Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: Increase in serum ghrelin levels

Diabetes

Volumn 51, Issue 6, 2002, Pages 1729-1736

  Dube, Michael G ^a   Beretta, Elena ^a   Dhillon, Harveen ^a   Ueno, Naohiko ^a   Kalra, Pushpa S ^a   Kalra, Satya P ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GHRELIN; GREEN FLUORESCENT PROTEIN; INSULIN; LEPTIN; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CONTROLLED STUDY; ENERGY EXPENDITURE; GENE THERAPY; HYPERINSULINEMIA; LIPID DIET; MALE; NONHUMAN; NONSHIVERING THERMOGENESIS; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VIRUS RECOMBINANT; WEIGHT GAIN;

EID: 0036263327     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.6.1729     Document Type: Article

References (40)

1. Obesity: How big a problem?
2. Obesity and the regulation of energy balance
3. Leptin and the regulation of body weight in mammals
4. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
5. Serum immunoreactive-leptin concentrations in normal-weight and obese humans
6. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
7. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
8. Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
9. Dynamic regulation of leptin entry into brain by the blood-brain barrier
10. Impaired transport of leptin across the blood-brain barrier in obesity
11. Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats
12. Leptin gene expression in the brain and pituitary gland
13. Cross-sectional and longitudinal analysis of age-associated changes in body composition of male Brown Norway rats: Association of serum leptin levels with peripheral adiposity
14. Regulation of leptin secretion: Effects of aging on daily patterns of serum leptin and food consumption
15. Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: A long-term study
16. Rodent mutant models of obesity and their correlations to human obesity
17. Adeno-associated viral vectors
18. Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus
19. Neural control of brown adipose tissue thermogenesis, hypertrophy, and atrophy
20. Towards a molecular understanding of adaptive thermogenesis
21. Ghrelin induces adiposity in rodents
22. Ghrelin: An orexigenic and somatotrophic signal from the stomach
23. Minireview: Ghrelin and the regulation of energy balance - A hypothalamic perspective
24. A role for ghrelin in the central regulation of feeding
25. Diet-induced obese mice develop peripheral, but not central, resistance to leptin
26. Production and purification of recombinant adeno-associated virus
27. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
28. Leptin regulation of neuroendocrine systems
29. Sex differences in the effects of high-fat feeding on behavior and carcass composition
30. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
31. Single intracerebro-ventricular bolus injection of a recombinant adenovirus expressing leptin results in reduction of food intake and body weight in both lean and obese Zucker fa/fa rats
32. Effects of the obese gene product on body weight regulation in ob/ob mice
33. Chronic leptin administration promotes lipid utilization until fat mass is greatly reduced and preserves lean mass of normal female rats
34. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
35. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy
36. Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors
37. Leptin physiology: A second look
38. The adipoinsular axis: Effects of leptin on pancreatic beta-cells
39. Obesity as a medical problem