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Volumn 18, Issue 21, 1999, Pages 5827-5833

Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2

Author keywords

Mitochondria; Obesity; Proton transport; Retinoic acid; Uncoupling protein

Indexed keywords

2 NAPHTHOIC ACID; 4 [(5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL)CARBOXAMIDO]BENZOIC ACID; 4 [2 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL) 1 PROPENYL]BENZOIC ACID; ACRYLIC ACID; BENZOIC ACID; CAFFEIC ACID; CINNAMIC ACID; DOCOSAHEXAENOIC ACID; FATTY ACID; FERULIC ACID; NORADRENALIN; PROTON; RETINOIC ACID; RETINOID; SORBIC ACID; UNCOUPLING PROTEIN; UROCANIC ACID;

EID: 0344678342     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.21.5827     Document Type: Article
Times cited : (183)

References (49)
  • 1
    • 0028955276 scopus 로고
    • A novel regulatory pathway of brown fat thermogenesis. Retinoic acid is a transcriptional activator of the mitochondrial uncoupling protein gene
    • Alvarez, R., de Andres, J., Yubero, P., Vinas, O., Mampel, T., Iglesias, R., Giralt, M. and Villarroya, F. (1995) A novel regulatory pathway of brown fat thermogenesis. Retinoic acid is a transcriptional activator of the mitochondrial uncoupling protein gene. J. Biol. Chem., 270, 5666-5673.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5666-5673
    • Alvarez, R.1    De Andres, J.2    Yubero, P.3    Vinas, O.4    Mampel, T.5    Iglesias, R.6    Giralt, M.7    Villarroya, F.8
  • 6
    • 0031972878 scopus 로고    scopus 로고
    • Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature
    • Boss, O., Samec, S., Kuhne, F., Bijlenga, P., Assimacopoulos-Jeannet, F., Seydoux, J., Giacobino, J.P. and Muzzin, P. (1998b) Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature. J. Biol. Chem., 273, 5-8.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5-8
    • Boss, O.1    Samec, S.2    Kuhne, F.3    Bijlenga, P.4    Assimacopoulos-Jeannet, F.5    Seydoux, J.6    Giacobino, J.P.7    Muzzin, P.8
  • 7
    • 0028207198 scopus 로고
    • A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein
    • Bouillaud, F., Arechaga, I., Petit, P.X., Raimbault, S., Levi-Meyrueis, C., Casteilla, L., Laurent, M., Rial, E. and Ricquier, D. (1994) A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein. EMBO J., 13, 1990-1997.
    • (1994) EMBO J. , vol.13 , pp. 1990-1997
    • Bouillaud, F.1    Arechaga, I.2    Petit, P.X.3    Raimbault, S.4    Levi-Meyrueis, C.5    Casteilla, L.6    Laurent, M.7    Rial, E.8    Ricquier, D.9
  • 8
    • 0000672457 scopus 로고
    • Metabolic regulation via intracellular pH
    • Busa, W.B. and Nuccitelli, R. (1984) Metabolic regulation via intracellular pH. Am. J. Physiol., 246, R409-R438.
    • (1984) Am. J. Physiol. , vol.246
    • Busa, W.B.1    Nuccitelli, R.2
  • 9
    • 0018337321 scopus 로고
    • Mitochondria from brown adipose tissue: Isolation and properties
    • Cannon, B. and Lindberg, O. (1979) Mitochondria from brown adipose tissue: isolation and properties. Methods Enzymol., 55, 65-78.
    • (1979) Methods Enzymol. , vol.55 , pp. 65-78
    • Cannon, B.1    Lindberg, O.2
  • 10
    • 0027938708 scopus 로고
    • In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets1, retinoid X receptor, thyroid hormone receptor and a CACCC box-binding protein
    • Cassard-Doulcier, A.M., Larose, M., Matamala, J.C., Champigny, O., Bouillaud, F. and Ricquier, D. (1994) In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets1, retinoid X receptor, thyroid hormone receptor and a CACCC box-binding protein. J. Biol. Chem., 269, 24335-24342.
    • (1994) J. Biol. Chem. , vol.269 , pp. 24335-24342
    • Cassard-Doulcier, A.M.1    Larose, M.2    Matamala, J.C.3    Champigny, O.4    Bouillaud, F.5    Ricquier, D.6
  • 11
    • 0033605261 scopus 로고    scopus 로고
    • Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion
    • Chavin, K.D. et al. (1999) Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J. Biol. Chem., 274, 5692-5700.
    • (1999) J. Biol. Chem. , vol.274 , pp. 5692-5700
    • Chavin, K.D.1
  • 12
    • 0021145070 scopus 로고
    • Does brown adipose tissue have a metabolic role in the rat?
    • Cooney, G.J. and Newsholme, E.A. (1984) Does brown adipose tissue have a metabolic role in the rat? Trends Biochem. Sci., 9, 303-305.
    • (1984) Trends Biochem. Sci. , vol.9 , pp. 303-305
    • Cooney, G.J.1    Newsholme, E.A.2
  • 14
    • 0032489269 scopus 로고    scopus 로고
    • Induction of UCP2 gene expression by LPS: A potential mechanism for increased thermogenesis during infection
    • Faggioni, R., Shigenaga, J., Moser, A., Feingold, K.R. and Grunfeld, C. (1998) Induction of UCP2 gene expression by LPS: a potential mechanism for increased thermogenesis during infection. Biochem. Biophys. Res. Commun., 244, 75-78.
    • (1998) Biochem. Biophys. Res. Commun. , vol.244 , pp. 75-78
    • Faggioni, R.1    Shigenaga, J.2    Moser, A.3    Feingold, K.R.4    Grunfeld, C.5
  • 15
    • 0014750409 scopus 로고
    • Conversion of carbohydrate to fat in adipose tissue: An energy-yielding and, therefore, self-limiting process
    • Flatt, J.P. (1970) Conversion of carbohydrate to fat in adipose tissue: an energy-yielding and, therefore, self-limiting process. J. Lipid Res., 11, 131-143.
    • (1970) J. Lipid Res. , vol.11 , pp. 131-143
    • Flatt, J.P.1
  • 16
    • 0031019249 scopus 로고    scopus 로고
    • Uncoupling-protein-2: A novel gene linked to obesity and hyperinsulinemia
    • Fleury, C. et al. (1997) Uncoupling-protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genet., 15, 269-272.
    • (1997) Nature Genet. , vol.15 , pp. 269-272
    • Fleury, C.1
  • 17
    • 0024289816 scopus 로고
    • The regulation of the intracellular pH in cells from vertebrates
    • Frelin, C., Vigne, P., Ladoux, A. and Lazdunski, M. (1988) The regulation of the intracellular pH in cells from vertebrates. Eur. J. Biochem., 174, 3-14.
    • (1988) Eur. J. Biochem. , vol.174 , pp. 3-14
    • Frelin, C.1    Vigne, P.2    Ladoux, A.3    Lazdunski, M.4
  • 18
    • 15144356206 scopus 로고    scopus 로고
    • Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis
    • Gimeno, R.E. et al. (1997) Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis. Diabetes, 46, 900-906.
    • (1997) Diabetes , vol.46 , pp. 900-906
    • Gimeno, R.E.1
  • 19
    • 0030869755 scopus 로고    scopus 로고
    • Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists and leptin
    • Gong, D.W., He, Y., Karas, M. and Reitman, M. (1997) Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists and leptin. J. Biol. Chem., 272, 24129-24132.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24129-24132
    • Gong, D.W.1    He, Y.2    Karas, M.3    Reitman, M.4
  • 21
    • 0342602044 scopus 로고    scopus 로고
    • Deletion of amino acids 261-269 in the brown fat uncoupling protein converts the carrier into a pore
    • Gonzalez-Barroso, M.M., Fleury, C., Levi-Meyrueis, C., Zaragoza, P., Bouillaud, F. and Rial, E. (1997) Deletion of amino acids 261-269 in the brown fat uncoupling protein converts the carrier into a pore. Biochemistry, 36, 10930-10935.
    • (1997) Biochemistry , vol.36 , pp. 10930-10935
    • Gonzalez-Barroso, M.M.1    Fleury, C.2    Levi-Meyrueis, C.3    Zaragoza, P.4    Bouillaud, F.5    Rial, E.6
  • 22
    • 0343900275 scopus 로고    scopus 로고
    • The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter
    • Gonzalez-Barroso, M.M., Fleury, C., Bouillaud, F., Nicholls, D.G. and Rial, E. (1998) The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter. J. Biol. Chem., 273, 15528-15532.
    • (1998) J. Biol. Chem. , vol.273 , pp. 15528-15532
    • Gonzalez-Barroso, M.M.1    Fleury, C.2    Bouillaud, F.3    Nicholls, D.G.4    Rial, E.5
  • 23
    • 0028947696 scopus 로고
    • Fluorescent nucleotide derivatives as specific probes for the uncoupling protein: Thermodynamics and kinetics of binding and the control by pH
    • Huang, S.G. and Klingenberg, M. (1995) Fluorescent nucleotide derivatives as specific probes for the uncoupling protein: thermodynamics and kinetics of binding and the control by pH. Biochemistry, 34, 349-360.
    • (1995) Biochemistry , vol.34 , pp. 349-360
    • Huang, S.G.1    Klingenberg, M.2
  • 24
    • 0024439087 scopus 로고
    • Retinobenzoic acids. 4. Conformation of aromatic amides with retinoidal activity. Importance of trans-amide structure for the activity
    • Kagechika, H., Himi, T., Kawachi, E. and Shudo, K. (1989) Retinobenzoic acids. 4. Conformation of aromatic amides with retinoidal activity. Importance of trans-amide structure for the activity. J. Med. Chem., 32, 2292-2296.
    • (1989) J. Med. Chem. , vol.32 , pp. 2292-2296
    • Kagechika, H.1    Himi, T.2    Kawachi, E.3    Shudo, K.4
  • 25
    • 0032506124 scopus 로고    scopus 로고
    • Retinoic acid alters the intracellular trafficking of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymes
    • Kang, J.X., Bell, J., Leaf, A., Beard, R.L. and Chandraratna, R.A. (1998) Retinoic acid alters the intracellular trafficking of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymes. Proc. Natl Acad. Sci. USA, 95, 13687-13691.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 13687-13691
    • Kang, J.X.1    Bell, J.2    Leaf, A.3    Beard, R.L.4    Chandraratna, R.A.5
  • 26
    • 0032901360 scopus 로고    scopus 로고
    • Structure and function of the uncoupling protein from brown adipose tissue
    • Klingenberg, M. and Huang, S.G. (1999) Structure and function of the uncoupling protein from brown adipose tissue. Biochim. Biophys. Acta, 1415, 271-296.
    • (1999) Biochim. Biophys. Acta , vol.1415 , pp. 271-296
    • Klingenberg, M.1    Huang, S.G.2
  • 30
    • 0020466940 scopus 로고
    • Fatty acids as acute regulators of the proton conductance of hamster brown-fat mitochondria
    • Locke, R.M., Rial, E., Scott, I.D. and Nicholls, D.G. (1982) Fatty acids as acute regulators of the proton conductance of hamster brown-fat mitochondria. Eur. J. Biochem., 129, 373-380.
    • (1982) Eur. J. Biochem. , vol.129 , pp. 373-380
    • Locke, R.M.1    Rial, E.2    Scott, I.D.3    Nicholls, D.G.4
  • 31
    • 0032175676 scopus 로고    scopus 로고
    • Characterization of the yeast mitochondria unselective channel: A counterpart to the mammalian permeability transition pore?
    • Manon, S., Roucou, X., Guerin, M., Rigoulet, M. and Guerin, B. (1998) Characterization of the yeast mitochondria unselective channel: a counterpart to the mammalian permeability transition pore? J. Bioenerg. Biomembr., 30, 419-429.
    • (1998) J. Bioenerg. Biomembr. , vol.30 , pp. 419-429
    • Manon, S.1    Roucou, X.2    Guerin, M.3    Rigoulet, M.4    Guerin, B.5
  • 32
    • 0032998265 scopus 로고    scopus 로고
    • UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
    • Mao, W., Yu, X.X., Zhong, A., Li, W., Brush, J., Sherwood, S.W., Adams, S.H. and Pan, G. (1999) UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett., 443, 326-330.
    • (1999) FEBS Lett. , vol.443 , pp. 326-330
    • Mao, W.1    Yu, X.X.2    Zhong, A.3    Li, W.4    Brush, J.5    Sherwood, S.W.6    Adams, S.H.7    Pan, G.8
  • 33
    • 0030733473 scopus 로고    scopus 로고
    • Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: Their gene expression in rats fed high-fat diet
    • Matsuda, J. et al. (1997) Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet. FEBS Lett., 418, 200-204.
    • (1997) FEBS Lett. , vol.418 , pp. 200-204
    • Matsuda, J.1
  • 34
    • 0017264191 scopus 로고
    • Hamster brown adipose tissue mitochondria. Purine nucleotides control of the ion conductance of the inner membrane, the nature of the nucleotide binding site
    • Nicholls, D.G. (1976) Hamster brown adipose tissue mitochondria. Purine nucleotides control of the ion conductance of the inner membrane, the nature of the nucleotide binding site. Eur. J. Biochem., 62, 223-228.
    • (1976) Eur. J. Biochem. , vol.62 , pp. 223-228
    • Nicholls, D.G.1
  • 35
    • 0021322138 scopus 로고
    • Thermogenic mechanisms in brown fat
    • Nicholls, D.G. and Locke, R.M. (1984) Thermogenic mechanisms in brown fat. Physiol. Rev., 64, 1-64.
    • (1984) Physiol. Rev. , vol.64 , pp. 1-64
    • Nicholls, D.G.1    Locke, R.M.2
  • 36
    • 0029052979 scopus 로고
    • The mechanism for the ATP-induced uncoupling of respiration in mitochondria of the yeast Saccharomyces cerevisiae
    • Prieto, S., Bouillaud, F. and Rial, E. (1995) The mechanism for the ATP-induced uncoupling of respiration in mitochondria of the yeast Saccharomyces cerevisiae. Biochem. J., 307, 657-661.
    • (1995) Biochem. J. , vol.307 , pp. 657-661
    • Prieto, S.1    Bouillaud, F.2    Rial, E.3
  • 37
    • 0029793299 scopus 로고    scopus 로고
    • In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid
    • Puigserver, P., Vazquez, F., Bonet, M.L., Pico, C. and Palou, A. (1996) In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid. Biochem. J., 317, 827-833.
    • (1996) Biochem. J. , vol.317 , pp. 827-833
    • Puigserver, P.1    Vazquez, F.2    Bonet, M.L.3    Pico, C.4    Palou, A.5
  • 38
    • 0021041042 scopus 로고
    • Brown adipose tissue mitochondria; the regulation of the 32 000 Mr uncoupling protein by fatty acids and nucleotides
    • Rial, E., Poustie, E. and Nicholls, D.G. (1983) Brown adipose tissue mitochondria; the regulation of the 32 000 Mr uncoupling protein by fatty acids and nucleotides. Eur. J. Biochem., 137, 197-203.
    • (1983) Eur. J. Biochem. , vol.137 , pp. 197-203
    • Rial, E.1    Poustie, E.2    Nicholls, D.G.3
  • 39
    • 0020628596 scopus 로고
    • An immunological study of the uncoupling protein of brown adipose tissue mitochondria
    • Ricquier, D., Barlet, J.P., Garel, J.M., Combes-George, M. and Dubois, M.P. (1983) An immunological study of the uncoupling protein of brown adipose tissue mitochondria. Biochem. J., 210, 859-866.
    • (1983) Biochem. J. , vol.210 , pp. 859-866
    • Ricquier, D.1    Barlet, J.P.2    Garel, J.M.3    Combes-George, M.4    Dubois, M.P.5
  • 40
    • 0022971574 scopus 로고
    • Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue. Evidence for a rapid beta-adrenoreceptor-mediated and transcriptionally regulated step during activation of thermogenesis
    • Ricquier, D., Bouillaud, F., Toumelin, P., Mory, G., Bazin, R., Arch, J. and Penicaud, L. (1986) Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue. Evidence for a rapid beta-adrenoreceptor-mediated and transcriptionally regulated step during activation of thermogenesis. J. Biol. Chem., 261, 13905-13910.
    • (1986) J. Biol. Chem. , vol.261 , pp. 13905-13910
    • Ricquier, D.1    Bouillaud, F.2    Toumelin, P.3    Mory, G.4    Bazin, R.5    Arch, J.6    Penicaud, L.7
  • 41
    • 0030854715 scopus 로고    scopus 로고
    • Cellular energy utilization and molecular origin of standard metabolic rate in mammals
    • Rolfe, D.F. and Brown, G.C. (1997) Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol. Rev., 77, 731-758.
    • (1997) Physiol. Rev. , vol.77 , pp. 731-758
    • Rolfe, D.F.1    Brown, G.C.2
  • 42
    • 0028556635 scopus 로고
    • Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat
    • Rolfe, D.F., Hulbert, A.J. and Brand, M.D. (1994) Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat. Biochim. Biophys. Acta, 1188, 405-416.
    • (1994) Biochim. Biophys. Acta , vol.1188 , pp. 405-416
    • Rolfe, D.F.1    Hulbert, A.J.2    Brand, M.D.3
  • 44
    • 0032545458 scopus 로고    scopus 로고
    • BMCPl, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents and respiration uncoupling activity in recombinant yeast
    • Sanchis, D. et al. (1998) BMCPl, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents and respiration uncoupling activity in recombinant yeast. J. Biol. Chem., 273, 34611-34615.
    • (1998) J. Biol. Chem. , vol.273 , pp. 34611-34615
    • Sanchis, D.1
  • 45
    • 0032564864 scopus 로고    scopus 로고
    • Uncoupling: New approaches to an old problem of bioenergetics
    • Skulachev, V.P. (1998) Uncoupling: new approaches to an old problem of bioenergetics. Biochim. Biophys. Acta, 1363, 100-124.
    • (1998) Biochim. Biophys. Acta , vol.1363 , pp. 100-124
    • Skulachev, V.P.1
  • 46
    • 0021077606 scopus 로고
    • Structure-activity relationships of a new series of retinoidal benzoic acid derivatives as measured by induction of differentiation of murine f9 teratocarcinoma cells and human hl-60 promyelocytic leukemia cells
    • Strickland, S., Breitman, T.R., Frickel, F., Nürrenbach, A., Hadicke, E. and Sporn, M.B. (1983) Structure-activity relationships of a new series of retinoidal benzoic acid derivatives as measured by induction of differentiation of murine f9 teratocarcinoma cells and human hl-60 promyelocytic leukemia cells. Cancer Res., 43, 5268-5272.
    • (1983) Cancer Res. , vol.43 , pp. 5268-5272
    • Strickland, S.1    Breitman, T.R.2    Frickel, F.3    Nürrenbach, A.4    Hadicke, E.5    Sporn, M.B.6
  • 48
    • 0031560941 scopus 로고    scopus 로고
    • UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
    • Vidal-Puig, A., Solanes, G., Grujic, D., Flier, J.S. and Lowell, B.B. (1997) UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem. Biophys. Res. Commun., 235, 79-82.
    • (1997) Biochem. Biophys. Res. Commun. , vol.235 , pp. 79-82
    • Vidal-Puig, A.1    Solanes, G.2    Grujic, D.3    Flier, J.S.4    Lowell, B.B.5
  • 49
    • 0032907853 scopus 로고    scopus 로고
    • Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system
    • Zhang, C.Y., Hagen, T., Mootha, V.K., Slieker, L.J. and Lowell, B.B. (1999) Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system. FEBS Lett., 449, 129-134.
    • (1999) FEBS Lett. , vol.449 , pp. 129-134
    • Zhang, C.Y.1    Hagen, T.2    Mootha, V.K.3    Slieker, L.J.4    Lowell, B.B.5


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