A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2

Molecular Cell

Volumn 2, Issue 6, 1998, Pages 751-759

  Ge, Hui ^a   Si, Yuanzheng ^a   Wolffe, Alan P ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR PROTEIN; PSIP1 PROTEIN, HUMAN; RNA PRECURSOR; SFRS1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1;

ARTICLE; CELL FREE SYSTEM; CONFOCAL MICROSCOPY; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; HELA CELL; HUMAN; METABOLISM; RNA SPLICING; TRANSACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL-FREE SYSTEM; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; NUCLEAR PROTEINS; RNA PRECURSORS; RNA SPLICING; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0032239750     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80290-7     Document Type: Article

References (80)

1. Amrein, H., Medley, M.L., and Maniatis, T. (1994). The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by transformer 2. Cell 76, 735-746.
2. Bauren, G., and Wieslander, L. (1994). Splicing of Balbiani Ring 1 gene pre-mRNA occurs simultaneously with transcription. Cell 76, 183-192.
3. Beyer, A.L., and Osheim, Y.N. (1988). Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. Genes Dev. 2, 754-765.
4. Bjorklund, S., and Kim, Y-J. (1996). Mediator of transcriptional regulation. Trends Biochem. Sci. 21, 335-337.
5. Buratowski, S., Hahn, S., Guarente, L., and Sharp, P.A. (1989). Five Intermediate complexes in transcription initiation by RNA polymerase II. Cell 56, 549-561.
6. Chabot, B., Bisotto, S., and Vincent, M. (1995). The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the U4/U6. US tri-snRNP particle. Nucleic Acids Res. 23, 3206-3213.
7. Chiang, C-M., Ge, H., Wang, Z., Hoffmann, A., and Roeder, R.G. (1993). Unique TATA-binding protein-containing complexes and co-factors involved in transcription by RNA polymerase II and III. EM BO J. 12, 2749-2762.
8. Corden, J.L. (1990). Tails of RNA polymerase II. Trends Biochem. Sci. 15, 383-387.
9. Corden, J.L., Cadena, D.L., Ahearn, J., and Dahmus, M.E. (1985). A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II. Proc. Natl. Acad. Sci. USA 82, 7934-7938.
10. Crispino, J.D., Blencowe, B.J., and Sharp, P.A. (1994). Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP. Science 265, 1866-1869.
11. Dahmus, M.E. (1996). Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem. 271, 19009-19012.
12. Du, L., and Warren, S.L. (1997). A functional interaction between the carboxy-terminal domain of RNA polymerase II and pre-mRNA splicing. J. Cell Biol. 136, 5-18.
13. Eperon, I.C., Ireland, D.C., Smith, R.A., Mayeda, A., and Krainer, A.R. (1993). Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF. EMBO J. 12, 3607-3617.
14. Fakan, S., Leser, G., and Martin, T.E. (1986). Immunoelectron microscope visualization of nuclear ribonucleoprotein antigens within spread transcription complexes. J. Cell Biol. 103, 1153-1157.
15. Flores, O., Lu, H., Killeen, M., Greenblatt, J., Burton, Z.F., and Reinberg, D. (1991). The small subunit of transcription factor TFIIF recruits RNA polymerase II into the preinitiation complex. Proc. Natl. Acad. Sci. USA 88, 9999-10003.
16. Forget, D., Robert, F., Grondin, G., Burton, Z.F., Greenblatt, J., and Coulombe, B. (1997). RAP74 induces promoter contacts by RNA polymerase II upstream and downstream of a DNA bend centered on the TATA box. Proc. Natl. Acad. Sci. USA 94, 7150-7155.
17. Fu, X.D. (1993). Specific commitment of different pre-mRNAs to splicing by single SR proteins. Nature 365, 82-85.
18. Fu, X.D. (1995). The superfamily of arginine/serine-rich splicing factors. RNA 1, 663-680.
19. Fu, X.D., Mayeda, A., Maniatis, T., and Krainer, A.R. (1992). General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5′ and 3′ splicing site selection. Proc. Natl. Acad. Sci. USA 89, 1725-1729.
20. Gallego, M.E., Gattoni, R., Stevenin, J., Marie, J., and Expert-Bezancon, A. (1997). The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the β-tropomyosin alternative exon 6A. EMBO J. 16, 1772-1782.
21. Ge, H., and Manley, J.L. (1990). A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro. Cell 62, 25-34.
22. Ge, H., and Roeder, R.G. (1994). Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell 78, 513-523.
23. Ge, H., Zuo, P., and Manley, J.L. (1991). Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. Cell 66, 373-382.
24. Ge, H., Martinez, E., Chiang, C.M., and Roeder, R.G. (1996). Activator-dependent transcription by mammalian RNA polymerase II: in vitro reconstitution with general transcription factors and cofactors. Methods Enzymol. 274, 57-71.
25. Ge, H., Si, Y-Z., and Roeder, R.G. (1998). Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. EMBO J. 17, 6723-6729.
26. Greenleaf, A.L. (1993). Positive patches and negative noodles: linking RNA processing to transcription. Trends Biochem. Sci. 18, 117-119.
27. Hanamura, A., Caceres, J.F., Mayeda, A., Franza, B.R., and Krainer, A.R. (1998). Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA 4, 430-444.
28. Heinrichs, V., and Baker, B.S. (1995). The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO J. 14, 3987-4000.
29. Horowitz, D.S., and Krainer, A.R. (1994). Mechanisms for selecting 5β splice sites in mammalian pre-mRNA splicing. Trends Genet. Sci. 10, 100-106.
30. Huang, S., and Spector, D.L. (1991). Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors. Genes Dev. 5, 2288-2302.
31. Huang, S., and Spector, D.L. (1996). Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription. J. Cell Biol. 133, 719-732.
32. Jackson, S.P., and Tjian, R. (1989). Purification and analysis of RNA polymerase II transcription factors by using wheat germ agglutinin affinity chromatography. Proc. Natl. Acad. Sci. USA 86, 1781-1785.
33. Jimenez-Garcia, L.F., and Spector, D.L. (1993). in vivo evidence that transcription and splicing are coordinated by a recruiting mechanism. Cell 73, 47-59.
34. Kadonaga, J.T., Carner, K.R., Masiarz, F.R., and Tjian, R. (1987). Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 51, 1079-1090.
35. Kaiser, K., and Meisterernst, M. (1996). The human general co-factors. Trends Biochem. Sci. 21, 342-345.
36. Kim, E., Du, L., Bregman, D.B., and Warren, S.L. (1997). Splicing factors associate with hyperphosphorylated RNA polymerase II in the absence of pre-mRNA. J. Cell. Biol. 136, 19-28.
37. Kim, Y.J., Zuo, P., Manley, J.L., and Baker, B.S. (1992). The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2. Genes Dev. 6, 2569-2579.
38. Kohtz, J.D., Jamison, S.F., Will, C.L., Zuo, P., Luhrmann, R., Garcia-Blanco, M.A., and Manley, J.L. (1994). Protein-protein interactions and 5′-splice site recognition in mammalian mRNA precursors. Nature 368, 119-124.
39. Koleske, A.J., and Young, R.A. (1994). An RNA polymerase II holoenzyme responsive to activators. Nature 368, 466-469.
40. Krainer, A.R., Conway, G.C., and Kozak, D. (1990). Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. Genes Dev. 4, 1158-1171.
41. Krainer, A.R., Mayeda, A., Kozak, D., and Binns, G. (1991). Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K and Drosophila splicing regulators. Cell 66, 383-394.
42. Lavigueur, A., Branche, H.La., Kornblihtt, A.R., and Chabot, B. (1993). A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes Dev. 7, 2405-2417.
43. Lee, K.A., Bindereif, A., and Green, M.R. (1988). A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing. Genet. Anal. Tech. 5, 22-31.
44. Madhani, H.D., and Guthrie, C. (1994). Dynamic RNA-RNA interactions in the spliceosome. Annu. Rev. Genet. 28, 1-26.
45. Maniatis, T. (1991). Mechanisms of alternative splicing. Science 251, 33-34.
46. Manley, J.L., and Tacke, R. (1996). SR proteins and splicing control. Genes Dev. 10, 1569-1579.
47. Mattaj, I.W. (1994). Splicing in space. Nature 372, 727-728.
48. Mayeda, A., Helfman, D.M., and Krainer, A.R. (1993). Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleo-protein A1 and pre-mRNA splicing factor SF2/ASF. Mol. Cell. Biol. 13, 2993-3001.
49. McCracken, S., Fong, N., Yankulov, K., Ballantyne, S., Pan, G.H., Greenblatt, J., Patterson, S.D., Wickens, M., and Bentley, D.L. (1997). The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature 385, 357-361.
50. Meisterernst, M., Roy, A.L., Lieu, H-M., and Roeder, R.G. (1991). Activation of class II gene transcription by regulatory factors is potentiated by a novel activity. Cell 66, 981-993.
51. Mermound, J.E., Cohen, P., and Lamond, A.I. (1994). Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism. EMBO J. 13, 5679-5688.
52. Moore, M. J., Query, C.C., and Sharp, P.A. (1993). Splicing of precursors to messenger RNAs by the spliceosome. In the RNA World, R.F. Gesteland and J.F. Atkins, eds. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press), pp. 303-358.
53. Mortillaro, M.J., Blencowe, B.J., Wei, X.Y., Nakayasu, H., Du, L., Warren, S.L., Sharp, P.A., and Berezney, R. (1996). A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix. Proc. Natl. Acad. Sci. USA 93, 8253-8257.
54. Neugebauer, K.M., and Roth, M.B. (1997). Transcription units as RNA processing units. Genes Dev. 11, 3279-3285.
55. Orphanides, G., Lagrange, T., and Reinberg, D. (1996). The general transcription factors of RNA polymerase II. Genes Dev. 10, 2657-2683.
56. Ptashne, M., and Gann, A. (1997). Transcriptional activation by recruitment. Nature 386, 569-577.
57. Reines, D., Conaway, J.W., and Conaway, R.C. (1996). The RNA polymerase II general elongation factors. Trends Biochem. Sci. 21, 351-355.
58. Roeder, R.G. (1996). The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem. Sci. 21, 327-337.
59. Sass, H., and Pederson, T. (1984). Transcription-dependent localization of U1 and U2 small nuclear ribonucleoprotein at major sites of gene activity in polytene chromosomes. J. Mol. Biol. 180, 911-926.
60. Sharp, P.A. (1994). Split genes and RNA splicing. Cell 77, 805-815.
61. Steinmetz, E.J. (1997). Pre-mRNA processing and the CTD of RNA polymerase II: the tail that wags the dog? Cell 89, 491-494.
62. Steitz, J.A., Black, D.L., Gerke, V., Parker, K., Kramer, A., Frendeway, D., and Keller, W. (1988). Functions of the abundant U-snRNPs. In Structure and Function of Major and Minor Small Nuclear Ribo-nucleoprotein Particles. M. Birnsteil, ed. (New York: Springer), pp. 115-154.
63. Tacke, R., and Manley, J.L. (1995). The human splicing factor ASF/ SF2 and SC35 possess distinct functionally significant RNA binding specificities. EMBO J. 14, 3540-3551.
64. Tan, S., Conaway, R.C., and Conaway, J.W. (1995). Dissection of transcription factor TFIIF functional domains required for initiation and elongation. Proc. Natl. Acad. Sci. USA 92, 6042-6046.
65. Tarn, W.Y., and Steitz, J.A. (1994). SR proteins can compensate for the loss of U1 snRNP functions in vitro. Genes Dev. 8, 2704-2717.
66. Tian, M., and Maniatis, T. (1993). A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell 74, 105-114.
67. Valcarcel, J., and Green, M .R. (1996). The SR protein family: pleiotropic functions in pre-mRNA splicing. Trends Biochem. Sci. 21, 296-301.
68. Verrijzer, C.P., and Tjian, R. (1996). TAFs mediate transcriptional activation and promoter selectivity. Trends Biochem. Sci. 21, 338-342.
69. Wang, Z., Huffman, H.M., and Grabowski, P.J. (1995). Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity. RNA 1, 21-35.
70. Wu, J.Y., and Maniatis, T. (1993). Specific interactions between proteins implicated in splicing site selection and regulated alternative splicing. Cell 75, 1061-1070.
71. Xiao, S-H., and Manley, J.L. (1997). Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev. 11, 34-344.
72. Xing, Y., Johnson, C.V., Dobner, P.R., and Lawrence, J.B. (1993). Higher level organization of individual gene transcription and RNA splicing. Science 259, 1326-1330.
73. Yuryev, A., Patturajan, M., Litingtung, Y., Joshi, R.V., Gentile, C., Gebara, M., and Corden, J.L. (1996). The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins. Proc. Natl. Acad. Sci. USA 93, 6975-6980.
74. Zahler, A.M., Lane, W.S., Lane, W.S., and Roth, M.B. (1992). SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev. 6, 837-847.
75. Zahler, A.M., Neugenbauer, K.M., Stolk, J.A., and Roth, M.B. (1993). Distinct functions of SR proteins in alternative pre-mRNA splicing. Science 260, 219-222.
76. Zamore, P.D., Patton, J.G., and Green, M.R. (1992). Cloning and domain structure of the mammalian splicing factor U2AF. Nature 355, 609-614.
77. Zeng, C., Kim, E., Warren, S.L., and Berget, S.M. (1997). Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity. EMBO J. 16, 1401-1412.
78. Zhang, G.H., Taneja, K.L., Singer, R.H., and Green, M.R. (1994). Localization of pre-mRNA splicing in mammalian nuclei. Nature 372, 809-812.
79. Zhuang, Y., and Weiner, A.M. (1986). A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation. Cell 46, 827-835.
80. Zuo, P., and Manley, J.L. (1994). The human splicing factor ASF/ SF2 can specifically recognize pre-mRNA 5′ splice sites. Proc. Natl. Acad. Sci. USA 91, 3363-3367.