Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

EMBO Journal

Volumn 17, Issue 22, 1998, Pages 6723-6729

  Ge, Hui ^a   Si, Yuanzheng ^a   Roeder, Robert G ^b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Coactivators; p52; p75; PC4; Transcriptional activation

Indexed keywords

COMPLEMENTARY DNA; ETOPOSIDE; MESSENGER RNA; TRANSCRIPTION FACTOR;

ALTERNATIVE RNA SPLICING; ARTICLE; HUMAN; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION;

EID: 0032538795     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.22.6723     Document Type: Article

References (66)

1. Bjorklund, S. and Kim, Y.-J. (1996) Mediator of transcriptional regulation. Trends Biochem. Sci., 21, 335-337.
2. Burke, T.W. and Kadonaga, J.T. (1996) Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters. Genes Dev., 10, 711-724.
3. II60 of Drosophila. Genes Dev., 11, 3020-3031.
4. Burley, S.K. and Roeder, R.G. (1996) Biochemistry and structural biology of transcription factor IID (TFIID). Annu. Rev. Biochem., 65, 769-799.
5. Bustin, M. and Reeves, R. (1996) High mobility group proteins. Prog. Nucleic Acids Res. Mol. Biol., 54, 35-100.
6. Carey, M. (1998) The enhanceosome and transcriptional synergy. Cell, 9, 5-8.
7. Choy, B. and Green, M.R. (1993) Eukaryotic activators function during multiple steps of preinitiation complex assembly. Nature, 366, 531-536.
8. Chrivia, J.C., Kwok, R.P., Lamb, N., Hagiwara, M., Montminy, M.R. and Goodman, R.H. (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature, 365, 855-859.
9. Corden, J.L. and Patturajan, M. (1997) A CTD function linking transcription to splicing. Trends Biochem. Sci., 22, 413-416.
10. Cress, W.D. and Triezenberg, S.J. (1990) Critical structural elements of the VP16 transcriptional activation domains. Science, 251, 87-90.
11. Dahmus, M.E. (1996) Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem., 271, 19009-19012.
12. Flores, O., Lu, H., Killeen, M., Greenblatt, J., Burton, Z.F. and Reinberg, D. (1991) The small subunit of transcription factor TFIIF recruits RNA polymerase II into the preinitiation complex. Proc. Natl Acad. Sci. USA, 88, 9999-10003.
13. Forget, D., Robert, F., Grondin, G., Burton, Z.F., Greenblatt, J. and Coulombe, B. (1997) RAP74 induces promoter contacts by RNA polymerase II upstream and downstream of a DNA bend centered on the TATA box. Proc. Natl Acad. Sci. USA, 94, 7150-7155.
14. Ge, H. and Roeder, R.G. (1994a) Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell, 78, 513-523.
15. Ge, H. and Roeder, R.G. (1994b) The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein. J. Biol. Chem., 269, 17136-17140.
16. Ge, H., Zhao, Y.M., Chait, B.T. and Roeder, R.G. (1994) Phosphorylation negatively regulates the function of coactivator PC4. Proc. Natl Acad. Sci. USA, 91, 12691-12695.
17. Ge, H., Martinez, E., Chiang, C.-M. and Roeder, R.G. (1996) Activator-dependent transcription by mammalian RNA polymerase II: in vitro reconstitution with general transcription factors and cofactors. Methods Enzymol., 274, 57-71.
18. Ge, H., Si, Y.Z. and Wolffe, A.P. (1998) A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. Mol. Cell, in press.
19. Giniger, E. and Ptashne, M. (1987) Transcription in yeast activated by a putative amphipathic a helix linked to a DNA binding unit. Nature, 330, 670-672.
20. Greenblatt, J. and Ingles, C.J. (1996) Interaction between acidic transcriptional activation domains of herpes simplex virus activator protein VP16 and transcriptional initiation factor IID. Methods Enzymol., 274, 120-133.
21. Guermah, M., Malik, S. and Roeder, R.G. (1998) Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-κB and Sp1. Mol. Cell. Biol., 18, 3234-3244.
22. Hahn, S. (1993) Efficiency in activation. Nature, 363, 672-673.
23. Halle, J.P., Stelzer, G., Goppelt, A. and Meisterernst, M. (1995) Activation of transcription by recombinant upstream stimulatory factor 1 is mediated by a novel positive cofactor. J. Biol. Chem., 270, 21307-21311.
24. Henry, N.L., Bushnell, D.A. and Kornberg, R.D. (1996) A yeast transcriptional stimulatory protein similar to human PC4. J. Biol. Chem., 271, 21842-21847.
25. Jayaraman, L., Moorthy, N.C., Murthy, K.G.K., Manley, J.L. and Prives, C. (1998) High mobility group protein-1 (HMG-1) is a unique activator of p53. Genes Dev., 12, 462-472.
26. Kaiser, K. and Meisterernst, M. (1996) The human general co-factors. Trends Biochem. Sci., 21, 342-345.
27. Kaiser, K., Stelzer, G. and Meisterernst, M. (1995) The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation. EMBO J., 14, 3520-3527.
28. Kim, Y.-J., Bjorklund, S., Li, Y., Sayre, M.H. and Kornberg, R.D. (1994) A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell, 77, 599-608.
29. Knaus, R., Pollock, R. and Guarente, L. (1996) Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4. EMBO J., 14, 1933-1944.
30. Koleske, A.J. and Young, R.A. (1994) An RNA polymerase II holoenzyme responsive to activators. Nature, 368, 466-469.
31. Koleske, A.J. and Young, R.A. (1995) The RNA polymerase II holoenzyme and its implications for gene regulation. Trends Biochem. Sci., 20, 113-116.
32. Kretzschmar, M., Meisterernst, M. and Roeder, R.G. (1993) Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II. Proc. Natl Acad. Sci. USA, 90, 11508-11512.
33. Kretzschmar, M., Kaiser, K., Lottspeich, F. and Meisterenst, M. (1994a) A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. Cell, 78, 525-534.
34. Kretzschmar, M., Stelzer, G., Roeder, R.G. and Meisterernst, M. (1994b) RNA polymerase II cofactor PC2 facilitates activation of transcription by GAL4-AH in vitro. Mol. Cell. Biol., 14, 3927-3937.
35. Levine, A.J. (1997) p53, the cellular gatekeeper for growth and division. Cell, 88, 323-331.
36. Lin, Y.-S. and Green, M.R. (1991) Mechanism of action of an acidic transcriptional activator in vitro. Cell, 64, 971-981.
37. Luo, Y. Fujii, H., Gerster, T. and Roeder, R.G. (1992) A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors. Cell, 71, 231-241.
38. Luo, Y., Ge, H., Stevens, S., Xiao, H. and Roeder, R.G. (1998) Coactivation by OCA-B: definition of critical regions and synergism with general cofactors. Mol. Cell. Biol., 18, 3803-3810.
39. Malik, S., Guermah, M. and Roeder, R.G. (1998) A dynamic model for PC4 coactivator function in RNA polymerase II transcription. Proc. Natl Acad. Sci. USA, 95, 2192-2197.
40. Martin, K.J., Lillie, J.W. and Green, M.R. (1990) Transcriptional activation by the pseudorabies virus immediate early protein. Genes Dev., 4, 2371-2382.
41. Martinez, E., Chiang, C.-M., Ge, H. and Roeder, R.G. (1994) TATA-binding protein-associated factor(s) in TFIID function through the initiator to direct basal transcription from a TATA-less class II promoter. EMBO J., 13, 3115-3126.
42. Meisterernst, M., Roy, A.L., Lieu, H.M. and Roeder, R.G. (1991) Activation of class II gene transcription by regulatory factors is potentiated by a novel activity. Cell, 66, 981-993.
43. Meisterernst, M., Stelzer, G. and Roeder, R.G. (1997) Poly(ADP-ribose) polymerase enhances activator-dependent transcription in vitro. Proc. Natl Acad. Sci. USA, 94, 2261-2265.
44. Merino, A., Madden, K.R., Lane, W.S., Champoux, J.J. and Reinberg, D. (1993) DNA topoisomerase I is involved in both repression and activation of transcription. Nature, 365, 227-232.
45. Moqtaderi, Z., Bai, Y., Poon, D., Weil, P.A. and Struhl, K. (1996) TBP-associated factors are not genetically required for transcriptional activation in yeast. Nature, 383, 188-191.
46. Nakamura, H., Izumoto, Y., Kambe, H., Kuroda, T., Mori, T., Kawamura, K., Yamamoto, H. and Kishimoto, T. (1994) Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. J. Biol. Chem., 269, 25143-25149.
47. Nakatani, Y., Horikoshi, M., Brenner, M., Yamamoto, T., Besnard.F., Roeder, R.G. and Freese, E. (1990) A downstream initiation element required for efficient TATA box binding and in vitro function of TFIID. Nature, 348, 86-88.
48. IIS. Mol. Cell, 1, 925-931.
49. Onate, S.A., Prendergast, P., Wagner, J.P., Nissen, M., Reeves, R., Pettijohn, D.E. and Edwards, D.P. (1994) The DNA-bending protein HMG-1 enhances progesterone receptor binding to its target DNA sequences. Mol. Cell. Biol., 14, 3376-3391.
50. Orphanides, G., Lagrange, T. and Reinberg, D. (1996) The general transcription factors of RNA polymerase II. Genes Dev., 10, 2657-2683.
51. Ptashne, M. and Gann, A.A.F. (1990) Activators and targets. Nature, 346, 329-331.
52. Ptashne, M. and Gann, A. (1997) Transcriptional activation by recruitment. Nature, 386, 569-577.
53. Pugh, B.F. (1996) Mechanisms of transcription complex assembly. Curr. Opin. Cell Biol., 8, 303-311.
54. Roeder, R.G. (1996) The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem. Sci., 21, 327-335.
55. Shen, W.C. and Green, M.R. (1997) Yeast TAF(II)145 functions as a core promoter selectivity factor, not a general coactivator. Cell, 90, 615-624.
56. Shykind, B., Kim, J. and Sharp, P.A. (1995) Activation of the TFIID-TFIIA complex with HMG-2. Genes Dev., 9, 1354-1365.
57. Steinmetz, E.J. (1997) Pre-mRNA processing and the CTD of RNA polymerase II: the tail that wags the dog? Cell, 89, 491-494.
58. Stelzer, G., Goppelt, A., Lottspeich, F. and Meisterernst, M. (1994) Repression of basal transcription by HMG2 is counteracted by TFIIH-associated factors in an ATP-dependent process. Mol. Cell. Biol., 14, 4712-4721.
59. Tan, S., Conaway, R.C. and Conaway, J.W. (1995) Dissection of transcription factor TFIIF functional domains required for initiation and elongation. Proc. Natl Acad. Sci. USA, 92, 6042-6046.
60. Triezenberg, S.J., Kingsbury, R.C. and McKnight, S.L. (1988) Functional dissection of VP16, the transactivator of herpes simplex virus immediate early gene expression. Genes Dev., 2, 718-729.
61. Verrijzer, C.P. and Tjian, R. (1996) TAFs mediate transcriptional activation and promoter selectivity. Trends Biochem. Sci., 21, 338-342.
62. Verrijzer, C.P., Chen, J.L., Yokomori, K. and Tjian, R. (1995) Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II. Cell, 81, 1115-1125.
63. IIS. Nature, 383, 185-88.
64. Wang, W., Gralla, J.D. and Carey, M. (1992) The acidic activator GAL4-AH can stimulate polymerase II transcription by promoting assembly of a closed complex requiring TFIID and TFIIA. Genes Dev., 6, 1716-1727.
65. Zappavigna, V., Falciola, L., Citterich, M., Mavilio, F. and Bianchi, M.E. (1996) HMG-1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation. EMBO J., 15, 4981-4991.
66. Zwilling, S., Konig, H. and Wirth, T. (1995) High mobility group protein 2 functionally interacts with POU domains of octamer transcription factors. EMBO J., 14, 1198-1208.