Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:Ubiquinone oxidoreductase)

Journal of Biological Chemistry

Volumn 274, Issue 5, 1999, Pages 2625-2630

  Okun, Jürgen G ^a   Lümmen, Peter ^b   Brandt, Ulrich ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPYRIDINE DERIVATIVE; CAPSAICIN; ENZYME INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE;

ANIMAL CELL; ARTICLE; CATALYSIS; CATTLE; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; ENZYME INHIBITOR COMPLEX; ENZYME KINETICS; HOUSE FLY; NONHUMAN; PRIORITY JOURNAL; SUBMITOCHONDRIAL PARTICLE;

ANIMALS; BINDING SITES; CATTLE; ENZYME INHIBITORS; FURANS; KINETICS; MUSCIDAE; NAD(P)H DEHYDROGENASE (QUINONE); PYRIDINES; PYRIMIDINES; QUINAZOLINES; ROTENONE; SPECTROMETRY, FLUORESCENCE;

ANIMALIA; BOS TAURUS; BOVINAE; MUSCA DOMESTICA;

EID: 0344820721     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.5.2625     Document Type: Article

References (58)

1. Wikström, M. K. F. (1984) FEBS Lett. 169, 300-304
2. Weiss, H., and Friedrich, T. (1991) J. Bioenerg. Biomembr. 23, 743-771
3. Buchanan, S. K., and Walker, J. E. (1996) Biochem. J. 318, 343-349
4. Yagi, T., Yano, T., and Matsuno-Yagi, A. (1993) J. Bioenerg. Biomembr. 25, 339-345
5. Weidner, U., Geier, S., Ptock, A., Friedrich, T., Leif, H., and Weiss, H. (1993) J. Mol. Biol. 233, 109-122
6. Guenebaut, V., Vincentelli, R., Mills, D., Weiss, H., and Leonard, K. R. (1997) J. Mol. Biol. 265, 409-418
7. Guenebaut, V., Schlitt, A., Weiss, H., Leonard, K., and Friedrich, T. (1998) J. Mol. Biol. 276, 105-112
8. Grigorieff, N. (1998) J. Mol. Biol. 277, 1033-1046
9. Hofhaus, G., Weiss, H., and Leonard, K. (1991) J. Mol. Biol. 221, 1027-1043
10. Schulte, U., Fecke, W., Krüll, C., Nehls, U., Schmiede, A., Schneider, R., Ohnishi, T., and Weiss, H. (1994) Biochim. Biophys. Acta 1187, 121-124
11. Finel, M., and Majander, A. S. (1994) FEBS Lett. 339, 142-146
12. Ohnishi, T. (1998) Biochim. Biophys. Acta 1364, 186-206
13. Brandt, U. (1997) Biochim. Biophys. Acta 1318, 79-91
14. Suzuki, H., and King, T. E. (1983) J. Biol. Chem. 258, 352-358
15. Brandt, U., and Trumpower, B. L. (1994) CRC Crit. Rev. Biochem. 29, 165-197
16. Dutton, P. L., Moser, C. C., Sled, V. D., Daldal, F., and Ohnishi, T. (1998) Biochim. Biophys. Acta 1364, 245-257
17. Degli Esposti, M. (1998) Biochim. Biophys. Acta 1364, 222-235
18. Lümmen, P. (1998) Biochim. Biophys. Acta 1364, 287-296
19. Friedrich, T., van Heek, P., Leif, H., Ohnishi, T., Forche, E., Kunze, B., Jansen, E., Trowitzsch-Kienast, W., Höfle, G., Reichenbach, H. X., and Weiss, H. (1994) Eur. J. Biochem. 219, 691-698
20. Degli Esposti, M., and Ghelli, A. X. (1994) Biochim. Biophys. Acta 1187, 116-120
21. Vinogradov, A. D., Sled, V. D., Burbaev, D. S., Grivennikova, V. G. X., Moroz, I. A., and Ohnishi, T. (1995) FEBS Lett. 370, 83-87
22. Albracht, S. P. J., and de Jong, A. M. P. (1997) Biochim. Biophys. Acta 1318, 92-106
23. Friedrich, T., Ohnishi, T., Forche, E., Kunze, B., Jansen, R., Trowitzech, W., Hofle, G., Reichenbach, H. X., and Weiss, H. (1994) Biochem. Soc. Trans. 22, 226-230
24. Fato, R., Estornell, E., Di Bernardo, S., Pallotti, F., Castelli, G. P., and Lenaz, G. (1996) Biochemistry 35, 2705-2716
25. Degli Esposti, M., Ngo, A., McMullen, G. L. X., Ghelli, A. X., Sparla, F., Benelli, B., Ratta, M. X., and Linnane, A. W. (1996) Biochem. J. 313, 327-334
26. Singer, T. P., and Ramsay, R. R. (1992) in Molecular Mechanisms in Bioenergetics (Ernster, L., ed) pp. 145-162, Elsevier Science Publishers B.V., Amsterdam
27. Gutman, M., Singer, T. P., and Casida, J. E. (1970) J. Biol. Chem. 245, 1992-1997
28. Satoh, T., Miyoshi, H., Sakamoto, K., and Iwamura, H. (1996) Biochim. Biophys. Acta 1273, 21-30
29. Ueno, H., Miyoshi, H., Ebisui, K., and Iwamura, H. (1994) Eur. J. Biochem. 225, 411-417
30. Hollingworth, R. M. (1994) Biochem. Soc. Trans. 22, 230-233
31. Smith, A. L. (1967) Methods Enzymol. 10, 81-86
32. Thierbach, G., and Reichenbach, H. X. (1981) Biochim. Biophys. Acta 638, 282-289
33. Nedergaard, J., and Cannon, B. (1979) Methods Enzymol. 55, 3-28
34. Lenaz, G. (1998) Biochim. Biophys. Acta 1364, 207-221
35. Wan, Y.-P., Williams, R. H., Folkers, K., Leung, K. H., and Racker, E. (1975) Biochem. Biophys. Res. Commun. 63, 11-15
36. Brandt, U., and von Jagow, G. (1991) Eur. J. Biochem. 195, 163-170
37. Kim, S. J., Lee, K. O., Takamiya, S., and Capaldi, R. A. (1987) Biochim. Biophys. Acta 894, 270-276
38. Cremona, T., and Kearney, E. B. (1964) J. Biol. Chem. 239, 2328-2334
39. Blandini, F., and Greenamyre, J. T. (1995) Anal. Biochem. 230, 16-19
40. Higgins, D. S., Jr., and Greenamyre, J. T. (1996) J. Neurosci. 16, 3807-3816
41. Jewess, P. J. (1994) Biochem. Soc. Trans. 22, 247-251
42. Cheng, Y.-C., and Prusoff, W. H. (1973) Biochem. Pharmacol. 22, 3099-3108
43. Weiland, G. A., and Molinoff, P. B. (1981) Life Sci. 29, 313-330
44. Vinogradov, A. D. (1998) Biochim. Biophys. Acta 1364, 169-185
45. Degli Esposti, M., Ghelli, A. X., Ratta, M. X., Cortes, D., and Estornell, E. (1994) Biochem. J. 301, 161-167
46. Burbaev, D. S., Moroz, I. A., Kotlyar, A. B., Sled, V. D., and Vinogradov, A. D. (1989) FEBS Lett. 254, 47-51
47. Ueno, H., Miyoshi, H., Inoue, M., Niidome, Y., and Iwamura, H. (1996) Biochim. Biophys. Acta 1276, 195-202
48. Horgan, D. J., Singer, T. P., and Casida, J. E. (1968) J. Biol. Chem. 243, 834-843
49. Brandt, U. (1998) BioFactors, in press
50. Gutman, M., Mersmann, H., Luthy, J., and Singer, T. P. (1970) Biochemistry 9, 2678-2687
51. Darrouzet, E., and Dupuis, A. (1997) Biochim. Biophys. Acta 1319, 1-4
52. Ohshima, M., Miyoshi, H., Sakamoto, K., Takegami, K., Iwata, J., Kuwabara, K., Iwamura, H., and Yagi, T. (1998) Biochemistry 37, 6436-6445
53. Gutman, M. (1980) Biochim. Biophys. Acta 594, 53-84
54. Sinning, I. (1992) Trends Biochem. Sci. 17, 150-155
55. Xia, D., Yu, C.-A., Kim, H., Xia, J. Z., Kachurin, A. M., Zhang, L., Yu, L., and Deisenhofer, J. (1997) Science 277, 60-66
56. Zhang, Z., Huang, L., Shulmeister, V. M., Chi, Y.-I., Kim, K. K., Hung, L.-W., Crofts, A. R., Berry, E. A., and Kim, S.-H. (1998) Nature 392, 677-684
57. Iwata, S., Lee, J. W., Okada, K., Lee, J. K., Iwata, M., Rasmussen, B., Link, T. A., and Jap, B. K. (1998) Science 281, 64-71
58. Deisenhofer, J., Epp, O., Miki, K., Huber, R., and Michel, H. (1985) Nature 318, 618-624