Importane of a deficiency in S-adenosyl-L-methionine sysnthesis in the pathogenesis of liver injury 1-4

American Journal of Clinical Nutrition

Volumn 76, Issue 5, 2002, Pages

  Luz Martinez Chantar M ^a   García Trevijano, Elena R ^a   Ujue Latasa, M ^a   Pérez Mato, Isabel ^a   Sánchez Del Pino, Manuel M ^a   Corrales, Fernando J ^a   Avila, Matias A ^a   Mato, José M ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Cirrhosis; Liver injury; Liver regeneration; Methionine; Methionine adenosyltransferase; Oxidative stress; Protein S nitrosylation; S adenosyl L methionine; SAMe

Indexed keywords

ADENOSINE TRIPHOSPHATE; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; S ADENOSYLMETHIONINE; ISOENZYME; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

AMINO ACID METABOLISM; ARTICLE; ENZYME ACTIVITY; HUMAN; LIVER CIRRHOSIS; LIVER INJURY; NUTRITIONAL DEFICIENCY; PATHOGENESIS; SYNTHESIS; ANIMAL; BIOSYNTHESIS; GENETICS; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; HUMANS; ISOENZYMES; LIVER CIRRHOSIS; METHIONINE ADENOSYLTRANSFERASE; NITRIC OXIDE; REACTIVE OXYGEN SPECIES; S-ADENOSYLMETHIONINE;

EID: 0036830205     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Cantoni GL. S-adenosylmethionine: A new intermediate formed enzymatically from L-methionine and adenosine triphosphate. J Biol Chem 1953;204:403-16.
2. Kotb M, Mudd HS, Mato JM, et al. Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products. Trends Genet 1997;13:51-2.
3. Mato JM, Alvarez L, Ortiz P, Pajares MA. S-Adenosylmethionine synthesis: Molecular mechanisms and clinical implications. Pharmacol Ther 1997;73:265-80.
4. Alvarez L, Asunción M, Corrales FJ, Pajares MA, Mato JM. Analysis of the 5′ non-coding region of rat liver S-adenosylmethionine synthetase mRNA and comparison of the Mr deduced from the cDNA sequence and the purified enzyme. FEBS Lett 1991;290:142-6.
5. Kinsell LW, Harper HA, Marton HC, Michael GD, Weiss HA. Rate of disappearance from plasma of intravenously administered methionine in patients with liver damage. Science 1947;106:589-90.
6. Mudd SH, Poole JR. Labile methyl balances for normal humans of various dietary regimens. Metabolism 1975;24:721-35.
7. Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem 1990;1:228-36.
8. Finkelstein JD, Kyle WE, Martin JJ, Pick AM. Activation of cystathionine synthase by S-adenosylmethionine and S-adenosylethionine. Biochem Biophys Res Commun 1975;66:81-7.
9. Finkelstein JD, Martin JJ. Inactivation of betaine-homocysteine methyltransferase by S-adenosylmethionine and S-adenosylhomocysteine. Biochem Biophys Res Commun 1984;118:14-9.
10. Finkelstein JD, Martin JJ. Methionine metabolism in mammals: Distribution of homocysteine between competitive pathways. J Biol Chem 1984;259:9508-13.
11. Kutzbach C, Stokstad ELR. Feedback inhibition of methylenetetrahydrofolate reductase in rat liver by S-adenosylmethionine. Biochim Biophys Acta 1967;139:217-20.
12. Kutzbach C, Stokstad ELR. Mammalian methylene-tetrahydrofolate reductase: partial purification, properties and inhibition by S-adenosylmethionine. Biochim Biophys Acta 1971;250:459-77.
13. Mato JM, Avila MA, Corrales FJ. Biosynthesis of S-adenosylmethionine. In: Carmel R, Jacobsen DW, eds. Homocysteine in Health and Disease. Cambridge, United Kingdom: Cambridge University Press, 2001:47-62.
14. Avila MA, Mingorance ML, Martinez-Chantar ML, et al. Regulation of rat liver S-adenosylmethionine synthetase during septic shock: Role of nitric oxide. Hepatology 1997;25:391-6.
15. Sánchez-Góngora E, Pasrtorino JG, Alvarez L, et al. Increased sensitivity to oxidative injury in Chinese hamster ovary cells stably transfected with rat liver S-adenosylmethionine synthetase cDNA. Biochem J 1996;319:767-73.
16. Pérez-Mato I, Castro C, Ruiz FA, Corrales FJ, Mato JM. Methionine adenosyltransferase S-nitrosylation is regulated by the basic and acidic amino acids surrounding the target thiol. J Biol Chem 1999; 274:17075-9.
17. Stamler JS, Toone EJ, Lipton SA, Sucher NJ. (S)NO signals: Translocation regulation, and a consensus motif. Neuron 1997;18:619-26.
18. Castro C, Ruiz FA, Perez-Mato I, et al. Creation of a functional S-nitrosylation site in vitro by single point mutation. FEBS Lett 1999; 459:319-22.
19. Ruiz F, Corrales FJ, Miqueo C, Mato JM. Nitric oxide inactivates rat hepatic methionine adenosyltransferase in vivo by S-nitrosylation. Hepatology 1998;28:1051-7.
20. Sánchez-Góngora E, Ruiz F, Mingorance J, An W, Corrales JM, Mato JM. Interaction of liver methionine adenosylltransferase with hydroxyl radical. FASEB J 1997;11:1013-9.
21. Corrales FJ, Ruiz F, Mato JM. In vivo regulation by glutathione of methionine adenosyltransferase S-nistrosylation in rat liver. J Hepatol 1999;31:887-94.
22. Corrales FJ, Ochoa, P, Rivas C, Martin-Lomas M, Mato JM, Pajares MA. Inhibition of glutathione synthesis in the liver leads to S-adenosyl-L-methionine synthetase reduction. Hepatology 1991;14: 528-33.
23. Avila MA, Carretero MV, Rodriguez N, Mato JM. Regulation by hypoxia of methionine adenosyltransferase activity and gene expression in rat hepatocytes. Gastroenterology 1998;114:364-71.
24. Cabrero C, Martin-Duce A, Ortiz P, Alemany S, Mato JM. Specific loss of the high molecular weight form of S-adenosylmethionine synthetase in human liver cirrhosis. Hepatology 1988;8:1530-4.
25. Corrales F, Giménez L, Alvarez L, et al. S-Adenosylmethionine treatment prevents carbon tetrachloride induced S-adenosylmethionine synthetase inactivation and attenuates liver injury. Hepatology 1992; 16:1022-7.
26. Lu SC, Huang ZZ, Yang HP, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver Am J Physiol 2000;379:G178-85.
27. Sakata SF, Shelly LL, Ruppert S, Schutz G, Chou JY. Cloning and expression of murine S-adenosylmethionine synthetase. J Biol Chem 1993;268:13978-86.
28. Alvarez L, Sánchez-Góngora E, Mingorance J, Pajares MA, Mato JM. Characterization of rat liver-specific methionine adenosyltransferase gene promoter. Role of distal upstream cis-acting elements in the regulation of the transcription activity. J Biol Chem 1997;272:22875-83.
29. Torres L, Avila MA, Carretero MV, et al. Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: Implications for MAT1A silencing during transformation. FASEB J 2000; 14:95-102.
30. Torres A, López-Rodas G, Latasa MU, et al. DNA methylation and histone acetylation of rat methionine adenosyltransferase 1A and 2A genes is tissue-specific. Int J Biochem Cell Biol 2000;32:397-404.
31. Singal R, Ginder GD. DNA methylation. Blood 1999;93:4059-70.
32. Cheung P, Allis CD, Sassone-Corsi P. Signaling to chromatin through histone modifications. Cell 2000;103:263-71.
33. Cai J, Sun W-M, Hwang J-J, Stain SC, Lu SC. Changes in S-adenosylmethionine synthetase in human liver cancer: Molecular characterization and significance. Hepatology 1996;24:1090-7.
34. Avila MA, Berasain C, Torres L, et al. Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. J Hepatol 2000;33:907-14.
35. Horowitz JH, Rypins EB, Henderson JM, et al. Evidence for impairment of transsulfuration pathway in cirrhosis. Gastroenterology 1981; 81:668-75.
36. Martín-Duce A, Ortiz P, Cabrero C, Mato JM. S-Adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology 1988;8:65-8.
37. Avila MA, García-Trevijano ER, Torres L, et al. Methyl groups in the regulation of MAT1A and MAT2A gene expression. In: Mato JM, Caballero A, eds. Methionine Metabolism: Molecular Mechanisms and Clinical Implications. Madrid: Master Line SL, 2000:91-104.
38. Yang H, Huang ZZ, Chen C, Selby RR, Lu SC. Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. Am J Physiol 2001;280:G184-90.
39. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997;276:60-6.
40. Horikawa S, Ozasa H, Ito K, Katsuyama I, Tsukada K, Sugiyama T. Expression of S-adenosylmethionine synthetase isoenzyme genes in regenerating liver after partial hepatectomy. Biochem Mol Biol Int 1996;40:807-14.
41. Huang ZZ, Mao Z, Cai J, Lu SC. Changes in methionine adenosyltransferase during liver regeneration in the rat. Am J Physiol 1999; 275:G14-21.
42. Latasa MU, Boukaba A, García-Trevijano ER, et al. Hepatocyte growth factor induces MAT2A expression and histone acetylation in rat hepatocytes: Role in liver regeneration. FASEB J 2001;15:1248-50.
43. García-Trevijano ER, Latasa MU, Carretero MV, Berasain C, Mato JM, Avila MA. S-Adenosylmethionine regulates MAT1A and MAT2T expression in cultured rat hepatocytes: A new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver. FASEB J 2001;15:1248-50.
44. Cai J, Mao Z, Hwang J, Lu SC. Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. Cancer Res 1998;58:1444-50.
45. Garcea R, Daino L, Pascale R, et al. Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: Role of remodeling and apoptosis. Cancer Res 1989; 49:1850-6.
46. Pascale RM, Marras V, Simile MM, et al. Chemoprevention of rat liver carcinogenesis by S-adenosylmethionine: A long-term study. Cancer Res 1992;52:4979-86.
47. Hortelano S, Dewez B, Genaro AM, Díaz-Guerra MJM, Bosca L. Nitric oxide is released in regenerating liver after partial hepatectomy. Hepatology 1995;21:776-86.
48. Rai RM, Lee FYJ, Rosen A, et al. Impaired liver regeneration in inducible nitric oxide synthase-deficient mice. Proc Natl Acad Sci U S A 1998;95:13829-34.
49. Lu SC, Alvarez L, Huang Z-Z, et al. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A 2001;98:5560-5.
50. Yang SQ, Lin HZ, Hwang J, Chacko VP, Diehl AM. Hepatic hyperplasia in noncirrhotic fatty livers: Is obesity-related hepatic steatosis a premalignant condition? Cancer Res 2001;61:5016-23.
51. Lieber CS. Role of S-adenosylmethionine in the treatment of liver diseases. J Hepatol 1999;30:1155-9.
52. Frezza M, Surrenti C, Manzillo G, Fiaccadori F, Bortolini M, Di Padova C. Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis: A double-blind placebo controlled study. Gastroenterology 1990;99:211-5.
53. Frezza M, Pozzato G, Chiesa L, Stramentinoli G, Di Padova C. Reversal of intrahepatic cholestasis of pregnancy in women after high dose S-adenosyl-L-methionine administration. Hepatology 1984;4:274-8.
54. Frezza M. A meta-analysis of therapeutic trials with ademethionine in the treatment of intrahepatic cholestasis. Ann Ital Med Int 1993; 8(suppl):48S-51S.
55. Vendemiale G, Altomare E, Trizio T, Le Grazie C, Di Padova C, Salerno MT. Effect of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol 1989; 24:407-15.
56. Lieber CS, Casini A, DeCarli LM, et al. S-adenosyl-L-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology 1990;11:165-72.
57. García-Ruiz C, Morales A, Colell A, et al. Feeding S-adenosylmethionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology 1995;21:207-14.
58. Mato JM, Cámara J, Fernandez P, et al. S-Adenosylmethionine in alcoholic liver cirrhosis: A randomized, placebo-controlled, doubleblind, multicenter clinical trial. J Hepatol 1999;30:1081-9.