Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (LEDGF/p75) and p52, in the nucleus

Cell and Tissue Research

Volumn 305, Issue 1, 2001, Pages 107-114

  Nishizawa, Yuji ^a   Usukura, Jiro ^a   Singh, Dhirendra P ^b,c   Chylack, Leo T ^b,c   Shinohara, Toshimichi ^b,c  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cell culture; Cell cycle; LEDGF p75; Nuclear compartmentalization; p52; Transcription factors

Indexed keywords

LENS EPITHELIUM DERIVED GROWTH FACTOR; PROTEIN P52; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL CYCLE; CELL NUCLEUS; FLUORESCENCE MICROSCOPE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; REGULATORY MECHANISM;

ALTERNATIVE SPLICING; ANIMALS; ANTIBODIES; CELL COMPARTMENTATION; CELL NUCLEUS; CHO CELLS; CHROMATIDS; CRICETINAE; G1 PHASE; G2 PHASE; GREEN FLUORESCENT PROTEINS; GROWTH SUBSTANCES; IMMUNOHISTOCHEMISTRY; INDICATORS AND REAGENTS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; LUMINESCENT PROTEINS; MITOSIS; PROTEIN BINDING; RATS; RNA PRECURSORS;

ANIMALIA;

EID: 0034917865     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410100398     Document Type: Article

References (23)

1. Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains
2. Discrete nuclear domains of poly (A) RNA and their relationship to the functional organization of the nucleus
3. Synthesis, processing, and transport of RNA within the three-dimensional context of the cell nucleus
4. Heparin's roles in stabilizing, protecting, and transporting LEDGF into the nucleus
5. Differential interaction of splicing snRNAs with coiled bodies and inter-chromatin granules during mitosis and assembly of daughter cell nuclei
6. Spatial organization of large-scale chromatin domain in the nucleus: A magnified view of single chromosome territories
7. Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternative regulatory mechanism of transcriptional activation
8. A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2
9. Nuclear distribution of transcription factors in relation to sites of transcription and RNA polymerase II
10. Active RNA polymerases are localized within discrete transcription "factors" in human nuclei
11. Chromatin structure and nuclear remodeling
12. The cdk7-cyclin H-MAT1 complex associated with TFIIH is localized in coiled bodies
13. Structure and function in the nucleus
14. The cellular organization of gene expression
15. RNA polymerase targets pre-mRNA splicing factors to transcription sites in vivo
16. The dynamics of a pre-mRNA splicing factor in living cells
17. LEDGF: Survival of embryonic chick retinal photoreceptor cells
18. Lens epithelium-derived growth factor: Increased resistance to thermal and oxidative stresses
19. Lens epithelium-derived growth factor: Effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts
20. LEDGF: Activation of transcription of many stress related genes
21. Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing
22. SR proteins: A conserved family of the pre-mRNA splicing factors
23. Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity