Crystal structure of the topoisomerase II poison 9-amino-[N-(2- dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2

Biochemistry

Volumn 38, Issue 29, 1999, Pages 9221-9233

  Adams, Adrienne ^b   Guss, J Mitchell ^b   Collyer, Charles A ^b   Denny, William A ^a   Wakelin, Laurence P G ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE DERIVATIVE; CYTOSINE; DNA TOPOISOMERASE (ATP HYDROLYSING); GUANINE; NUCLEOTIDE;

ARTICLE; CHEMICAL ANALYSIS; CRYSTAL STRUCTURE; CYTOTOXICITY; DNA BINDING; DNA HELIX; ENZYME INHIBITION; HYDROGEN BOND; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ACRIDINES; AMSACRINE; ANTINEOPLASTIC AGENTS; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DEOXYRIBONUCLEOTIDES; DNA; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; INTERCALATING AGENTS; KINETICS; LIGANDS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 0033587654     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990352m     Document Type: Article

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