Synthesis and antitumor evaluation of 2,5-disubstituted-indazolo [4,3- gh]isoquinolin-6(2H)-ones (9-aza-anthrapyrazoles)

Journal of Medicinal Chemistry

Volumn 41, Issue 27, 1998, Pages 5429-5444

  Paul Krapcho, A ^a   Menta, Ernesto ^b   Oliva, Ambrogio ^b   Di Domenico, Roberto ^b   Fiocchi, Luigi ^b   Maresch, Martin E ^a   Gallagher, Cynthia E ^a   Hacker, Miles P ^a   Beggiolin, Gino ^b   Giuliani, Fernando C ^b   Pezzoni, Gabriella ^b   Spinelli, Silvano ^b  

^a UNIVERSITY OF VERMONT   (United States)

^b Boehringer Mannheim Italia   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; INDAZOLO[4,3 GH]ISOQUINOLIN 6(2H) ONE; ISOQUINOLINE DERIVATIVE; LOSOXANTRONE; MITOXANTRONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INDAZOLES; INHIBITORY CONCENTRATION 50; ISOQUINOLINES; LEUKEMIA P388; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; TUMOR CELLS, CULTURED;

EID: 20644462135     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9804432     Document Type: Article

References (16)

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