How does calcium trigger neurotransmitter release?

Current Opinion in Neurobiology

Volumn 11, Issue 3, 2001, Pages 320-326

  Augustine, G J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM BINDING PROTEIN; CALCIUM CHANNEL; CALCIUM ION; MEMBRANE LIPID; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNAPTOTAGMIN; SYNTAXIN;

CALCIUM SIGNALING; DIFFUSION; NERVE ENDING; NEUROTRANSMITTER RELEASE; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; REVIEW; SYNAPSE VESICLE;

EID: 0035368680     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(00)00214-2     Document Type: Review

References (62)

1. 2+-dependent responses
2. Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release
3. Calretinin modifies presynaptic calcium signaling in frog saccular hair cells
4. 2+ binding proteins and synaptic plasticity
5. From vesicle docking to endocytosis: Intermediate reactions of exocytosis
6. Microdomains of high calcium concentration in a presynaptic terminal
7. Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cells
8. Subcellular calcium transients visualized by confocal microscopy in a voltage-clamped vertebrate neuron
9. 2+ gradients in adrenal chromaffin cells
10. The calcium signal for transmitter secretion from presynaptic nerve terminals
11. The calcium channel and the organization of the presynaptic transmitter release face
12. Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse
13. Calcium dependence of the rate of exocytosis in a synaptic terminal
14. 2+-triggered exocytosis in presynaptic terminals
15. 2+-activated K+ channels
16. The inhibitory effects of omega-conotoxins on Ca channels and synapses
17. Asynchronous transmitter release: Control of exocytosis and endocytosis at the salamander rod synapse
18. Differential release of amino acids, neuropeptides, and catecholamines from isolated nerve terminals
19. 2+ elevation above a threshold level in bullfrog sympathetic ganglia
20. Calcium influx and transmitter release in a fast CNS synapse
21. Calcium sensitivity of glutamate release in a calyx-type terminal
22. Intracellular calcium dependence of transmitter release rates at a fast central synapse
23. Multiple calcium channel types control glutamatergic synaptic transmission in the hippocampus
24. Different types of calcium channels mediate central synaptic transmission
25. Control of neurotransmitter release by presynaptic waveform at the granule cell to Purkinje cell synapse
26. Modulation of transmitter release by action potential duration at the hippocampal CA3-CA1 synapse
27. 2+
28. 2+ sensors for exocytosis in rat phaeochromocytoma cells
29. 2+ binding domain
30. 2+ and inositol polyphosphate binding protein, in neurotransmitter release and neurite outgrowth
31. 2+-dependent exocytosis
32. 2+ induce a conformational change?
33. 2+-independent snare complex interaction
34. 2+-dependent protein interactions mediated by the C2A domains of synaptotagmins
35. Synaptotagmin: A calcium sensor on the synaptic vesicle surface
36. 2+-dependent and -independent activities of neural and non-neural synaptotagmins
37. 2+ and assembly with the core SNARE complex onto membranes
38. Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin
39. Synaptic function modulated by changes in the ratio of synaptotagmin I and IV
40. Calcium-dependent oligomerization of synaptotagmins I and II
41. Functional and biochemical analysis of the C2 domains of synaptotagmin IV
42. Calcium-dependent and -independent hetero-oligomerization in the synaptotagmin family
43. 2+-sensing module essential for exocytosis
44. Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis
45. Drosophila AD3 mutation of synaptotagmin impairs calcium-dependent self- oligomerization activity
46. Mutations in the C2B domain of synaptotagmin disrupt synaptic transmission at Drosophila neuromuscular junctions
47. Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II
48. Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling
49. Mechanisms of intracellular protein transport
50. SNAREpins: Minimal machinery for membrane fusion
51. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
52. 2+ regulates the interaction between synaptotagmin and syntaxin 1
53. Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo
54. The relation of protein binding to function: What is the significance of munc18 and synaptotagmin binding to syntaxin 1, and where are the corresponding binding sites?
55. Calcium-dependent dissociation of synaptotagmin from synaptic SNARE complexes
56. Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses
57. 2+-dependent binding of synaptotagmin to SNARE complexes
58. Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin
59. Calcium triggers an intramolecular association of the C2 domains in synaptotagmin
60. Synaptotagmin I functions as a calcium regulator of release probability
61. 2+-triggered fusion and recycling of synaptic vesicles in vivo