binetruy, B.1
Smeal, T.2
Karin, M.3
-
17
-
-
0025788098
-
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
-
Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 1991;354:494-496.
-
(1991)
Nature
, vol.354
, pp. 494-496
-
-
Smeal, T.1
Binetruy, B.2
Mercola, D.A.3
Birrer, M.4
Karin, M.5
-
18
-
-
0029032249
-
The regulation of AP-1 activity by mitogen-activated protein kinases
-
Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 1995;270:16483-16486.
-
(1995)
J Biol Chem
, vol.270
, pp. 16483-16486
-
-
Karin, M.1
-
19
-
-
0028329953
-
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
-
Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994;76:1025-1037.
-
(1994)
Cell
, vol.76
, pp. 1025-1037
-
-
Derijard, B.1
Hibi, M.2
Wu, I.H.3
Barrett, T.4
Su, B.5
Deng, T.6
Karin, M.7
Davis, R.J.8
-
20
-
-
0028229012
-
The stress-activated protein kinase subfamily of c-Jun kinases
-
Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 1994;369:156-160.
-
(1994)
Nature
, vol.369
, pp. 156-160
-
-
Kyriakis, J.M.1
Banerjee, P.2
Nikolakaki, E.3
Dai, T.4
Rubie, E.A.5
Ahmad, M.F.6
Avruch, J.7
Woodgett, J.R.8
-
21
-
-
0033499801
-
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
-
Yamamoto K, Ichijo H, Korsmeyer SJ. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 1999;19:8469-8478.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 8469-8478
-
-
Yamamoto, K.1
Ichijo, H.2
Korsmeyer, S.J.3
-
22
-
-
15644381250
-
Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac 1
-
Maundrell K, et al. Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac 1. J Biol Chem 1997;272:25238-25242.
-
(1997)
J Biol Chem
, vol.272
, pp. 25238-25242
-
-
Maundrell, K.1
-
23
-
-
0028943245
-
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
-
Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercuric F, Johnson GL, Karin M. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 1995;268:286-290.
-
(1995)
Science
, vol.268
, pp. 286-290
-
-
Lin, A.1
Minden, A.2
Martinetto, H.3
Claret, F.X.4
Lange-Carter, C.5
Mercuric, F.6
Johnson, G.L.7
Karin, M.8
-
24
-
-
0028935974
-
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
-
Derijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ, Davis RJ. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 1995;267:682-685.
-
(1995)
Science
, vol.267
, pp. 682-685
-
-
Derijard, B.1
Raingeaud, J.2
Barrett, T.3
Wu, I.H.4
Han, J.5
Ulevitch, R.J.6
Davis, R.J.7
-
25
-
-
0028558986
-
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
-
Sanchez I, Hughes RT, Mayer BJ, Yee K, Woodgett JR, Avruch J, Kyriakis JM, Zon LI. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 1994;372:794-798.
-
(1994)
Nature
, vol.372
, pp. 794-798
-
-
Sanchez, I.1
Hughes, R.T.2
Mayer, B.J.3
Yee, K.4
Woodgett, J.R.5
Avruch, J.6
Kyriakis, J.M.7
Zon, L.I.8
-
26
-
-
0030770419
-
Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38
-
Lu X, Nemoto S, Lin A. Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. J Biol Chem 1997;272:24751-24754.
-
(1997)
J Biol Chem
, vol.272
, pp. 24751-24754
-
-
Lu, X.1
Nemoto, S.2
Lin, A.3
-
27
-
-
0034992168
-
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines
-
Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev 2001;15:1419-1426.
-
(2001)
Genes Dev
, vol.15
, pp. 1419-1426
-
-
Tournier, C.1
Dong, C.2
Turner, T.K.3
Jones, S.N.4
Flavell, R.A.5
Davis, R.J.6
-
28
-
-
0034668860
-
Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7
-
Fleming Y, Armstrong CG, Mortice N, Paterson A, Goedert M, Cohen P. Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. Biochem J 2000;352 Pt 1:145-154.
-
(2000)
Biochem J
, vol.352
, Issue.PART 1
, pp. 145-154
-
-
Fleming, Y.1
Armstrong, C.G.2
Mortice, N.3
Paterson, A.4
Goedert, M.5
Cohen, P.6
-
29
-
-
0028568217
-
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
-
Minden A, Lin A, McMahon M, Lange-Carter C, Derijard B, Davis RJ, Johnson GL, Karin M. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 1994;266:1719-1723.
-
(1994)
Science
, vol.266
, pp. 1719-1723
-
-
Minden, A.1
Lin, A.2
McMahon, M.3
Lange-Carter, C.4
Derijard, B.5
Davis, R.J.6
Johnson, G.L.7
Karin, M.8
-
30
-
-
14444281569
-
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
-
Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 1997;275:90-94.
-
(1997)
Science
, vol.275
, pp. 90-94
-
-
Ichijo, H.1
Nishida, E.2
Irie, K.3
Ten Dijke, P.4
Saitoh, M.5
Moriguchi, T.6
Takagi, M.7
Matsumoto, K.8
Miyazono, K.9
Gotoh, Y.10
-
31
-
-
0030462564
-
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6
-
Tibbles LA, Ing YL, Kiefer F, Chan J, Iscove N, Woodgett JR, Lassam NJ. MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6. EMBO J 1996;15:7026-7035.
-
(1996)
EMBO J
, vol.15
, pp. 7026-7035
-
-
Tibbles, L.A.1
Ing, Y.L.2
Kiefer, F.3
Chan, J.4
Iscove, N.5
Woodgett, J.R.6
Lassam, N.J.7
-
32
-
-
0029940355
-
TAB1: An activator of the TAK1 MAPKKK in TGF-beta signal transduction
-
Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science 1996;272:1179-1182.
-
(1996)
Science
, vol.272
, pp. 1179-1182
-
-
Shibuya, H.1
Yamaguchi, K.2
Shirakabe, K.3
Tonegawa, A.4
Gotoh, Y.5
Ueno, N.6
Irie, K.7
Nishida, E.8
Matsumoto, K.9
-
33
-
-
0030059508
-
Activation of MEK-1 and SEK-1 by Tp1-2 proto-oncoprotein, a novel MAP kinase kinase kinase
-
Salmeron A, Ahmad TB, Carlile GW, Pappin D, Narsimhan RP. Ley SC. Activation of MEK-1 and SEK-1 by Tp1-2 proto-oncoprotein, a novel MAP kinase kinase kinase. EMBO J 1996;1:817-826.
-
(1996)
EMBO J
, vol.1
, pp. 817-826
-
-
Salmeron, A.1
Ahmad, T.B.2
Carlile, G.W.3
Pappin, D.4
Narsimhan, R.P.5
Ley, S.C.6
-
34
-
-
0034625170
-
MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration
-
Xia Y, Makris C, Su B, Li E, Yang J, Nemerow GR, Karin M. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci USA 2000;97:5243-5248.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 5243-5248
-
-
Xia, Y.1
Makris, C.2
Su, B.3
Li, E.4
Yang, J.5
Nemerow, G.R.6
Karin, M.7
-
35
-
-
0032483967
-
Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption
-
Yujiri T, Sather S, Fanger GR, Johnson GL. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science 1998;282:1911-1914.
-
(1998)
Science
, vol.282
, pp. 1911-1914
-
-
Yujiri, T.1
Sather, S.2
Fanger, G.R.3
Johnson, G.L.4
-
36
-
-
0032508714
-
A mammalian scaffold complex that selectively mediates MAP kinase activation
-
Whitmarsh AJ, Cavanagh J, Tournier C, Yasuda J, Davis RJ. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 1998;281:1671-1674.
-
(1998)
Science
, vol.281
, pp. 1671-1674
-
-
Whitmarsh, A.J.1
Cavanagh, J.2
Tournier, C.3
Yasuda, J.4
Davis, R.J.5
-
37
-
-
0034711397
-
Beta-arrestin 2: A receptor-regulated MAPK scaffold for the activation of JNK3
-
McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science 2000;290:1574-1577.
-
(2000)
Science
, vol.290
, pp. 1574-1577
-
-
McDonald, P.H.1
Chow, C.W.2
Miller, W.E.3
Laporte, S.A.4
Field, M.E.5
Lin, F.T.6
Davis, R.J.7
Lefkowitz, R.J.8
-
38
-
-
0032694245
-
JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK Signaling pathway
-
Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI. JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK Signaling pathway. Mol Cell Biol 1999; 19:7539-7548.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 7539-7548
-
-
Ito, M.1
Yoshioka, K.2
Akechi, M.3
Yamashita, S.4
Takamatsu, N.5
Sugiyama, K.6
Hibi, M.7
Nakabeppu, Y.8
Shiba, T.9
Yamamoto, K.I.10
-
39
-
-
0036009115
-
NF-κB at the crossroads of life and death
-
Karin M, Lin A. NF-κB at the crossroads of life and death. Nat Immunol 2002;3:221-227.
-
(2002)
Nat Immunol
, vol.3
, pp. 221-227
-
-
Karin, M.1
Lin, A.2
-
40
-
-
0035891320
-
Inhibition of JNK activation through NF-κB target genes
-
Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. Inhibition of JNK activation through NF-κB target genes. Nature 2001;414:313-317.
-
(2001)
Nature
, vol.414
, pp. 313-317
-
-
Tang, G.1
Minemoto, Y.2
Dibling, B.3
Purcell, N.H.4
Li, Z.5
Karin, M.6
Lin, A.7
-
41
-
-
0035913158
-
NF-κB activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: A mechanism for the anti-apoptotic effect of NF-κB
-
Javelaud D Besancon F. NF-κB activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-κB. Oncogene 2001;20:4365-4372.
-
(2001)
Oncogene
, vol.20
, pp. 4365-4372
-
-
Javelaud, D.1
Besancon, F.2
-
42
-
-
0035889252
-
Induction of gadd45beta by NF-κB downregulates pro-apoptotic JNK signalling
-
De Smaele E, Zazzeroni F. Papa S, Nguyen DU, Jin R, Jones J, Cong R, Franzoso G. Induction of gadd45beta by NF-κB downregulates pro-apoptotic JNK signalling. Nature 2001;414:308-313.
-
(2001)
Nature
, vol.414
, pp. 308-313
-
-
De Smaele, E.1
Zazzeroni, F.2
Papa, S.3
Nguyen, D.U.4
Jin, R.5
Jones, J.6
Cong, R.7
Franzoso, G.8
-
43
-
-
33748501280
-
Resistance to TNF-α cytotoxicity can be achieved through different signaling pathways in rat mesangial cells
-
Guo YL, Kang B, Williamson JR. Resistance to TNF-α cytotoxicity can be achieved through different signaling pathways in rat mesangial cells. Am J Physiol 1999;276:C435-C441.
-
(1999)
Am J Physiol
, vol.276
-
-
Guo, Y.L.1
Kang, B.2
Williamson, J.R.3
-
44
-
-
0008206988
-
TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival
-
Lee SY, Reichlin A, Santana A, Sokol KA, Nussenzweig MC, Choi Y. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival. Immunity 1997;7:703-713.
-
(1997)
Immunity
, vol.7
, pp. 703-713
-
-
Lee, S.Y.1
Reichlin, A.2
Santana, A.3
Sokol, K.A.4
Nussenzweig, M.C.5
Choi, Y.6
-
45
-
-
0031013545
-
Activation of SAPK/JNK by TNF receptor 1 through a non-cytotoxic TRAF2-dependent pathway
-
Natoli G, Costanzo A, Ianni A. Templeton DJ, Woodgett JR, Balsano C, Levrero M. Activation of SAPK/JNK by TNF receptor 1 through a non-cytotoxic TRAF2-dependent pathway. Science 1997;275:200-203.
-
(1997)
Science
, vol.275
, pp. 200-203
-
-
Natoli, G.1
Costanzo, A.2
Ianni, A.3
Templeton, D.J.4
Woodgett, J.R.5
Balsano, C.6
Levrero, M.7
-
46
-
-
0030298294
-
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death
-
Liu ZG, Hsu H, Goeddel DV, Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 1996;87:565-576.
-
(1996)
Cell
, vol.87
, pp. 565-576
-
-
Liu, Z.G.1
Hsu, H.2
Goeddel, D.V.3
Karin, M.4
-
47
-
-
0027242180
-
c-jun is essential for normal mouse development and hepatogenesis
-
Hilberg F. Aguzzi A, Howells N, Wagner EF. c-jun is essential for normal mouse development and hepatogenesis. Nature 1993;365:179-181.
-
(1993)
Nature
, vol.365
, pp. 179-181
-
-
Hilberg, F.1
Aguzzi, A.2
Howells, N.3
Wagner, E.F.4
-
48
-
-
0032979438
-
Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
-
Behrens A, Sibilia M, Wagner EF. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet 1999;21:326-329
-
(1999)
Nat Genet
, vol.21
, pp. 326-329
-
-
Behrens, A.1
Sibilia, M.2
Wagner, E.F.3
-
49
-
-
0034607702
-
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
-
Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 2000; 288:870-874.
-
(2000)
Science
, vol.288
, pp. 870-874
-
-
Tournier, C.1
Hess, P.2
Yang, D.D.3
Xu, J.4
Turner, T.K.5
Nimnual, A.6
Bar-Sagi, D.7
Jones, S.N.8
Flavell, R.A.9
Davis, R.J.10
-
50
-
-
0033545386
-
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development
-
Sabapathy K, Hu Y, Kallunki T, Schreiber M, David JP, Jochum W, Wagner EF, Karin M. JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr Biol 1999;9:116-125.
-
(1999)
Curr Biol
, vol.9
, pp. 116-125
-
-
Sabapathy, K.1
Hu, Y.2
Kallunki, T.3
Schreiber, M.4
David, J.P.5
Jochum, W.6
Wagner, E.F.7
Karin, M.8
-
51
-
-
0035808769
-
c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation
-
Sabapathy K, Kallunki T, David JP, Graef I, Karin M, Wagner EF. c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. J Exp Med 2001;193:317-328.
-
(2001)
J Exp Med
, vol.193
, pp. 317-328
-
-
Sabapathy, K.1
Kallunki, T.2
David, J.P.3
Graef, I.4
Karin, M.5
Wagner, E.F.6
-
52
-
-
0033063568
-
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4
-
Nishina H, et al. Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 1999;126:505-516.
-
(1999)
Development
, vol.126
, pp. 505-516
-
-
Nishina, H.1
-
53
-
-
0032499687
-
SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis
-
Ganiatsas S, Kwee L, Fujiwara Y, Perkins A, Ikeda T, Labow MA, Zon LI. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci USA 1998;95:6881-6886.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6881-6886
-
-
Ganiatsas, S.1
Kwee, L.2
Fujiwara, Y.3
Perkins, A.4
Ikeda, T.5
Labow, M.A.6
Zon, L.I.7
-
54
-
-
0029012476
-
Rubin LL A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
-
Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, Yaniv M, Rubin LL A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 1995;14:927-939.
-
(1995)
Neuron
, vol.14
, pp. 927-939
-
-
Ham, J.1
Babij, C.2
Whitfield, J.3
Pfarr, C.M.4
Lallemand, D.5
Yaniv, M.6
-
55
-
-
0028880006
-
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
-
Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995;270:1326-1331.
-
(1995)
Science
, vol.270
, pp. 1326-1331
-
-
Xia, Z.1
Dickens, M.2
Raingeaud, J.3
Davis, R.J.4
Greenberg, M.E.5
-
56
-
-
0032937879
-
Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
-
Le-Niculescu H, Bonfoco E, Kasuya Y, Claret FX, Green DR, Karin M. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol 1999;19:751-763.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 751-763
-
-
Le-Niculescu, H.1
Bonfoco, E.2
Kasuya, Y.3
Claret, F.X.4
Green, D.R.5
Karin, M.6
-
57
-
-
0030780804
-
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
-
Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic P, Flavell RA. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 1997;389:865-870.
-
(1997)
Nature
, vol.389
, pp. 865-870
-
-
Yang, D.D.1
Kuan, C.Y.2
Whitmarsh, A.J.3
Rincon, M.4
Zheng, T.S.5
Davis, R.J.6
Rakic, P.7
Flavell, R.A.8
-
58
-
-
0034918203
-
JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons
-
Bruckner SR, Tammariello SP, Kuan CY, Flavell RA, Rakic P, Estus S. JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons. J Neurochem 2001;78:298-303.
-
(2001)
J Neurochem
, vol.78
, pp. 298-303
-
-
Bruckner, S.R.1
Tammariello, S.P.2
Kuan, C.Y.3
Flavell, R.A.4
Rakic, P.5
Estus, S.6
-
59
-
-
0032724021
-
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
-
Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev 1999;89:115-124.
-
(1999)
Mech Dev
, vol.89
, pp. 115-124
-
-
Sabapathy, K.1
Jochum, W.2
Hochedlinger, K.3
Chang, L.4
Karin, M.5
Wagner, E.F.6
-
60
-
-
0033118607
-
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
-
Kuan CY, Yang D, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 1999;22:667-676.
-
(1999)
Neuron
, vol.22
, pp. 667-676
-
-
Kuan, C.Y.1
Yang, D.2
Samanta Roy, D.R.3
Davis, R.J.4
Rakic, P.5
Flavell, R.A.6
-
61
-
-
0035883958
-
Requirement of the JIP1 scaffold protein for stress-induced JNK activation
-
Whitmarsh AJ, et al. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev 2001;15:2421-2432.
-
(2001)
Genes Dev
, vol.15
, pp. 2421-2432
-
-
Whitmarsh, A.J.1
-
62
-
-
0030067803
-
Programmed cell death in the absence of c-Fos and c-Jun
-
Roffler-Tarlov S, Brown JJ, Tarlov E, Stolarov J, Chapman DL, Alexiou M, Papaioannou VE. Programmed cell death in the absence of c-Fos and c-Jun. Development 1996;122:1-9.
-
(1996)
Development
, vol.122
, pp. 1-9
-
-
Roffler-Tarlov, S.1
Brown, J.J.2
Tarlov, E.3
Stolarov, J.4
Chapman, D.L.5
Alexiou, M.6
Papaioannou, V.E.7
-
63
-
-
0031029214
-
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
-
Nishina H, Fischer KD, Radvanyi L, Shahinian A, Hakem R, Rubie EA, Bernstein A, Mak TW, Woodgett JR, Penninger JM. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 1997;385:350-353.
-
(1997)
Nature
, vol.385
, pp. 350-353
-
-
Nishina, H.1
Fischer, K.D.2
Radvanyi, L.3
Shahinian, A.4
Hakem, R.5
Rubie, E.A.6
Bernstein, A.7
Mak, T.W.8
Woodgett, J.R.9
Penninger, J.M.10
-
65
-
-
0032980723
-
The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells
-
Bost F, McKay R, Bost M, Potapova O, Dean NM, Mercola D. The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells. Mol Cell Biol 1999;19:1938-1949.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1938-1949
-
-
Bost, F.1
McKay, R.2
Bost, M.3
Potapova, O.4
Dean, N.M.5
Mercola, D.6
-
66
-
-
0036606371
-
Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression
-
Potapova O, Anisimov SV, Gorospe M, Dougherty RH, Gaarde WA, Boheler KR, Holbrook NJ. Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression. Cancer Res 2002;82:3257-3263.
-
(2002)
Cancer Res
, vol.82
, pp. 3257-3263
-
-
Potapova, O.1
Anisimov, S.V.2
Gorospe, M.3
Dougherty, R.H.4
Gaarde, W.A.5
Boheler, K.R.6
Holbrook, N.J.7
-
67
-
-
0033969883
-
Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner
-
Potapova O, Gorospe M, Dougherty RH, Dean NM, Gaarde WA, Holbrook NJ. Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Mol Cell Biol 2000;20:1713-1722.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1713-1722
-
-
Potapova, O.1
Gorospe, M.2
Dougherty, R.H.3
Dean, N.M.4
Gaarde, W.A.5
Holbrook, N.J.6
-
68
-
-
0033638915
-
The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest
-
Shaulian E, Schreiber M, Piu F, Beeche M, Wagner EF, Karin M. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell 2000;103:897-907.
-
(2000)
Cell
, vol.103
, pp. 897-907
-
-
Shaulian, E.1
Schreiber, M.2
Piu, F.3
Beeche, M.4
Wagner, E.F.5
Karin, M.6
-
69
-
-
0035872409
-
Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice
-
Chen N, Nomura M, She QB, Ma WY, Bode AM, Wang L, Flavell RA, Dong Z. Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice. Cancer Res 2001;61:3908-3912.
-
(2001)
Cancer Res
, vol.61
, pp. 3908-3912
-
-
Chen, N.1
Nomura, M.2
She, Q.B.3
Ma, W.Y.4
Bode, A.M.5
Wang, L.6
Flavell, R.A.7
Dong, Z.8
-
70
-
-
0036494195
-
Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate
-
She QB, Chen N, Bode AM, Flavell RA, Dong Z. Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 2002;62:1343-1348.
-
(2002)
Cancer Res
, vol.62
, pp. 1343-1348
-
-
She, Q.B.1
Chen, N.2
Bode, A.M.3
Flavell, R.A.4
Dong, Z.5
-
71
-
-
0035444539
-
Signal transduction by tumor necrosis factor and its relatives
-
Baud V, Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol 2001;11:372-377.
-
(2001)
Trends Cell Biol
, vol.11
, pp. 372-377
-
-
Baud, V.1
Karin, M.2
-
72
-
-
0035137882
-
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
-
Baldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J Clin Invest 2001;107:241-246.
-
(2001)
J Clin Invest
, vol.107
, pp. 241-246
-
-
Baldwin, A.S.1
-
73
-
-
0347537940
-
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
-
Verheij M, Bose XX, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996;380:75-79.
-
(1996)
Nature
, vol.380
, pp. 75-79
-
-
Verheij, M.1
Bose, X.X.2
Lin, X.H.3
Yao, B.4
Jarvis, W.D.5
Grant, S.6
Birrer, M.J.7
Szabo, E.8
Zon, L.I.9
Kyriakis, J.M.10
Haimovitz-Friedman, A.11
Fuks, Z.12
Kolesnick, R.N.13
-
74
-
-
0035037802
-
Characterization of XIAP-deficient mice
-
Harlin H, Reffey SB, Duckett CS, Lindsten T, Thompson CB. Characterization of XIAP-deficient mice. Mol Cell Biol 2001;21:3604-3608.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3604-3608
-
-
Harlin, H.1
Reffey, S.B.2
Duckett, C.S.3
Lindsten, T.4
Thompson, C.B.5
-
75
-
-
0036882166
-
Absence of NF-κB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor α induced apoptosis
-
Tang F, Tang G, Xiang J, Dai Q, Rosner MR, Lin A. Absence of NF-κB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor α induced apoptosis. Mol Cell Biol 2002;22(24): 8571-8579.
-
(2002)
Mol Cell Biol
, vol.22
, Issue.24
, pp. 8571-8579
-
-
Tang, F.1
Tang, G.2
Xiang, J.3
Dai, Q.4
Rosner, M.R.5
Lin, A.6
-
76
-
-
0030041536
-
Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis
-
Chen YR, Meyer CF, Tan TH. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J Biol Chem 1996;271:631-634.
-
(1996)
J Biol Chem
, vol.271
, pp. 631-634
-
-
Chen, Y.R.1
Meyer, C.F.2
Tan, T.H.3
-
77
-
-
0030755579
-
The regulation of anoikis: MEKK-1 activation requires cleavage by caspases
-
Cardone MH, Salvesen GS, Widmann C, Johnson G, Frisch SM. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 1997;90:315-323.
-
(1997)
Cell
, vol.90
, pp. 315-323
-
-
Cardone, M.H.1
Salvesen, G.S.2
Widmann, C.3
Johnson, G.4
Frisch, S.M.5
-
78
-
-
0032831780
-
The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity
-
Zheng C, Xiang J, Hunter T, Lin A. The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity. J Biol Chem 1999;274:28966-28971.
-
(1999)
J Biol Chem
, vol.274
, pp. 28966-28971
-
-
Zheng, C.1
Xiang, J.2
Hunter, T.3
Lin, A.4
-
79
-
-
0036269755
-
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase
-
Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB, Bar-Sagi D, Davis RJ. The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol 2002;22:4929-4942.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 4929-4942
-
-
Lei, K.1
Nimnual, A.2
Zong, W.X.3
Kennedy, N.J.4
Flavell, R.A.5
Thompson, C.B.6
Bar-Sagi, D.7
Davis, R.J.8
-
80
-
-
18444396889
-
Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): Signaling to multidrug-efflux and hyperproliferation
-
Cripe LD, et al. Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation. Leukemia 2002;16:799-812.
-
(2002)
Leukemia
, vol.16
, pp. 799-812
-
-
Cripe, L.D.1
-
81
-
-
18544372157
-
Elevated JNK activation contributes to the pathogenesis of human brain tumors
-
Antonyak MA, Kenyon LC, Godwin AK, James DC, Emlet DR, Okamoto I, Tnani M, Holgado-Madruga M, Moscatello DK, Wong AJ. Elevated JNK activation contributes to the pathogenesis of human brain tumors. Oncogene 2002;21:5038-5046.
-
(2002)
Oncogene
, vol.21
, pp. 5038-5046
-
-
Antonyak, M.A.1
Kenyon, L.C.2
Godwin, A.K.3
James, D.C.4
Emlet, D.R.5
Okamoto, I.6
Tnani, M.7
Holgado-Madruga, M.8
Moscatello, D.K.9
Wong, A.J.10
-
83
-
-
0035964358
-
Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease
-
Xia XG, Harding T, Weller M, Bieneman A, Uney JB, Schulz JB. Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease. Proc Natl Acad Sci USA 2001;98:10433-10438.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10433-10438
-
-
Xia, X.G.1
Harding, T.2
Weller, M.3
Bieneman, A.4
Uney, J.B.5
Schulz, J.B.6
-
84
-
-
0031844392
-
Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy
-
Nemoto S, Sheng Z, Lin A. Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy. Mol Cell Biol 1998;18:3518-3526.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 3518-3526
-
-
Nemoto, S.1
Sheng, Z.2
Lin, A.3
-
85
-
-
0036074371
-
The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
-
Sadoshima J, et al. The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J Clin Invest 2002;110:271-279.
-
(2002)
J Clin Invest
, vol.110
, pp. 271-279
-
-
Sadoshima, J.1
-
86
-
-
0032757190
-
Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia
-
He H, Li HL, Lin A, Gottlieb RA. Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia. Cell Death Differ 1999;6:987-991.
-
(1999)
Cell Death Differ
, vol.6
, pp. 987-991
-
-
He, H.1
Li, H.L.2
Lin, A.3
Gottlieb, R.A.4
|