메뉴 건너뛰기




Volumn 2, Issue 5, 2003, Pages 290-297

LEDGF/p75: A novel nuclear autoantigen at the crossroads of cell survival and apoptosis

Author keywords

Apoptosis; Atopic dermatitis; Autoantibodies; Cell survival; LEDGF p75

Indexed keywords

AUTOANTIGEN; CASPASE; LENS EPITHELIUM DERIVED GROWTH FACTOR; PROTEIN P75;

EID: 0042763088     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1568-9972(03)00063-6     Document Type: Review
Times cited : (68)

References (38)
  • 1
    • 0031863698 scopus 로고    scopus 로고
    • Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens
    • Utz P.J., Anderson P. Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens. Arthritis Rheum. 41:1998;1152-1160.
    • (1998) Arthritis Rheum , vol.41 , pp. 1152-1160
    • Utz, P.J.1    Anderson, P.2
  • 2
    • 0032917731 scopus 로고    scopus 로고
    • Autoantigens as substrates for apoptotic proteases: Implications for the pathogenesis of systemic autoimmune disease
    • Rosen A., Casciola-Rosen L. Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease. Cell Death Differ. 6:1999;6-12.
    • (1999) Cell Death Differ , vol.6 , pp. 6-12
    • Rosen, A.1    Casciola-Rosen, L.2
  • 3
    • 0028881847 scopus 로고
    • DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis
    • Casciola-Rosen L.A., Anhalt G., Rosen A. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J Exp Med. 182:1995;1625-1634.
    • (1995) J Exp Med , vol.182 , pp. 1625-1634
    • Casciola-Rosen, L.A.1    Anhalt, G.2    Rosen, A.3
  • 4
    • 0029789073 scopus 로고    scopus 로고
    • Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis
    • Casiano C.A., Martin S.J., Green D.R., Tan E.M. Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis. J Exp Med. 184:1996;765-770.
    • (1996) J Exp Med , vol.184 , pp. 765-770
    • Casiano, C.A.1    Martin, S.J.2    Green, D.R.3    Tan, E.M.4
  • 5
    • 0031819578 scopus 로고    scopus 로고
    • Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes
    • Casiano C.A., Ochs R.L., Tan E.M. Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes. Cell Death Differ. 5:1998;183-190.
    • (1998) Cell Death Differ , vol.5 , pp. 183-190
    • Casiano, C.A.1    Ochs, R.L.2    Tan, E.M.3
  • 6
    • 0033588955 scopus 로고    scopus 로고
    • Cleavage by granzyme B is strongly predictive of autoantigen status: Implications for initiation of autoimmunity
    • Casciola-Rosen L., Andrade F., Ulanet D., Wong W.B., Rosen A. Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J Exp Med. 190:1999;815-826.
    • (1999) J Exp Med , vol.190 , pp. 815-826
    • Casciola-Rosen, L.1    Andrade, F.2    Ulanet, D.3    Wong, W.B.4    Rosen, A.5
  • 7
    • 0035153242 scopus 로고    scopus 로고
    • Secondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens: Implications for autoimmunity
    • Wu X., Molinaro C., Johnson N., Casiano C.A. Secondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens: implications for autoimmunity. Arthritis Rheum. 44:2001;2642-2652.
    • (2001) Arthritis Rheum , vol.44 , pp. 2642-2652
    • Wu, X.1    Molinaro, C.2    Johnson, N.3    Casiano, C.A.4
  • 8
    • 84925548538 scopus 로고    scopus 로고
    • Fragmentation of Golgi complex and Golgi autoantigens during apoptosis and necrosis
    • Epub
    • Nozawa K., Casiano C.A., Hamel J.C., Molinaro C., Fritzler M.J., Chan E.K. Fragmentation of Golgi complex and Golgi autoantigens during apoptosis and necrosis. Arthritis Res. 4(4):(R3):2002;1-9. Epub.
    • (2002) Arthritis Res , vol.4 , Issue.4 R3 , pp. 1-9
    • Nozawa, K.1    Casiano, C.A.2    Hamel, J.C.3    Molinaro, C.4    Fritzler, M.J.5    Chan, E.K.6
  • 9
    • 0037100407 scopus 로고    scopus 로고
    • Prevention and induction of autoimmune exocrinopathy is dependent on pathogenic autoantigen cleavage in murine Sjogren's syndrome
    • Saegusa K., Ishimaru N., Yanagi K., et al. Prevention and induction of autoimmune exocrinopathy is dependent on pathogenic autoantigen cleavage in murine Sjogren's syndrome. J Immunol. 169:2002;1050-1057.
    • (2002) J Immunol , vol.169 , pp. 1050-1057
    • Saegusa, K.1    Ishimaru, N.2    Yanagi, K.3
  • 11
    • 0033916267 scopus 로고    scopus 로고
    • Autoantibodies to DFS70 kd/transcription coactivator p75 in atopic dermatitis and other conditions
    • Ochs R.L., Muro Y., Si Y., Ge H., Chan E.K., Tan E.M. Autoantibodies to DFS70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. J Allergy Clin Immunol. 105:2000;1211-1220.
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 1211-1220
    • Ochs, R.L.1    Muro, Y.2    Si, Y.3    Ge, H.4    Chan, E.K.5    Tan, E.M.6
  • 12
    • 0032538795 scopus 로고    scopus 로고
    • Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation
    • Ge H., Si Y., Roeder R.G. Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. EMBO J. 17:1998;6723-6729.
    • (1998) EMBO J , vol.17 , pp. 6723-6729
    • Ge, H.1    Si, Y.2    Roeder, R.G.3
  • 13
    • 0035123417 scopus 로고    scopus 로고
    • Autoantibodies in atopic dermatitis
    • Muro Y. Autoantibodies in atopic dermatitis. J Dermatol Sci. 25:2001;171-178.
    • (2001) J Dermatol Sci , vol.25 , pp. 171-178
    • Muro, Y.1
  • 14
    • 0036700503 scopus 로고    scopus 로고
    • Detection of cytotoxic anti-LEDGF autoantibodies in atopic dermatitis
    • Ayaki M., Ohogoro N., Azuma N., et al. Detection of cytotoxic anti-LEDGF autoantibodies in atopic dermatitis. Autoimmunity. 35:2002;319-327.
    • (2002) Autoimmunity , vol.35 , pp. 319-327
    • Ayaki, M.1    Ohogoro, N.2    Azuma, N.3
  • 15
    • 0035478339 scopus 로고    scopus 로고
    • Humoral immune response directed against LEDGF in patients with VKH
    • Yamada K., Senju S., Shinohara T., et al. Humoral immune response directed against LEDGF in patients with VKH. Immunol Lett. 78:2001;161-168.
    • (2001) Immunol Lett , vol.78 , pp. 161-168
    • Yamada, K.1    Senju, S.2    Shinohara, T.3
  • 16
    • 0035987224 scopus 로고    scopus 로고
    • LEDGF, a survival factor, activates stress-related genes
    • Shinohara T., Singh D.P., Fatma N. LEDGF, a survival factor, activates stress-related genes. Prog Retin Eye Res. 21:2002;341-358.
    • (2002) Prog Retin Eye Res , vol.21 , pp. 341-358
    • Shinohara, T.1    Singh, D.P.2    Fatma, N.3
  • 18
    • 0035153766 scopus 로고    scopus 로고
    • Cellular and immunologic mechanisms in atopic dermatitis
    • Leung D.Y., Soter N.A. Cellular and immunologic mechanisms in atopic dermatitis. J Am Acad Dermatol. 44:2001;S1-S12.
    • (2001) J Am Acad Dermatol , vol.44 , pp. 1-S12
    • Leung, D.Y.1    Soter, N.A.2
  • 19
    • 0034029426 scopus 로고    scopus 로고
    • Autoallergy: A pathogenetic factor in atopic dermatitis?
    • Valenta R., Seiberler S., Natter S., et al. Autoallergy: a pathogenetic factor in atopic dermatitis? J Allergy Clin Immunol. 105:2000;432-437.
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 432-437
    • Valenta, R.1    Seiberler, S.2    Natter, S.3
  • 21
    • 0033967955 scopus 로고    scopus 로고
    • Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing
    • Singh D.P., Kimura A., Chylack L.T. Jr., Shinohara T. Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing. Gene. 242:2000;265-273.
    • (2000) Gene , vol.242 , pp. 265-273
    • Singh, D.P.1    Kimura, A.2    Chylack L.T., Jr.3    Shinohara, T.4
  • 22
    • 0034917865 scopus 로고    scopus 로고
    • Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus
    • Nishizawa Y., Usukura J., Singh D.P., Chylack L.T. Jr., Shinohara T. Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus. Cell Tissue Res. 305:2001;107-114.
    • (2001) Cell Tissue Res , vol.305 , pp. 107-114
    • Nishizawa, Y.1    Usukura, J.2    Singh, D.P.3    Chylack L.T., Jr.4    Shinohara, T.5
  • 23
    • 0034614581 scopus 로고    scopus 로고
    • Lens epithelium-derived growth factor: Effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts
    • Singh D.P., Ohguro N., Kikuchi T., et al. Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts. Biochem Biophys Res Commun. 267:2000;373-381.
    • (2000) Biochem Biophys Res Commun , vol.267 , pp. 373-381
    • Singh, D.P.1    Ohguro, N.2    Kikuchi, T.3
  • 24
    • 0036714175 scopus 로고    scopus 로고
    • The family of hepatoma-derived growth factor proteins: Characterization of a new member HRP-4 and classification of its subfamilies
    • Dietz F., Franken S., Yoshida K., Nakamura H., Kappler J., Gieselmann V. The family of hepatoma-derived growth factor proteins: characterization of a new member HRP-4 and classification of its subfamilies. Biochem J. 366:2002;491-500.
    • (2002) Biochem J , vol.366 , pp. 491-500
    • Dietz, F.1    Franken, S.2    Yoshida, K.3    Nakamura, H.4    Kappler, J.5    Gieselmann, V.6
  • 25
    • 0034603990 scopus 로고    scopus 로고
    • The PWWP domain: A potential protein-protein interaction domain in nuclear proteins influencing differentiation?
    • Stec I., Nagl S.B., van Ommen G.J., den Dunnen J.T. The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? FEBS Lett. 473:2000;1-5.
    • (2000) FEBS Lett , vol.473 , pp. 1-5
    • Stec, I.1    Nagl, S.B.2    Van Ommen, G.J.3    Den Dunnen, J.T.4
  • 26
    • 0036176982 scopus 로고    scopus 로고
    • The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds
    • Qiu C., Sawada K., Zhang X., Cheng X. The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nat Struct Biol. 9:2002;217-224.
    • (2002) Nat Struct Biol , vol.9 , pp. 217-224
    • Qiu, C.1    Sawada, K.2    Zhang, X.3    Cheng, X.4
  • 27
    • 0032976273 scopus 로고    scopus 로고
    • Lens epithelium-derived growth factor: Increased resistance to thermal and oxidative stresses
    • Singh D.P., Ohguro N., Chylack L.T. Jr., Shinohara T. Lens epithelium-derived growth factor: increased resistance to thermal and oxidative stresses. Invest Ophthalmol Vis Sci. 40:1999;1444-1451.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 1444-1451
    • Singh, D.P.1    Ohguro, N.2    Chylack L.T., Jr.3    Shinohara, T.4
  • 28
    • 0033854216 scopus 로고    scopus 로고
    • Heparin's roles in stabilizing, potentiating, and transporting LEDGF into the nucleus
    • Fatma N., Singh D.P., Shinohara T., Chylack L.T. Jr. Heparin's roles in stabilizing, potentiating, and transporting LEDGF into the nucleus. Invest Ophthalmol Vis Sci. 41:2000;2648-2657.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 2648-2657
    • Fatma, N.1    Singh, D.P.2    Shinohara, T.3    Chylack L.T., Jr.4
  • 29
    • 0032768257 scopus 로고    scopus 로고
    • Antibodies to lens epithelium-derived growth factor (LEDGF) kill epithelial cells of whole lenses in organ culture
    • Ayaki M., Sueno T., Singh D.P., Chylack L.T. Jr., Shinohara T. Antibodies to lens epithelium-derived growth factor (LEDGF) kill epithelial cells of whole lenses in organ culture. Exp Eye Res. 69:1999;139-142.
    • (1999) Exp Eye Res , vol.69 , pp. 139-142
    • Ayaki, M.1    Sueno, T.2    Singh, D.P.3    Chylack L.T., Jr.4    Shinohara, T.5
  • 30
    • 0041950160 scopus 로고    scopus 로고
    • Apoptotic cleavage of the LEDGF/p75 autoantigen: Mechanism, impact on function, and possible role in the induction of autoantibodies
    • K. Conrad, M. Fritzler, M. Meurer, U. Sack, & Y. Shoenfeld. Germany: PABST Science Publishers
    • Ganapathy V., Wu X., Brown T., Daniels T., Casiano C.A. Apoptotic cleavage of the LEDGF/p75 autoantigen: mechanism, impact on function, and possible role in the induction of autoantibodies. Conrad K., Fritzler M., Meurer M., Sack U., Shoenfeld Y. Autoimmunity, autoantigens, autoantibodies, vol. 3. 2002;220-246 PABST Science Publishers, Germany.
    • (2002) Autoimmunity, Autoantigens, Autoantibodies, Vol. 3 , pp. 220-246
    • Ganapathy, V.1    Wu, X.2    Brown, T.3    Daniels, T.4    Casiano, C.A.5
  • 32
    • 0034761304 scopus 로고    scopus 로고
    • Lens epithelium-derived growth factor: Increased survival and decreased DNA breakage of human RPE cells induced by oxidative stress
    • Matsui H., Lin L.R., Singh D.P., Shinohara T., Reddy V.N. Lens epithelium-derived growth factor: increased survival and decreased DNA breakage of human RPE cells induced by oxidative stress. Invest Ophthalmol Vis Sci. 42:2001;2935-2941.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 2935-2941
    • Matsui, H.1    Lin, L.R.2    Singh, D.P.3    Shinohara, T.4    Reddy, V.N.5
  • 33
    • 0035068821 scopus 로고    scopus 로고
    • Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats
    • Machida S., Chaudhry P., Shinohara T., et al. Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats. Invest Ophthalmol Vis Sci. 42:2001;1087-1095.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1087-1095
    • Machida, S.1    Chaudhry, P.2    Shinohara, T.3
  • 34
    • 0034811440 scopus 로고    scopus 로고
    • LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes
    • Singh D.P., Fatma N., Kimura A., Chylack L.T. Jr., Shinohara T. LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes. Biochem Biophys Res Commun. 283:2001;943-955.
    • (2001) Biochem Biophys Res Commun , vol.283 , pp. 943-955
    • Singh, D.P.1    Fatma, N.2    Kimura, A.3    Chylack L.T., Jr.4    Shinohara, T.5
  • 35
    • 0035966103 scopus 로고    scopus 로고
    • Transcriptional regulation of the AOP2 gene, a thiol-specific antioxidant, by LEDGF to protect cells from oxidative stress
    • Fatma N., Singh D.P., Shinohara T., Chylack L.T. Jr. Transcriptional regulation of the AOP2 gene, a thiol-specific antioxidant, by LEDGF to protect cells from oxidative stress. J Bio Chem. 276:2001;48899-48907.
    • (2001) J Bio Chem , vol.276 , pp. 48899-48907
    • Fatma, N.1    Singh, D.P.2    Shinohara, T.3    Chylack L.T., Jr.4
  • 36
    • 0036071810 scopus 로고    scopus 로고
    • Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived growth factor (LEDGF)
    • Kubo E., Fatma N., Sharma P., et al. Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived growth factor (LEDGF). J Mol Biol. 320:2002;1053-1063.
    • (2002) J Mol Biol , vol.320 , pp. 1053-1063
    • Kubo, E.1    Fatma, N.2    Sharma, P.3
  • 37
    • 0033676752 scopus 로고    scopus 로고
    • T(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor
    • Ahuja H.G., Hong J., Aplan P.D., Tcheurekdjian L., Forman S.J., Slovak M.L. t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor. Cancer Res. 60:2000;6227-6229.
    • (2000) Cancer Res , vol.60 , pp. 6227-6229
    • Ahuja, H.G.1    Hong, J.2    Aplan, P.D.3    Tcheurekdjian, L.4    Forman, S.J.5    Slovak, M.L.6
  • 38
    • 0036715347 scopus 로고    scopus 로고
    • Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: Implications for autoimmunity in atopic disorders
    • Wu X., Daniels T., Molinaro C., Lilly M.B., Casiano C.A. Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders. Cell Death Differ. 9:2002;915-925.
    • (2002) Cell Death Differ , vol.9 , pp. 915-925
    • Wu, X.1    Daniels, T.2    Molinaro, C.3    Lilly, M.B.4    Casiano, C.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.