E6-AP promotes misfolded polyglutamine proteins for proteasomal degradation and suppresses polyglutamine protein aggregation and toxicity

Journal of Biological Chemistry

Volumn 283, Issue 12, 2008, Pages 7648-7656

  Mishra, Amit ^b   Dikshit, Priyanka ^b   Purkayastha, Sudarshana ^b   Sharma, Jaiprakash ^b   Nukina, Nobuyuki ^a   Jana, Nihar Ranjan ^b  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b NATIONAL BRAIN RESEARCH CENTRE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; AGGREGATES; CELL DEATH; CONTROL SYSTEMS; CUSTOMER SATISFACTION; DEGRADATION; DISEASE CONTROL; ENZYMES; PROTEINS; QUALITY ASSURANCE; QUALITY FUNCTION DEPLOYMENT; TOTAL QUALITY MANAGEMENT; TOXICITY;

AGGREGATE FORMATIONS; CELLULAR QUALITY CONTROLS; INCLUSION BODIES; INTRACELLULAR PROTEINS; NEURODEGENERATIVE DISORDERS; NEURONAL RESPONSES; POLYGLUTAMINE DISEASES; POLYGLUTAMINE PROTEINS; POTENTIAL THERAPEUTIC TARGETS; PROTEASOMAL DEGRADATIONS; TRANSGENIC MOUSE MODELS; UBIQUITIN LIGASE;

QUALITY CONTROL;

E6 AP PROTEIN; POLYGLUTAMINE; PROTEASOME; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; CHIP PROTEIN, MOUSE; PEPTIDE; STUB1 PROTEIN, HUMAN; UBE3A PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL EXPANSION; CELL STRESS; CONTROLLED STUDY; CYTOTOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; DISEASE MODEL; ENZYMOLOGY; GENETICS; HUMAN; HUNTINGTON CHOREA; METABOLISM; MUSCLE ATROPHY;

MUS MUSCULUS;

ANIMALS; CELL DEATH; CERCOPITHECUS AETHIOPS; COS CELLS; DISEASE MODELS, ANIMAL; HUMANS; HUNTINGTON DISEASE; MICE; MICE, TRANSGENIC; MUSCULAR DISORDERS, ATROPHIC; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; UBIQUITIN-PROTEIN LIGASES;

EID: 43149120469     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M706620200     Document Type: Article

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