Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness

Virology

Volumn 357, Issue 1, 2007, Pages 79-90

  Rahman, Shaila ^a   Lu, Richard ^a,b   Vandegraaff, Nick ^a,b   Cherepanov, Peter ^c   Engelman, Alan ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

AIDS; HIV 1; Integrase; Integration; LEDGF p75; Protein interaction

Indexed keywords

GLUTATHIONE TRANSFERASE; HISTIDINE; INTEGRASE; LENS EPITHELIUM DERIVED GROWTH FACTOR; PROTEIN P75;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEFECTIVE VIRUS; ENZYME ASSAY; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; VIRUS INFECTIVITY; WILD TYPE;

CELL LINE; HELA CELLS; HIV INFECTIONS; HIV INTEGRASE; HIV-1; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; JURKAT CELLS; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN BINDING; VIRUS INTEGRATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33751417052     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2006.08.011     Document Type: Article

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