Overexpression of Cyclooxygenase-2 is Sufficient to Induce Tumorigenesis in Transgenic Mice

Journal of Biological Chemistry

Volumn 276, Issue 21, 2001, Pages 18563-18569

  Liu, Catherine H ^a   Chang, Sung Hee ^a   Narko, Kirsi ^a   Trifan, Ovidiu C ^a   Wu, Ming Tao ^a   Smith, Elizabeth ^b   Haudenschild, Christian ^b   Lane, Timothy F ^c   Hla, Timothy ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b HOLLAND LABORATORY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; ENZYME KINETICS; GENETIC ENGINEERING; PROTEINS; RNA; TUMORS;

GENE EXPRESSION;

BIOCHEMISTRY;

BETA CASEIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; INHIBITOR OF APOPTOSIS PROTEIN; MESSENGER RNA; PROSTAGLANDIN SYNTHASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; ISOENZYME;

ADENOCARCINOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CARCINOGENESIS; BREAST DYSPLASIA; BREAST EPITHELIUM; BREAST HYPERPLASIA; CANCER INCIDENCE; CELL DIFFERENTIATION; CONTROLLED STUDY; FEMALE; GENE INDUCTION; GENE OVEREXPRESSION; INTESTINE TUMOR; LACTATION; MALIGNANT TRANSFORMATION; METASTASIS; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; ENZYMOLOGY; EXPERIMENTAL NEOPLASM; GENE EXPRESSION REGULATION; GENETICS;

ANIMALIA; MOUSE MAMMARY TUMOR VIRUS; MURINAE; MUS MUSCULUS; ONCOVIRINAE; MAMMARY TUMOR VIRUS; MURINE MAMMARY TUMOR VIRUS; TUMOR VIRUS;

ANIMALS; CYCLOOXYGENASE 2; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; ISOENZYMES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, TRANSGENIC; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0035947709     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010787200     Document Type: Article

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