Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency

Nature Medicine

Volumn 7, Issue 7, 2001, Pages 847-852

  Jiang, Xian Cheng ^a   Qin, Shucun ^a   Qiao, Chunping ^b   Kawano, Koichi ^a   Lin, Min ^a   Skold, Anna ^b   Xiao, Xiao ^b   Tall, Alan R ^a  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; PHOSPHOLIPID TRANSFER PROTEIN;

ADENOVIRUS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DYSLIPIDEMIA; HYPERLIPIDEMIA; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN SECRETION; REGULATORY MECHANISM; TRANSGENIC MOUSE;

ANIMALS; APOLIPOPROTEINS B; ARTERIOSCLEROSIS; CELLS, CULTURED; HEPATOCYTES; LIPID METABOLISM, INBORN ERRORS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC;

EID: 0034920010     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/89977     Document Type: Article

References (40)

1. Recent progress in understanding apolipoprotein B
2. Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon
3. A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine
4. Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia
5. Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia
6. Metabolic abnormalities of apolipoprotein B-containing lipoproteins in non-insulin-dependent diabetes: A stable isotope kinetic study
7. Hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 studied with a stable isotope technique in men with visceral obesity
8. Role of lipid synthesis, chaperone proteins and proteasomes in the assembly and secretion of apoprotein B-containing lipoproteins from cultured liver cells
9. Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia
10. Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein
11. Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man
12. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels
13. Expression of human apolipoprotein B and assembly of lipoprotein(a) in transgenic mice
14. Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100
15. Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
16. Severe hypercholesterolemia in apolipoprotein E-deficient mice created by homologous recombination in ES cells
17. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
18. Apolipoprotein E and the apolipoprotein E-deficient mouse
19. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
20. Mechanism of hypertriglyceridemia in human apoCIII transgenic mice: Diminished VLDL fractional catabolic rate associated with increased apoCIII and reduced ApoE on the particles
21. Ubiquitin-proteasome pathway mediates intracellular degradation of apolipoprotein B
22. The role of the LDLR in apolipoprotein B secretion
23. The unstirred water layer as a site of control of apolipoprotein B secretion
24. Seperation of a plasma phospholipid transfer protein from cholesteryl ester/phospholipid exchange protein
25. Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency
26. The contribution of lipids and lipid metabolism to cellular functions of the Golgi complex
27. Insights into apolipoprotein B biology from transgenic and gene-targeted mice
28. An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits
29. Plasma lipid transfer proteins
30. Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoprotein
31. The implications of the structure of the bactericidal/permeability-increasing protein on the lipid-transfer function of the cholesteryl ester transfer protein
32. Structure and phospholipid transfer activity of human PLTP: Analysis by molecular modeling and site-directed mutagenesis
33. A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits
34. Probucol enhances selective uptake of HDL-associated cholesteryl esters in vitro by a scavenger receptor B-l-dependent mechanism
35. 131l-labeled plasma proteins
36. Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes
37. rAAV vector-mediated sarcogylcan gene transfer in a hamster model for limb girdle muscular dystrophy