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Volumn 6, Issue 10, 2005, Pages 766-773

The molecular genetics of Huntington disease - A history

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN;

EID: 25844443895     PISSN: 14710056     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrg1686     Document Type: Review
Times cited : (150)

References (118)
  • 4
    • 0002781574 scopus 로고
    • Versuche über Pflanzenhybriden
    • in German
    • Mendel, G. Versuche über Pflanzenhybriden. Proc. Nat. Hist. Soc. Brunn 4, 3-A7 (1865) (in German).
    • (1865) Proc. Nat. Hist. Soc. Brunn , vol.4
    • Mendel, G.1
  • 5
    • 84903116828 scopus 로고
    • Mendelian inheritance in man
    • Punnett, R. C. Mendelian inheritance in man. Proc. R. Soc. Med. 1, 135-168 (1908).
    • (1908) Proc. R. Soc. Med. , vol.1 , pp. 135-168
    • Punnett, R.C.1
  • 6
    • 25844494037 scopus 로고
    • Über Chorea chronica progressiva Huntingtonsche Chorea, Chorea hereditaria
    • in German
    • Hoffmann, J. Über Chorea chronica progressiva (Huntingtonsche Chorea, Chorea hereditaria). Virchows Arch. A 111, 513-548 (1888) (in German).
    • (1888) Virchows Arch. A , vol.111 , pp. 513-548
    • Hoffmann, J.1
  • 7
    • 0023715807 scopus 로고
    • Anticipation in Huntington's disease is inherited through the male line but may originate in the female
    • Ridley, R. M., Frith, C. D., Crow, T. J. & Conneally, P. M. Anticipation in Huntington's disease is inherited through the male line but may originate in the female. J. Med. Genet. 25, 589-595 (1988).
    • (1988) J. Med. Genet. , vol.25 , pp. 589-595
    • Ridley, R.M.1    Frith, C.D.2    Crow, T.J.3    Conneally, P.M.4
  • 8
    • 0027240431 scopus 로고
    • Trinucleotide repeat length instability and age of onset in Huntington's disease
    • Duyao, M. et al. Trinucleotide repeat length instability and age of onset in Huntington's disease. Nature Genet. 4, 387-392 (1993).
    • (1993) Nature Genet. , vol.4 , pp. 387-392
    • Duyao, M.1
  • 9
    • 0027381482 scopus 로고
    • Molecular analysis of juvenile Huntington disease: The major influence on (CAG)n repeat length is the sex of the affected parent
    • Telenius, H. et al. Molecular analysis of juvenile Huntington disease: the major influence on (CAG)n repeat length is the sex of the affected parent. Hum. Mol. Genet. 2, 1535-1540 (1993).
    • (1993) Hum. Mol. Genet. , vol.2 , pp. 1535-1540
    • Telenius, H.1
  • 10
    • 0004287173 scopus 로고
    • Times Books, New York
    • Wexler, A. Mapping Fate (Times Books, New York, 1995).
    • (1995) Mapping Fate
    • Wexler, A.1
  • 11
    • 0018255639 scopus 로고
    • Genetic linkage studies in Huntington disease
    • Pericak-Vance, M. A. et al. Genetic linkage studies in Huntington disease. Cytogenet. Cell Genet. 22, 640-645 (1978).
    • (1978) Cytogenet. Cell Genet. , vol.22 , pp. 640-645
    • Pericak-Vance, M.A.1
  • 12
    • 0007758208 scopus 로고
    • Polymorphism of DNA sequence adjacent to human β-globin structural gene: Relationship to sickle mutation
    • Kan, Y. W. & Dozy, A. M. Polymorphism of DNA sequence adjacent to human β-globin structural gene: relationship to sickle mutation. Proc. Natl Acad. Sci. USA 75, 5631-5635 (1978).
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 5631-5635
    • Kan, Y.W.1    Dozy, A.M.2
  • 13
    • 0019302053 scopus 로고
    • Construction of a genetic linkage map in man using restriction fragment length polymorphisms
    • Botstein, D., White, R. L., Skolnick, M. & Davis, R. W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32, 314-331 (1980).
    • (1980) Am. J. Hum. Genet. , vol.32 , pp. 314-331
    • Botstein, D.1    White, R.L.2    Skolnick, M.3    Davis, R.W.4
  • 14
    • 0023115076 scopus 로고
    • Homozygotes for Huntington's disease
    • Wexler, N. S. et al. Homozygotes for Huntington's disease. Nature 326, 194-197 (1987).
    • (1987) Nature , vol.326 , pp. 194-197
    • Wexler, N.S.1
  • 15
    • 0021028244 scopus 로고
    • A polymorphic DNA marker genetically linked to Huntington's disease
    • Gusella, J. F. et al. A polymorphic DNA marker genetically linked to Huntington's disease. Nature 306, 234-238 (1983).
    • (1983) Nature , vol.306 , pp. 234-238
    • Gusella, J.F.1
  • 16
    • 12144288251 scopus 로고    scopus 로고
    • Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
    • Wexler, N. S. et al. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc. Natl Acad. Sci. USA 101, 3498-503 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 3498-3503
    • Wexler, N.S.1
  • 17
    • 0023624183 scopus 로고
    • Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere
    • Gilliam, T. C. et al. Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere. Cell 50, 565-571 (1987).
    • (1987) Cell , vol.50 , pp. 565-571
    • Gilliam, T.C.1
  • 18
    • 0024709641 scopus 로고
    • Huntington disease: No evidence for locus heterogeneity
    • Conneally, P. M. et al. Huntington disease: no evidence for locus heterogeneity. Genomics 5, 304-308 (1989).
    • (1989) Genomics , vol.5 , pp. 304-308
    • Conneally, P.M.1
  • 19
    • 0024708132 scopus 로고
    • Recombination events suggest potential sites for the Huntington's disease gene
    • MacDonald, M. E. et al. Recombination events suggest potential sites for the Huntington's disease gene. Neuron 3, 183-190 (1989).
    • (1989) Neuron , vol.3 , pp. 183-190
    • MacDonald, M.E.1
  • 20
    • 0025275405 scopus 로고
    • A yeast artificial chromosome telomere clone spanning a possible location of the Huntington disease gene
    • Bates, G. P. et al. A yeast artificial chromosome telomere clone spanning a possible location of the Huntington disease gene. Am. J. Hum. Genet. 46, 762-775 (1990).
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 762-775
    • Bates, G.P.1
  • 21
    • 0024448993 scopus 로고
    • Linkage disequilibrium in Huntington's disease: An improved localisation for the gene
    • Snell, R. G. et al. Linkage disequilibrium in Huntington's disease: an improved localisation for the gene. J. Med. Genet. 26, 673-675 (1989).
    • (1989) J. Med. Genet. , vol.26 , pp. 673-675
    • Snell, R.G.1
  • 22
    • 0024456037 scopus 로고
    • Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene
    • Theilmann, J. et al. Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene. J. Med. Genet. 26, 676-681 (1989).
    • (1989) J. Med. Genet. , vol.26 , pp. 676-681
    • Theilmann, J.1
  • 23
    • 0025945229 scopus 로고
    • Complex patterns of linkage disequilibrium in the Huntington disease region
    • MacDonald, M. E. et al. Complex patterns of linkage disequilibrium in the Huntington disease region. Am. J. Hum. Genet. 49, 723-734 (1991).
    • (1991) Am. J. Hum. Genet. , vol.49 , pp. 723-734
    • MacDonald, M.E.1
  • 24
    • 0025896024 scopus 로고
    • Defined physical limits of the Huntington disease gene candidate region
    • Bates, G. P. et al. Defined physical limits of the Huntington disease gene candidate region. Am. J. Hum. Genet. 49, 7-16 (1991).
    • (1991) Am. J. Hum. Genet. , vol.49 , pp. 7-16
    • Bates, G.P.1
  • 25
    • 0025860287 scopus 로고
    • Exon amplification: A strategy to isolate mammalian genes based on RNA splicing
    • Buckler, A. J. et al. Exon amplification: a strategy to isolate mammalian genes based on RNA splicing. Proc. Natl Acad. Sci. USA 88, 4005-4009 (1991).
    • (1991) Proc. Natl. Sci. USA , vol.88 , pp. 4005-4009
    • Buckler, A.J.1
  • 26
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72, 971-983 (1993).
    • (1993) Cell , vol.72 , pp. 971-983
  • 27
    • 0025905795 scopus 로고
    • Identification of a gene(FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
    • Verkerk, A. J. et al. Identification of a gene(FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell 65, 905-914 (1991).
    • (1991) Cell , vol.65 , pp. 905-914
    • Verkerk, A.J.1
  • 28
    • 0025800526 scopus 로고
    • Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
    • La Spada, A. R., Wilson, E. M., Lubahn, D. B., Harding, A. E. & Fischbeck, K. H. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 352, 77-79 (1991).
    • (1991) Nature , vol.352 , pp. 77-79
    • La Spada, A.R.1    Wilson, E.M.2    Lubahn, D.B.3    Harding, A.E.4    Fischbeck, K.H.5
  • 29
    • 0026566108 scopus 로고
    • Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member
    • Brook, J. D. et al. Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member. Cell 68, 799-808 (1992).
    • (1992) Cell , vol.68 , pp. 799-808
    • Brook, J.D.1
  • 30
    • 0027261537 scopus 로고
    • Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease
    • Snell, R. G. et al. Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease. Nature Genet. 4, 393-397 (1993).
    • (1993) Nature Genet. , vol.4 , pp. 393-397
    • Snell, R.G.1
  • 31
    • 0027176364 scopus 로고
    • The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease
    • Andrew, S. E. et al. The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. Nature Genet. 4, 398-403 (1993).
    • (1993) Nature Genet. , vol.4 , pp. 398-403
    • Andrew, S.E.1
  • 32
    • 0029997090 scopus 로고    scopus 로고
    • Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats
    • Rubinsztein, D. C. et al. Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats. Am. J. Hum. Genet. 59, 16-22 (1996).
    • (1996) Am. J. Hum. Genet. , vol.59 , pp. 16-22
    • Rubinsztein, D.C.1
  • 34
    • 0033556344 scopus 로고    scopus 로고
    • Analysis of a very large trinucleotide repeat in a patient with juvenile Huntington's disease
    • Nance, M. A., Mathias-Hagen, V., Breningstall, G., Wick, M. J. & McGlennen, R. C. Analysis of a very large trinucleotide repeat in a patient with juvenile Huntington's disease. Neurology 52, 392-394 (1999).
    • (1999) Neurology , vol.52 , pp. 392-394
    • Nance, M.A.1    Mathias-Hagen, V.2    Breningstall, G.3    Wick, M.J.4    McGlennen, R.C.5
  • 35
    • 0030937818 scopus 로고    scopus 로고
    • Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease
    • Rubinsztein, D. C. et al. Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease. Proc. Natl Acad. Sci. USA 94, 3872-3876 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3872-3876
    • Rubinsztein, D.C.1
  • 36
    • 0032867615 scopus 로고    scopus 로고
    • Evidence for the GluR6 gene associated with younger onset age of Huntington's disease
    • MacDonald, M. E. et al. Evidence for the GluR6 gene associated with younger onset age of Huntington's disease. Neurology 53, 1330-1332 (1999).
    • (1999) Neurology , vol.53 , pp. 1330-1332
    • MacDonald, M.E.1
  • 37
    • 0028986597 scopus 로고
    • Somatic mosaicism in sperm is associated with intergenerational (CAG)n changes in Huntington disease
    • erratum in Hum. Mol. Genet. 4, 974 (1995)
    • Telenius, H. et al. Somatic mosaicism in sperm is associated with intergenerational (CAG)n changes in Huntington disease. Hum. Mol. Genet. 4, 189-195 (1995); erratum in Hum. Mol. Genet. 4, 974 (1995).
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 189-195
    • Telenius, H.1
  • 38
    • 0029130324 scopus 로고
    • Anticipation and instability of IT-15 (CAG)n repeats in parent-offspring pairs with Huntington disease
    • Ranen, N. G. et al. Anticipation and instability of IT-15 (CAG)n repeats in parent-offspring pairs with Huntington disease. Am. J. Hum. Genet. 57, 593-602 (1995).
    • (1995) Am. J. Hum. Genet. , vol.57 , pp. 593-602
    • Ranen, N.G.1
  • 39
    • 0027435939 scopus 로고
    • De novo expansion of a (CAG)n repeat in sporadic Huntington's disease
    • Myers, R. H. et al. De novo expansion of a (CAG)n repeat in sporadic Huntington's disease. Nature Genet. 5, 168-173 (1993).
    • (1993) Nature Genet. , vol.5 , pp. 168-173
    • Myers, R.H.1
  • 40
    • 0028882509 scopus 로고
    • Increased instability of intermediate alleles in families with sporadic Huntington disease compared to similar sized intermediate alleles in the general population
    • Goldberg, Y. P. et al. Increased instability of intermediate alleles in families with sporadic Huntington disease compared to similar sized intermediate alleles in the general population. Hum. Mol. Genet. 4, 1911-1918 (1995).
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 1911-1918
    • Goldberg, Y.P.1
  • 41
    • 0035128291 scopus 로고    scopus 로고
    • Measurement of mutational flow implies both a high new-mutation rate for Huntington disease and substantial underascertainment of late-onset cases
    • Falush, D., Almqvist, E. W., Brinkmann, R. R., Iwasa, Y. & Hayden, M. R. Measurement of mutational flow implies both a high new-mutation rate for Huntington disease and substantial underascertainment of late-onset cases. Am. J. Hum. Genet. 68, 373-385 (2000).
    • (2000) Am. J. Hum. Genet. , vol.68 , pp. 373-385
    • Falush, D.1    Almqvist, E.W.2    Brinkmann, R.R.3    Iwasa, Y.4    Hayden, M.R.5
  • 42
    • 0028339385 scopus 로고
    • Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm
    • erratum in Nature Genet. 7, 113 (1994)
    • Telenius, H. et al. Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm. Nature Genet. 6, 409-414 (1994); erratum in Nature Genet. 7, 113 (1994).
    • (1994) Nature Genet. , vol.6 , pp. 409-414
    • Telenius, H.1
  • 43
    • 0346752132 scopus 로고    scopus 로고
    • Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis
    • Kennedy, L. et al. Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis. Hum. Mol. Genet. 12, 3359-3367 (2003).
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 3359-3367
    • Kennedy, L.1
  • 44
    • 0027432418 scopus 로고
    • Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues
    • Strong, T. V. et al. Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues. Nature Genet. 5, 259-265 (1993).
    • (1993) Nature Genet. , vol.5 , pp. 259-265
    • Strong, T.V.1
  • 45
    • 0027484673 scopus 로고
    • Huntington's disease gene (IT15) is widely expressed in human and rat tissues
    • Li, S. H. et al. Huntington's disease gene (IT15) is widely expressed in human and rat tissues. Neuron 11, 985-993 (1993).
    • (1993) Neuron , vol.11 , pp. 985-993
    • Li, S.H.1
  • 46
    • 0028989602 scopus 로고
    • Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
    • DiFiglia, M. et al. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 14, 1075-1081 (1995).
    • (1995) Neuron , vol.14 , pp. 1075-1081
    • DiFiglia, M.1
  • 47
    • 0029152808 scopus 로고
    • Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies
    • Gutekunst, C. A. et al. Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. Proc. Natl Acad. Sci. USA 92, 8710-8714 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8710-8714
    • Gutekunst, C.A.1
  • 48
    • 9444286388 scopus 로고    scopus 로고
    • Expression of normal and mutant huntingtin in the developing brain
    • Bhide, P. G. et al. Expression of normal and mutant huntingtin in the developing brain. J. Neurosci. 16, 5523-5535 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 5523-5535
    • Bhide, P.G.1
  • 49
    • 0029082383 scopus 로고
    • Inactivation of the mouse Huntington's disease gene homolog Hdh
    • Duyao, M. P. et al. Inactivation of the mouse Huntington's disease gene homolog Hdh. Science 269, 407-410 (1995).
    • (1995) Science , vol.269 , pp. 407-410
    • Duyao, M.P.1
  • 50
    • 0029055717 scopus 로고
    • Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
    • Nasir, J. et al. Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell 81, 811-823 (1995).
    • (1995) Cell , vol.81 , pp. 811-823
    • Nasir, J.1
  • 51
    • 84993912315 scopus 로고
    • Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue
    • Zeitlin, S., Liu, J. P., Chapman, D. L., Papaioannou, V. E. & Efstratiadis, A. Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nature Genet. 11, 155-163 (1995).
    • (1995) Nature Genet. , vol.11 , pp. 155-163
    • Zeitlin, S.1    Liu, J.P.2    Chapman, D.L.3    Papaioannou, V.E.4    Efstratiadis, A.5
  • 52
    • 0029392854 scopus 로고
    • HEAT repeats in the Huntington's disease protein
    • Andrade, M. A. & Bork, P. HEAT repeats in the Huntington's disease protein. Nature Genet. 11, 115-116 (1995).
    • (1995) Nature Genet. , vol.11 , pp. 115-116
    • Andrade, M.A.1    Bork, P.2
  • 53
    • 0041656292 scopus 로고    scopus 로고
    • The hunt for huntingtin function: Interaction partners tell many different stories
    • Harjes, P. & Wanker, E. E. The hunt for huntingtin function: interaction partners tell many different stories. Trends Biochem. Sci. 28, 425-433 (2003).
    • (2003) Trends Biochem. Sci. , vol.28 , pp. 425-433
    • Harjes, P.1    Wanker, E.E.2
  • 54
    • 4644231870 scopus 로고    scopus 로고
    • A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease
    • Goehler, H. et al. A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Mol. Cell 15, 853-865 (2004).
    • (2004) Mol. Cell , vol.15 , pp. 853-865
    • Goehler, H.1
  • 55
    • 0028283985 scopus 로고
    • Glutamine repeats as polar zippers: Their possible role in inherited neurodegenerative diseases
    • Perutz, M. F., Johnson, T., Suzuki, M. & Finch, J. T. Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases. Proc. Natl Acad. Sci. USA 91, 5355-5358 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5355-5358
    • Perutz, M.F.1    Johnson, T.2    Suzuki, M.3    Finch, J.T.4
  • 56
    • 18544400323 scopus 로고    scopus 로고
    • Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
    • Scherzinger, E. et al. Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Cell 90, 549-558 (1997).
    • (1997) Cell , vol.90 , pp. 549-558
    • Scherzinger, E.1
  • 57
    • 0038701684 scopus 로고    scopus 로고
    • Huntingtin aggregation and toxicity in Huntington's disease
    • Bates, G. Huntingtin aggregation and toxicity in Huntington's disease. Lancet 361, 1642-1644 (2003).
    • (2003) Lancet , vol.361 , pp. 1642-1644
    • Bates, G.1
  • 58
    • 16044373842 scopus 로고    scopus 로고
    • Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    • Mangiarini, L. et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87, 493-506 (1996).
    • (1996) Cell , vol.87 , pp. 493-506
    • Mangiarini, L.1
  • 59
    • 18544410106 scopus 로고    scopus 로고
    • Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
    • Davies, S. W. et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90, 537-548 (1997).
    • (1997) Cell , vol.90 , pp. 537-548
    • Davies, S.W.1
  • 60
    • 0030752709 scopus 로고    scopus 로고
    • Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    • DiFiglia, M. et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990-1993 (1997).
    • (1997) Science , vol.277 , pp. 1990-1993
    • DiFiglia, M.1
  • 61
    • 0032568517 scopus 로고    scopus 로고
    • Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene
    • Cha, J. H. et al. Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene. Proc. Natl Acad. Sci. USA 95, 6480-6485 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6480-6485
    • Cha, J.H.1
  • 62
    • 0041451498 scopus 로고    scopus 로고
    • eds Bates, G. P., Harper, P. S. & Jones, A. L. Oxford Univ. Press, Oxford
    • Bates, G. P. & Murphy, K. P. in Huntington's Disease (eds Bates, G. P., Harper, P. S. & Jones, A. L.) 387-426 (Oxford Univ. Press, Oxford, 2002).
    • (2002) Huntington's Disease , pp. 387-426
    • Bates, G.P.1    Murphy, K.P.2
  • 63
    • 0344961865 scopus 로고    scopus 로고
    • The use of transgenic and knock-in mice to study Huntington's disease
    • Hickey, M. A. & Chesselet, M. F. The use of transgenic and knock-in mice to study Huntington's disease. Cytogenet. Genome Res. 100, 276-286 (2003).
    • (2003) Cytogenet. Genome Res. , vol.100 , pp. 276-286
    • Hickey, M.A.1    Chesselet, M.F.2
  • 64
    • 0037444426 scopus 로고    scopus 로고
    • Transgenic rat model of Huntington's disease
    • von Horsten, S. et al. Transgenic rat model of Huntington's disease. Hum. Mol. Genet. 12, 617-624 (2003).
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 617-624
    • Von Horsten, S.1
  • 65
    • 25844526181 scopus 로고    scopus 로고
    • Gene expression in Huntington's disease skeletal muscle: A potential biomarker
    • Strand, A. D. et al. Gene expression in Huntington's disease skeletal muscle: a potential biomarker. Hum. Mol. Genet. (2005).
    • (2005) Hum. Mol. Genet.
    • Strand, A.D.1
  • 66
    • 20044392282 scopus 로고    scopus 로고
    • The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient β-cell mass and exocytosis
    • Bjorkqvist, M. et al. The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient β-cell mass and exocytosis. Hum. Mol. Genet. 14, 565-574 (2005).
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 565-574
    • Bjorkqvist, M.1
  • 67
    • 0034737299 scopus 로고    scopus 로고
    • Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
    • Yamamoto, A., Lucas, J. J. & Hen, R. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell 101, 57-66 (2000).
    • (2000) Cell , vol.101 , pp. 57-66
    • Yamamoto, A.1    Lucas, J.J.2    Hen, R.3
  • 68
    • 0034652127 scopus 로고    scopus 로고
    • Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins
    • Krobitsch, S. & Lindquist, S. Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. Proc. Natl Acad. Sci. USA 97, 1589-1594 (2000).
    • (2000) Proc. Natl. Sci. USA , vol.97 , pp. 1589-1594
    • Krobitsch, S.1    Lindquist, S.2
  • 69
    • 0034703869 scopus 로고    scopus 로고
    • Q111 striatal cells
    • Q111 striatal cells. Hum. Mol. Genet. 9, 2799-2809 (2000).
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2799-2809
    • Trettel, F.1
  • 70
    • 0037947662 scopus 로고    scopus 로고
    • A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila
    • Apostol, B. L. et al. A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proc. Natl Acad. Sci. USA 100, 5950-5955 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 5950-5955
    • Apostol, B.L.1
  • 71
    • 0033524413 scopus 로고    scopus 로고
    • Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron
    • Faber, P. W., Alter, J. R., MacDonald, M. E. & Hart, A. C. Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron. Proc. Natl Acad. Sci. USA 96, 179-184 (1999).
    • (1999) Proc. Natl. Sci. USA , vol.96 , pp. 179-184
    • Faber, P.W.1    Alter, J.R.2    MacDonald, M.E.3    Hart, A.C.4
  • 72
    • 0034705224 scopus 로고    scopus 로고
    • Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans
    • Satyal, S. H. et al. Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 97, 5750-5755 (2000).
    • (2000) Proc. Natl. Sci. USA , vol.97 , pp. 5750-5755
    • Satyal, S.H.1
  • 73
    • 0035818590 scopus 로고    scopus 로고
    • Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death
    • Parker, J. A. et al. Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death. Proc. Natl Acad. Sci. USA 98, 13318-13323 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13318-13323
    • Parker, J.A.1
  • 74
    • 0032168160 scopus 로고    scopus 로고
    • Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons
    • Jackson, G. R. et al. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron 21, 633-642 (1998).
    • (1998) Neuron , vol.21 , pp. 633-642
    • Jackson, G.R.1
  • 75
    • 0034110465 scopus 로고    scopus 로고
    • Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila
    • Marsh, J. L. et al. Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila. Hum. Mol. Genet. 9, 13-25 (2000).
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 13-25
    • Marsh, J.L.1
  • 76
    • 0034629073 scopus 로고    scopus 로고
    • Genetic suppression of polyglutamine toxicity in Drosophila
    • Kazemi-Esfarjani, P. & Benzer, S. Genetic suppression of polyglutamine toxicity in Drosophila. Science 287, 1837-1840 (2000).
    • (2000) Science , vol.287 , pp. 1837-1840
    • Kazemi-Esfarjani, P.1    Benzer, S.2
  • 77
    • 0036678146 scopus 로고    scopus 로고
    • The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
    • Morley, J. F., Brignull, H. R., Weyers, J. J. & Morimoto, R. I. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 99, 10417-10422 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10417-10422
    • Morley, J.F.1    Brignull, H.R.2    Weyers, J.J.3    Morimoto, R.I.4
  • 78
    • 0034703863 scopus 로고    scopus 로고
    • Mechanisms of chaperone suppression of polyglutamine disease: Selectivity, synergy and modulation of protein solubility in Drosophila
    • Chan, H. Y., Warrick, J. M., Gray-Board, G. L., Paulson, H. L. & Bonini, N. M. Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila. Hum. Mol. Genet. 9, 2811-2820 (2000).
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2811-2820
    • Chan, H.Y.1    Warrick, J.M.2    Gray-Board, G.L.3    Paulson, H.L.4    Bonini, N.M.5
  • 79
    • 0034608868 scopus 로고    scopus 로고
    • Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils
    • Muchowski, P. J. et al. Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils. Proc. Natl Acad. Sci. USA 97, 7841-7846 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7841-7846
    • Muchowski, P.J.1
  • 80
    • 0345189365 scopus 로고    scopus 로고
    • Yeast genes that enhance the toxicity of a mutant huntingtin fragment or α-synuclein
    • Willingham, S., Outeiro, T. F., DeVit, M. J., Lindquist, S. L. & Muchowski, P. J. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or α-synuclein. Science 302, 1769-1772 (2003).
    • (2003) Science , vol.302 , pp. 1769-1772
    • Willingham, S.1    Outeiro, T.F.2    DeVit, M.J.3    Lindquist, S.L.4    Muchowski, P.J.5
  • 81
    • 18144406846 scopus 로고    scopus 로고
    • A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease
    • Giorgini, F., Guidetti, P., Nguyen, Q., Bennett, S. C. & Muchowski, P. J. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nature Genet. 37, 526-531 (2005).
    • (2005) Nature Genet. , vol.37 , pp. 526-531
    • Giorgini, F.1    Guidetti, P.2    Nguyen, Q.3    Bennett, S.C.4    Muchowski, P.J.5
  • 82
    • 2342652188 scopus 로고    scopus 로고
    • Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation
    • Nollen, E. A. et al. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc. Natl Acad. Sci. USA 101, 6403-6408 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 6403-6408
    • Nollen, E.A.1
  • 83
    • 0035909330 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
    • Steffan, J. S. et al. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413, 739-743 (2001).
    • (2001) Nature , vol.413 , pp. 739-743
    • Steffan, J.S.1
  • 84
    • 0024426983 scopus 로고
    • Uptake of presymptomatic predictive testing for Huntington's disease
    • Craufurd, D., Dodge, A., Kerzin-Storrar, L. & Harris, R. Uptake of presymptomatic predictive testing for Huntington's disease. Lancet 2, 603-605 (1989).
    • (1989) Lancet , vol.2 , pp. 603-605
    • Craufurd, D.1    Dodge, A.2    Kerzin-Storrar, L.3    Harris, R.4
  • 85
    • 0024467131 scopus 로고
    • Problems in genetic prediction for Huntington's disease
    • Morris, M. J., Tyler, A., Lazarou, L., Meredith, L. & Harper, P. S. Problems in genetic prediction for Huntington's disease. Lancet 2, 601-603 (1989).
    • (1989) Lancet , vol.2 , pp. 601-603
    • Morris, M.J.1    Tyler, A.2    Lazarou, L.3    Meredith, L.4    Harper, P.S.5
  • 86
    • 0026514328 scopus 로고
    • Predictive testing for Huntington disease in Canada: The experience of those receiving an increased risk
    • Bloch, M., Adam, S., Wiggins, S., Huggins, M. & Hayden, M. R. Predictive testing for Huntington disease in Canada: the experience of those receiving an increased risk. Am. J. Med. Genet. 42, 499-507 (1992).
    • (1992) Am. J. Med. Genet. , vol.42 , pp. 499-507
    • Bloch, M.1    Adam, S.2    Wiggins, S.3    Huggins, M.4    Hayden, M.R.5
  • 87
    • 0024523933 scopus 로고
    • Presymptomatic diagnosis of delayed-onset disease with linked DNA markers. The experience in Huntington's disease
    • Brandt, J. et al. Presymptomatic diagnosis of delayed-onset disease with linked DNA markers. The experience in Huntington's disease. JAMA 261, 3108-3114 (1989).
    • (1989) JAMA , vol.261 , pp. 3108-3114
    • Brandt, J.1
  • 88
    • 0026524216 scopus 로고
    • Predictive testing for Huntington disease in Canada: Adverse effects and unexpected results in those receiving a decreased risk
    • Huggins, M. et al. Predictive testing for Huntington disease in Canada: adverse effects and unexpected results in those receiving a decreased risk. Am. J. Med. Genet. 42, 508-515 (1992).
    • (1992) Am. J. Med. Genet. , vol.42 , pp. 508-515
    • Huggins, M.1
  • 89
    • 0028470671 scopus 로고
    • Guidelines for the molecular genetics predictive test in Huntington's disease
    • International Huntington Association and the World Federation of Neurology Research Group on Huntington's Chorea. Guidelines for the molecular genetics predictive test in Huntington's disease. J. Med. Genet. 31, 555-559 (1994).
    • (1994) J. Med. Genet. , vol.31 , pp. 555-559
  • 90
    • 85047696356 scopus 로고    scopus 로고
    • Predictive DNA-testing for Huntington's disease and reproductive decision making: A European collaborative study
    • Evers-Kiebooms, G. et al. Predictive DNA-testing for Huntington's disease and reproductive decision making: a European collaborative study. Eur. J. Hum. Genet. 10, 167-176 (2002).
    • (2002) Eur. J. Hum. Genet. , vol.10 , pp. 167-176
    • Evers-Kiebooms, G.1
  • 91
    • 0033865906 scopus 로고    scopus 로고
    • Ten years of presymptomatic testing for Huntington's disease: The experience of the UK Huntington's Disease Prediction Consortium
    • Harper, P. S., Lim, C. & Craufurd, D. Ten years of presymptomatic testing for Huntington's disease: the experience of the UK Huntington's Disease Prediction Consortium. J. Med. Genet. 37, 567-571 (2000).
    • (2000) J. Med. Genet. , vol.37 , pp. 567-571
    • Harper, P.S.1    Lim, C.2    Craufurd, D.3
  • 92
    • 25844482890 scopus 로고    scopus 로고
    • eds Bates, G. P., Harper, P. S. & Jones, A. L. Oxford Univ. Press, Oxford
    • Tibben, A. in Huntington's Disease (eds Bates, G. P., Harper, P. S. & Jones, A. L.) 198-248 (Oxford Univ. Press, Oxford, 2002).
    • (2002) Huntington's Disease , pp. 198-248
    • Tibben, A.1
  • 93
    • 10744221876 scopus 로고    scopus 로고
    • Predictive, pre-natal and diagnostic genetic testing for Huntington's disease: The experience in Canada from 1987 to 2000
    • Creighton, S. et al. Predictive, pre-natal and diagnostic genetic testing for Huntington's disease: the experience in Canada from 1987 to 2000. Clin. Genet. 63, 462-475 (2003).
    • (2003) Clin. Genet. , vol.63 , pp. 462-475
    • Creighton, S.1
  • 94
    • 0027945216 scopus 로고
    • The genetic testing of children
    • Working Party of the Clinical Genetics Society (UK)
    • Clarke, A. The genetic testing of children. Working Party of the Clinical Genetics Society (UK). J. Med. Genet. 31, 785-797 (1994).
    • (1994) J. Med. Genet. , vol.31 , pp. 785-797
    • Clarke, A.1
  • 95
    • 0033926497 scopus 로고    scopus 로고
    • United Kingdom experience with presymptomatic testing of individuals at 25% risk for Huntington's disease
    • Benjamin, C. M. & Lashwood, A. United Kingdom experience with presymptomatic testing of individuals at 25% risk for Huntington's disease. Clin. Genet. 58, 41-49 (2000).
    • (2000) Clin. Genet. , vol.58 , pp. 41-49
    • Benjamin, C.M.1    Lashwood, A.2
  • 96
    • 0035036935 scopus 로고    scopus 로고
    • Prenatal testing for Huntington's disease: Experience within the UK 1994-1998
    • Simpson, S. A. & Harper, P. S. Prenatal testing for Huntington's disease: experience within the UK 1994-1998. J. Med. Genet. 38, 333-335 (2001).
    • (2001) J. Med. Genet. , vol.38 , pp. 333-335
    • Simpson, S.A.1    Harper, P.S.2
  • 97
    • 10044250985 scopus 로고    scopus 로고
    • New tools for preimplantation genetic diagnosis of Huntington's disease and their clinical applications
    • Moutou, C., Gardes, N. & Viville, S. New tools for preimplantation genetic diagnosis of Huntington's disease and their clinical applications. Eur. J. Hum. Genet. 12, 1007-1014 (2004).
    • (2004) Eur. J. Hum. Genet. , vol.12 , pp. 1007-1014
    • Moutou, C.1    Gardes, N.2    Viville, S.3
  • 98
    • 20244378556 scopus 로고    scopus 로고
    • RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model
    • Harper, S. Q. et al. RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proc. Natl Acad. Sci. USA 102, 5820-5825 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5820-5825
    • Harper, S.Q.1
  • 99
    • 0042126676 scopus 로고    scopus 로고
    • Experimental therapeutics in Huntington's disease: Are models useful for therapeutic trials?
    • Bates, G. P. & Hockly, E. Experimental therapeutics in Huntington's disease: are models useful for therapeutic trials? Curr. Opin. Neurol. 16, 465-470 (2003).
    • (2003) Curr. Opin. Neurol. , vol.16 , pp. 465-470
    • Bates, G.P.1    Hockly, E.2
  • 100
    • 0037452775 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
    • Hockly, E. et al. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease. Proc. Natl Acad. Sci. USA 100, 2041-2046. (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100
    • Hockly, E.1
  • 101
    • 0142157600 scopus 로고    scopus 로고
    • Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice
    • Ferrante, R. J. et al. Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J. Neurosci. 23, 9418-9427 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 9418-9427
    • Ferrante, R.J.1
  • 102
    • 19944431703 scopus 로고    scopus 로고
    • Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease
    • Gardian, G. et al. Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease. J. Biol. Chem. 280, 556-563 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 556-563
    • Gardian, G.1
  • 103
    • 14844341251 scopus 로고    scopus 로고
    • Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila
    • Agrawal, N. et al. Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila. Proc. Natl Acad. Sci. USA 102, 3777-3781 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 3777-3781
    • Agrawal, N.1
  • 104
    • 18744369020 scopus 로고    scopus 로고
    • Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay
    • Heiser, V. et al. Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay. Proc. Natl Acad. Sci. USA 99 (Suppl. 4), 16400-16406 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , Issue.4 SUPPL. , pp. 16400-16406
    • Heiser, V.1
  • 105
    • 20044390015 scopus 로고    scopus 로고
    • A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo
    • Zhang, X. et al. A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc. Natl Acad. Sci. USA 102, 892-897 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 892-897
    • Zhang, X.1
  • 106
    • 12944335007 scopus 로고    scopus 로고
    • Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation
    • Wang, J., Gines, S., MacDonald, M. E. & Gusella, J. F. Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation. BMC Neurosci. 6, 1 (2005).
    • (2005) BMC Neurosci. , vol.6 , pp. 1
    • Wang, J.1    Gines, S.2    MacDonald, M.E.3    Gusella, J.F.4
  • 107
    • 85009226418 scopus 로고    scopus 로고
    • Arandomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease
    • Huntington Study Group. Arandomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 57, 397-404 (2001).
    • (2001) Neurology , vol.57 , pp. 397-404
  • 108
    • 0023410641 scopus 로고
    • A somatic cell hybrid panel for localizing DNA segments near the Huntington's disease gene
    • MacDonald, M. E. et al. A somatic cell hybrid panel for localizing DNA segments near the Huntington's disease gene. Genomics 1, 29-34 (1987).
    • (1987) Genomics , vol.1 , pp. 29-34
    • MacDonald, M.E.1
  • 109
    • 0023951790 scopus 로고
    • Isolation of DNA markers in the direction of the Huntington disease gene from the G8 locus
    • Smith, B. et al. Isolation of DNA markers in the direction of the Huntington disease gene from the G8 locus. Am. J. Hum. Genet. 42, 335-344 (1988).
    • (1988) Am. J. Hum. Genet. , vol.42 , pp. 335-344
    • Smith, B.1
  • 110
    • 0024651106 scopus 로고
    • Isolation and field-inversion gel electrophoresis analysis of DNA markers located close to the Huntington disease gene
    • Pritchard, C. A., Casher, D., Uglum, E., Cox, D. R. & Myers, R. M. Isolation and field-inversion gel electrophoresis analysis of DNA markers located close to the Huntington disease gene. Genomics 4, 408-418 (1989).
    • (1989) Genomics , vol.4 , pp. 408-418
    • Pritchard, C.A.1    Casher, D.2    Uglum, E.3    Cox, D.R.4    Myers, R.M.5
  • 111
    • 38249043236 scopus 로고
    • Jumping libraries and linking libraries: The next generation of molecular tools in mammalian genetics
    • Poustka, A. & Lehrach, H. Jumping libraries and linking libraries: the next generation of molecular tools in mammalian genetics. Trends Genet. 2, 174-179 (1986).
    • (1986) Trends Genet. , vol.2 , pp. 174-179
    • Poustka, A.1    Lehrach, H.2
  • 112
    • 0023749189 scopus 로고
    • Chromosome jumping from D4S10 (GS) toward the Huntington disease gene
    • Richards, J. E. et al. Chromosome jumping from D4S10 (GS) toward the Huntington disease gene. Proc. Natl Acad. Sci. USA 85, 6437-6441 (1988).
    • (1988) Proc. Natl. Sci. USA , vol.85 , pp. 6437-6441
    • Richards, J.E.1
  • 113
    • 0025329337 scopus 로고
    • Physical maps of 4p16.3, the area expected to contain the Huntington disease mutation
    • Bucan, M. et al. Physical maps of 4p16.3, the area expected to contain the Huntington disease mutation. Genomics 6, 1-15 (1990).
    • (1990) Genomics , vol.6 , pp. 1-15
    • Bucan, M.1
  • 114
    • 0023730930 scopus 로고
    • Construction of a Notl linking library and isolation of new markers close to the Huntington's disease gene
    • Pohl, T. M. et al. Construction of a Notl linking library and isolation of new markers close to the Huntington's disease gene. Nucleic Acids Res. 16, 9185-9198 (1988).
    • (1988) Nucleic Acids Res. , vol.16 , pp. 9185-9198
    • Pohl, T.M.1
  • 115
    • 0023349389 scopus 로고
    • Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors
    • Burke, D. T., Carle, G. F. & Olson, M. V. Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science 236, 806-812 (1987).
    • (1987) Science , vol.236 , pp. 806-812
    • Burke, D.T.1    Carle, G.F.2    Olson, M.V.3
  • 116
    • 0026878945 scopus 로고
    • Characterization of a yeast artificial chromosome contig spanning the Huntington's disease gene candidate region
    • Bates, G. P. et al. Characterization of a yeast artificial chromosome contig spanning the Huntington's disease gene candidate region. Nature Genet. 1, 180-187 (1992).
    • (1992) Nature Genet. , vol.1 , pp. 180-187
    • Bates, G.P.1
  • 117
    • 0027310529 scopus 로고
    • A cosmid contig and high resolution restriction map of the 2 megabase region containing the Huntington's disease gene
    • Baxendale, S. et al. A cosmid contig and high resolution restriction map of the 2 megabase region containing the Huntington's disease gene. Nature Genet. 4, 181-186 (1993).
    • (1993) Nature Genet. , vol.4 , pp. 181-186
    • Baxendale, S.1
  • 118
    • 25844506896 scopus 로고
    • Huntington number
    • Browning, W. Huntington number. Neurographs 1, 1-164 (1908).
    • (1908) Neurographs , vol.1 , pp. 1-164
    • Browning, W.1


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