Intracellular transport of human immunodeficiency virus type 1 integrase

Journal of Cell Science

Volumn 116, Issue 21, 2003, Pages 4401-4408

  Devroe, Eric ^a,b   Engelman, Alan ^a,b   Silver, Pamela A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

HIV 1; Integrase; Nuclear transport; Preintegration complex

Indexed keywords

DNA; HYBRID PROTEIN; INTEGRASE; PROTEASOME;

ARTICLE; BIOACCUMULATION; CELL NUCLEUS; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VIVO STUDY; INTRACELLULAR TRANSPORT; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN TRANSPORT;

CELL NUCLEUS; CHROMOSOMES; CLONING, MOLECULAR; CYTOPLASM; HELA CELLS; HIV INFECTIONS; HIV INTEGRASE; HIV-1; HUMANS; MICROSCOPY, FLUORESCENCE; MUTATION; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PORE; PROTEIN TRANSPORT;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0242550989     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00747     Document Type: Article

References (33)

1. Bouyac-Bertoia, M., Dvorin, J. D., Fouchier, R. A., Jenkins, Y., Meyer, B. E., Wu, L. I., Emerman, M. and Malim, M. H. (2001). HIV-1 infection requires a functional integrase NLS. Mol. Cell. 7, 1025-1035.
2. Cherepanov, P., Pluymers, W., Claeys, A., Proost, P., de Clercq, E. and Debyser, Z. (2000). High-level expression of active HIV-1 integrase from a synthetic gene in human cells. FASEB J. 14, 1389-1399.
3. Cherepanov, P., Maertens, G., Proost, P., Devreese, B., van Beeumen, J., Engelborghs, Y., de Clercq, E. and Debyser, Z. (2003). HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. J. Biol. Chem. 278, 372-381.
4. Depienne, C., Mousnier, A., Leh, H., le Rouzic, E., Dormont, D., Benichou, S. and Dargemont, C. (2001). Characterization of the nuclear import pathway for HIV-1 integrase. J. Biol. Chem. 276, 18102-18107.
5. Devroe, E. and Silver, P. A. (2002). Retrovirus-delivered siRNA. BMC Biotechnol. 2, 15.
6. Dvorin, J. D., Bell, P., Maul, G. G., Yamashita, M., Emerman, M. and Malim, M. H. (2002). Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import. J. Virol. 76, 12087-12096.
7. Engelman, A., Hickman, A. B. and Craigie, R. (1994). The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding. J. Virol. 68, 5911-5917.
8. Engelman, A., Liu, Y., Chen, H., Farzan, M. and Dyda, E. (1997). Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase. J. Virol. 71, 3507-3514.
9. Fouchier, R. A. and Malim, M. H. (1999). Nuclear import of human immunodeficiency virus type-1 preintegration complexes. Adv. Virus. Res. 52, 275-299.
10. Gallay, P., Hope, T., Chin, D. and Trono, D. (1997). HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherine pathway. Proc. Natl. Acad. Sci. USA 94, 9825-9830.
11. Gao, K., Butler, S. L. and Bushman, E. (2001). Human immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes. EMBO J. 20, 3565-3576.
12. Heuer, T. S. and Brown, P. O. (1997). Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking. Biochemistry 36, 10655-10665.
13. Jenkins, T. M., Esposito, D., Engelman, A. and Craigie, R. (1997). Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking. EMBO J. 16, 6849-6859.
14. Katzman, M. and Sudol, M. (1995). Mapping domains of retroviral integrase responsible for viral DNA specificity and target site selection by analysis of chimeras between human immunodeficiency virus type 1 and visna virus integrases. J. Virol. 69, 5687-5696.
15. Kukolj, G., Jones, K. S. and Skalka, M. (1997). Subcellular localization of avian sarcoma virus and human immunodeficiency virus type 1 integrases. J. Virol. 71, 843-847.
16. Lightfoote, M. M., Coligan, J. E., Folks, T. M., Fauci, A. S., Martin, M. A. and Venkatesan, S. (1986). Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus. J. Virol. 60, 771-775.
17. Limón, A., Devroe, E., Lu, R., Ghory, H. Z., Silver, P. A. and Engelman, A. (2002). Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import. J. Virol. 76, 10598-10607.
18. Lutzke, R. A. and Plasterk, R. H. (1998). Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: critical residues for protein oligomerization and DNA binding. J. Virol. 72, 4841-4848.
19. Lutzke, R. A., Vink, C. and Plasterk, R. H. (1994). Characterization of the minimal DNA-binding domain of the HIV integrase protein. Nucleic Acids Res. 22, 4125-4131.
20. Maertens, G., Cherepanov, P., Pluymers, W., Busschots, K., de Clercq, E., Debyser, Z. and Engelborghs, Y. (2003). LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J. Biol Chem. 278, 33528-33539.
21. Mattaj, I. W. and Englmeier, L. (1998). Nucleocytoplasmic transport: the soluble phase. Annu. Rev. Biochem. 67, 265-306.
22. Mulder, L. C. F. and Muesing, M. A. (2000). Degradation of HIV-1 integrase by the N-end rule pathway. J. Biol. Chem. 275, 29749-29753.
23. Petit, C., Schwartz, O. and Mammano, F. (1999). Oligomerization within virions and subcellular localization of human immunodeficiency virus type 1 integrase. J. Virol. 73, 5079-5088.
24. Petit, C., Schwartz, O. and Mammano, E. (2000). The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA. J. Virol. 74, 7119-7126.
25. Pluymers, W., Cherepanov, P., Schols, D., de Clercq, E. and Debyser, Z. (1999). Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein. Virology. 258, 327-332.
26. Sherman, M. P., de Noronha, C. M., Heusch, M. I., Greene, S. and Greene, W. C. (2001). Nucleocytoplasmic shuttling by human immunodeficiency virus type 1 Vpr. J. Virol. 75, 1522-1532.
27. Shibagaki, Y. and Chow, S. A. (1997). Central core domain of retroviral integrase is responsible for target site selection. J. Biol. Chem. 272, 8361-8369.
28. Tsurutani, N., Kubo, M., Maeda, Y., Ohashi, T., Yamamoto, N., Kannagi, M. and Masuda, T. (2000). Identification of critical amino acid residues in human immunodeficiency virus type 1 IN required for efficient proviral DNA formation at steps prior to integration in dividing and nondividing cells. J. Virol. 74, 4795-4806.
29. Varshavsky, A. (1996). The N-end rule: functions, mysteries, uses. Proc. Natl. Acad. Sci. USA 93, 12142-12149.
30. Vink, C., Oude Groeneger, A. M. and Plasterk, R. H. (1993). Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein. Nucleic Acids Res. 21, 1419-1425.
31. Wen, W., Meinkoth, J. L., Tsien, R. Y. and Taylor, S. S. (1995). Identification of a signal for rapid export of proteins from the nucleus. Cell 82, 463-473.
32. Wiskerchen, M. and Muesing, M. A. (1995). Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells. J. Virol. 69, 376-386.
33. Woerner, A. M. and Marcus-Sekura, C. J. (1993). Characterization of a DNA binding domain in the C-terminus of HIV-1 integrase by deletion mutagenesis. Nucleic Acids Res. 21, 3507-3511.