Strategies for Hedgehog inhibition and its potential role in cancer treatment

Drug Discovery Today: Therapeutic Strategies

Volumn 4, Issue 4, 2007, Pages 229-235

  Kolterud, Åsa ^a   Toftgård, Rune ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

3 KETO N (AMINOETHYLAMINOCAPROYLDIHYDROCINNAMOYL)CYCLOPAMINE; ANTINEOPLASTIC AGENT; BMI1 PROTEIN; CYCLIN D; CYCLOPAMINE; GANT 58; GANT 61; GDC 0449; HHANTAG 691; IPI 926; MONOCLONAL ANTIBODY 5E1; MYC PROTEIN; N (3 METHOXYBENZYL) 3,3 DIMETHYL N [1 (3,4 METHYLENEDIOXYBENZYL) 2 (1 PIPERAZINYLCARBONYL) 4 PYRROLIDINYL]BUTYRAMIDE; PROTEIN BCL 2; PROTEIN PATCHED 1; PROTEIN PATCHED 1 ANTIBODY; RAS PROTEIN; SANT 1; SANT 2; SANT 3; SANT 4; SMALL INTERFERING RNA; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; TRANSCRIPTION FACTOR SNAIL; UNINDEXED DRUG; XLI 39;

ABSENCE OF SIDE EFFECTS; ANTINEOPLASTIC ACTIVITY; BASAL CELL CARCINOMA; BASAL CELL NEVUS SYNDROME; BREAST CANCER; CANCER INHIBITION; CANCER INVASION; CANCER STEM CELL; CANCER THERAPY; CARCINOGENESIS; CELL PROLIFERATION; CLINICAL TRIAL; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG MEGADOSE; DRUG POTENCY; DRUG RESEARCH; DRUG TARGETING; ESOPHAGUS CANCER; GENE MUTATION; HUMAN; MEDULLOBLASTOMA; METASTASIS POTENTIAL; NONHUMAN; PANCREAS CANCER; PROSTATE CANCER; PROTEIN EXPRESSION; REVIEW; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; STROMA;

EID: 46749103655     PISSN: 17406773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddstr.2008.03.002     Document Type: Review

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