Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain

Biochemical and Biophysical Research Communications

Volumn 358, Issue 2, 2007, Pages 585-589

  Koizumi, Ayako ^a   Nakajima, Ken ichiro ^a   Asakura, Tomiko ^a   Morita, Yuji ^a   Ito, Keisuke ^a   Shmizu Ibuka, Akiko ^b   Misaka, Takumi ^a   Abe, Keiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

Calcium imaging; G protein coupled receptor; Neoculin; Sweet protein; Sweet taste receptor; Taste modifying protein

Indexed keywords

CALCIUM; HUMAN SWEET TASTE RECEPTOR 1; HUMAN SWEET TASTE RECEPTOR 2; NEOCULIN; RECEPTOR; SWEET PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CURCULIGO; IMAGE ANALYSIS; LIGAND BINDING; PRIORITY JOURNAL; SWEETNESS; TASTE BUD;

AMINO ACID SEQUENCE; BINDING SITES; CELL LINE; HUMANS; KIDNEY; MOLECULAR SEQUENCE DATA; PLANT PROTEINS; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; SWEETENING AGENTS;

CURCULIGO LATIFOLIA; MUS;

EID: 34248570475     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.04.171     Document Type: Article

References (28)

1. Yamashita H., Theerasilp S., Aiuchi T., Nakaya K., Nakamura Y., and Kurihara Y. Purification and complete amino acid sequence of a new type of sweet protein taste-modifying activity, curculin. J. Biol. Chem. 265 (1990) 15770-15775
2. Nakajo S., Akabane T., Nakaya K., Nakamura Y., and Kurihara Y. An enzyme immunoassay and immunoblot analysis for curculin, a new type of taste-modifying protein: cross-reactivity of curculin and miraculin to both antibodies. Biochim. Biophys. Acta 1118 (1992) 293-297
3. Yamashita H., Akabane T., and Kurihara Y. Activity and stability of a new sweet protein with taste-modifying action, curculin. Chem. Senses 20 (1995) 239-243
4. Shirasuka Y., Nakajima K., Asakura T., Yamashita H., Yamamoto A., Hata S., Nagata S., Abo M., Sorimachi H., and Abe K. Neoculin as a new taste-modifying protein occurring in the fruit of Curculigo latifolia. Biosci. Biotechnol. Biochem. 68 (2004) 1403-1407
5. Kurihara K., and Beidler L.M. Taste-modifying protein from miracle fruit. Science 161 (1968) 1241-1243
6. Theerasilp S., and Kurihara Y. Complete purification and characterization of the taste-modifying protein, miraculin, from miracle fruit. J. Biol. Chem. 263 (1988) 11536-11539
7. Theerasilp S., Hitotsuya H., Nakajo S., Nakaya K., Nakamura Y., and Kurihara Y. Complete amino acid sequence and structure characterization of the taste-modifying protein, miraculin. J. Biol. Chem. 264 (1989) 6655-6659
8. Shimizu-Ibuka A., Morita Y., Terada T., Asakura T., Nakajima K., Iwata S., Misaka T., Sorimachi H., Arai S., and Abe K. Crystal structure of neoculin: insights into its sweetness and taste-modifying activity. J. Mol. Biol. 359 (2006) 148-158
9. Nakajima K., Asakura T., Maruyama J., Morita Y., Oike H., Shimizu-Ibuka A., Misaka T., Sorimachi H., Arai S., Kitamoto K., and Abe K. Extracellular production of neoculin, a sweet-tasting heterodimeric protein with taste-modifying activity, by Aspergillus oryzae. Appl. Environ. Microbiol. 72 (2006) 3716-3723
10. Nakajima K., Asakura T., Oike H., Morita Y., Shimizu-Ibuka A., Misaka T., Sorimachi H., Arai S., and Abe K. Neoculin, a taste-modifying protein, is recognized by human sweet taste receptor. Neuroreport 17 (2006) 1241-1244
11. Hoon M.A., Adler E., Lindemeier J., Battey J.F., Ryba N.J., and Zuker C.S. Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell 96 (1999) 541-551
12. Kitagawa M., Kusakabe Y., Miura H., Ninomiya Y., and Hino A. Molecular genetic identification of a candidate receptor gene for sweet taste. Biochem. Biophys. Res. Commun. 283 (2001) 236-242
13. Max M., Shanker Y.G., Huang L., Rong M., Liu Z., Campagne F., Weinstein H., Damak S., and Margolskee R.F. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat. Genet. 28 (2001) 58-63
14. Montmayeur J.P., Liberles S.D., Matsunami H., and Buck L.B. A candidate taste receptor gene near a sweet taste locus. Nat. Neurosci. 4 (2001) 492-498
15. Sainz E., Korley J.N., Battey J.F., and Sullivan S.L. Identification of a novel member of the T1R family of putative taste receptors. J. Neurochem. 77 (2001) 896-903
16. Pin J.P., Galvez T., and Prezeau L. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol. Ther. 98 (2003) 325-354
17. Nelson G., Hoon M.A., Chandrashekar J., Zhang Y., Ryba N.J., and Zuker C.S. Mammalian sweet taste receptors. Cell 106 (2001) 381-390
18. Li X., Staszewski L., Xu H., Durick K., Zoller M., and Adler E. Human receptors for sweet and umami taste. Proc. Natl. Acad. Sci. USA 99 (2002) 4692-4696
19. Zhao G.Q., Zhang Y., Hoon M.A., Chandrashekar J., Erlenbach I., Ryba N.J., and Zuker C.S. The receptors for mammalian sweet and umami taste. Cell 115 (2003) 255-266
20. Jiang P., Ji Q., Liu Z., Snyder L.A., Benard L.M., Margolskee R.F., and Max M. The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. J. Biol. Chem. 279 (2004) 45068-45075
21. Xu H., Staszewski L., Tang H., Adler E., Zoller M., and Li X. Different functional roles of T1R subunits in the heteromeric taste receptors. Proc. Natl. Acad. Sci. USA 101 (2004) 14258-14263
22. Jiang P., Cui M., Ji Q., Snyder L., Liu Z., Benard L., Margolskee R.F., Osman R., and Max M. Molecular mechanisms of sweet receptor function. Chem. Senses 30 Suppl. 1 (2005) i17-i18
23. Jiang P., Cui M., Zhao B., Liu Z., Snyder L.A., Benard L.M., Osman R., Margolskee R.F., and Max M. Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. J. Biol. Chem. 280 (2005) 15238-15246
24. Winnig M., Bufe B., and Meyerhof W. Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor. BMC Neurosci. 6 (2005) 22
25. Cui M., Jiang P., Maillet E., Max M., Margolskee R.F., and Osman R. The heterodimeric sweet taste receptor has multiple potential ligand binding sites. Curr. Pharm. Des. 12 (2006) 4591-4600
26. Jiang P., Cui M., Zhao B., Snyder L.A., Benard L.M., Osman R., Max M., and Margolskee R.F. Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J. Biol. Chem. 280 (2005) 34296-34305
27. Horton R.M., Hunt H.D., Ho S.N., Pullen J.K., and Pease L.R. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77 (1989) 61-68
28. Nelson G., Chandrashekar J., Hoon M.A., Feng L., Zhao G., Ryba N.J., and Zuker C.S. An amino-acid taste receptor. Nature 416 (2002) 199-202