The Saccharomyces retrotransposon Ty5 integrates preferentially into regions of silent chromatin at the telomeres and mating loci

Genes and Development

Volumn 10, Issue 5, 1996, Pages 634-645

  Zou, Sige ^a   Ke, Ning ^a   Kim, Jin M ^a   Voytas, Daniel F ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

integration; Retrotransposon; silent chromatin; telomere; transposition; Ty5

Indexed keywords

DNA;

ARTICLE; CHROMATIN; CONTROLLED STUDY; DNA INTEGRATION; DNA SEQUENCE; DNA TRANSPOSITION; GENE LOCUS; GENE TARGETING; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; RETROPOSON; SACCHAROMYCES; TELOMERE;

EID: 0029985540     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.5.634     Document Type: Article

References (58)

1. Atwood, A., J. Lin, and H.L. Levin. 1996. The retrotransposon Tf1 assembles VLPs that contain excess gag relative to integrase because of a regulated degradation process. Mol. Cell. Biol. 16: 338-346.
2. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. 1987. Current protocols in molecular biology. Greene/Wiley Interscience, New York.
3. Bell, S.P., R. Kobayashi, and B. Stillman. 1993. Yeast origin recognition complex functions in transcription silencing and DNA replication. Science 262: 1844-1849.
4. Biessmann, H., J.M. Mason, K. Ferry, M. d'Hulst, K. Valgeirsdottir, K.L. Traverse, and M.L. Pardue. 1990. Addition of telomere-associated HeT DNA sequences "heals" broken chromosome ends in Drosophila. Cell 61: 663-673.
5. Boeke, J.D., and S.B. Sandmeyer. 1991. Yeast transposable elements. In The Molecular and cellular biology of the yeast Saccharomyces (ed. J.R. Broach, J.R. Pringle, and E.W. Jones), pp. 193-261. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
6. Boeke, J.D., D.J. Garfinkel, C.A. Style, and G.R. Fink. 1985. Ty elements transpose through an RNA intermediate. Cell 40: 491-500.
7. Brand, A.H., L. Breeden, J. Abraham, R. Sternglanz, and K. Nasmyth. 1985. Characterization of a "silencer" in yeast: A DNA sequence with properties opposite to those of a transcriptional enhancer. Cell 41: 41-48.
8. Brown, P. and H. Varmus. 1989. Retroviruses. In Mobile DNA (ed. D.E. Berg and M.M. Howe), pp. 53-108. American Society for Microbiology, Washington, D.C.
9. Bryan, T M., A. Englezou, J. Gupta, S. Bacchetti, and R.R. Reddel. 1995. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14: 4240-4248.
10. Chalker, D.L. and S.B. Sandmeyer. 1990. Transfer RNA genes are genomic targets for de novo transposition of the yeast retrotransposon Ty3. Genetics 126: 837-850.
11. _. 1992. Ty3 integrates within the region of RNA polymerase III transcription initiation. Genes & Dev. 6: 117-128.
12. Chapman, K.B., A.S. Bystrom, and J.D. Boeke. 1992. Initiator methionine tRNA is essential for Ty1 transposition in yeast Proc. Natl. Acad. Sci. 89: 3236-3240.
13. Craigie, R. 1992. Hotspots and warm spots: integration specificity of retroelements. Trends Genet. 8: 187-190.
14. Curcio, M.J. and D.J. Garfinkel. 1991. Single-step selection for Ty1 element retrotransposition. Proc. Natl. Acad. Sci. 88: 936-940.
15. Devereux, J., P. Haeberli, and O. Smithies. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12: 387-395.
16. Devine, S.E. and J.D. Boeke. 1996. Integration of the yeast retrotransposon Ty1 is targeted to regions upstream of genes transcribed by RNA polymerase III. Genes & Dev. (this issue).
17. Diffley, J.F.X. and B. Stillman. 1988. Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer. Proc. Natl. Acad. Sci. 85: 2120-2124.
18. Foss, M., F.J. McNally, P. Laurenson, and J. Rine. 1993. Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae. Science 262: 1838-1844.
19. Gottschling, D.E., O.M. Aparicio, B.L. Billington, and V.A. Zakian. 1990. Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription. Cell 63: 751-762.
20. Haber, J.E. 1992. Mating-type gene switching in Saccharomyces cerevisiae. Trends Genet. 8: 446-452.
21. Hardy, C.F., L. Sussel, and D. Shore. 1992. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes & Dev. 6: 801-814.
22. Hecht, A., T. Laroche, S. Strahl-Bolsinger, S.M. Gasser, and M. Grunstein. 1995 Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast. Cell 80: 583-592.
23. Hull, M.W., J. Erickson, M. Johnston, and D.R. Engelke. 1994. tRNA genes as transcriptional repressor elements. Mol. Cell. Biol. 14: 1266-1277.
24. Jacks, T. 1990. Translational suppression in gene expression in retroviruses and retrotransposons. Curr. Topics Microbiol. Immunol. 157: 93-124.
25. Ji, H., D.P. Moore, M.A. Blomberg, L.T. Braiterman, D.F. Voytas, G. Natsoulis, and J.D. Boeke. 1993. Hotspots for unselected Ty1 transposition events on yeast chromosome III are near tRNA genes and LTR sequences. Cell 73: 1007-1018.
26. Kalpana, G.V., S. Marmon, W. Wang, G.R. Crabtree, and S.P. Goff. 1994. Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. Science 266: 2002-2006.
27. Karpen, G.H. and A.C. Spradling. 1992. Analysis of subtelomeric heterochromatin in the Drosophila minichromosome Dpi 187 by single P element insertional mutagenesis. Genetics 132: 737-753.
28. Kayne, P.S., U.J. Kim, M. Han, J.R. Mullen, F. Yoshizaki, and M. Grunstein. 1988. Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast. Cell 55: 27-39.
29. Keeney, J.B., K.B. Chapman, V. Lauermann, D.F. Voytas, S.U. Astrom, U. von Pawel-Rammingen, A. Bystrom, and J.D. Boeke. 1995. Multiple molecular determinants for retrotransposition in a primer tRNA. Mol. Cell. Biol. 15:217-226.
30. Kikuchi, Y., Y. Ando, and T. Shiba. 1986. Unusual priming mechanism of RNA-directed DNA synthesis in copia retrovirus-like particles of Drosophila. Nature 323: 824-826.
31. Kirchner, J., C.M. Connolly, and S.B. Sandmeyer. 1995. Requirement of RNA polymerase III transcription factors for in vitro postion-specific integration of a retroviruslike element. Science 267: 1488-1491.
32. Kurtz, S. and D. Shore. 1991. RAP1 protein activates and silences transcription of mating-type genes in yeast. Genes & Dev. 5: 616-628.
33. Laurenson, P. and J Rine. 1992. Silencers, silencing, and heritable transcriptional states. Microbiol. Rev. 56: 543-560.
34. Levin, H.L., D.C. Weaver, and J.D. Boeke. 1990. Two related families of retrotransposons from Schizosaccharomyces pombe. Mol. Cell. Biol. 10: 6791-6798.
35. Levis, R.W., R. Ganesan, K. Houtchens, L.A. Tolar, and F.M. Sheen. 1993. Transposons in place of telomeric repeats at a Drosophila telomere. Cell 75: 1083-1093.
36. Longtine, M.S., S. Enomoto, S.L. Finstad, and J. Berman. 1993. Telomere-mediated plasmid segregation in Saccharomyces cerevisiae involves gene products required for transcriptional repression at silencers and telomeres. Genetics 133: 171-182.
37. Loo, S. and J. Rine. 1994. Silencers and domains of generalized repression. Science 264: 1768-1771.
38. Louis, E.J., E.S. Naumova, A. Lee, G. Naumov, and J.E. Haber. 1994. The chromosome end in yeast: its mosaic nature and influence on recombinational dynamics. Genetics 136: 789-802.
39. Lundblad, V. and E.H. Blackburn. 1993. An alternative pathway for yeast telomere maintenance rescues est1 - senescence. Cell 73: 347-360.
40. Micklem, G., A. Rowley, J. Harwood, K. Nasmyth, and J.F. Diffley. 1993. Yeast origin recognition complex is involved in DNA replication and transcriptional silencing. Nature 366: 87-89.
41. Mount, S.M. and G.M. Rubin. 1985. Complete nucleotide sequence of the Drosophila transposable element copia: homology between copia and retroviral proteins. Mol. Cell. Biol. 5: 1630-1638.
42. Mullen, J.R., P.S. Kayne, R.P. Moerschell, S. Tsunasawa, M. Gribskov, M. Colavito-Shepanski, M. Grunstein, F. Sherman, and R. Sternglanz. 1989. Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. EMBO J. 8: 2067-2075.
43. Ochman, H., A.S. Gerber, and D.L. Hartl. 1988. Genetic applications of an inverse polymerase chain reaction. Genetics 120: 621-623.
44. Oliver, S.G., Q.J.M. van der Aart, M.L. Agostoni-Carbone, M. Aigle, L. Alberghina, D. Alexandraki, G. Antoine, R. Anwar, J.P.G. Ballesta, P. Benit, et al. 1992. The complete DNA sequence of yeast chromosome III. Nature 357: 38-46.
45. Pimpinelli, S., M. Berloco, L. Fanti, P. Dimitri, S. Bonaccorsi, E. Marchetti, R. Caizzi, C. Caggese, and M. Gatti. 1995. Transposable elements are stable structural components of Drosophila melanogaster heterochromatin. Proc. Natl. Acad. Sci. 92: 3804-3808.
46. Rine, J. and I. Herskowitz. 1987. Four genes responsible for a position, effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116: 9-22.
47. Roth, S. 1995. Chromatin-mediated transcriptional repression in yeast Curr. Opin. Genet. Dev. 5: 168-173.
48. Rymond, B.C. and M. Rosbash. 1992. Yeast pre-mRNA splicing. In The molecular and cellular biology of the yeast Saccharomyces (ed. J.R. Bioach, J.R. Pringle, and E.W. Jones), pp. 143-192. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
49. Sandmeyer, S.B., L.J. Hansen, and D.L. Chalker. 1990. Integration specificity of retrotransposons and retroviruses. Annu. Rev. Genet. 24: 491-518.
50. Sharon, G., T.J. Burkett, and D.J. Garfinkel. 1994. Efficient homologous recombination of Ty1 element cDNA when integration is blocked. Mol. Cell. Biol. 14: 6540-6551.
51. Thompson, J.S., X. Ling, and M. Grunstein. 1994. Histone H3 aminno terminus is required for telomeric and silent mating locus repression in yeast. Nature 369: 245-247.
52. Voytas, D.F. and F.M. Ausubel. 1988. A copia-like transposable element family in Arabidopsis thaliana. Nature 336: 242-244.
53. Voytas, D.F. and J.D. Boeke. 1992. Yeast retrotransposon revealed. Nature 358: 717.
54. _. 1993. Yeast retrotransposons and tRNAs. Trends Genet. 9: 421-427.
55. Weinstock, K.G., M.F. Mastrangelo, T.J. Burkett, D.J. Garfinkel, and J.N. Strathem. 1990. Multimeric arrays of the yeast retrotransposon Ty1. Mol. Cell. Biol. 10: 2882-2892.
56. Xiong, Y. and T.H. Eickbush. 1990. Origin and evolution of retroelements based upon their reverse transcriptase sequences. EMBO J 9: 3353-3362.
57. Yoshioka, K., H. Honma, M. Zushi, S. Kondo, S. Togashi, T. Miyake, and T. Shiba. 1990. Virus-like particle formation of Drosophila copia through autocatalytic processing. EMBO J. 9: 535-541.
58. Zou, S., D.A. Wright, and D.F. Voytas. 1995. The Saccharomyces Ty5 retrotransposon family is associated with origins of DNA replication at the telomeres and the silent mating locus HMR. Proc. Natl. Acad. Sci. 92: 920-924.