Cetirizine, loratadine, or placebo in subjects with seasonal allergic rhinitis: Effects after controlled ragweed pollen challenge in an environmental exposure unit

Journal of Allergy and Clinical Immunology

Volumn 101, Issue 5, 1998, Pages 638-645

  Day, James H ^a,c   Briscoe, Maureen ^a   Widlitz, Michael D ^b  

^a QUEEN S UNIVERSITY   (Canada)

^b PFIZER INC   (United States)

^c QUEEN S UNIVERSITY   (Canada)

Author keywords

Allergic rhinitis; Cetirizine; Environmental exposure unit; Loratadine; Placebo; Pollen challenge; Seasonal allergic rhinitis

Indexed keywords

CETIRIZINE; LORATADINE;

ADULT; AGED; ALLERGIC RHINITIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; ENVIRONMENTAL EXPOSURE; FATIGUE; FEMALE; FEVER; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROVOCATION TEST; RAGWEED POLLEN; RANDOMIZED CONTROLLED TRIAL; THORAX PAIN;

EID: 0031971826     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(98)70172-1     Document Type: Article

References (41)

1. Naclerio RM. Allergic rhinitis. N Engl J Med 1991;325:860-9.
2. Centers for Disease Control and Prevention: Vital and Health Statistics, Current Estimates From the National Health Interview Survey, 1994. US Dept of Health and Human Services, Public Health Service, National Center for Health Statistics; DHHS Publication PHS 96-1521; December 1995. p. 82.
3. Centers for Disease Control and Prevention: Vital and Health Statistics, National Ambulatory Medical Care Survey: 1991 Summary. US Dept of Health and Human Services, Public Health Service, National Center for Health Statistics; DHHS Publication PHS 94-1777; May 1994. p. 24.
4. McMenamin P. Costs of hay fever in the United States in 1990. Ann Allergy 1994;73:35-9.
5. 1 antihistamines. J Allergy Clin Immunol 1990;86: 1040-6.
6. Lockey RF, Findley S, Mitchell DQ, Woehler T, Lieberman P, Nicodemus CF. Effects of cetirizine versus terfenadine in seasonal allergic rhinitis. Ann Allergy 1993;70:311-5.
7. Mansmann HC, Altman RA, Berman BA, Buchman E, Dockhorn RJ, Leese PT, et al. Efficacy and safety of cetirizine therapy in perennial allergic rhinitis. Ann Allergy 1992;68:348-53.
8. Kalivas J, Breneman D, Tharp M, Bruce S, Bigby M, et al. Urticaria: clinical efficacy of cetirizine in comparison with hydroxyzine and placebo. J Allergy Clin Immunol 1990;86:1014-8.
9. Spencer CM, Faulds D, Peters DH. Cetirizine: a reappraisal of its pharmacological properties and therapeutic use in selected allergic disorders. Drugs 1993;46:1055-80.
10. 14C-cetirizine in humans. Ann Allergy 1987;59:31-4.
11. Snyder SH, Snowman AM. Receptor effects of cetirizine. Ann Allergy 1987;59:4-8.
12. Dockhorn RJ, Bergner A, Connell JT, Falliers CJ, Grabiec SV, Weiler JM, et al. Safety and efficacy of loratadine (Sch-29851): a new non-sedating antihistamine in seasonal allergic rhinitis. Ann Allergy 1987;58:407-11.
13. Simons FER, McMillan JL, Simons KJ. A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects. J Allergy Clin Immunol 1990;86:540-7.
14. Backhouse CI, Renton R, Fidler C, Rosenberg RM. Multicentre, double-blind comparison of terfenadine and cetirizine in patients with seasonal allergic rhinitis. Br J Clin Pharmacol 1990;44:88-91.
15. Caiaffa MF, Iudice A, Macchia L, Tursi A, Vergallo G, Sacerdoti G, et al. Multicenter double-blind comparative study of terfenadine and cetirizine in hay fever. J Invest Allergol Clin Immunol 1992;2:162-6.
16. Lockey RF, Widlitz MD, Mitchell DQ, Lumry W, Dockhorn R, Woehler T, et al. Comparative study of cetirizine and terfenadine versus placebo in the symptomatic management of seasonal allergic rhinitis. Ann Allergy Asthma Immunol 1996;76:448-54.
17. Rijntjes E, Ghys L, Rihoux J-P. Astemizole and cetirizine in the treatment of seasonal allergic rhinitis: a comparative double-blind, multicentre study. J Int Med Res 1990;18:219-24.
18. Harcup JW, Hawkes G, Saul PA. The efficacy and sedative profile of astemizole and cetirizine in the treatment of grass pollen hayfever in general practice. Br J Clin Pharmacol 1993;47:131-5.
19. Berkowitz RB, Dockhorn R, Lockey R, Findlay S, Howland WC, Mitchell DQ, et al. Comparison of efficacy, safety, and skin test inhibition of cetirizine and astemizole. Ann Allergy Asthma Immunol 1996;76:363-8.
20. Braun JJ, Conraux C, Bebear JP, Pignat JC, Haguenauer JP, Dubreuil C, et al. Evaluation of the effectiveness and tolerability of loratadine in seasonal allergic rhinitis [in French]. C R Ther Pharmacol Clin (France) 1992;10/98:19-24.
21. Herman D, Arnaud A, Dry J, Latil G, Pauli G, Perrin-Fayolle M, et al. Clinical effectiveness and tolerance of loratadine versus cetirizine in the treatment of seasonal allergic rhinitis [in French]. Allerg Immunol (Paris) 1992;24:270-4.
22. Tarchalska-Krynska B, Zawisza E. A 6-week, cross-over study comparing cetirizine and loratadine in seasonal allergic rhinitis [in Polish]. Pneumonol Alergol Pol 1994;62:573-7.
23. Cave J-P, Billardon M. Comparaison de l'efficacité de la cétirizine à celle de la loratadine sur la rhinite saisonnière ou per-annuelle. Immunologie Médicale 1991;8:87-90.
24. Meltzer EO, Weiler JM, Widlitz MD. Comparative outdoor study of the efficacy, onset and duration of action, and safety of cetirizine, loratadine, and placebo for seasonal allergic rhinitis. J Allergy Clin Immunol 1996;97:617-26.
25. Day JH, Briscoe M, Clark RH, Ellis AK, Gervais P. Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis. Ann Allergy Asthma Immunol 1997;79:163-72.
26. Donovan JP, Buckeridge DL, Briscoe MP, Clark RH, Day JH. Efficacy of immunotherapy to ragweed antigen tested by controlled antigen exposure. Ann Allergy Asthma Immunol 1996;77:74-80.
27. Day JH, Buckeridge DL, Clark RH, Briscoe MP, Phillips R. A randomized, double-blind, placebo-controlled, controlled antigen delivery study of the onset of action of aerosolized triamcinolone acetonide nasal spray in subjects with ragweed-induced allergic rhinitis. J Allergy Clin Immunol 1996;97:1050-7.
28. Frenz DA, Palmer MA, Hokanson JM, Scamehorn RT. Seasonal characteristics of ragweed pollen dispersal in the United States. Ann Allergy Asthma Immunol 1995;75:417-22.
29. Buck P, Levetin E. Weather patterns and ragweed pollen production in Tulsa, Oklahoma. Ann Allergy 1982;49:272-5.
30. Solomon WR. Volumetric studies of aeroallergen prevalence. I. Pollens of weedy forbs at a Midwestern station. J Allergy Clin Immunol 1976;57:318-27.
31. Ogden EC, Hayes JV, Raynor GS. Diurnal patterns of pollen emission in ambrosia, phleum, zea, and ricinus. Am J Bot 1969;56: 16-21.
32. Arbesman CE. Buffalo and Western New York State. In: Samter M, Durham OC, editors. Regional allergy of the United States, Canada, Mexico, and Cuba. Springfield: Charles C. Thomas Publisher; 1955. p. 31-8.
33. Connell JT. A novel method to assess antihistamine and decongestant efficacy. Ann Allergy 1979;42:278-85.
34. Habenicht HA, Burge HA, Muilenberg ML, Solomon WR. Allergen carriage by atmospheric aerosol. II. Ragweed-pollen determinants in submicronic atmospheric fractions. J Allergy Clin Immunol 1984;74: 64-7.
35. Solomon WR. Aerobiology of pollinosis. J Allergy Clin Immunol 1984;74:449-61.
36. Driessen MNBM, Quanjer PH. Pollen deposition in intrathoracic airways. Eur Respir J 1991;4:359-63.
37. Solomon WR, Matthews KP. Aerobiology and inhalant allergens. In: Middleton E, Reed CE, Ellis EF, editors. Allergy: principles and practice. 2nd ed. St. Louis: Mosby, Inc.; 1983. p. 1143-202.
38. Fleiss JL. Statistical methods for rates and proportions. 2nd ed. New York: John Wiley & Sons; 1973. p. 14-22.
39. Winer BJ. Statistical principles in experimental design. 2nd ed. New York: McGraw-Hill Book Company; 1971. p. 205-10, 228-32, 240-4, 752-65.
40. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959;22: 719-48.
41. SAS Procedures Guide. Version 6. 3rd ed. SAS/STAT User's Guide, Version 6. 4th ed. Vol I and II. Cary (NC): SAS Institute Inc.