Genetic manipulation in nutrition, metabolism, and obesity research

Nutrition Reviews

Volumn 62, Issue 8, 2004, Pages 321-330

  Campión, Javier ^a   Milagro, Fermín I ^a   Martínez, J Alfredo ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Gene therapy; RNAi; Rodents; Transgenic

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INACTIVATION; GENE OVEREXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC MANIPULATION; GENETIC REGULATION; METABOLISM; MOUSE; NONHUMAN; NUTRITION; OBESITY; PROGENY; RESEARCH; REVIEW; RNA INTERFERENCE; TRANSGENIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC PREDISPOSITION TO DISEASE; GENETIC RESEARCH; GENOMICS; HUMANS; NUTRITION PHYSIOLOGY; OBESITY; TRANSGENES;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 4444277819     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1301/nr.2004.aug.321-330     Document Type: Review

References (83)

1. Martinez JA. Body-weight regulation: causes of obesity. Proc Nutr Soc. 2000;59:337-345.
2. Moreno-Aliaga MJ, Marti A, Garcia-Foncillas J, Alfredo Martinez J. DNA hybridization arrays: a powerful technology for nutritional and obesity research. Br J Nutr. 2001;86:119-122.
3. Marti A, De Miguel C, Jebb SA, et al. Methodological approaches to assess body-weight regulation and aetiology of obesity. Proc Nutr Soc. 2000;59:405-411.
4. van der Weyden L, Adams DJ, Bradley A. Tools for targeted manipulation of the mouse genome. Physiol Genomics. 2002;11:133-164.
5. Valet P, Tavernier G, Castan-Laurell I, Saulnier-Blache JS, Langin D. Understanding adipose tissue development from transgenic animal models. J Lipid Res. 2002;43:835-860.
6. Robinson SW, Dinulescu DM, Cone RD. Genetic models of obesity and energy balance in the mouse. Annu Rev Genet. 2000;34:687-745.
7. Palou A, Pico C, Bonet ML. The molecular basis of body weight control. In: Elmadfa I, Anklam E, König JS, eds. Modern Aspects of Nutrition: Present Knowledge and Future Perspectives. International Congress of Nutrition, Vienna, August 2001. Basel: S. Karger AG; 2003;56:164-168.
8. Fruhbeck G, Gomez-Ambrosi J. Control of body weight: a physiologic and transgenic perspective. Diabetologia. 2003;46:143-172.
9. Snyder EE, Walts B, Perusse L, et al. The human obesity gene map: the 2003 update. Obes Res. 2004;12:369-439.
10. Primrose SB, Twyman R, Old RW. Principles of Gene Manipulation. 6th ed. Oxford, England: Blackwell Publishing; 2001.
11. Swift GH, Hammer RE, MacDonald RJ, Brinster RL. Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. Cell. 1984;38:639-646.
12. Palmiter RD, Brinster RL, Hammer RE, et al. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature. 1982;300:611-615.
13. Shepherd PR, Gnudi L, Tozzo E, Yang H, Leach F, Kahn BB. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem. 1993;268:22243-22246.
14. Luetteke NC, Lee DC, Palmiter RD, Brinster RL, Sandgren EP. Regulation of fat and muscle development by transforming growth factor alpha in transgenic mice and in cultured cells. Cell Growth Differ. 1993;4:203-213.
15. Bothe GW, Haspel JA, Smith CL, Wiener HH, Burden SJ. Selective expression of Cre recombinase in skeletal muscle fibers. Genesis. 2000;26:165-166.
16. Imai T, Jiang M, Chambon P, Metzger D. Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes. Proc Natl Acad Sci U S A. 2001;98:224-228.
17. Schonig K, Schwenk F, Rajewsky K, Bujard H. Stringent doxycycline dependent control of CRE recombinase in vivo. Nucleic Acids Res. 2002;30:e134.
18. Barton MD, Dunlop JW, Psaltis G, Kulik J, DeGennaro L, Kwak SP. Modified GFAP promoter auto-regulates tet-activator expression for increased transactivation and reduced tTA-associated toxicity. Brain Res Mol Brain Res. 2002;101:71-81.
19. Lijnen HR, Maquoi E, Morange P, et al. Nutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol. 2003;23:78-84.
20. Horvath TL, Diano S, Miyamoto S, et al. Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice. Int J Obes Relat Metab Disord. 2003;27:433-442.
21. Ryding AD, Sharp MG, Mullins JJ. Conditional transgenic technologies. J Endocrinol. 2001;171:1-14.
22. Babinet C, Cohen-Tannoudji M. Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology. An Acad Bras Cienc. 2001;73:365-383.
23. Hayes E, Galea S, Verkuylen A, et al. Nuclear transfer of adult and genetically modified fetal cells of the rat. Physiol Genomics. 2001;5:193-204.
24. Kulkarni AB, Huh CG, Becker D, et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A. 1993;90:770-774.
25. Weinstock PH, Bisgaier CL, Aalto-Setala K, et al. Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice: mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. J Clin Invest. 1995;96:2555-2568.
26. Chirala SS, Chang H, Matzuk M, et al. Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci U S A. 2003;100:6358-6363.
27. Ma K, Cabrero A, Saha PK, et al. Increased beta-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem. 2002;277:34658-34661.
28. Sun Y, Ahmed S, Smith RG. Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol. 2003;23:7973-7981.
29. Maeda K, Uysal KT, Makowski L, et al. Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes. 2003;52:300-307.
30. Bluher M, Michael MD, Peroni OD, et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell. 2002;3:25-38.
31. Abel ED, Peroni O, Kim JK, et al. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature. 2001;409:729-733.
32. Norris AW, Chen L, Fisher SJ, et al. Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest. 2003;112:608-618.
33. Kelley VR, Sukhatme VP. Gene transfer in the kidney. Am J Physiol. 1999;276:F1-F9.
34. Fauci AS, Braunwald E, Isselbacher KJ, et al. Harrison's Principles of Internal Medicine. 14th ed. New York: McGraw Hill; 1998.
35. Romano G, Michell P, Pacilio C, Giordano A. Latest developments in gene transfer technology: achievements, perspectives, and controversies over therapeutic applications. Stem Cells. 2000;18:19-39.
36. Larcher F, Del Rio M, Serrano F, et al. A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts. FASEB J. 2001;15:1529-1538.
37. Utvik JK, Nja A, Gundersen K. DNA injection into single cells of intact mice. Hum Gene Ther. 1999;10:291-300.
38. Muzzin P, Cusin I, Charnay Y, Rohner-Jeanrenaud F. Single intracerebroventricular bolus injection of a recombinant adenovirus expressing leptin results in reduction of food intake and body weight in both lean and obese Zucker fa/fa rats. Regul Pept. 2000;92:57-64.
39. Nagamatsu S, Nakamichi Y, Ohara-Imaizumi M, et al. Adenovirus-mediated preproinsulin gene transfer into adipose tissues ameliorates hyperglycemia in obese diabetic KKA(y) mice. FEBS Lett. 2001;509:106-110.
40. Jimenez-Chillaron JC, Newgard CB, Gomez-Foix AM. Increased glucose disposal induced by adenovirus-mediated transfer of glucokinase to skeletal muscle in vivo. FASEB J. 1999;13:2153-2160.
41. Shklyaev S, Aslanidi G, Tennant M, et al. Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. Proc Natl Acad Sci U S A. 2003;100:14217-14222.
42. Dube MG, Beretta E, Dhillon H, Ueno Nm, Kalra PS, Kalra SP. Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels. Diabetes. 2002;51:1729-1736.
43. Huard J, Goins WF, Glorioso JC. Herpes simplex virus type 1 vector mediated gene transfer to muscle. Gene Ther. 1995;2:385-392.
44. Neumaier JF, Vincow ES, Arvanitogiannis A, Wise RA, Carlezon WA Jr. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. J Neurosci. 2002;22:10856-10863.
45. Aubert D, Pichard V, Durand S, Moullier P, Ferry N. Cytotoxic immune response after retroviral-mediated hepatic gene transfer in rat does not preclude expression from adeno-associated virus 1 transduced muscles. Hum Gene Ther. 2003;14:473-481.
46. Fleury S, Simeoni E, Zuppinger C, et al. Multiply attenuated, self-inactivating lentiviral vectors efficiently deliver and express genes for extended periods of time in adult rat cardiomyocytes in vivo. Circulation. 2003;107:2375-2382.
47. O'Rourke JP, Hiraragi H, Urban K, Patel M, Olsen JC, Bunnell BA. Analysis of gene transfer and expression in skeletal muscle using enhanced EIAV lentivirus vectors. Mol Ther. 2003;7:632-639.
48. Blomer U, Naldini L, Kafri T, Trono D, Verma IM, Gage FH. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol. 1997;71:6641-6649.
49. Makimura H, Mizuno TM, Mastaitis JW, Agami R, Mobbs CV. Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. BMC Neurosci. 2002;3:18.
50. McCaffrey AP, Meuse L, Pham TT, Conklin DS, Hannon GJ, Kay MA. RNA interference in adult mice. Nature. 2002;418:38-39.
51. Larrarte E, Margareto J, Novo FJ, Marti A, Alfredo Martinez J. UCP1 muscle gene transfer and mitochondrial proton leak mediated thermogenesis. Arch Biochem Biophys. 2002;404:166-171.
52. Marti A, Larrarte E, Novo FJ, Garcia M, Martinez JA. UCP2 muscle gene transfer modifies mitochondrial membrane potential. Int J Obes Relat Metab Disord. 2001;25:68-74.
53. Marti A, Novo FJ, Martinez-Anso E, Zarategui M, Aguado M, Martinez JA. Leptin gene transfer into muscle increases lipolysis and oxygen consumption in white fat tissue in ob/ob mice. Biochem Biophys Res Commun. 1998;246:859-862.
54. Kondoh T, Motooka Y, Bhattacharjee AK, Kokunai T, Saito N, Tamaki N. In vivo gene transfer into the periventricular region by electroporation. Neurol Med Chir (Tokyo). 2000;40:618-622.
55. Croze F, Prud'homme GJ. Gene therapy of streptozotocin-induced diabetes by intramuscular delivery of modified preproinsulin genes. J Gene Med. 2003;5:425-437.
56. Liu F, Huang L. Electric gene transfer to the liver following systemic administration of plasmid DNA. Gene Ther. 2002;9:1116-1119.
57. Matsuura M, Yamazaki Y, Sugiyama M, et al. Polycation liposome-mediated gene transfer in vivo. Biochim Biophys Acta. 2003;1612:136-143.
58. Lakey JR, Young AT, Pardue D, et al. Nonviral transfection of intact pancreatic islets. Cell Transplant. 2001;10:697-708.
59. Kawakami S, Yamashita F, Nishida K, Nakamura J, Hashida M. Glycosylated cationic liposomes for cell-selective gene delivery. Crit Rev Ther Drug Carrier Syst. 2002;19:171-190.
60. Kato N, Nakanishi K, Nemoto K, et al. Efficient gene transfer from innervated muscle into rat peripheral and central nervous systems using a non-viral haemagglutinating virus of Japan (HVJ)-liposome method. J Neurochem. 2003;85:810-815.
61. Dykxhoorn DM, Novina CD, Sharp PA. Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol. 2003;4:457-467.
62. Hannon GJ. RNA interference. Nature. 2002;418:244-251.
63. Kamath RS, Fraser AG, Dong Y, et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature. 2003;421:231-237.
64. Katome T, Obata T, Matsushima R, et al. Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions. J Biol Chem. 2003;278:28312-28323.
65. De Schrijver E, Brusselmans K, Heyns W, Verhoeven G, Swinnen JV. RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Res. 2003;63:3799-3804.
66. Yamauchi T, Kamon J, Ito Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423:762-769.
67. Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, Czech MP. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci USA. 2003;100:7569-7574.
68. Donze O, Picard D. RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase. Nucleic Acids Res. 2002;30:e46.
69. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 2001;411:494-498.
70. Gou D, Jin N, Liu L. Gene silencing in mammalian cells by PCR-based short hairpin RNA. FEBS Lett. 2003;548:113-118.
71. Shen C, Buck AK, Liu X, Winkler M, Reske SN. Gene silencing by adenovirus-delivered siRNA. FEBS Lett. 2003;539:111-114.
72. An DS, Xie Y, Mao SH, Morizono K, Kung SK, Chen IS. Efficient lentiviral vectors for short hairpin RNA delivery into human cells. Hum Gene Ther. 2003;14:1207-1212.
73. Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science. 2002;296:550-553.
74. Lewis DL, Hagstrom JE, Loomis AG, Woolff JA, Herweijer H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet. 2002;32:107-108.
75. Sorensen DR, Leirdal M, Sioud M. Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J Mol Biol. 2003;327:761-766.
76. Rubinson DA, Dillon CP, Kwiatkowski AV, et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet. 2003;33:401-406.
77. Zhao LJ, Jian H, Zhu H. Specific gene inhibition by adenovirus-mediated expression of small interfering RNA. Gene. 2003;316:137-141.
78. Pekarik V, Bourikas D, Miglino N, Joset P, Preiswerk S, Stoeckli ET. Screening for gene function in chicken embryo using RNAi and electroporation. Nat Biotechnol. 2003;21:93-96.
79. Carmell MA, Zhang L, Conklin DS, Hannon GJ, Rosenquist TA. Germline transmission of RNAi in mice. Nat Struct Biol. 2003;10:91-92.
80. Stein P, Svoboda P, Schultz RM. Transgenic RNAi in mouse oocytes: a simple and fast approach to study gene function. Dev Biol. 2003;256:187-193.
81. Lois C, Hong EJ, Pease S, Brown EJ, Baltimore D. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science. 2002;295:868-872.
82. Jiang XC, Qin S, Qiao C, et al. Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat Med. 2001;7:847-852.
83. Wiznerowicz M, Trono D. Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J Virol. 2003;77:8957-8961.