Comparing the new antihistamines: The role of pharmacological parameters

Clinical and Experimental Allergy

Volumn 36, Issue 1, 2006, Pages 5-7

  Devillier, P ^a  

^a FOCH HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; ASTEMIZOLE; CETIRIZINE; DESLORATADINE; ERYTHROMYCIN; FEXOFENADINE; GLYCOPROTEIN P; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; KETOCONAZOLE; LEVOCETIRIZINE; LORATADINE; MUSCARINIC RECEPTOR; TERFENADINE;

ALLERGIC DISEASE; ALLERGIC RHINITIS; ANTICHOLINERGIC EFFECT; ANTICHOLINERGIC SYNDROME; BLOOD FLOW; BRAIN; CARDIOTOXICITY; CARDIOVASCULAR EFFECT; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; DRUG DISTRIBUTION; EDITORIAL; HEART DISEASE; HEART REPOLARIZATION; HEART VENTRICLE TACHYCARDIA; HUMAN; MYDRIASIS; NOSE MUCOSA; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; QT PROLONGATION; RECEPTOR BINDING; SEDATION; SIDE EFFECT; SOMNOLENCE; TORSADE DES POINTES; XEROSTOMIA;

ANTI-ALLERGIC AGENTS; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG TOXICITY; HISTAMINE H1 ANTAGONISTS; HUMANS; HYPERSENSITIVITY; PROTEIN BINDING; RECEPTORS, HISTAMINE H1;

EID: 33645032466     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2006.02421.x     Document Type: Editorial

References (23)

1. Tillement J-P. Pharmacological profile of the new antihistamines Clin Exp Allergy Rev 2005 5 7 11
2. Leurs R Church MK Taglialatela M. H1-antihistamines inverse agonism, anti-inflammatory actions and cardiac effects Clin Exp Allergy 2002 32 489 98
3. Bousquet J Vignola AM Campbell AM Michel FB. Pathophysiology of allergic rhinitis Int Arch Allergy Immunol 1996 110 207 18
4. Kreutner W Hey JA Anthes J Barnett A Young S Tozzi S. Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 1st communication receptor selectivity, antihistaminic activity, and antiallergenic effects Arzneimittelforschung 2000 50 345 52
5. Cardelus I Anton F Beleta J Palacios JM. Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle Eur J Pharmacol 1999 374 249 54
6. Liu H Farley JM. Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport BMC Pharmacol 2005 5 8
7. ® (desloratadine) Product Information Kenilworth, NJ, USA Schering-Plough Corporation
8. Pagliara A Testa B Carrupt PA et al Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist J Med Chem 1998 41 853 63
9. Timmerman H. Why are non-sedating antihistamines non-sedating? Clin Exp Allergy 1999 29 S13, 13 8
10. Chen C Hanson E Watson JW Lee JS. P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists Drug Metab Dispos 2003 31 312 8
11. Ishiguro N Nozawa T Tsujihata A et al Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier Drug Metab Dispos 2004 32 519 24
12. Vuurman EF Rikken GH Muntjewerff ND de Halleux F Ramaekers JG. Effects of desloratadine, diphenhydramine and placebo on driving performance and psychomotor performance measurements Eur J Clin Pharmacol 2004 60 307 13
13. Verster JC de Weert AM Bijtjes SI et al Driving ability after acute and sub-chronic administration of levocetirizine and diphenhydramine a randomized, double-blind, placebo-controlled trial Psychopharmacology 2003 169 84 90
14. Hindmarch I Johnson S Meadows R Kirkpatrick T Shamsi Z. The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance and weal and flare Curr Med Res Opin 2001 17 241 55
15. Mann RD Pearce GL Dunn N Shakir S. Sedation with "non-sedating" antihistamines four prescription-event monitoring studies in general practice BMJ 2000 320 1184 6
16. Bachert C Bousquet J Canonica GW et al Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis J Allergy Clin Immunol 2004 114 838 44
17. 1-antihistamines N Engl J Med 2004 351 2203 17
18. Crumb WJ Jr. Loratadine blockade of K(+) channels in human heart comparison with terfenadine under physiological conditions J Pharmacol Exp Ther 2000 292 261 4
19. Lacerda AE Roy ML Lewis EW Rampe D. Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart Mol Pharmacol 1997 52 314 22
20. 1 receptor blocker cetirizine compared with other second-generation antihistamines Mol Pharmacol 1998 54 113 21
21. Murdoch D Goa KL Keam SJ. Desloratadine An update of its efficacy in the management of allergic disorders. Drugs 2003 63 2051 77
22. 1-receptor antagonists Dermatol Ther 2000 13 337 43
23. Walsh GM Annunziato L Frossard N et al New insights into the second generation antihistamines Drugs 2001 61 207 36