Prostaglandin E2, transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

Nature Medicine

Volumn 8, Issue 3, 2002, Pages 289-293

  Pai, Rama ^a   Soreghan, Brian ^a   Szabo, Imre L ^a   Pavelka, Meredith ^a   Baatar, Dolgor ^a   Tarnawski, Andrzej S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN E2; TRANSFORMING GROWTH FACTOR ALPHA; 4 ((3 BROMOPHENYL)AMINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4-((3-BROMOPHENYL)AMINO)-6,7-DIMETHOXYQUINAZOLINE; ENZYME INHIBITOR; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; QUINAZOLINE DERIVATIVE; TYRPHOSTIN;

ARTICLE; CELL PROLIFERATION; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; ENZYME INACTIVATION; GASTROINTESTINAL DISEASE; GASTROINTESTINAL MUCOSA; HUMAN; HUMAN CELL; HYPERTROPHY; MITOGENICITY; ONCOGENE SRC; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; ANIMAL; CELL LINE; COLON TUMOR; CYTOLOGY; DRUG EFFECT; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; STOMACH MUCOSA; TRANSACTIVATION;

ANIMALS; CELL LINE; COLONIC NEOPLASMS; DINOPROSTONE; ENZYME INHIBITORS; GASTRIC MUCOSA; GENES, SRC; HUMANS; HYPERTROPHY; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHORYLATION; QUINAZOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANS-ACTIVATION (GENETICS); TYRPHOSTINS;

EID: 0036006453     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0302-289     Document Type: Article

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