Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: Implications for autoimmunity in atopic disorders

Cell Death and Differentiation

Volumn 9, Issue 9, 2002, Pages 915-925

  Wu, X ^a   Daniels, T ^a   Molinaro, C ^a   Lilly, M B ^a   Casiano, C A ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Atopy; Autoimmunity; Caspases; Cell survival; LEDGF p75

Indexed keywords

AUTOANTIGEN; CASPASE; CASPASE 3; CASPASE 7; GROWTH FACTOR; LENS EPITHELIUM DERIVED GROWTH FACTOR; PROTEIN P75;

APOPTOSIS; ARTICLE; ATOPY; AUTOIMMUNITY; CELL DEATH; CELL PROTECTION; CELL STRAIN HEPG2; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; IMMUNOGENICITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRESS;

APOPTOSIS; ASTHMA; AUTOIMMUNE DISEASES; BINDING SITES; CASPASE 3; CASPASE 7; CASPASES; CELL SURVIVAL; CULTURE MEDIA, SERUM-FREE; DERMATITIS, ATOPIC; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; JURKAT CELLS; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE FRAGMENTS; PEPTIDE HYDROLASES; RHINITIS; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 0036715347     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401063     Document Type: Article

References (54)

1. Atopic dermatitis: New insights and opportunities for therapeutic intervention
2. Atopic dermatitis: Is it an allergic disease?
3. Immune regulation in atopic dermatitis
4. Autoantibodies to DFS70 kd/transcription coactivator p75 in atopic dermatitis and other conditions
5. Auto antibodies in atopic dermatitis
6. Autoallergy: A pathogenetic factor in atopic dermatitis?
7. Anti-elongation factor-1alpha autoantibody in adult atopic dermatitis patients
8. Characterization of IgE-reactive autoantigens in atopic dermatitis. 1. Subcellular distribution and tissue-specific expression
9. Characterization of IgE-reactive autoantigens in atopic dermatitis. 2. A pilot study on IgE versus IgG subclass response and seasonal variation of IgE autoreactivity
10. Immunoglobulin E response to human proteins in atopic patients
11. Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation
12. Lens epithelium-derived growth factor: Increased resistance to thermal and oxidative stresses
13. Humoral immune response directed against LEDGF in patients with VKH
14. Lens epithelium-derived growth factor: Effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts
15. LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes
16. Lens epithelium-derived growth factor: Increased survival and decreased DNA breakage of human RPE cells induced by oxidative stress
17. Transcriptional regulation of the AOP2 gene, a thiol-specific antioxidant, by LEDGF to protect cells from oxidative stress
18. Lens epithelium-derived growth factor (LEDGF) delays photoreceptor degeneration in explants of rd/rd mouse retina
19. Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus
20. Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats
21. LEDGF: Survival of embryonic chick retinal photoreceptor cells
22. Activation of LEDGF gene by thermal-and oxidative-stresses
23. Role of apoptosis in atopic dermatitis
24. Cytokine network and dysregulated apoptosis in atopic dermatitis
25. T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis
26. Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)- mediated T cell apoptosis
27. Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes
28. Secondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens: Implications for autoimmunity
29. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis
30. Cleavage by granzyme B is strongly predictive of autoantigen status: Implications for initiation of autoimmunity
31. Auto antigens as substrates for apoptotic proteases: Implications for the pathogenesis of systemic autoimmune disease
32. Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens
33. Remnants of suicidal cells fostering systemic autoaggression. Apoptosis in the origin and maintenance of autoimmunity
34. Cell death: A trigger of autoimmunity?
35. The mitochondrial apoptosome: A killer unleashed by the cytochrome seas
36. Proteases for cell suicide: Functions and regulation of caspases
37. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
38. Caspases: The executioners of apoptosis
39. Caspase-3 mediated cleavage of HsRad51 at an unconventional site
40. Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis
41. The PWWP domain: A potential protein-protein interaction domain in nuclear proteins influencing differentiation?
42. Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing
43. Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells
44. Conversion of Bcl-2 to a Bax-like death effector by caspases
45. Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases
46. Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis
47. Molecular biology of HMGA proteins; hubs of nuclear function
48. Defective phagocytosis of apoptotic cells: Possible explanation for the induction of autoantibodies in SLE
49. Clearing the way to mechanisms of autoimmunity
50. Corpse clearance defines the meaning of cell death
51. Apoptosis. Gone but not forgotten
52. Apoptosis, necrosis, and the genesis of antinuclear autoantibodies: An integrated view
53. Antibodies to lens epithelium-derived growth factor (LEDGF) kill epithelial cells of whole lenses in organ culture
54. Necrotic death pathway in Fas receptor signaling