Mechanism of action of key enzymes associated with cancer propagation and their inhibition by various chemotherapeutic agents

Mini-Reviews in Medicinal Chemistry

Volumn 8, Issue 4, 2008, Pages 388-398

  Singh, Palwinder ^a   Bhardwaj, Atul ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

Author keywords

Active site residues; Cancer; Cell multiplication; Enzymes; Inhibitors; Mechanism of action; Multiple target ligands

Indexed keywords

1 NAPHTHOL DERIVATIVE; 4 [5 (4 BROMOPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; ALOIN; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DAUNORUBICIN; DEFEROXAMINE; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ENZYME INHIBITOR; FLUOROURACIL; GYRASE INHIBITOR; IDARUBICIN; IRON CHELATING AGENT; LACTATE DEHYDROGENASE; MITOXANTRONE; RAZOXANE; RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDE REDUCTASE INHIBITOR; ROFECOXIB; THYMIDINE PHOSPHORYLASE; THYMIDINE PHOSPHORYLASE INHIBITOR; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UNINDEXED DRUG; URACIL DERIVATIVE;

ANTIANGIOGENIC ACTIVITY; ARACHIDONIC ACID METABOLISM; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; DNA REPLICATION; DRUG DNA BINDING; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; REVIEW; TUMOR VASCULARIZATION;

ANTINEOPLASTIC AGENTS; DNA TOPOISOMERASES, TYPE II; HUMANS; L-LACTATE DEHYDROGENASE; LIGANDS; NEOPLASMS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RIBONUCLEOTIDE REDUCTASES; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE;

EID: 42949151976     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955708783955962     Document Type: Review

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