메뉴 건너뛰기




Volumn 9, Issue 12, 2007, Pages 1419-1427

MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUCIN 1; PROTEIN TAB2; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG;

EID: 36749092728     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1661     Document Type: Article
Times cited : (170)

References (35)
  • 1
    • 0442307969 scopus 로고    scopus 로고
    • IκB kinases: Key regulators of the NF-κB pathway
    • Yamamoto, Y. & Gaynor, R. IκB kinases: Key regulators of the NF-κB pathway. Trends Biochem. Sci. 29, 72-79 (2003).
    • (2003) Trends Biochem. Sci , vol.29 , pp. 72-79
    • Yamamoto, Y.1    Gaynor, R.2
  • 2
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-κB
    • Hayden, M. S. & Ghosh, S. Signaling to NF-κB. Genes Dev. 18 2195-2224 (2004).
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 3
    • 0041850346 scopus 로고    scopus 로고
    • Human DF3/MUC1 carcinoma-associated protein functions as an oncogene
    • Li, Y., Liu, D., Chen, D., Kharbanda, S. & Kufe, D. Human DF3/MUC1 carcinoma-associated protein functions as an oncogene. Oncogene 22, 6107-6110 (2003).
    • (2003) Oncogene , vol.22 , pp. 6107-6110
    • Li, Y.1    Liu, D.2    Chen, D.3    Kharbanda, S.4    Kufe, D.5
  • 4
    • 10744220453 scopus 로고    scopus 로고
    • Human MUC1 carcinoma-associated protein confers resistance to genotoxic anti-cancer agents
    • Ren, J. et al. Human MUC1 carcinoma-associated protein confers resistance to genotoxic anti-cancer agents. Cancer Cell 5, 163-175 (2004).
    • (2004) Cancer Cell , vol.5 , pp. 163-175
    • Ren, J.1
  • 5
    • 13844262819 scopus 로고    scopus 로고
    • Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
    • Wei, X., Xu, H. & Kufe, D. Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell 17, 167-178 (2005).
    • (2005) Cancer Cell , vol.17 , pp. 167-178
    • Wei, X.1    Xu, H.2    Kufe, D.3
  • 6
    • 28544448610 scopus 로고    scopus 로고
    • MUC1 oncoprotein blocks GSK3β-mediated phosphorylation and degradation of β-catenin
    • Huang, L. et al. MUC1 oncoprotein blocks GSK3β-mediated phosphorylation and degradation of β-catenin. Cancer Res. 65 10413-10422 (2005).
    • (2005) Cancer Res , vol.65 , pp. 10413-10422
    • Huang, L.1
  • 7
    • 30744474431 scopus 로고    scopus 로고
    • MUC1 oncoprotein stabilizes and activates estrogen receptor alpha
    • Wei, X., Xu, H. & Kufe, D. MUC1 oncoprotein stabilizes and activates estrogen receptor alpha. Mol. Cell 21, 295-305 (2006).
    • (2006) Mol. Cell , vol.21 , pp. 295-305
    • Wei, X.1    Xu, H.2    Kufe, D.3
  • 8
    • 0032589935 scopus 로고    scopus 로고
    • IκB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
    • Mercurio, F. et al. IκB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol. Cell Biol. 19, 1526-1538 (1999).
    • (1999) Mol. Cell Biol , vol.19 , pp. 1526-1538
    • Mercurio, F.1
  • 9
    • 0025129726 scopus 로고
    • Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10
    • Soule, H. D. et al. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res. 50, 6075-6086 (1990).
    • (1990) Cancer Res , vol.50 , pp. 6075-6086
    • Soule, H.D.1
  • 10
    • 0034854417 scopus 로고    scopus 로고
    • Muthuswamy, S. K., Li, D., Lelievre, S., Bissell, M. J. & Brugge, J. S. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nature Cell Biol. 3, 785-792 (2001).
    • Muthuswamy, S. K., Li, D., Lelievre, S., Bissell, M. J. & Brugge, J. S. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nature Cell Biol. 3, 785-792 (2001).
  • 11
    • 0029850644 scopus 로고    scopus 로고
    • Tumor necrosis factor-α: A multifunctional regulator of mammary gland development
    • Varela, L. M. & Ip, M. M. Tumor necrosis factor-α: A multifunctional regulator of mammary gland development. Endocrinology 137, 4915-4924 (1996).
    • (1996) Endocrinology , vol.137 , pp. 4915-4924
    • Varela, L.M.1    Ip, M.M.2
  • 12
    • 0030752475 scopus 로고    scopus 로고
    • The epidermal growth factor receptor is not required for tumor necrosis factor-α action in normal mammary epithelial cells
    • Varela, L. M., Darcy, K. M. & Ip, M. M. The epidermal growth factor receptor is not required for tumor necrosis factor-α action in normal mammary epithelial cells. Endocrinology 138, 3891-3900 (1997).
    • (1997) Endocrinology , vol.138 , pp. 3891-3900
    • Varela, L.M.1    Darcy, K.M.2    Ip, M.M.3
  • 13
    • 0033752746 scopus 로고    scopus 로고
    • Functional significance of MMP-9 in tumor necrosis factor-induced proliferation and branching morphogenesis of mammary epithelial cells
    • Lee, P. P., Hwang, J. J., Murphy, G. & Ip, M. M. Functional significance of MMP-9 in tumor necrosis factor-induced proliferation and branching morphogenesis of mammary epithelial cells. Endocrinology 141 3764-3773 (2000).
    • (2000) Endocrinology , vol.141 , pp. 3764-3773
    • Lee, P.P.1    Hwang, J.J.2    Murphy, G.3    Ip, M.M.4
  • 14
    • 0342844268 scopus 로고    scopus 로고
    • Dynamic expression and activity of NF-κB during post-natal mammary gland morphogenesis
    • Brantley, D. M. et al. Dynamic expression and activity of NF-κB during post-natal mammary gland morphogenesis. Mech. Dev. 97 149-155 (2000).
    • (2000) Mech. Dev , vol.97 , pp. 149-155
    • Brantley, D.M.1
  • 15
    • 0035007465 scopus 로고    scopus 로고
    • Regulation of milk protein gene expression in normal mammary epithelial cells by tumor necrosis factor
    • Shea-Eaton, W. K., Lee, P. P. & Ip, M. M. Regulation of milk protein gene expression in normal mammary epithelial cells by tumor necrosis factor. Endocrinology 142, 2558-2568 (2001).
    • (2001) Endocrinology , vol.142 , pp. 2558-2568
    • Shea-Eaton, W.K.1    Lee, P.P.2    Ip, M.M.3
  • 16
    • 0029858348 scopus 로고    scopus 로고
    • RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/ APO-1-initiated apoptosis
    • Ting, A. T., Pimentel-Muinos, F. X. & Seed, B. RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/ APO-1-initiated apoptosis. EMBO J. 15, 6189-6196 (1996).
    • (1996) EMBO J , vol.15 , pp. 6189-6196
    • Ting, A.T.1    Pimentel-Muinos, F.X.2    Seed, B.3
  • 17
    • 0032033132 scopus 로고    scopus 로고
    • The death domain kinase RIP mediates the TNF-induced NF-κB signal
    • Kelliher, M. A. et al. The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity 8, 297-303 (1998).
    • (1998) Immunity , vol.8 , pp. 297-303
    • Kelliher, M.A.1
  • 18
    • 0035021123 scopus 로고    scopus 로고
    • The alpha and beta subunits of IκB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF
    • Devin, A. et al. The alpha and beta subunits of IκB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. Mol. Cell Biol. 21, 3986-3994 (2001).
    • (2001) Mol. Cell Biol , vol.21 , pp. 3986-3994
    • Devin, A.1
  • 19
    • 0030032106 scopus 로고    scopus 로고
    • TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
    • Hsu, H., Shu, H.-B., Pan, M.-G. & Goeddel, D. V. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 184, 299-308 (1996).
    • (1996) Cell , vol.184 , pp. 299-308
    • Hsu, H.1    Shu, H.-B.2    Pan, M.-G.3    Goeddel, D.V.4
  • 20
    • 0033537719 scopus 로고    scopus 로고
    • Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation
    • Delhase, M., Hayakawa, M., Chen, Y. & Karin, M. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science 284, 309-313 (1999).
    • (1999) Science , vol.284 , pp. 309-313
    • Delhase, M.1    Hayakawa, M.2    Chen, Y.3    Karin, M.4
  • 21
    • 0021740104 scopus 로고
    • Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors
    • Kufe, D. et al. Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma 3, 223-232 (1984).
    • (1984) Hybridoma , vol.3 , pp. 223-232
    • Kufe, D.1
  • 22
    • 0842288993 scopus 로고    scopus 로고
    • Interaction of human MUC1 and β-catenin is regulated by Lck and ZAP-70 in activated Jurkat T cells
    • Li, Q., Ren, J. & Kufe, D. Interaction of human MUC1 and β-catenin is regulated by Lck and ZAP-70 in activated Jurkat T cells. Biochem. Biophys. Res. Commun. 315, 471-476 (2004).
    • (2004) Biochem. Biophys. Res. Commun , vol.315 , pp. 471-476
    • Li, Q.1    Ren, J.2    Kufe, D.3
  • 23
    • 0035913278 scopus 로고    scopus 로고
    • TAK1 is a ubiquitin-dependent kinase of MKK and IKK
    • Wang, C. et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (2001).
    • (2001) Nature , vol.412 , pp. 346-351
    • Wang, C.1
  • 24
    • 0037422858 scopus 로고    scopus 로고
    • TAK1 is critical for IκB kinase-mediated activation of the NF-κB pathway
    • Takaesu, G. et al. TAK1 is critical for IκB kinase-mediated activation of the NF-κB pathway. J. Mol. Biol. 326, 105-115 (2003).
    • (2003) J. Mol. Biol , vol.326 , pp. 105-115
    • Takaesu, G.1
  • 25
    • 0033605575 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase/ERK kinase kinases-2 and 3 activate nuclear factor-kB through IκB kinase-α and IκB kinase-β
    • Zhao, Q. & Lee, F. S. Mitogen-activated protein kinase/ERK kinase kinases-2 and 3 activate nuclear factor-kB through IκB kinase-α and IκB kinase-β. J. Biol.Chem. 274, 8355-8358 (1999).
    • (1999) J. Biol.Chem , vol.274 , pp. 8355-8358
    • Zhao, Q.1    Lee, F.S.2
  • 26
    • 0346243941 scopus 로고    scopus 로고
    • Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling
    • Ishitani, T. et al. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. 22, 6277-6288 (2003).
    • (2003) EMBO J , vol.22 , pp. 6277-6288
    • Ishitani, T.1
  • 27
    • 4344712350 scopus 로고    scopus 로고
    • TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains
    • Kanayama, A. et al. TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains. Mol. Cell 15, 535-548 (2004).
    • (2004) Mol. Cell , vol.15 , pp. 535-548
    • Kanayama, A.1
  • 28
    • 0036895537 scopus 로고    scopus 로고
    • Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis
    • Komatsu, Y. et al. Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech. Dev. 119, 239-249 (2002).
    • (2002) Mech. Dev , vol.119 , pp. 239-249
    • Komatsu, Y.1
  • 29
    • 30044449755 scopus 로고    scopus 로고
    • TAK1 is recruited to the tumor necrosis factor-alpha (TNF-α) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-κB activation
    • Blonska, M. et al. TAK1 is recruited to the tumor necrosis factor-alpha (TNF-α) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-κB activation. J. Biol. Chem. 280, 43056-43063 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 43056-43063
    • Blonska, M.1
  • 30
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-κB in cancer development and progression
    • Karin, M. Nuclear factor-κB in cancer development and progression. Nature 441, 431-436 (2006).
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 32
    • 0034655650 scopus 로고    scopus 로고
    • MUC1 is activated in a B-cell lymphoma by the t(1;14)(q21;q32) translocation and is rearranged and amplified in B-cell lymphoma subsets
    • Dyomin, V. G. et al. MUC1 is activated in a B-cell lymphoma by the t(1;14)(q21;q32) translocation and is rearranged and amplified in B-cell lymphoma subsets. Blood 95, 2666-2671 (2000).
    • (2000) Blood , vol.95 , pp. 2666-2671
    • Dyomin, V.G.1
  • 33
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
    • Baldwin, A. S. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J. Clin. Invest. 107, 241-246 (2001).
    • (2001) J. Clin. Invest , vol.107 , pp. 241-246
    • Baldwin, A.S.1
  • 34
    • 0030927167 scopus 로고    scopus 로고
    • Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth
    • Nakshatri, H., Bhat-Nakshatri, P., Martin, D. A., Goulet, R. J., Jr. & Sledge, G. W., Jr Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth. Mol. Cell Biol. 17, 3629-3639 (1997).
    • (1997) Mol. Cell Biol , vol.17 , pp. 3629-3639
    • Nakshatri, H.1    Bhat-Nakshatri, P.2    Martin, D.A.3    Goulet Jr., R.J.4    Sledge Jr, G.W.5
  • 35
    • 30344437854 scopus 로고    scopus 로고
    • Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness
    • Sotgia, F. et al. Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness. Am. J. Pathol. 168 292-309 (2006).
    • (2006) Am. J. Pathol , vol.168 , pp. 292-309
    • Sotgia, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.