Presynaptic lonotropic Receptors

Handbook of Experimental Pharmacology

Volumn 184, Issue , 2008, Pages 479-527

  Dorostkar, M M ^a   Boehm, S ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ION CHANNEL; NEUROTRANSMITTER RECEPTOR; PRESYNAPTIC RECEPTOR;

ANIMAL; CLASSIFICATION; DRUG EFFECT; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; HUMANS; ION CHANNELS; NEUROTRANSMITTER AGENTS; RECEPTORS, NEUROTRANSMITTER; RECEPTORS, PRESYNAPTIC;

EID: 39349104519     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-540-74805-2_15     Document Type: Article

References (294)

1. Ahluwalia J, Urban L, Bevan S, Nagy I (2003) Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid1 receptor and the vanilloid receptor1 in vitro. Eur J Neurosci 17:2611-18
2. Alkondon M, Albuquerque EX (2001) Nicotinic acetylcholine receptor alpha 7 and alpha 4beta 2 subtypes differentially control GABAergic input to CA1 neurons in rat hippocampus. J Neurophysiol 86:3043-55
3. Alkondon M, Albuquerque EX (2002) A non-alpha 7 nicotinic acetylcholine receptor modulates excitatory input to hippocampal CA1 interneurons. J Neurophysiol 87: 651-4
4. Alkondon M, Rocha ES, Maelicke A, Albuquerque EX (1996) Diversity of nicotinic acetylcholine receptors in rat brain. V. alpha-Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release. J Pharmacol Exp Ther 278:1460-71
5. Allgaier C, Warnke P, Stangl AP, Feuerstein TJ (1995) Effects of 5-HT receptor agonists on depolarization-induced [3H]-noradrenaline release in rabbit hippocampus and human neocortex. Br J Pharmacol 116:1769-74
6. Amara SG, Fontana ACK (2002) Excitatory amino acid transporters: keeping up with glutamate. Neurochem Internat 41:313
7. Armstrong JN, Brust TB, Lewis RG, MacVicar BA (2002) Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated proteink. J Neurosci 22:5938-45
8. Artalejo CR, Ariano MA, Perlman RL, Fox AP (1990) Activation of facilitation calcium channels in chromaffin cells by D1 dopamine receptors through a cAMP/protein kinase A-dependent mechanism. Nature 348:239-42
9. Attwell D, Barbour B, Szatkowski M (1993) Nonvesicular release of neurotransmitter. Neuron 11:401-7
10. Augustine GJ (2001) How does calcium trigger neurotransmitter release? Curr Opin Neurobiol 11:320-6
11. Awatramani GB, Price GD, Trussell LO (2005) Modulation of transmitter release by presynaptic resting potential and background calcium levels. Neuron 48:109-21
12. Axmacher N, Draguhn A (2004) Inhibition of GABA release by presynaptic ionotropic GABA receptors in hippocampal CA3. Neuroreport 15:329-34
13. Axmacher N,Winterer J, Stanton PK, Draguhn A, MullerW (2004) Two-photon imaging of spontaneous vesicular release in acute brain slices and its modulation by presynaptic GABAA receptors. NeuroImage 22:1014
14. Azam L, McIntosh JM (2006) Characterization of nicotinic acetylcholine receptors that modulate nicotine-evoked [3H]norepinephrine release from mouse hippocampal synaptosomes. Mol Pharmacol 70:967-76
15. Barajas-Lopez C, Montano LM, Espinosa-Luna R (2002) Inhibitory interactions between 5-HT3 and P2X channels in submucosal neurons. Am J Physiol Gastrointest Liver Physiol 283:G1238-48
16. Barazangi N, Role LW (2001) Nicotine-induced enhancement of glutamatergic and GABAergic synaptic transmission in the mouse amygdala. J Neurophysiol 86:463-74
17. Bardoni R, Torsney C, Tong C-K, Prandini M, MacDermott AB (2004) Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn. J Neurosci 24: 2774-81
18. Barik J, Wonnacott S (2006) Indirect modulation by {alpha}7 nicotinic acetylcholine receptors of noradrenaline release in rat hippocampal slices: interaction with glutamate and GABA systems and effect of nicotine withdrawal. Mol Pharmacol 69: 618-28
19. Barnes JM, Barnes NM, Costall B, Naylor RJ, Tyers MB (1989) 5-HT3 receptors mediate inhibition of acetylcholine release in cortical tissue. Nature 338:762-3
20. Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-1152
21. Barnoya J, Glantz SA (2005) Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation 111:2684-98
22. Belenky MA, Sagiv N, Fritschy JM, Yarom Y (2003) Presynaptic and postsynaptic GABAA receptors in rat suprachiasmatic nucleus. Neuroscience 118:909
23. Benowitz NL (1997) The role of nicotine in smoking-related cardiovascular disease. Prev Med 26:412-17
24. Benowitz NL, Hansson A, Jacob P, 3rd (2002) Cardiovascular effects of nasal and transdermal nicotine and cigarette smoking. Hypertension 39:1107-12
25. Berretta N, Jones RSG (1996) Tonic facilitation of glutamate release by presynaptic N-methyl-Daspartate autoreceptors in the entorhinal cortex. Neuroscience 75:339
26. Betz H, Laube B (2006) Glycine receptors: recent insights into their structural organization and functional diversity. J Neurochem 97:1600-10
27. Blandina P, Goldfarb J, Craddock-Royal B, Green JP (1989) Release of endogenous dopamine by stimulation of 5-hydroxytryptamine3 receptors in rat striatum. J Pharmacol Exp Ther 251:803-9
28. Blier P, Bouchard C (1993) Functional characterization of a 5-HT3 receptor which modulates the release of 5-HT in the guinea-pig brain. Br J Pharmacol 108:13-22
29. Boczan J, Leenders AG, Sheng ZH (2004) Phosphorylation of syntaphilin by cAMP-dependent protein kinase modulates its interaction with syntaxin-1 and annuls its inhibitory effect on vesicle exocytosis. J Biol Chem 279:18911-19
30. Boehm S (1999) ATP stimulates sympathetic transmitter release via presynaptic P2X purinoceptors. J Neurosci 19: 737-46
31. Boehm S, Drobny H, Singer E (1991) Electrically evoked noradrenaline release from cultured chick sympathetic neurons: modulation via presynaptic α2-adrenoceptors and lack of autoinhibition. Naunyn Schmiedebergs Arch Pharmacol 344:130-2
32. Boehm S, Huck S, Drobny H, Singer EA (1992) Pertussis toxin abolishes the inhibition of Ca2+ currents and of noradrenaline release via alpha 2-adrenoceptors in chick sympathetic neurons. Naunyn Schmiedebergs Arch Pharmacol 345:606-9
33. Bonanno G, Raiteri M (1987) Release-regulating GABAA receptors are present on noradrenergic nerve terminals in selective areas of the rat brain. Synapse 1: 254-7
34. Bonanno G, Fontana G, Fedele E, Robino G, RaiteriM (1989) Presynaptic mechanisms underlying the gamma-aminobutyric acid-evoked receptor-independent release of [3H]norepinephrine in rat hippocampus. J Neurochem 52:1854-8
35. Boue-Grabot E, Emerit MB, Toulme E, Seguela P, Garret M (2004) Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels. J Biol Chem 279:6967-75
36. Bouron A, Reuter H (1996) A role of intracellular Na+ in the regulation of synaptic transmission and turnover of the vesicular pool in cultured hippocampal cells. Neuron 17:969-78
37. Bowman W, Gibb A, Harvey A, Marshall I (1986) Prejunctional actions of cholinoceptor agonists and antagonists, and of anticholinesterase drugs. Handb Exp Pharmacol 79:141-70
38. BragaMF, Aroniadou-Anderjaska V, Xie J, Li H (2003) Bidirectional modulation of GABA release by presynaptic glutamate receptor 5 kainate receptors in the basolateral amygdala. J Neurosci 23:442-52
39. Breukel AIM, Besselsen E, da Silva FHL, Ghijsen WEJM (1998) A presynaptic N methyl d aspartate autoreceptor in rat hippocampus modulating amino acid release from a cytoplasmic pool. Eur J Neurosci 10:106-14
40. Brown AM, Birnbaumer L (1990) Ionic channels and their regulation by G protein subunits. Annu Rev Physiol 52:197-213
41. Cao YJ, Surowy CS, Puttfarcken PS (2005a) Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release. Neuropharmacology 48:72-9
42. Cao YJ, Surowy CS, Puttfarcken PS (2005b) Nicotinic acetylcholine receptor-mediated [3H]dopamine release from hippocampus. J Pharmacol Exp Ther 312: 1298-1304
43. Casado M, Isope P, Ascher P (2002) Involvement of presynaptic N-methyl-D-aspartate receptors in cerebellar long-term depression. Neuron 33:123
44. Cattaert D, El Manira A (1999) Shunting versus inactivation: analysis of presynaptic inhibitory mechanisms in primary afferents of the crayfish. J Neurosci 19:6079-89
45. Cerrito F, Aloisi G, Arminio P, Fanini D (1998) A new GABA-A receptor subtype coupled with Ca++/Cl-synporter modulates aminergic release from rat brain neuron terminals. J Neurosci Res 51:15-22
46. Chameau P, van Hooft JA (2006) Serotonin 5-HT (3) receptors in the central nervous system. Cell Tissue Res 326:573-81
47. Chergui K, Bouron A, Normand E, Mulle C (2000) Functional GluR6 kainate receptors in the striatum: indirect downregulation of synaptic transmission. J Neurosci 20:2175-82
48. Chheda MG, Ashery U, Thakur P, Rettig J, Sheng ZH (2001) Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex. Nat Cell Biol 3: 331-8
49. Chittajallu R, Vignes M, Dev KK, Barnes JM, Collingridge GL, Henley JM (1996) Regulation of glutamate release by presynaptic kainate receptors in the hippocampus. Nature 379:78
50. Christensen JK, Paternain AV, Selak S, Ahring PK, Lerma J (2004) A mosaic of functional kainate receptors in hippocampal interneurons. J Neurosci 24:8986-93
51. Clarke VRJ, Collingridge GL (2004) Characterisation of the effects of ATPA, a GLUK5 kainate receptor agonist, on GABAergic synaptic transmission in the CA1 region of rat hippocampal slices. Neuropharmacology 47:363
52. Clarke VRJ, Ballyk BA, Hoo KH , Mandelzys A, Pellizzari A, Bath CP, Thomas J, Sharpe EF, Davies CH, Ornstein PL, Schoepp DD, Kamboj RK, Collingridge GL, Lodge D, Bleakman D (1997) A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 389:599
53. Conradi S (1969) Ultrastructure of dorsal root boutons on lumbosacral motoneurons of the adult cat, as revealed by dorsal root section. Acta Physiol Scand Suppl 332: 85-115
54. Contractor A, Sailer AW, Darstein M, Maron C, Xu J, Swanson GT, Heinemann SF (2003) Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/-mice. J Neurosci 23:422-9
55. Contractor A, Swanson GT, Sailer A, O'Gorman S, Heinemann SF (2000) Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus. J Neurosci 20:8269-78
56. Cossart R, Tyzio R, Dinocourt C, Esclapez M, Hirsch JC, Ben-Ari Y, Bernard C (2001) Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons. Neuron 29:497
57. Crespi D, Gobbi M, Mennini T (1997) 5-HT3 serotonin hetero-receptors inhibit [3H]acetylcholine release in rat cortical synaptosomes. Pharmacological Res 35:351
58. Cunha RA, Ribeiro JA (2000) ATP as a presynaptic modulator. Life Sci 68:119-37
59. DeWaard M, Hering J,Weiss N, Feltz A (2005) How do G proteins directly control neuronal Ca2+ channel function? Trends Pharmacol Sci 26:427-36
60. Cunha RA, Constantino MD, Ribeiro JA (1997) Inhibition of [3H][gamma]-aminobutyric acid release by kainate receptor activation in rat hippocampal synaptosomes. Eur J Pharmacol 323:167
61. Delaney AJ, Jahr CE (2002) Kainate receptors differentially regulate release at two parallel fiber synapses. Neuron 36:475-82
62. Derbenev AV, Monroe MJ, Glatzer NR, Smith BN (2006) Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus. J Neurosci 26:9666-72
63. Dingledine R, Borges K, Bowie D, Traynelis SF (1999) The glutamate receptor ion channels. Pharmacol Rev 51:7-61
64. Dixon W (1924) Nicotin, Coniin, Piperidin, Lupetidin, Cytisin, Lobelin, Spartein, Gelsemin. Mittel, welche auf bestimmte Nervenzellen wirken. Handb Exp Pharmacol 2:656-36
65. Dooley DJ, Lupp A, Hertting G (1987) Inhibition of central neurotransmitter release by omegaconotoxin GVIA, a peptide modulator of the N-type voltage-sensitive calcium channel. Naunyn Schmiedebergs Arch Pharmacol 336:467-70
66. Dorostkar MM, Boehm S (2007) Opposite effects of presynaptic 5-HT3 receptor activation on spontaneous and action potential-evoked GABA release at hippocampal synapses. J Neurochem, in press
67. Doyle MW, Bailey TW, Jin Y-H, Andresen MC (2002) Vanilloid receptors presynaptically modulate cranial visceral afferent synaptic transmission in nucleus tractus solitarius. J Neurosci 22:8222-9
68. Dudel J, Kuffler SW (1961) Presynaptic inhibition at the crayfish neuromuscular junction. J Physiol 155:543-62
69. Duguid IC, Smart TG (2004) Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron-Purkinje cell synapses. Nat Neurosci 7:525
70. Eccles JC, Kostyuk PG, Schmidt RF (1962) Central pathways responsible for depolarization of primary afferent fibres. J Physiol 161:237-57
71. Elmslie KS (2003) Neurotransmitter modulation of neuronal calcium channels. J Bioenerg Biomembr 35:477-89
72. Engelman HS, Anderson RL, Daniele C, MacDermott AB (2006) Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate release of inhibitory amino acids in rat spinal cord dorsal horn. Neuroscience 139: 539
73. Engelman HS, MacDermott AB (2004) Presynaptic ionotropic receptors and control of transmitter release. Nat Rev Neurosci 5:135-45
74. Faist M, Dietz V, Pierrot-Deseilligny E (1996) Modulation, probably presynaptic in origin, of monosynaptic Ia excitation during human gait. Exp Brain Res 109:441-9
75. Felmy F, Neher E, Schneggenburger R (2003) The timing of phasic transmitter release is Ca2+-dependent and lacks a direct influence of presynaptic membrane potential. Proc Natl Acad Sci USA 100:15200-5
76. Ferezou I, Cauli B, Hill EL, Rossier J, Hamel E, Lambolez B (2002) 5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons. J Neurosci 22:7389-97
77. Ferkany JW, Zaczek R, Coyle JT (1982) Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors. Nature 298:757-9
78. Fink K, Gothert M, Molderings G, Schlicker E (1989) N-methyl-D-aspartate (NMDA) receptormediated stimulation of noradrenaline release, but not release of other neurotransmitters, in the rat brain cortex: receptor location, characterization and desensitization. Naunyn Schmiedeberg's Arch Pharmacol 339:514-21
79. Fozard JR, Ali AT (1978) Receptors for 5-hydroxytryptamine on the sympathetic nerves of the rabbit heart. Naunyn Schmiedeberg's Arch Pharmacol 301:223-35
80. Frank K, Fuortes MGF (1957) Presynaptic and postsynaptic inhibition of neurosynaptic reflex. Fed Proc 16:39-40
81. Frerking M, Schmitz D, Zhou Q, Johansen J, Nicoll RA (2001) Kainate receptors depress excitatory synaptic transmission at CA3{right-arrow} CA1synapses in the hippocampus via a direct presynaptic action. J Neurosci 21:2958-66
82. Fu WM, Huang FL (1994) Potentiation by endogenously released ATP of spontaneous transmitter secretion at developing neuromuscular synapses in Xenopus cell cultures. Br J Pharmacol 111:880-6
83. Fuder H, Muscholl E (1995) Heteroreceptor-mediated modulation of noradrenaline and acetylcholine release from peripheral nerves. Rev Physiol Biochem Pharmacol 126:265-412
84. Funahashi M, Mitoh Y, Matsuo R (2004a) Activation of presynaptic 5-HT3 receptors facilitates glutamatergic synaptic inputs to area postrema neurons in rat brain slices. Methods Find Exp Clin Pharmacol 26:615-22
85. Funahashi M, Mitoh Y, Matsuo R (2004b) Nicotinic modulation of area postrema neuronal excitability in rat brain slices. Brain Res 1017:227
86. Gamper N, Reznikov V, Yamada Y, Yang J, Shapiro MS (2004) Phosphatidylinositol 4,5-bisphosphate signals underlie receptor-specific Gq/11-mediated modulation of N-type Ca2+ channels. J Neurosci 24:10980-92
87. Garcia AG, Albillos A, Cano-Abad MF, Garcia-Palomero E, Hernandez-Guijo M, Herrero CJ, Lomax RB, Gandia L (1998) Calcium channels for exocytosis in chromaffin cells. Adv Pharmacol 42:91-4
88. Gerstbrein K, Sitte HH (2006) Currents in neurotransmitter transporters. Handb Exp Pharmacol:95-111
89. Gothert M, Duhrsen U (1979) Effects of 5-hydroxytryptamine and related compounds on the sympathetic nerves of the rabbit heart. Naunyn Schmiedebergs Arch Pharmacol 308:9-18
90. Gotti C, Zoli M, Clementi F (2006) Brain nicotinic acetylcholine receptors: native subtypes and their relevance. Trends Pharmacol Sci 27:482-91
91. Grady SR, Meinerz NM, Cao J, Reynolds AM, Picciotto MR, Changeux JP, McIntosh JM, Marks MJ, Collins AC (2001) Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum. J Neurochem 76:258-68
92. Grady SR, Murphy KL, Cao J, Marks MJ, McIntosh JM, Collins AC (2002) Characterization of nicotinic agonist-induced [ (3) H]dopamine release from synaptosomes prepared from four mouse brain regions. J Pharmacol Exp Ther 301: 651-60
93. Graham B, Redman S (1994) A simulation of action potentials in synaptic boutons during presynaptic inhibition. J Neurophysiol 71:538-49
94. Grassi G, Seravalle G, Calhoun DA, Bolla GB, Giannattasio C, Marabini M, Del Bo A, Mancia G (1994) Mechanisms responsible for sympathetic activation by cigarette smoking in humans. Circulation 90:248-53
95. Gray R, Rajan AS, Radcliffe KA, Yakehiro M, Dani JA (1996) Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature 383:713-16
96. Gu JG, MacDermott AB (1997) Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature 389:749-53
97. Haass M, Kubler W (1997) Nicotine and sympathetic neurotransmission. Cardiovasc Drugs Ther 10:657-65
98. Heidelberger R, Heinemann C, Neher E, Matthews G (1994) Calcium dependence of the rate of exocytosis in a synaptic terminal. Nature 371:513-15
99. Henningfield JE (1995) Nicotine medications for smoking cessation. N Engl J Med 333:1196-1203
100. Hille B (1994) Modulation of ion-channel function by G-protein-coupled receptors. Trends Neurosci 17:531-6
101. Hirai H, Launey T, Mikawa S, Torashima T, Yanagihara D, Kasaura T, Miyamoto A, Yuzaki M (2003) New role of delta2-glutamate receptors in AMPA receptor trafficking and cerebellar function. Nat Neurosci 6:869-76
102. Hirling H, Scheller RH (1996) Phosphorylation of synaptic vesicle proteins: modulation of the alpha SNAP interaction with the core complex. Proc Natl Acad Sci USA 93:11945-9
103. Hirning LD, Fox AP, McCleskey EW, Olivera BM, Thayer SA, Miller RJ, Tsien RW (1988) Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons. Science 239:57-61
104. Hultborn H, Meunier S, Pierrot-Deseilligny E, Shindo M (1987) Changes in presynaptic inhibition of Ia fibres at the onset of voluntary contraction in man. J Physiol 389:757-72
105. Ireland MF, Noakes PG, Bellingham MC (2004) P2X7-like receptor subunits enhance excitatory synaptic transmission at central synapses by presynaptic mechanisms. Neuroscience 128:269
106. Jang I-S, Jeong H-J, Katsurabayashi S, Akaike N (2002) Functional roles of presynaptic GABAA receptors on glycinergic nerve terminals in the rat spinal cord. J Physiol (Lond) 541:423-34
107. Jang IS, Ito Y, Akaike N (2005) Feed-forward facilitation of glutamate release by presynaptic GABAA receptors. Neuroscience 135:737
108. Jang IS, Nakamura M, Ito Y, Akaike N (2006) Presynaptic GABAA receptors facilitate spontaneous glutamate release from presynaptic terminals on mechanically dissociated rat CA3 pyramidal neurons. Neuroscience 138:25
109. Jeong H-J, Jang I-S, Moorhouse AJ, Akaike N (2003) Activation of presynaptic glycine receptors facilitates glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus neurons. J Physiol (Lond) 550: 373-83
110. Jiang L, Xu J, Nedergaard M, Kang J (2001) A kainate receptor increases the efficacy of GABAergic synapses. Neuron 30:503
111. Jin Y-H, Bailey TW, Li B-y, Schild JH, Andresen MC (2004) Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius. J Neurosci 24:4709-17
112. Johnson RM, Inouye GT, Eglen RM, Wong EH (1993) 5-HT3 receptor ligands lack modulatory influence on acetylcholine release in rat entorhinal cortex. Naunyn Schmiedebergs Arch Pharmacol 347:241-7
113. Kaczmarek L, Levitan I (1987) Neuromodulation: the biochemical control of neuronal excitability. Oxford University Press, New York
114. Kaiser S, Wonnacott S (2000) alpha-Bungarotoxin-sensitive nicotinic receptors indirectly modulate [3H]dopamine release in rat striatal slices via glutamate release. Mol Pharmacol 58:312-318
115. Kamp MA, Krieger A, Henry M, Hescheler J, Weiergraber M, Schneider T (2005) Presynaptic 'Ca2. 3-containing' E-type Ca channels share dual roles during neurotransmitter release. Eur J Neurosci 21:1617-25
116. Kandel ER (2001) The molecular biology of memory storage: a dialogue between genes and synapses. Science 294:1030-8
117. Karnovsky AM, Gotow LF, McKinley DD, Piechan JL, Ruble CL, Mills CJ, Schellin KAB, Slightom JL, Fitzgerald LR, Benjamin CW, Roberds SL (2003) A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene 319:137
118. Kato F, Shigetomi E (2001) Distinct modulation of evoked and spontaneous EPSCs by purinoceptors in the nucleus tractus solitarii of the rat. J Physiol (Lond) 530:469-86
119. Katsurabayashi S, Kubota H, Tokutomi N, Akaike N (2003) A distinct distribution of functional presynaptic 5-HT receptor subtypes on GABAergic nerve terminals projecting to single hippocampal CA1 pyramidal neurons. Neuropharmacology 44: 1022-30
120. Kawa K (1994) Distribution and functional properties of 5-HT3 receptors in the rat hippocampal dentate gyrus: a patch-clamp study. J Neurophysiol. 71:1935-47
121. Kerchner GA, Wang GD, Qiu CS, Huettner JE, Zhuo M (2001a) Direct presynaptic regulation of GABA/glycine release by kainate receptors in the dorsal horn: an ionotropic mechanism. Neuron 32:477-88
122. Kerchner GA, Wilding TJ, Huettner JE, Zhuo M (2002) Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn. J Neurosci 22:8010-17
123. Kerchner GA, Wilding TJ, Li P, Zhuo M, Huettner JE (2001b) Presynaptic kainate receptors regulate spinal sensory transmission. J Neurosci 21:59-66
124. Khakh BS, Henderson G (1998) ATP receptor-mediated enhancement of fast excitatory neurotransmitter release in the brain. Mol Pharmacol 54:372-8
125. Khakh BS, Henderson G (2000) Modulation of fast synaptic transmission by presynaptic ligandgated cation channels. J Autonom Nerv Sys 81:110
126. Khakh BS, North RA (2006) P2X receptors as cell-surface ATP sensors in health and disease. Nature 442:527
127. Khakh BS, Zhou X, Sydes J, Galligan JJ, Lester HA (2000) State-dependent cross-inhibition between transmitter-gated cation channels. Nature 406:405-10
128. Khakh BS, Gittermann D, Cockayne DA, Jones A (2003) ATP Modulation of excitatory synapses onto interneurons. J Neurosci 23:7426-37
129. Khakh BS, Fisher JA, Nashmi R, Bowser DN, Lester HA (2005) An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with fluorescence resonance energy transfer and total internal reflection fluorescence microscopy. J Neurosci 25:6911-20
130. Kirischuk S, Akyeli J, Iosub R, Grantyn R (2003) Pre-and postsynaptic contribution of GABAC receptors to GABAergic synaptic transmission in rat collicular slices and cultures. Eur J Neurosci 18:752-8
131. Kiyosawa A, Katsurabayashi S, Akaike N, Pang ZP, Akaike N (2001) Nicotine facilitates glycine release in the rat spinal dorsal horn. J Physiol (Lond) 536:101-10
132. Ko S, Zhao MG, Toyoda H, Qiu CS, Zhuo M (2005) Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)-or GluR6-deficient mice. J Neurosci 25:977-84
133. Koga H, Ishibashi H, Shimada H, Jang I-S, Nakamura TY, Nabekura J (2005) Activation of presynaptic GABAA receptors increases spontaneous glutamate release onto noradrenergic neurons of the rat locus coeruleus. Brain Res 1046:24
134. Koh DS, Hille B (1997) Modulation by neurotransmitters of catecholamine secretion from sympathetic ganglion neurons detected by amperometry. Proc Natl Acad Sci USA 94:1506-11
135. Korpi ER, Sinkkonen ST (2006) GABA (A) receptor subtypes as targets for neuropsychiatric drug development. Pharmacol Ther 109:12-32
136. Koyama S, Matsumoto N, Kubo C, Akaike N (2000) Presynaptic 5-HT3 receptor-mediated modulation of synaptic GABA release in the mechanically dissociated rat amygdala neurons. J Physiol (Lond) 529:373-83
137. Koyama S, Matsumoto N, Murakami N, Kubo C, Nabekura J, Akaike N (2002) Role of presynaptic 5-HT1A and 5-HT3 receptors in modulation of synaptic GABA transmission in dissociated rat basolateral amygdala neurons. Life Sciences 72:375-87
138. Kristufek D, Koth G, Motejlek A, Schwarz K, Huck S, Boehm S (1999a) Modulation of spontaneous and stimulation-evoked transmitter release from rat sympathetic neurons by the cognition enhancer linopirdine: insights into its mechanisms of action. J Neurochem 72:2083-91
139. Kristufek D, Stocker E, Boehm S, Huck S (1999b) Somatic and prejunctional nicotinic receptors in cultured rat sympathetic neurones show different agonist profiles. J Physiol 516 (Pt 3) :739-56
140. Kubista H, Boehm S (2006) Molecular mechanisms underlying the modulation of exocytotic noradrenaline release via presynaptic receptors. Pharmacol Ther 112: 213-42
141. Langer S (1977) Presynaptic receptors and their role in the regulation of transmitter release. Br J Pharmacol 60:481-97
142. Lappin SC, Randall AD, Gunthorpe MJ, Morisset V (2006) TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. Eur J Pharmacol 540:73
143. Lauri SE, Bortolotto ZA, Nistico R, Bleakman D, Ornstein PL, Lodge D, Isaac JT, Collingridge GL (2003) A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus. Neuron 39:327-41
144. Lauri SE, Segerstrale M, Vesikansa A, Maingret F, Mulle C, Collingridge GL, Isaac JT, Taira T (2005) Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus. J Neurosci 25:4473-84
145. Lechner SG, Hussl S, Schicker KW, Drobny H, Boehm S (2005) Presynaptic inhibition via a phospholipase C-and phosphatidylinositol bisphosphate-dependent regulation of neuronal Ca2+ channels. Mol Pharmacol 68:1387-96
146. Lechner SG, Mayer M, Boehm S (2003) Activation of M1 muscarinic receptors triggers transmitter release from rat sympathetic neurons through an inhibition of M-type K+ channels. J Physiol 553:789-802
147. Lee CJ, Bardoni R, Tong C-K, Engelman HS, Joseph DJ, Magherini PC, MacDermott AB (2002a) Functional expression of AMPA receptors on central terminals of rat dorsal root ganglion neurons and presynaptic inhibition of glutamate release. Neuron 35:135
148. Lee FJ, Xue S, Pei L, Vukusic B, Chery N, Wang Y, Wang YT, Niznik HB, Yu XM, Liu F (2002b) Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Cell 111:219-30
149. Lena C, Changeux JP (1997) Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus. J Neurosci 17:576-85
150. Lena C, Changeux JP, Mulle C (1993) Evidence for preterminal nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus. J Neurosci 13:2680-8
151. Lena C, de Kerchove D'Exaerde A, Cordero-Erausquin M, Le Novere N, del Mar Arroyo-Jimenez M, Changeux JP (1999) Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons. Proc Natl Acad Sci USA 96: 12126-31
152. Lerma J (2006) Kainate receptor physiology. Cur Op Pharmacol 6:89-97
153. Lester HA, Dibas MI, Dahan DS, Leite JF, Dougherty DA (2004) Cys-loop receptors: new twists and turns. Trends Neurosci 27:329-36
154. Li D-P, Chen S-R, Pan H-L (2004) VR1 Receptor activation induces glutamate release and postsynaptic firing in the paraventricular nucleus. J Neurophysiol 92: 1807-16
155. Li Y, Xu TL (2002) State-dependent cross-inhibition between anionic GABA (A) and glycine ionotropic receptors in rat hippocampal CA1 neurons. Neuroreport 13: 223-6
156. LiedtkeW, Kim C (2005) Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon! Cell Mol Life Sci 62:2985-3001
157. Lien C-C, Mu Y, Vargas-Caballero M, Poo M-m (2006) Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors. Nat Neurosci 9:372
158. Lipscombe D, Kongsamut S, Tsien RW (1989) Alpha-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating. Nature 340:639-42
159. Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB (2000) Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors. Nature 403:274-80
160. Liu H, Mantyh PW, Basbaum AI (1997) NMDA-receptor regulation of substance P release from primary afferent nociceptors. Nature 386:721
161. Liu L, Zhao R, Bai Y, Stanish LF, Evans JE, Sanderson MJ, Bonventre JV, Rittenhouse AR (2006) M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades. J Neurosci 26:11588-98
162. Liu Q-S, Patrylo PR, Gao X-B, van den Pol AN (1999) Kainate acts at presynaptic receptors to increase GABA release from hypothalamic neurons. J Neurophysiol 82: 1059-62
163. Lloyd GK, Menzaghi F, Bontempi B, Suto C, Siegel R, Akong M, Stauderman K, Velicelebi G, Johnson E, Harpold MM, Rao TS, Sacaan AI, Chavez-Noriega LE, Washburn MS, Vernier JM, Cosford ND, McDonald LA (1998) The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents. Life Sci 62:1601-6
164. Loewi O (1921) Uber humorale Ubertragbarkeit der Herznervenwirkung. Pflugers Arch 189:239-42
165. Loffelholz K (1970) Autoinhibition of nicotinic release of noradrenaline from postganglionic sympathetic nerves. Naunyn Schmiedebergs Arch Pharmakol 267: 49-63
166. Luetje CW (2004) Getting past the asterisk: the subunit composition of presynaptic nicotinic receptors that modulate striatal dopamine release. Mol Pharmacol 65:1333-5
167. Lukas RJ, Changeux J-P, le Novere N, Albuquerque EX, Balfour DJK, Berg DK, Bertrand D, Chiappinelli VA, Clarke PBS, Collins AC, Dani JA, Grady SR, Kellar KJ, Lindstrom JM, Marks MJ, Quik M, Taylor PW, Wonnacott S (1999) International Union of Pharmacology. XX. Current Status of the Nomenclature for Nicotinic Acetylcholine Receptors and Their Subunits. Pharmacol Rev 51:397-401
168. Luo S, Kulak JM, Cartier GE, Jacobsen RB, Yoshikami D, Olivera BM, McIntosh JM (1998) alpha-conotoxin AuIB selectively blocks alpha3 beta4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release. J Neurosci 18:8571-9
169. MacDermott AB, Role LW, Siegelbaum SA (1999) Presynaptic ionotropic receptors and the control of transmitter release. Annu Rev Neurosci 22:443-85
170. Madden DR (2002) The structure and function of glutamate receptor ion channels. Nat Rev Neurosci 3:91-101
171. Maingret F, Lauri SE, Taira T, Isaac JT (2005) Profound regulation of neonatal CA1 rat hippocampal GABAergic transmission by functionally distinct kainate receptor populations. J Physiol 567:131-42
172. Marchi M, Risso F, Viola C, Cavazzani P, RaiteriM (2002) Direct evidence that release-stimulating alpha7? nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals. J Neurochem 80:1071-8
173. Martire M, Altobelli D, Cannizzaro C, Maurizi S, Preziosi P (2002) Prenatal diazepam exposure functionally alters the GABA (A) receptor that modulates [3H]noradrenaline release from rat hippocampal synaptosomes. Dev Neurosci 24:71-8
174. Martire M, Castaldo P, D'Amico M, Preziosi P, Annunziato L, Taglialatela M (2004) M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals. J Neurosci 24:592-7
175. McGehee DS, Heath MJ, Gelber S, Devay P, Role LW (1995) Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science 269:1692-6
176. McGehee DS, Role LW (1996) Presynaptic ionotropic receptors. Curr Opin Neurobiol 6:342
177. McMahon LL, Kauer JA (1997) Hippocampal interneurons are excited via serotonin-gated ion channels. J Neurophysiol 78:2493-2502
178. Meir A, Ginsburg S, Butkevich A, Kachalsky SG, Kaiserman I, Ahdut R, Demirgoren S, Rahamimoff R (1999) Ion channels in presynaptic nerve terminals and control of transmitter release. Physiol Rev 79:1019-88
179. Michaelevski I, Chikvashvili D, Tsuk S, Fili O, Lohse MJ, Singer-Lahat D, Lotan I (2002) Modulation of a brain voltage-gated K+ channel by syntaxin 1A requires the physical interaction of Gbetagamma with the channel. J Biol Chem 277:34909-17
180. Mochida S, Sheng ZH, Baker C, Kobayashi H, Catterall WA (1996) Inhibition of neurotransmission by peptides containing the synaptic protein interaction site of N-type Ca2+ channels. Neuron 17:781-8
181. Mochida S, Westenbroek RE, Yokoyama CT, Zhong H, Myers SJ, Scheuer T, Itoh K, Catterall WA (2003) Requirement for the synaptic protein interaction site for reconstitution of synaptic transmission by P/Q-type calcium channels. Proc Natl Acad Sci USA 100:2819-24
182. Mongeau R, De Montigny C, Blier P (1994) Activation of 5-HT3 receptors enhances the electrically evoked release of [3H]noradrenaline in rat brain limbic structures. Eur J Pharmacol 256:269-79
183. Moores TS, Hasdemir B, Vega-Riveroll L, Deuchars J, Parson SH (2005) Properties of presynaptic P2X7-like receptors at the neuromuscular junction. Brain Res 1034:40
184. Morales M, Wang SD (2002) Differential composition of 5-hydroxytryptamine3 receptors synthesized in the rat CNS and peripheral nervous system. J Neurosci 22: 6732-41
185. Morales M, Battenberg E, de Lecea L, Bloom FE (1996) The type 3 serotonin receptor is expressed in a subpopulation of GABAergic neurons in the rat neocortex and hippocampus. Brain Res 731:199-202
186. Morales M, Battenberg E, Bloom FE (1998) Distribution of neurons expressing immunoreactivity for the 5HT3 receptor subtype in the rat brain and spinal cord. J Comp Neurol 402:385-401
187. Morita H, Crone C, Christenhuis D, Petersen NT, Nielsen JB (2001) Modulation of presynaptic inhibition and disynaptic reciprocal Ia inhibition during voluntary movement in spasticity. Brain 124:826-37
188. Nakatsuka T, Gu JG (2001) ATP P2X Receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord. J Neurosci 21:6522-31
189. Nakazawa K (1994) ATP-activated current and its interaction with acetylcholine-activated current in rat sympathetic neurons. J Neurosci 14:740-50
190. Narkiewicz K, van de Borne PJ, Hausberg M, Cooley RL, Winniford MD, Davison DE, Somers VK (1998) Cigarette smoking increases sympathetic outflow in humans. Circulation 98:528-34
191. Nicoll RA, Schmitz D (2005) Synaptic plasticity at hippocampal mossy fibre synapses. Nat Rev Neurosci 6:863-76
192. Niesler B, Frank B, Kapeller J, Rappold GA (2003) Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene 310:101
193. North RA (2002) Molecular Physiology of P2X Receptors. Physiol Rev 82:1013-67
194. Ohta K, Araki N, Shibata M, Komatsumoto S, Shimazu K, Fukuuchi Y (1994) Presynaptic ionotropic glutamate receptors modulate in vivo release and metabolism of striatal dopamine, noradrenaline, and 5-hydroxytryptamine: involvement of both NMDA and AMPA/kainate subtypes. Neurosci Res 21:83-9
195. Owens DF, Boyce LH, Davis MB, Kriegstein AR (1996) Excitatory GABA responses in embryonic and neonatal cortical slices demonstrated by gramicidin perforated-patch recordings and calcium imaging. J Neurosci 16:6414-23
196. Parker RM, Barnes JM, Ge J, Barber PC, Barnes NM (1996) Autoradiographic distribution of [3H]-(S)-zacopride-labelled 5-HT3 receptors in human brain. J Neurol Sci 144:119-27
197. Partovi D, Frerking M (2006) Presynaptic inhibition by kainate receptors converges mechanistically with presynaptic inhibition by adenosine and GABAB receptors. Neuropharmacology 51:1030
198. Patti L, Raiteri L, Grilli M, Parodi M, Raiteri M, Marchi M (2006) P2X7 receptors exert a permissive role on the activation of release-enhancing presynaptic [alpha]7 nicotinic receptors co-existing on rat neocortex glutamatergic terminals. Neuropharmacology 50:705
199. Perkinton MS, Sihra TS (1999) A high-affinity presynaptic kainate-type glutamate receptor facilitates glutamate exocytosis from cerebral cortex nerve terminals (synaptosomes) . Neuroscience 90:1281-92
200. Petrov VI, Sergeyev VS, Onishchenko NV (2001) The effect of N-acetyl-aspartic acid dilithium salt on dopamine release and synthesis in the rat striatum in vivo. Eur J Pharmacol 416:69
201. Pittaluga A, Raiteri M (1990) Release-enhancing glycine-dependent presynaptic NMDA receptors exist on noradrenergic terminals of hippocampus. Eur J Pharmacol 191:231-4
202. Poelchen W, Sieler D, Wirkner K, Illes P (2001) Co-transmitter function of ATP in central catecholaminergic neurons of the rat. Neuroscience 102:593-602
203. Poncer JC, McKinney RA, Gahwiler BH, Thompson SM (1997) Either N-or P-type calcium channels mediate GABA release at distinct hippocampal inhibitory synapses. Neuron 18:463-72
204. Price TJ, Patwardhan A, Akopian AN, Hargreaves KM, Flores CM (2004) Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide. 141 1118
205. Puig MV, Santana N, Celada P, Mengod G, Artigas F (2004) In vivo excitation of GABA interneurons in the medial prefrontal cortex through 5-HT3 receptors. Cereb Cortex 14:1365-75
206. Radcliffe KA, Dani JA (1998) Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission. J Neurosci 18:7075-83
207. Raffaelli G, Saviane C, Mohajerani MH, Pedarzani P, Cherubini E (2004) BK potassium channels control transmitter release at CA3-CA3 synapses in the rat hippocampus. J Physiol 557:147-57
208. Rapier C, Lunt GG, Wonnacott S (1990) Nicotinic modulation of [3H]dopamine release from striatal synaptosomes: pharmacological characterisation. J Neurochem 54:937-45
209. Rashid MH, Furue H, Yoshimura M, Ueda H (2006) Tonic inhibitory role of [alpha]4[beta]2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice. Pain 125:125
210. Reno LAC, Zago W, Markus RP (2004) Release of [3H]glutamate by stimulation of nicotinic acetylcholine receptors in rat cerebellar slices. Neuroscience 124:647
211. Reuben M, Clarke PBS (2000) Nicotine-evoked [3H]5-hydroxytryptamine release from rat striatal synaptosomes. Neuropharmacology 39:290
212. Rhee JS, Wang ZM, Nabekura J, Inoue K, Akaike N (2000) ATP facilitates spontaneous glycinergic IPSC frequency at dissociated rat dorsal horn interneuron synapses. J Physiol (Lond) 524:471-83
213. Riker WF, Jr., Roberts J, Standaert FG, Fujimori H (1957) The motor nerve terminal as the primary focus for drug-in-duced facilitation of neuromuscular transmission. J Pharmacol Exp Ther 121:286-312
214. Rivera C, Voipio J, Kaila K (2005) Two developmental switches in GABAergic signalling: the K+-Cl? cotransporter KCC2 and carbonic anhydrase CAVII. J Physiol (Lond) 562:27-36
215. Rivera C, Voipio J, Payne JA, Ruusuvuori E, Lahtinen H, Lamsa K, Pirvola U, Saarma M, Kaila K (1999) The K+/Cl? co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 397:251
216. Rodriguez-Moreno A, Herreras O, Lerma J (1997) Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus. Neuron 19:893
217. Rodriguez-Moreno A, Lerma J (1998) Kainate receptor modulation of GABA release involves a metabotropic function. Neuron 20:1211
218. Rodriguez-Moreno A, Lopez-Garcia JC, Lerma J (2000) Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons. PNAS 97:1293-8
219. Rodriguez-Moreno A, Sihra TS (2004) Presynaptic kainate receptor facilitation of glutamate release involves protein kinase A in the rat hippocampus. J Physiol (Lond) 557:733-45
220. Rogers M, Dani JA (1995) Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels. Biophys J 68:501-6
221. Ronde P, Nichols RA (1998) High calcium permeability of serotonin 5-HT3 receptors on presynaptic nerve terminals from rat striatum. J Neurochem 70:1094-1103
222. Rosenstein RE, Chuluyan HE, Cardinali DP (1990) Presynaptic effects of gamma-aminobutyric acid on norepinephrine release and uptake in rat pineal gland. J Neural Transm 82:131-40
223. Rousseau SJ, Jones IW, Pullar IA, Wonnacott S (2005) Presynaptic [alpha]7 and non-[alpha]7 nicotinic acetylcholine receptors modulate [3H]d-aspartate release from rat frontal cortex in vitro. Neuropharmacology 49:59
224. Rozas JL, Paternain AV, Lerma J (2003) Noncanonical signaling by ionotropic kainate receptors. Neuron 39:543-53
225. Rudolph U, Mohler H (2004) Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annu Rev Pharmacol Toxicol 44:475-98
226. Ruiz A, Fabian-Fine R, Scott R,Walker MC, Rusakov DA, Kullmann DM (2003) GABAA Receptors at hippocampal mossy fibers. Neuron 39:961
227. Rusakov DA, Saitow F, Lehre KP, Konishi S (2005) Modulation of presynaptic Ca2+ entry by AMPA receptors at individual GABAergic synapses in the cerebellum. J Neurosci 25:4930-40
228. Rustioni A (2005) Modulation of sensory input to the spinal cord by presynaptic ionotropic glutamate receptors. Arch Ital Biol 143:103-12
229. Sacaan AI, Dunlop JL, Lloyd GK (1995) Pharmacological characterization of neuronal acetylcholine gated ion channel receptor-mediated hippocampal norepinephrine and striatal dopamine release from rat brain slices. J Pharmacol Exp Ther 274:224-30
230. Sagdullaev BT, McCall MA, Lukasiewicz PD (2006) Presynaptic inhibition modulates spillover, creating distinct dynamic response ranges of sensory output. Neuron 50: 923-35
231. Sailer A, Swanson GT, Perez-Otano I, O'Leary L, Malkmus SA, Dyck RH, Dickinson-Anson H, Schiffer HH, Maron C, Yaksh TL, Gage FH, O'Gorman S, Heinemann SF (1999) Generation and analysis of GluR5 (Q636R) kainate receptor mutant mice. J Neurosci 19:8757-64
232. Saitow F, Suzuki H, Konishi S (2005) beta-Adrenoceptor-mediated long-term up-regulation of the release machinery at rat cerebellar GABAergic synapses. J Physiol 565:487-502
233. Salminen O, Murphy KL, McIntosh JM, Drago J, Marks MJ, Collins AC, Grady SR (2004) Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice. Mol Pharmacol 65: 526-35
234. Sang CN, Hostetter MP, Gracely RH, Chappell AS, Schoepp DD, Lee G, Whitcup S, Caruso R, Max MB (1998) AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans. Anesthesiology 89: 1060-7
235. Sang CN, Ramadan NM,Wallihan RG, Chappell AS, Freitag FG, Smith TR, Silberstein SD, Johnson KW, Phebus LA, Bleakman D, Ornstein PL, Arnold B, Tepper SJ, Vandenhende F (2004) LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine. Cephalalgia 24:596-602
236. Satake SI, Saitow F, Rusakov D, Konishi S (2004) AMPA receptor-mediated presynaptic inhibition at cerebellar GABAergic synapses: a characterization of molecular mechanisms. Eur J Neurosci 19:2464-74
237. ScanzianiM, Capogna M, Gahwiler BH, Thompson SM (1992) Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus. Neuron 9:919-27
238. Schlicker E, GothertM (1998) Interactions between the presynaptic alpha2-autoreceptor and presynaptic inhibitory heteroreceptors on noradrenergic neurones. Brain Res Bull 47:129-32.
239. Schmitz D, Mellor J, Nicoll RA (2001) Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses. Science 291:1972-6
240. Schneggenburger R, Neher E (2005) Presynaptic calcium and control of vesicle fusion. Curr Opin Neurobiol 15:266-74
241. Scholz KP, Miller RJ (1992) Inhibition of quantal transmitter release in the absence of calcium influx by a G protein-linked adenosine receptor at hippocampal synapses. Neuron 8:1139-50
242. Seddik R, Schlichter R, Trouslard J (2006) Modulation of GABAergic synaptic transmission by terminal nicotinic acetylcholine receptors in the central autonomic nucleus of the neonatal rat spinal cord. Neuropharmacology 51:77
243. Shigetomi E, Kato F (2004) Action potential-independent release of glutamate by Ca2+ entry through presynaptic P2X receptors elicits postsynaptic firing in the brainstem autonomic network. J Neurosci 24:3125-35
244. Sjostrom PJ, Turrigiano GG, Nelson SB (2003) Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors. Neuron 39: 41
245. Somogyi P, Klausberger T (2005) Defined types of cortical interneurone structure space and spike timing in the hippocampus. J Physiol (Lond) 562:9-26
246. Spafford JD, Zamponi GW (2003) Functional interactions between presynaptic calcium channels and the neurotransmitter release machinery. Curr Opin Neurobiol 13:308-14
247. Staley K (1992) Enhancement of the excitatory actions of GABA by barbiturates and benzodiazepines. Neurosci Lett 146:105-7
248. Starke K (1977) Regulation of noradrenaline release by presynaptic receptor systems. Rev Physiol Biochem Pharmacol 77:1-124
249. Starke K (1981) Presynaptic receptors. Annu Rev Pharmacol Toxicol 21:7-30
250. Suarez LM, Solis JM (2006) Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons. European Journal of Neuroscience 24:405-18
251. Suarez LM, Suarez F, del Olmo N, Ruiz M, Gonzalez-Escalada JR, Solis JM (2005) Presynaptic NMDA autoreceptors facilitate axon excitability: a new molecular target for the anticonvulsant gabapentin. European Journal of Neuroscience 21:197-209
252. Sudhof TC (2004) The synaptic vesicle cycle. Annu Rev Neurosci 27:509-47
253. Sundstrom E, Holmberg L, Souverbie F (1998) NMDA and AMPA receptors evoke transmitter release from noradrenergic axon terminals in the rat spinal cord. Neurochem Res V23:1501
254. Swope SL, Moss SJ, Raymond LA, Huganir RL (1999) Regulation of ligand-gated ion channels by protein phosphorylation. Adv Sec Mess Phosph Res 33:49-78
255. Takago H, Nakamura Y, Takahashi T (2005) G protein-dependent presynaptic inhibition mediated by AMPA receptors at the calyx of Held. PNAS 102:7368-73
256. Tani Y, Saito K, Imoto M, Ohno T (1998) Pharmacological characterization of nicotinic receptormediated acetylcholine release in rat brain-an in vivo microdialysis study. Eur J Pharmacol 351:181-8
257. Tashiro A, Dunaevsky A, Blazeski R, Mason CA, Yuste R (2003) Bidirectional regulation of hippocampal mossy fiber filopodial motility by kainate receptors: a two-step model of synaptogenesis. Neuron 38:773-84
258. Todd KJ, Slatter CAB, Ali DW (2004) Activation of ionotropic glutamate receptors on peripheral axons of [primary motoneurons mediates transmitter release at the zebrafish NMJ. J Neurophysiol 91:828-40
259. Trendelenburg U (1957) The action of morphine on the superior cervical ganglion and on the nictitating membrane of the cat. Br J Pharmacol Chemother 12:79-85
260. Turecek R, Trussell LO (2001) Presynaptic glycine receptors enhance transmitter release at a mammalian central synapse. Nature 411:587
261. Turecek R, Trussell LO (2002) Reciprocal developmental regulation of presynaptic ionotropic receptors. Proc Natl Acad Sci USA 99:13884-9
262. Turner TJ, Dunlap K (1995) Pharmacological characterization of presynaptic calcium channels using subsecond biochemical measurements of synaptosomal neurosecretion. Neuropharmacology 34:1469-78
263. Turner TJ, Mokler DJ, Luebke JI (2004) Calcium influx through presynaptic 5-HT3 receptors facilitates GABA release in the hippocampus: in vitro slice and synaptosome studies. Neuroscience 129:703-18
264. van Hooft JA, Vijverberg HPM (2000) 5-HT3 receptors and neurotransmitter release in the CNS: a nerve ending story? Trends Neurosci 23:605-10
265. van Hooft JA, Yakel JL (2003) 5-HT3 receptors in the CNS: 3B or not 3B? Trends iPharmacolog Sci 24:157-60
266. Veruki ML, Morkve SH, Hartveit E (2006) Activation of a presynaptic glutamate transporter regulates synaptic transmission through electrical signaling. Nat Neurosci 9:1388-96
267. Vignes M (2001) Regulation of spontaneous inhibitory synaptic transmission by endogenous glutamate via non-NMDA receptors in cultured rat hippocampal neurons. Neuropharmacology 40:737
268. von Kugelgen I, Starke K (1991) Noradrenaline-ATP co-transmission in the sympathetic nervous system. Trends Pharmacol Sci 12:319-24
269. Wang Y, Small DL, Stanimirovic DB, Morley P, Durkin JP (1997) AMPA receptor-mediated regulation of a Gi-protein in cortical neurons. Nature 389:502
270. Wersinger E, Schwab Y, Sahel J-A, Rendon A, Pow DV, Picaud S, Roux MJ (2006) The glutamate transporter EAAT5 works as a presynaptic receptor in mouse rod bipolar cells. J Physiol (Lond) 577:221-34
271. Wessler I (1989) Control of transmitter release from the motor nerve by presynaptic nicotinic and muscarinic autoreceptors. Trends Pharmacol Sci 10:110-14
272. Wheeler DB, Randall A, Tsien RW (1994) Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission. Science 264:107-11
273. Whittaker VP (1993) Thirty years of synaptosome research. J Neurocytol 22:735-42
274. Wolk R, Shamsuzzaman AS, Svatikova A, Huyber CM, Huck C, Narkiewicz K, Somers VK (2005) Hemodynamic and autonomic effects of smokeless tobacco in healthy young men. J Am Coll Cardiol 45:910-14
275. Wonnacott S (1997) Presynaptic nicotinic ACh receptors. Trends Neurosci 20:92
276. Woodhall G, Evans DI, Cunningham MO, Jones RSG (2001) NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons. J Neurophysiol 86: 1644-51
277. Wu LG, Saggau P (1997) Presynaptic inhibition of elicited neurotransmitter release. Trends Neurosci 20:204-12
278. Xu H, Wu L-J, Zhao M-G, Toyoda H, Vadakkan K, Jia Y, Pinaud R, Zhuo M (2006) Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. Molec Pain 2:29
279. Yang J, Woodhall GL, Jones RSG (2006) Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors Is increased in the entorhinal cortex of chronically epileptic rats. J Neurosci 26:406-10
280. Yang K, Kumamoto E, Furue H, Li Y-Q, Yoshimura M (1999) Action of capsaicin on dorsal rootevoked synaptic transmission to substantia gelatinosa neurons in adult rat spinal cord slices. Brain Res 830:268
281. Yang K, Kumamoto E, Furue H, Yoshimura M (1998) Capsaicin facilitates excitatory but not inhibitory synaptic transmission in substantia gelatinosa of the rat spinal cord. Neurosci Lett 255:135
282. Ye J-H,Wang F, Krnjevic K,WangW, Xiong Z-G, Zhang J (2004) Presynaptic glycine receptors on GABAergic terminals facilitate discharge of dopaminergic neurons in ventral tegmental area. J Neurosci 24:8961-74
283. Yevenes GE, Peoples RW, Tapia JC, Parodi J, Soto X, Olate J, Aguayo LG (2003) Modulation of glycine-activated ion channel function by G-protein betagamma subunits. Nat Neurosci 6:819-24
284. Youn DH, RandicM (2004) Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit. J Physiol 555:683-98
285. Yue H-Y, Fujita T, Kawasaki Y, Kumamoto E (2004) AM404 enhances the spontaneous release of-glutamate in a manner sensitive to capsazepine in adult rat substantia gelatinosa neurones. Brain Res 1018:283
286. Zahniser NR, Doolen S (2001) Chronic and acute regulation of Na+/Cldependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems. Pharmacol Ther 92:21-55
287. Zamponi GW (2003) Regulation of presynaptic calcium channels by synaptic proteins. J Pharmacol Sci 92:79-83
288. Zhai RG, Bellen HJ (2004) The architecture of the active zone in the presynaptic nerve terminal. Physiology (Bethesda) 19:262-70
289. Zhang D, Pan ZH, Awobuluyi M, Lipton SA (2001) Structure and function of GABA (C) receptors: a comparison of native versus recombinant receptors. Trends Pharmacol Sci 22:121-32
290. Zhang LI, Poo MM (2001) Electrical activity and development of neural circuits. Nat Neurosci 4 Suppl:1207-14
291. Zhang SJ, Jackson MB (1995) GABAA receptor activation and the excitability of nerve terminals in the rat posterior pituitary. J Physiol 483 (Pt 3) :583-95
292. Zheng F, Johnson SW (2001) Glycine receptor-mediated inhibition of dopamine and non-dopamine neurons of the rat ventral tegmental area in vitro. Brain Res 919: 13
293. Zhou F-M, Hablitz JJ (1999) Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex. J Neurophysiol 82:2989-99
294. Zucker RS, Regehr WG (2002) Short-term synaptic plasticity. Annu Rev Physiol 64: 355-405