Down-regulation of DNA repair in human CD34+ progenitor cells corresponds to increased drug sensitivity and apoptotic response

Blood

Volumn 100, Issue 3, 2002, Pages 845-853

  Buschfort Papewalis, Claudia ^a   Moritz, Thomas ^a   Liedert, Bernd ^a   Thomale, Jürgen ^a  

^a UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; ANTINEOPLASTIC AGENT; CD19 ANTIGEN; CD33 ANTIGEN; CD34 ANTIGEN; CISPLATIN; ETHYLNITROSOUREA; MELPHALAN; SINGLE STRANDED DNA;

APOPTOSIS; ARTICLE; BONE MARROW; BONE MARROW SUPPRESSION; COMET ASSAY; DNA REPAIR; DNA STRAND BREAKAGE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG SENSITIVITY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; UMBILICAL CORD BLOOD;

EID: 0036683450     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-01-0022     Document Type: Article

References (40)

1. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
2. Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells
3. Human DNA repair genes
4. Mammalian base excision repair and DNA polymerase beta
5. Molecular mechanism of nucleotide excision repair
6. DNA repair: Enzymatic mechanisms and relevance to drug response
7. DNA repair mechanisms associated with cellular resistance to antitumor drugs: Potential novel targets
8. Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4
9. Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents
10. A monoclonal antibody that recognizes alkali-stabilized melphalan-DNA adducts and its application in immunofluorescence microscopy
11. DNA excision repair profiles of normal and leukemic human lymphocytes: Functional analysis at the single-cell level
12. Quantification of specific DNA O-alkylation products in individual cells by monoclonal antibodies and digital imaging of intensified nuclear fluorescence
13. Alterations of DNA repair: Implications for leukemia cell biology
14. Identification of apoptotic cells by formamide-induced DNA denaturation in condensed chromatin
15. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents
16. Repair of O6-alkylguanines in the nuclear DNA of human lymphocytes and leukaemic cells: Analysis at the single-cell level
17. Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues
18. The nitrosoureas: Carmustine (BCNU) and lomustine (CCNU)
19. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase
20. Transfer of drug resistance genes into hematopoietic progenitors to improve chemotherapy tolerance
21. Marrow protection-transduction of hematopoietic cells with drug resistance genes
22. Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N, N′, N′-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo
23. + hematopoletic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU
24. - bone marrow cells
25. Cisplatin: From DNA damage to cancer chemotherapy
26. DNA adducts from chemotherapeutic agents
27. Mismatch repair deficiency is associated with resistance to DNA minor groove alkylating agents
28. Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen
29. Separation of killing and tumotigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
30. Principles of cancer therapy
31. Hematopoietic stem cell deficit of transplanted bone marrow previously exposed to cytotoxic agents
32. Differential effects of cytotoxic agents on hematopoietic progenitors
33. Increased survival and multilineage hematopoietic protection from delayed and severe myelosuppressive effects of a nitrosourea with recombinant interleukin-11
34. O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells
35. Determinants of O6-alkylguanine-DNA alkyltransferase activity in human colon cancer
36. Leukemia following Hodgkin's disease
37. Secondary leukaemia after epipodophyllotoxins
38. Risk of leukemia after platinum-based chemotherapy for ovarian cancer