Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors

Journal of Biological Chemistry

Volumn 276, Issue 17, 2001, Pages 14170-14177

  Phan, Jason ^a   Steadman, David J ^a   Koli, Sangita ^a   Ding, Weirong C ^a   Minor, Wladek ^b   Dunlap, R Bruce ^a   Berger, Sondra H ^a   Lebioda, Lukasz ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; CHEMOTHERAPY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG PRODUCTS; FLUORESCENCE; RNA; TUMORS;

FEEDBACK REGULATORY MECHANISM;

ENZYMES;

2' DEOXYTHYMIDINE 5' MONOPHOSPHATE; DEOXYURIDINE PHOSPHATE; MESSENGER RNA; METHYLENETETRAHYDROFOLIC ACID; RALTITREXED; RNA; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; 2'-DEOXYURIDYLIC ACID; BACTERIAL PROTEIN; CYSTEINE; DNA; LIGAND;

ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CATALYSIS; COLORECTAL CANCER; CRYSTAL STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME STRUCTURE; FLUORESCENCE; GENE EXPRESSION; HUMAN; PRIORITY JOURNAL; RNA BINDING; STEADY STATE; X RAY DIFFRACTION; AMINO ACID SEQUENCE; BINDING COMPETITION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COLORECTAL TUMOR; DRUG RESISTANCE; ENZYME ACTIVATION; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; SEQUENCE HOMOLOGY; SPECTROFLUOROMETRY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS);

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; BINDING, COMPETITIVE; COLORECTAL NEOPLASMS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DEOXYURACIL NUCLEOTIDES; DNA; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS; THYMIDYLATE SYNTHASE;

EID: 0035957952     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009493200     Document Type: Article

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