Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier

Drug Metabolism and Disposition

Volumn 32, Issue 5, 2004, Pages 519-524

  Ishiguro, Naoki ^a,b   Nozawa, Takashi ^a   Tsujihata, Akiko ^b   Saito, Asami ^b   Kishimoto, Wataru ^b   Yokoyama, Kazutoshi ^b   Yotsumoto, Takafumi ^a   Sakai, Kenji ^b   Igarashi, Takashi ^a,c   Tamai, Ikumi ^a,b  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPHENIRAMINE; CYPROHEPTADINE; DESLORATADINE; EPINASTINE; KETOTIFEN; MEPYRAMINE; ZOSUQUIDAR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG INHIBITION; DRUG UPTAKE; GENETIC TRANSFECTION; MALE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES COMPARISON; TEMPERATURE DEPENDENCE; WILD TYPE;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CELL LINE, TRANSFORMED; DIBENZAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HISTAMINE H1 ANTAGONISTS; IMIDAZOLES; LLC-PK1 CELLS; MALE; MICE; MICE, KNOCKOUT; RATS; RECEPTORS, HISTAMINE H1; SWINE;

ANIMALIA;

EID: 11144356916     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.5.519     Document Type: Article

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