Interference by toxic metal ions with DNA repair processes and cell cycle control: Molecular mechanisms

Environmental Health Perspectives

Volumn 110, Issue SUPPL. 5, 2002, Pages 797-799

  Hartwig, A ^a   Asmuss, M ^a   Ehleben, I ^a   Herzer, U ^a   Kostelac, D ^a   Pelzer, A ^a   Schwerdtle, T ^a   Burkle A ^a  

^a UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Cell cycle control; DNA repair; Fpg; Metal ions; PARP; XPA

Indexed keywords

ARSENIC; BACTERIAL PROTEIN; BENZO[A]PYRENE; CADMIUM; COBALT; COPPER; DNA; DNA GLYCOSYLTRANSFERASE; METAL ION; NICKEL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ZINC FINGER PROTEIN;

ARTICLE; CARCINOGENICITY; CELL CYCLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; GENOMICS; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN INTERACTION; ULTRAVIOLET C RADIATION; XERODERMA PIGMENTOSUM;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 0036805905     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.02110s5797     Document Type: Article

References (38)

1. Kasprzak KS, Possible role of oxidative damage in metal-induced carcinogenesis. Cancer Invest 13:411-430 (1995).
2. Bal W, Kozlowski H, Kasprzak KS. Molecular models in nickel carcinogenesis. J Inorg Biochem 79:213-218 (2000).
3. Klein CB, Costa M. DNA methylation, heterochromatin and epigenetic carcinogens. Mutat Res 386:163-180 (1997).
4. Mass MJ, Wang L. Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis. Mutat Res 386:263-277 (1997).
5. Hartwig A. Current aspects in metal genotoxicity. Biometals 8:3-11 (1995).
6. Rossman TG, Uddin AN, Burns FJ, Bosland MC. Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis. Toxicol Appl Pharmacol 176:64-71 (2001).
7. Hartwig A. Recent advances in metal carcinogenicity. Pure Appl Chem 72:1007-1014 (2000).
8. Lindahl T. Instability and decay of the primary structure of DNA. Nature 362:709-715 (1993).
9. de Boer J, Hoeijmakers JH. Nucleotide excision repair and human syndromes. Carcinogenesis 21:453-460 (2000).
10. Li JH, Rossman TG. Inhibition of DNA ligase activity by arsenite: a possible mechanism on its comutagenesisis. Mol Toxicol 2:1-9 (1989).
11. Dally H, Hartwig A. Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells. Carcinogenesis 18:1021-1026 (1997).
12. Hartwig A. Carcinogenicity of metal compounds: possible role of DNA repair inhibition. Toxicol Lett 102-103:235-239 (1998).
13. Hartmann M, Hartwig A. Disturbance of DNA damage recognition after UV-irradiation by nickel(II) and cadmium(II) in mammalian cells. Carcinogenesis 19:617-621 (1998).
14. Kasten U, Mullenders LH, Hartwig A. Cobalt(II) inhibits the incision and the polymerization step of nucleotide excision repair in human fibroblasts. Mutat Res 383:81-89 (1997).
15. Hartwig A, Groblinghoff UD, Beyersmann D, Natarajan AT, Filon R, Mullenders LH. Interaction of arsenic(III) with nucleotide excision repair in UV-irradiated human fibroblasts. Carcinogenesis 18:399-405 (1997).
16. Melendez-Colon VJ, Luch A, Seidel A, Baird WM. Cancer initiation by polyclinic aromatic hydrocarbons results from formation on stable DNA adducts rather than apurinic sites. Carcinogenesis 20:1885-1891 (1999).
17. Alexandrov K, Rojas M, Geneste O, Castegnaro M, Camus AM, Petruzzelli S, Giuntini C, Bartsch H. An improved fluorometric assay for dosimetry of benzo[a]pyrene diolepoxide-DNA adducts in smokers' lung: comparisons with total bulky adducts and aryl hydrocarbon hydroxylase activity. Cancer Res 52:6248-6253 (1992).
18. Schwerdtle T, Seidel A, Hartwig A. Effect of soluble and particulate nickel compounds on the formation and repair of stable benzo[a]pyrene DNA adducts in human lung cells. Carcinogenesisi 23:47-53 (2002).
19. Dunnick JK, Elwell MR, Radovsky AE, Benson JM, Hahn FF, Nikula KJ, Barr EB, Hobbs CH. Comparative carcinogenic effects of nickel subsulfide, nickel oxide, or nickel sulfate hexahydrate chronic exposures in the lung. Cancer Res 55:5251-5256 (1995).
20. Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature 108:433-439 (2000).
21. Kaufmann Wk, Paules RS. DNA damage and cell cycle checkpoints. FASEB J 10:238-247 (1996).
22. Ehleben I, Herzer U, Kostelac D. Hartwig A. Unpublished data.
23. Mackay JP, Crossley M. Zinc fingers are sticking together. Trends Biochem Sci 23:1-4 (1998).
24. Asmuss M, Mullenders LHF, Eker A, Hartwig A. Differential effects of toxic metal compounds on the activities of Fpg and XPA, two zinc finger proteins involved in DNA repair. Carcinogenesis 21:2097-2104 (2000).
25. Hartwig A. Zinc finger proteins as potential targets for toxic metal ions: differential effects on structure and function. Antioxid Redox Signal 3:625-634 (2001).
26. Bürkle A. Physiology and pathophysiology of poly(ADP-ribosyl)ation. Bioessays 23:795-806 (2001).
27. Gradwohl G, Menissier de Murcia JM, Molinete M, Simonin F, Koken M, Hoeijmakers JH, de Murcia G. The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA. Proc Natl Acad Sci USA 87:2990-2994 (1990).
28. Yager JW, Wiencke JK, inhibition of poly(ADP-ribose) polymerase by arsenite. Mutat Ress 386:345-351 (1997).
29. Asmuss M, Jahnke G, Pelzer A, Khandelwal S, Bürkle A, Hartwig A. Unpublished data.
30. Hainaut P, Hollstein M. p53 and human cancer: the first ten thousand mutations. Adv Cancer Res 77:81-137 (2000).
31. Meplan C, Mann K, Hainaut P. Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells. J Biol Chem 274:31663-31670 (1999).
32. Palecek E, Brazdova M, Cernocka H, Litsen D, Brazda V, Vojtesek B. Effect of transition metals on binding of p53 protein to supercoiled DNA and to consensus sequence in DNA fragments. Oncogene 18:3617-3625 (1999).
33. Yih LH, Lee TC. Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts. Cancer Res 60:6346-6352 (2000).
34. Menendez D, Mora G, Salazar AM, Ostrosky-Wegman P. ATM status confers sensitivity to arsenic cytotoxic effects. Mutagenesis 16:443-448 (2001).
35. Vogt BL, Rossman TG. Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts-a possible mechanism for arsenite's comutagenecity. Mutat Res 178:159-168 (2001).
36. Hamadeh HK, Vargas M, Lee E, Menzel DB. Arsenic disrupts cellular of p53 and mdm2: a potential mechanism of carcinogenesis. Biochem Biophys Res Commun 263:446-449 (1999).
37. Mass Mj, Wang L. Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis. Mutat Res 386:263-277 (1997).
38. Peltomaki P. Deficient mismatch repair repair: a common etiologic factor for colon cancer. Hum Mol Genet 10:735-740 (2001).