An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability

Human Molecular Genetics

Volumn 13, Issue 20, 2004, Pages 2385-2397

  Demuth, Ilja ^a,c   Frappart, Pierre Olivier ^b   Hildebrand, Gabriele ^a   Melchers, Anna ^a   Lobitz, Stephan ^a   Stöckl, Lars ^a   Varon, Raymonda ^a   Herceg, Zdenko ^b   Sperling, Karl ^a   Wang, Zhang Qi ^b   Digweed, Martin ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^c BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CRE RECOMBINASE; DOUBLE STRANDED DNA; NIBRIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CANCER RISK; CELL CYCLE; CELL CYCLE G2 PHASE; CELL DEATH; CELL FUNCTION; CELL VIABILITY; CHROMOSOME; CHROMOSOME DAMAGE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; FIBROBLAST; FOUNDER EFFECT; GENE DELETION; GENE TRANSFER; GENETIC DISORDER; GENETIC STABILITY; HOMOZYGOSITY; HYPOTHESIS; IMMUNE DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LETHALITY; LIVER; LYMPHATIC SYSTEM DISEASE; LYMPHOID TISSUE; MITOSIS; MOUSE; MUSCLE; NIJMEGEN BREAKAGE SYNDROME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; SPLEEN; THYMUS;

ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; CELL SURVIVAL; CELLS, CULTURED; CHROMOSOMAL INSTABILITY; CHROMOSOME BREAKAGE; CHROMOSOME DISORDERS; DISEASE MODELS, ANIMAL; DNA REPAIR; DNA, COMPLEMENTARY; FIBROBLASTS; GENE TARGETING; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INTEGRASES; MICE; MICE, MUTANT STRAINS; NUCLEAR PROTEINS; SEQUENCE DELETION; SYNDROME; VIRAL PROTEINS;

MURINAE;

EID: 19544389992     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddh278     Document Type: Article

References (40)

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