메뉴 건너뛰기




Volumn 25, Issue 1, 2003, Pages 17-24

Activation of the JNK signaling pathway: Breaking the brake on apoptosis

Author keywords

[No Author keywords available]

Indexed keywords


EID: 0037230304     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.10204     Document Type: Review
Times cited : (382)

References (86)
  • 1
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26:239-257.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 3
    • 0030947095 scopus 로고    scopus 로고
    • Programmed cell death in animal development
    • Jacobson MD, Weil M, Raff MC. Programmed cell death in animal development. Cell 1997;88:347-354.
    • (1997) Cell , vol.88 , pp. 347-354
    • Jacobson, M.D.1    Weil, M.2    Raff, M.C.3
  • 4
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456-1462.
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 5
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998;281:1305-1308.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 6
    • 0030931876 scopus 로고    scopus 로고
    • Cohen GM Caspases: The executioners of apoptosis
    • Cohen GM Caspases: the executioners of apoptosis. Biochem J 1997; 326:1-16.
    • (1997) Biochem J , vol.326 , pp. 1-16
  • 7
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281:1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 8
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998; 281:1312-1316.
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 10
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000;103:239-252.
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 11
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001;410:37-40.
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 12
    • 0036098552 scopus 로고    scopus 로고
    • AP-1 as a regulator of cell life and death
    • Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 2002;4:E131-E136.
    • (2002) Nat Cell Biol , vol.4
    • Shaulian, E.1    Karin, M.2
  • 13
    • 0027423418 scopus 로고
    • Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
    • Hibi M, Lin A, Smeal T, Minden A, Karin M. Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993;7:2135-2148.
    • (1993) Genes Dev , vol.7 , pp. 2135-2148
    • Hibi, M.1    Lin, A.2    Smeal, T.3    Minden, A.4    Karin, M.5
  • 15
    • 0026635602 scopus 로고
    • Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: Regulation by the N-terminal delta domain
    • Adler V, Franklin CC, Kraft AS. Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain. Proc Natl Acad Sci USA 1992;89:5341-5345.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5341-5345
    • Adler, V.1    Franklin, C.C.2    Kraft, A.S.3
  • 16
    • 0025806587 scopus 로고
    • Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain
    • Binetruy B, Smeal T, Karin M. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 1991;351: 122-127.
    • (1991) Nature , vol.351 , pp. 122-127
    • Binetruy, B.1    Smeal, T.2    Karin, M.3
  • 17
    • 0025788098 scopus 로고
    • Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
    • Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 1991;354:494-496.
    • (1991) Nature , vol.354 , pp. 494-496
    • Smeal, T.1    Binetruy, B.2    Mercola, D.A.3    Birrer, M.4    Karin, M.5
  • 18
    • 0029032249 scopus 로고
    • The regulation of AP-1 activity by mitogen-activated protein kinases
    • Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 1995;270:16483-16486.
    • (1995) J Biol Chem , vol.270 , pp. 16483-16486
    • Karin, M.1
  • 19
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994;76:1025-1037.
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Derijard, B.1    Hibi, M.2    Wu, I.H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 21
    • 0033499801 scopus 로고    scopus 로고
    • BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
    • Yamamoto K, Ichijo H, Korsmeyer SJ. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 1999;19:8469-8478.
    • (1999) Mol Cell Biol , vol.19 , pp. 8469-8478
    • Yamamoto, K.1    Ichijo, H.2    Korsmeyer, S.J.3
  • 22
    • 15644381250 scopus 로고    scopus 로고
    • Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac 1
    • Maundrell K, et al. Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac 1. J Biol Chem 1997;272:25238-25242.
    • (1997) J Biol Chem , vol.272 , pp. 25238-25242
    • Maundrell, K.1
  • 26
    • 0030770419 scopus 로고    scopus 로고
    • Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38
    • Lu X, Nemoto S, Lin A. Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. J Biol Chem 1997;272:24751-24754.
    • (1997) J Biol Chem , vol.272 , pp. 24751-24754
    • Lu, X.1    Nemoto, S.2    Lin, A.3
  • 27
    • 0034992168 scopus 로고    scopus 로고
    • MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines
    • Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev 2001;15:1419-1426.
    • (2001) Genes Dev , vol.15 , pp. 1419-1426
    • Tournier, C.1    Dong, C.2    Turner, T.K.3    Jones, S.N.4    Flavell, R.A.5    Davis, R.J.6
  • 28
    • 0034668860 scopus 로고    scopus 로고
    • Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7
    • Fleming Y, Armstrong CG, Mortice N, Paterson A, Goedert M, Cohen P. Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. Biochem J 2000;352 Pt 1:145-154.
    • (2000) Biochem J , vol.352 , Issue.PART 1 , pp. 145-154
    • Fleming, Y.1    Armstrong, C.G.2    Mortice, N.3    Paterson, A.4    Goedert, M.5    Cohen, P.6
  • 33
    • 0030059508 scopus 로고    scopus 로고
    • Activation of MEK-1 and SEK-1 by Tp1-2 proto-oncoprotein, a novel MAP kinase kinase kinase
    • Salmeron A, Ahmad TB, Carlile GW, Pappin D, Narsimhan RP. Ley SC. Activation of MEK-1 and SEK-1 by Tp1-2 proto-oncoprotein, a novel MAP kinase kinase kinase. EMBO J 1996;1:817-826.
    • (1996) EMBO J , vol.1 , pp. 817-826
    • Salmeron, A.1    Ahmad, T.B.2    Carlile, G.W.3    Pappin, D.4    Narsimhan, R.P.5    Ley, S.C.6
  • 34
    • 0034625170 scopus 로고    scopus 로고
    • MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration
    • Xia Y, Makris C, Su B, Li E, Yang J, Nemerow GR, Karin M. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci USA 2000;97:5243-5248.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 5243-5248
    • Xia, Y.1    Makris, C.2    Su, B.3    Li, E.4    Yang, J.5    Nemerow, G.R.6    Karin, M.7
  • 35
    • 0032483967 scopus 로고    scopus 로고
    • Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption
    • Yujiri T, Sather S, Fanger GR, Johnson GL. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science 1998;282:1911-1914.
    • (1998) Science , vol.282 , pp. 1911-1914
    • Yujiri, T.1    Sather, S.2    Fanger, G.R.3    Johnson, G.L.4
  • 36
    • 0032508714 scopus 로고    scopus 로고
    • A mammalian scaffold complex that selectively mediates MAP kinase activation
    • Whitmarsh AJ, Cavanagh J, Tournier C, Yasuda J, Davis RJ. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 1998;281:1671-1674.
    • (1998) Science , vol.281 , pp. 1671-1674
    • Whitmarsh, A.J.1    Cavanagh, J.2    Tournier, C.3    Yasuda, J.4    Davis, R.J.5
  • 39
    • 0036009115 scopus 로고    scopus 로고
    • NF-κB at the crossroads of life and death
    • Karin M, Lin A. NF-κB at the crossroads of life and death. Nat Immunol 2002;3:221-227.
    • (2002) Nat Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 41
    • 0035913158 scopus 로고    scopus 로고
    • NF-κB activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: A mechanism for the anti-apoptotic effect of NF-κB
    • Javelaud D Besancon F. NF-κB activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-κB. Oncogene 2001;20:4365-4372.
    • (2001) Oncogene , vol.20 , pp. 4365-4372
    • Javelaud, D.1    Besancon, F.2
  • 43
    • 33748501280 scopus 로고    scopus 로고
    • Resistance to TNF-α cytotoxicity can be achieved through different signaling pathways in rat mesangial cells
    • Guo YL, Kang B, Williamson JR. Resistance to TNF-α cytotoxicity can be achieved through different signaling pathways in rat mesangial cells. Am J Physiol 1999;276:C435-C441.
    • (1999) Am J Physiol , vol.276
    • Guo, Y.L.1    Kang, B.2    Williamson, J.R.3
  • 44
    • 0008206988 scopus 로고    scopus 로고
    • TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival
    • Lee SY, Reichlin A, Santana A, Sokol KA, Nussenzweig MC, Choi Y. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival. Immunity 1997;7:703-713.
    • (1997) Immunity , vol.7 , pp. 703-713
    • Lee, S.Y.1    Reichlin, A.2    Santana, A.3    Sokol, K.A.4    Nussenzweig, M.C.5    Choi, Y.6
  • 46
    • 0030298294 scopus 로고    scopus 로고
    • Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death
    • Liu ZG, Hsu H, Goeddel DV, Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 1996;87:565-576.
    • (1996) Cell , vol.87 , pp. 565-576
    • Liu, Z.G.1    Hsu, H.2    Goeddel, D.V.3    Karin, M.4
  • 47
    • 0027242180 scopus 로고
    • c-jun is essential for normal mouse development and hepatogenesis
    • Hilberg F. Aguzzi A, Howells N, Wagner EF. c-jun is essential for normal mouse development and hepatogenesis. Nature 1993;365:179-181.
    • (1993) Nature , vol.365 , pp. 179-181
    • Hilberg, F.1    Aguzzi, A.2    Howells, N.3    Wagner, E.F.4
  • 48
    • 0032979438 scopus 로고    scopus 로고
    • Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
    • Behrens A, Sibilia M, Wagner EF. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet 1999;21:326-329
    • (1999) Nat Genet , vol.21 , pp. 326-329
    • Behrens, A.1    Sibilia, M.2    Wagner, E.F.3
  • 51
    • 0035808769 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation
    • Sabapathy K, Kallunki T, David JP, Graef I, Karin M, Wagner EF. c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. J Exp Med 2001;193:317-328.
    • (2001) J Exp Med , vol.193 , pp. 317-328
    • Sabapathy, K.1    Kallunki, T.2    David, J.P.3    Graef, I.4    Karin, M.5    Wagner, E.F.6
  • 52
    • 0033063568 scopus 로고    scopus 로고
    • Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4
    • Nishina H, et al. Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 1999;126:505-516.
    • (1999) Development , vol.126 , pp. 505-516
    • Nishina, H.1
  • 53
    • 0032499687 scopus 로고    scopus 로고
    • SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis
    • Ganiatsas S, Kwee L, Fujiwara Y, Perkins A, Ikeda T, Labow MA, Zon LI. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci USA 1998;95:6881-6886.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6881-6886
    • Ganiatsas, S.1    Kwee, L.2    Fujiwara, Y.3    Perkins, A.4    Ikeda, T.5    Labow, M.A.6    Zon, L.I.7
  • 54
    • 0029012476 scopus 로고
    • Rubin LL A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    • Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, Yaniv M, Rubin LL A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 1995;14:927-939.
    • (1995) Neuron , vol.14 , pp. 927-939
    • Ham, J.1    Babij, C.2    Whitfield, J.3    Pfarr, C.M.4    Lallemand, D.5    Yaniv, M.6
  • 56
    • 0032937879 scopus 로고    scopus 로고
    • Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
    • Le-Niculescu H, Bonfoco E, Kasuya Y, Claret FX, Green DR, Karin M. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol 1999;19:751-763.
    • (1999) Mol Cell Biol , vol.19 , pp. 751-763
    • Le-Niculescu, H.1    Bonfoco, E.2    Kasuya, Y.3    Claret, F.X.4    Green, D.R.5    Karin, M.6
  • 58
    • 0034918203 scopus 로고    scopus 로고
    • JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons
    • Bruckner SR, Tammariello SP, Kuan CY, Flavell RA, Rakic P, Estus S. JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons. J Neurochem 2001;78:298-303.
    • (2001) J Neurochem , vol.78 , pp. 298-303
    • Bruckner, S.R.1    Tammariello, S.P.2    Kuan, C.Y.3    Flavell, R.A.4    Rakic, P.5    Estus, S.6
  • 59
    • 0032724021 scopus 로고    scopus 로고
    • Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
    • Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev 1999;89:115-124.
    • (1999) Mech Dev , vol.89 , pp. 115-124
    • Sabapathy, K.1    Jochum, W.2    Hochedlinger, K.3    Chang, L.4    Karin, M.5    Wagner, E.F.6
  • 60
    • 0033118607 scopus 로고    scopus 로고
    • The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
    • Kuan CY, Yang D, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 1999;22:667-676.
    • (1999) Neuron , vol.22 , pp. 667-676
    • Kuan, C.Y.1    Yang, D.2    Samanta Roy, D.R.3    Davis, R.J.4    Rakic, P.5    Flavell, R.A.6
  • 61
    • 0035883958 scopus 로고    scopus 로고
    • Requirement of the JIP1 scaffold protein for stress-induced JNK activation
    • Whitmarsh AJ, et al. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev 2001;15:2421-2432.
    • (2001) Genes Dev , vol.15 , pp. 2421-2432
    • Whitmarsh, A.J.1
  • 65
    • 0032980723 scopus 로고    scopus 로고
    • The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells
    • Bost F, McKay R, Bost M, Potapova O, Dean NM, Mercola D. The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells. Mol Cell Biol 1999;19:1938-1949.
    • (1999) Mol Cell Biol , vol.19 , pp. 1938-1949
    • Bost, F.1    McKay, R.2    Bost, M.3    Potapova, O.4    Dean, N.M.5    Mercola, D.6
  • 66
    • 0036606371 scopus 로고    scopus 로고
    • Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression
    • Potapova O, Anisimov SV, Gorospe M, Dougherty RH, Gaarde WA, Boheler KR, Holbrook NJ. Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression. Cancer Res 2002;82:3257-3263.
    • (2002) Cancer Res , vol.82 , pp. 3257-3263
    • Potapova, O.1    Anisimov, S.V.2    Gorospe, M.3    Dougherty, R.H.4    Gaarde, W.A.5    Boheler, K.R.6    Holbrook, N.J.7
  • 67
    • 0033969883 scopus 로고    scopus 로고
    • Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner
    • Potapova O, Gorospe M, Dougherty RH, Dean NM, Gaarde WA, Holbrook NJ. Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Mol Cell Biol 2000;20:1713-1722.
    • (2000) Mol Cell Biol , vol.20 , pp. 1713-1722
    • Potapova, O.1    Gorospe, M.2    Dougherty, R.H.3    Dean, N.M.4    Gaarde, W.A.5    Holbrook, N.J.6
  • 68
    • 0033638915 scopus 로고    scopus 로고
    • The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest
    • Shaulian E, Schreiber M, Piu F, Beeche M, Wagner EF, Karin M. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell 2000;103:897-907.
    • (2000) Cell , vol.103 , pp. 897-907
    • Shaulian, E.1    Schreiber, M.2    Piu, F.3    Beeche, M.4    Wagner, E.F.5    Karin, M.6
  • 70
    • 0036494195 scopus 로고    scopus 로고
    • Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate
    • She QB, Chen N, Bode AM, Flavell RA, Dong Z. Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 2002;62:1343-1348.
    • (2002) Cancer Res , vol.62 , pp. 1343-1348
    • She, Q.B.1    Chen, N.2    Bode, A.M.3    Flavell, R.A.4    Dong, Z.5
  • 71
    • 0035444539 scopus 로고    scopus 로고
    • Signal transduction by tumor necrosis factor and its relatives
    • Baud V, Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol 2001;11:372-377.
    • (2001) Trends Cell Biol , vol.11 , pp. 372-377
    • Baud, V.1    Karin, M.2
  • 72
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
    • Baldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J Clin Invest 2001;107:241-246.
    • (2001) J Clin Invest , vol.107 , pp. 241-246
    • Baldwin, A.S.1
  • 75
    • 0036882166 scopus 로고    scopus 로고
    • Absence of NF-κB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor α induced apoptosis
    • Tang F, Tang G, Xiang J, Dai Q, Rosner MR, Lin A. Absence of NF-κB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor α induced apoptosis. Mol Cell Biol 2002;22(24): 8571-8579.
    • (2002) Mol Cell Biol , vol.22 , Issue.24 , pp. 8571-8579
    • Tang, F.1    Tang, G.2    Xiang, J.3    Dai, Q.4    Rosner, M.R.5    Lin, A.6
  • 76
    • 0030041536 scopus 로고    scopus 로고
    • Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis
    • Chen YR, Meyer CF, Tan TH. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J Biol Chem 1996;271:631-634.
    • (1996) J Biol Chem , vol.271 , pp. 631-634
    • Chen, Y.R.1    Meyer, C.F.2    Tan, T.H.3
  • 77
    • 0030755579 scopus 로고    scopus 로고
    • The regulation of anoikis: MEKK-1 activation requires cleavage by caspases
    • Cardone MH, Salvesen GS, Widmann C, Johnson G, Frisch SM. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 1997;90:315-323.
    • (1997) Cell , vol.90 , pp. 315-323
    • Cardone, M.H.1    Salvesen, G.S.2    Widmann, C.3    Johnson, G.4    Frisch, S.M.5
  • 78
    • 0032831780 scopus 로고    scopus 로고
    • The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity
    • Zheng C, Xiang J, Hunter T, Lin A. The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity. J Biol Chem 1999;274:28966-28971.
    • (1999) J Biol Chem , vol.274 , pp. 28966-28971
    • Zheng, C.1    Xiang, J.2    Hunter, T.3    Lin, A.4
  • 79
  • 80
    • 18444396889 scopus 로고    scopus 로고
    • Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): Signaling to multidrug-efflux and hyperproliferation
    • Cripe LD, et al. Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation. Leukemia 2002;16:799-812.
    • (2002) Leukemia , vol.16 , pp. 799-812
    • Cripe, L.D.1
  • 83
    • 0035964358 scopus 로고    scopus 로고
    • Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease
    • Xia XG, Harding T, Weller M, Bieneman A, Uney JB, Schulz JB. Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease. Proc Natl Acad Sci USA 2001;98:10433-10438.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10433-10438
    • Xia, X.G.1    Harding, T.2    Weller, M.3    Bieneman, A.4    Uney, J.B.5    Schulz, J.B.6
  • 84
    • 0031844392 scopus 로고    scopus 로고
    • Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy
    • Nemoto S, Sheng Z, Lin A. Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy. Mol Cell Biol 1998;18:3518-3526.
    • (1998) Mol Cell Biol , vol.18 , pp. 3518-3526
    • Nemoto, S.1    Sheng, Z.2    Lin, A.3
  • 85
    • 0036074371 scopus 로고    scopus 로고
    • The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
    • Sadoshima J, et al. The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J Clin Invest 2002;110:271-279.
    • (2002) J Clin Invest , vol.110 , pp. 271-279
    • Sadoshima, J.1
  • 86
    • 0032757190 scopus 로고    scopus 로고
    • Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia
    • He H, Li HL, Lin A, Gottlieb RA. Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia. Cell Death Differ 1999;6:987-991.
    • (1999) Cell Death Differ , vol.6 , pp. 987-991
    • He, H.1    Li, H.L.2    Lin, A.3    Gottlieb, R.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.