DNA repair, damage signaling and carcinogenesis

DNA Repair

Volumn 7, Issue 4, 2008, Pages 670-680

  Lavelle, Christophe ^a   Salles, Bernard ^b   Wiesmüller, Lisa ^c  

^a CNRS   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

DNA repair meeting; French Society of Genotoxicology; German Society for Research on DNA repair

Indexed keywords

CARCINOGENESIS; CHROMATIN; CONFERENCE PAPER; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; EXCISION REPAIR; GENOTOXICITY; MEDICAL INFORMATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; GENETICS; HUMAN;

ANIMALS; CARCINOGENESIS; DNA DAMAGE; DNA REPAIR; HUMANS; SIGNAL TRANSDUCTION;

EID: 40649121691     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2007.12.007     Document Type: Conference Paper

References (85)

1. Jankovic M., Nussenzweig A., and Nussenzweig M.C. Antigen receptor diversification and chromosome translocations. Nat. Immunol. 8 (2007) 801-808
2. Ramiro A.R., Jankovic M., Callen E., Difilippantonio S., Chen H.T., McBride K.M., Eisenreich T.R., Chen J., Dickins R.A., Lowe S.W., Nussenzweig A., and Nussenzweig M.C. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440 (2006) 105-109
3. Callen E., Jankovic M., Difilippantonio S., Daniel J.A., Chen H.T., Celeste A., Pellegrini M., McBride K., Wangsa D., Bredemeyer A.L., Sleckman B.P., Ried T., Nussenzweig M., and Nussenzweig A. ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell 130 (2007) 63-75
4. Kozmin S., Slezak G., Reynaud-Angelin A., Elie C., de Rycke Y., Boiteux S., and Sage E. UVA radiation is highly mutagenic in cells that are unable to repair 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 13538-13543
5. van der Kemp P.A., Thomas D., Barbey R., de Oliveira R., and Boiteux S. Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 5197-5202
6. de Padula M., Slezak G., Auffret van Der Kemp P., and Boiteux S. The post-replication repair RAD18 and RAD6 genes are involved in the prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae. Nucleic Acids Res. 32 (2004) 5003-5010
7. Schreiber V., Dantzer F., Ame J.C., de G., and Murcia. Poly(ADP-ribose): novel functions for an old molecule. Nat. Rev. Mol. Cell Biol. 7 (2006) 517-528
8. Dantzer F., Mark M., Quenet D., Scherthan H., Huber A., Liebe B., Monaco L., Chicheportiche A., Sassone-Corsi P., de Murcia G., and Menissier-de Murcia J. Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 14854-14859
9. Yelamos J., Monreal Y., Saenz L., Aguado E., Schreiber V., Mota R., Fuente T., Minguela A., Parrilla P., de Murcia G., Almarza E., Aparicio P., and Menissier-de Murcia J. PARP-2 deficiency affects the survival of CD4 + CD8+ double-positive thymocytes. EMBO J. 25 (2006) 4350-4360
10. Riedl T., Hanaoka F., and Egly J.M. The comings and goings of nucleotide excision repair factors on damaged DNA. EMBO J. 22 (2003) 5293-5303
11. Coin F., Oksenych V., and Egly J.M. Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. Mol. Cell 26 (2007) 245-256
12. Flohr C., Burkle A., Radicella J.P., and Epe B. Poly(ADP-ribosyl)ation accelerates DNA repair in a pathway dependent on Cockayne syndrome B protein. Nucleic Acids Res. 31 (2003) 5332-5337
13. Osterod M., Larsen E., Le Page F., Hengstler J.G., Van Der Horst G.T., Boiteux S., Klungland A., and Epe B. A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage. Oncogene 21 (2002) 8232-8239
14. Trapp C., Reite K., Klungland A., and Epe B. Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice. Oncogene 26 (2007) 4044-4048
15. Tabbert A., Kappes F., Knippers R., Kellermann J., Lottspeich F., and Ferrando-May E. Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform. Proteomics 6 (2006) 5758-5772
16. Luijsterburg M.S., Goedhart J., Moser J., Kool H., Geverts B., Houtsmuller A.B., Mullenders L.H., Vermeulen W., and van Driel R. Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC. J. Cell Sci. 120 (2007) 2706-2716
17. Meyer A., Wilhelm B., Dork T., Bremer M., Baumann R., Karstens J.H., and Machtens S. ATM missense variant P1054R predisposes to prostate cancer. Radiother. Oncol. 83 (2007) 283-288
18. Brennan P., McKay J., Moore L., Zaridze D., Mukeria A., Szeszenia-Dabrowska N., Lissowska J., Rudnai P., Fabianova E., Mates D., Bencko V., Foretova L., Janout V., Chow W.H., Rothman N., Chabrier A., Gaborieau V., Odefrey F., Southey M., Hashibe M., Hall J., Boffetta P., Peto J., Peto R., and Hung R.J. Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study. Hum. Mol. Genet. 16 (2007) 1794-1801
19. Cohet C., Borel S., Nyberg F., Mukeria A., Bruske-Hohlfeld I., Constantinescu V., Benhamou S., Brennan P., Hall J., and Boffetta P. Exon 5 polymorphisms in the O6-alkylguanine DNA alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke. Cancer Epidemiol. Biomarkers Prev. 13 (2004) 320-323
20. Winnepenninckx V., Lazar V., Michiels S., Dessen P., Stas M., Alonso S.R., Avril M.F., Ortiz Romero P.L., Robert T., Balacescu O., Eggermont A.M., Lenoir G., Sarasin A., Tursz T., van den Oord J.J., and Spatz A. Gene expression profiling of primary cutaneous melanoma and clinical outcome. J. Natl. Cancer Inst. 98 (2006) 472-482
21. Kauffmann A., Rosselli F., Lazar V., Winnepenninckx V., Mansuet-Lupo A., Dessen P., van den Oord J.J., Spatz A., and Sarasin A. High expression of DNA repair pathways is associated with metastasis in melanoma patients. Oncogene (2007)
22. Poplawski T., Arabski M., Kozirowska D., Blasinska-Morawiec M., Morawiec Z., Morawiec-Bajda A., Klupinska G., Jeziorski A., Chojnacki J., and Blasiak J. DNA damage and repair in gastric cancer-a correlation with the hOGG1 and RAD51 genes polymorphisms. Mutat. Res. 601 (2006) 83-91
23. Gemignani F., Moreno V., Landi S., Moullan N., Chabrier A., Gutierrez-Enriquez S., Hall J., Guino E., Peinado M.A., Capella G., and Canzian F. A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA. Oncogene 23 (2004) 1954-1956
24. Rothkamm K., Kruger I., Thompson L.H., and Lobrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell Biol. 23 (2003) 5706-5715
25. Rothkamm K., and Lobrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 5057-5062
26. Lobrich M., and Jeggo P.A. Harmonising the response to DSBs: a new string in the ATM bow. DNA Rep. (Amst.) 4 (2005) 749-759
27. Riballo E., Kuhne M., Rief N., Doherty A., Smith G.C., Recio M.J., Reis C., Dahm K., Fricke A., Krempler A., Parker A.R., Jackson S.P., Gennery A., Jeggo P.A., and Lobrich M. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol. Cell 16 (2004) 715-724
28. Demuth I., Frappart P.O., Hildebrand G., Melchers A., Lobitz S., Stockl L., Varon R., Herceg Z., Sperling K., Wang Z.Q., and Digweed M. An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability. Hum. Mol. Genet. 13 (2004) 2385-2397
29. Yang Y.G., Saidi A., Frappart P.O., Min W., Barrucand C., Dumon-Jones V., Michelon J., Herceg Z., and Wang Z.Q. Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks. EMBO J. 25 (2006) 5527-5538
30. Frappart P.O., Tong W.M., Demuth I., Radovanovic I., Herceg Z., Aguzzi A., Digweed M., and Wang Z.Q. An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat. Med. 11 (2005) 538-544
31. Wang H., Perrault A.R., Takeda Y., Qin W., Wang H., and Iliakis G. Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res. 31 (2003) 5377-5388
32. Wang H., Rosidi B., Perrault R., Wang M., Zhang L., Windhofer F., and Iliakis G. DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res. 65 (2005) 4020-4030
33. Wang M., Wu W., Wu W., Rosidi B., Zhang L., Wang H., and Iliakis G. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res. 34 (2006) 6170-6182
34. Moshous D., Callebaut I., de Chasseval R., Corneo B., Cavazzana-Calvo M., Le Deist F., Tezcan I., Sanal O., Bertrand Y., Philippe N., Fischer A., and de Villartay J.P. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 105 (2001) 177-186
35. Buck D., Malivert L., de Chasseval R., Barraud A., Fondaneche M.C., Sanal O., Plebani A., Stephan J.L., Hufnagel M., le Deist F., Fischer A., Durandy A., de Villartay J.P., and Revy P. Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell 124 (2006) 287-299
36. Ahnesorg P., Smith P., and Jackson S.P. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 124 (2006) 301-313
37. Callebaut I., Malivert L., Fischer A., Mornon J.P., Revy P., and de Villartay J.P. Cernunnos interacts with the XRCC4 × DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1. J. Biol. Chem. 281 (2006) 13857-13860
38. Soulas-Sprauel P., Le Guyader G., Rivera-Munoz P., Abramowski V., Olivier-Martin C., Goujet-Zalc C., Charneau P., and de Villartay J.P. Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination. J. Exp. Med. 204 (2007) 1717-1727
39. Corneo B., Wendland R.L., Deriano L., Cui X., Klein I.A., Wong S.Y., Arnal S., Holub A.J., Weller G.R., Pancake B.A., Shah S., Brandt V.L., Meek K., and Roth D.B. Rag mutations reveal robust alternative end joining. Nature 449 (2007) 483-486
40. Yan C.T., Boboila C., Souza E.K., Franco S., Hickernell T.R., Murphy M., Gumaste S., Geyer M., Zarrin A.A., Manis J.P., Rajewsky K., and Alt F.W. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449 (2007) 478-482
41. Alt A., Lammens K., Chiocchini C., Lammens A., Pieck J.C., Kuch D., Hopfner K.P., and Carell T. Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta. Science 318 (2007) 967-970
42. Liu W., Bagaitkar J., and Watabe K. Roles of AKT signal in breast cancer. Front Biosci. 12 (2007) 4011-4019
43. S.A. Gatz, M. Keimling, C. Baumann, T. Dörk, K.M. Debatin, D. Fulda, L. Wiesmüller, Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner, Carcinogenesis, 2008 Jan 3, in press (epub ahead of print).
44. S.A. Gatz, L. Wiesmüller, Take a break-resveratrol in action on DNA, Carcinogenesis, 2008 Jan 3, in press (epub ahead of print).
45. Buchholz F., Kittler R., Slabicki M., and Theis M. Enzymatically prepared RNAi libraries. Nat. Methods 3 (2006) 696-700
46. Wu P.Y., Frit P., Malivert L., Revy P., Biard D., Salles B., and Calsou P. Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell. J. Biol. Chem. 282 (2007) 31937-31943
47. Mari P.O., Florea B.I., Persengiev S.P., Verkaik N.S., Bruggenwirth H.T., Modesti M., Giglia-Mari G., Bezstarosti K., Demmers J.A., Luider T.M., Houtsmuller A.B., and van Gent D.C. Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 18597-18602
48. Chan C.Y., Kiechle M., Manivasakam P., and Schiestl R.H. Ionizing radiation and restriction enzymes induce microhomology-mediated illegitimate recombination in Saccharomyces cerevisiae. Nucleic Acids Res. 35 (2007) 5051-5059
49. Peng M., Litman R., Xie J., Sharma S., Brosh Jr. R.M., and Cantor S.B. The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells. EMBO J. 26 (2007) 3238-3249
50. Delbos F., Aoufouchi S., Faili A., Weill J.C., and Reynaud C.A. DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. J. Exp. Med. 204 (2007) 17-23
51. Delbos F., De Smet A., Faili A., Aoufouchi S., Weill J.C., and Reynaud C.A. Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse. J. Exp. Med. 201 (2005) 1191-1196
52. Ulrich H.D. How to activate a damage-tolerant polymerase: consequences of PCNA modifications by ubiquitin and SUMO. Cell Cycle 3 (2004) 15-18
53. Ulrich H.D. Mutual interactions between the SUMO and ubiquitin systems: a plea of no contest. Trends Cell Biol. 15 (2005) 525-532
54. Ulrich H.D. PCNA(SUMO) and Srs2: a model SUMO substrate-effector pair. Biochem. Soc. Trans. 35 (2007) 1385-1388
55. Braet C., Stephan H., Dobbie I.M., Togashi D.M., Ryder A.G., Foldes-Papp Z., Lowndes N., and Nasheuer H.P. Mobility and distribution of replication protein A in living cells using fluorescence correlation spectroscopy. Exp. Mol. Pathol. 82 (2007) 156-162
56. Leonce S., Kraus-Berthier L., Golsteyn R.M., David-Cordonnier M.H., Tardy C., Lansiaux A., Poindessous V., Larsen A.K., and Pierre A. Generation of replication-dependent double-strand breaks by the novel N2-G-alkylator S23906-1. Cancer Res. 66 (2006) 7203-7210
57. Soares D.G., Escargueil A.E., Poindessous V., Sarasin A., de Gramont A., Bonatto D., Henriques J.A., and Larsen A.K. Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 13062-13067
58. Kaina B., Christmann M., Naumann S., and Roos W.P. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Rep. (Amst.) 6 (2007) 1079-1099
59. Wiewrodt D., Nagel G., Dreimuller N., Hundsberger T., Perneczky A., and Kaina B. MGMT in primary and recurrent human glioblastomas after radiation and chemotherapy and comparison with p53 status and clinical outcome. Int. J. Cancer (2007)
60. Mischo H.E., Hemmerich P., Grosse F., and Zhang S. Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. J. Biol. Chem. 280 (2005) 9586-9594
61. Friedemann J., Grosse F., and Zhang S. Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity. J. Biol. Chem. 280 (2005) 31303-31313
62. Buschfort-Papewalis C., Moritz T., Liedert B., and Thomale J. Down-regulation of DNA repair in human CD34(+) progenitor cells corresponds to increased drug sensitivity and apoptotic response. Blood 100 (2002) 845-853
63. Bracker T.U., Giebel B., Spanholtz J., Sorg U.R., Klein-Hitpass L., Moritz T., and Thomale J. Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis. Stem Cells 24 (2006) 722-730
64. Difilippantonio S., Celeste A., Kruhlak M.J., Lee Y., Difilippantonio M.J., Feigenbaum L., Jackson S.P., McKinnon P.J., and Nussenzweig A. Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J. Exp. Med. 204 (2007) 1003-1011
65. Difilippantonio S., and Nussenzweig A. The NBS1-ATM connection revisited. Cell Cycle 6 (2007)
66. Mielke C., Kalfalah F.M., Christensen M.O., and Boege F. Rapid and prolonged stalling of human DNA topoisomerase I in UVA-irradiated genomic areas. DNA Rep. (Amst.) 6 (2007) 1757-1763
67. Christmann M., Tomicic M.T., Aasland D., and Kaina B. A role for UV-light-induced c-Fos: stimulation of nucleotide excision repair and protection against sustained JNK activation and apoptosis. Carcinogenesis 28 (2007) 183-190
68. Christmann M., Tomicic M.T., Origer J., Aasland D., and Kaina B. c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the re-synthesis of XPF. Nucleic Acids Res. 34 (2006) 6530-6539
69. Bourdon J.C., Fernandes K., Murray-Zmijewski F., Liu G., Diot A., Xirodimas D.P., Saville M.K., and Lane D.P. p53 isoforms can regulate p53 transcriptional activity. Genes Dev. 19 (2005) 2122-2137
70. Bourdon J.C. p53 and its isoforms in cancer. Br. J. Cancer 97 (2007) 277-282
71. Legube G., Linares L.K., Tyteca S., Caron C., Scheffner M., Chevillard-Briet M., and Trouche D. Role of the histone acetyl transferase Tip60 in the p53 pathway. J. Biol. Chem. 279 (2004) 44825-44833
72. Tyteca S., Vandromme M., Legube G., Chevillard-Briet M., and Trouche D. Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. EMBO J. 25 (2006) 1680-1689
73. Groth A., Rocha W., Verreault A., and Almouzni G. Chromatin challenges during DNA replication and repair. Cell 128 (2007) 721-733
74. Polo S.E., and Almouzni G. Chromatin assembly: a basic recipe with various flavours. Curr. Opin. Genet. Dev. 16 (2006) 104-111
75. Ray-Gallet D., Quivy J.P., Scamps C., Martini E.M., Lipinski M., and Almouzni G. HIRA is critical for a nucleosome assembly pathway independent of DNA synthesis. Mol. Cell 9 (2002) 1091-1100
76. Tagami H., Ray-Gallet D., Almouzni G., and Nakatani Y. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell 116 (2004) 51-61
77. Groth A., Ray-Gallet D., Quivy J.P., Lukas J., Bartek J., and Almouzni G. Human Asf1 regulates the flow of S phase histones during replicational stress. Mol. Cell 17 (2005) 301-311
78. Polo S.E., Roche D., and Almouzni G. New histone incorporation marks sites of UV repair in human cells. Cell 127 (2006) 481-493
79. Lavelle C. Transcription elongation through a chromatin template. Biochimie 89 (2007) 516-527
80. Bancaud A., Wagner G., Conde E.S.N., Lavelle C., Wong H., Mozziconacci J., Barbi M., Sivolob A., Le Cam E., Mouawad L., Viovy J.L., Victor J.M., and Prunell A. Nucleosome chiral transition under positive torsional stress in single chromatin fibers. Mol. Cell 27 (2007) 135-147
81. Lavelle C., and Prunell A. Chromatin polymorphism and the nucleosome superfamily: a genealogy. Cell Cycle 6 (2007) 2113-2119
82. Kirkland D., Pfuhler S., Tweats D., Aardema M., Corvi R., Darroudi F., Elhajouji A., Glatt H., Hastwell P., Hayashi M., Kasper P., Kirchner S., Lynch A., Marzin D., Maurici D., Meunier J.R., Muller L., Nohynek G., Parry J., Parry E., Thybaud V., Tice R., van Benthem J., Vanparys P., and White P. How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: report of an ECVAM Workshop. Mutat. Res. 628 (2007) 31-55
83. Nesslany F., Zennouche N., Simar-Meintieres S., Talahari I., Nkili-Mboui E.N., and Marzin D. In vivo Comet assay on isolated kidney cells to distinguish genotoxic carcinogens from epigenetic carcinogens or cytotoxic compounds. Mutat. Res. 630 (2007) 28-41
84. Hartwig A., Asmuss M., Ehleben I., Herzer U., Kostelac D., Pelzer A., Schwerdtle T., and Burkle A. Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms. Environ Health Perspect 110 Suppl 5 (2002) 797-799
85. Guerniou V., Rapin D., Millau J.F., Bufflier E., Favier A., Cadet J., and Sauvaigo S. Repair of oxidative damage of thymine by HeLa whole-cell extracts: simultaneous analysis using a microsupport and comparison with traditional PAGE analysis. Biochimie 87 (2005) 151-159