The role of nicotine in smoking-related cardiovascular disease

Preventive Medicine

Volumn 26, Issue 4, 1997, Pages 412-417

  Benowitz, Neal L ^a,b  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cardiovascular; Cigarette smoking; Nicotine; Tobacco; Toxicity

Indexed keywords

LIPID; NICOTINE;

ADRENERGIC STIMULATION; ARTICLE; ATHEROSCLEROSIS; CARDIOTOXICITY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CIGARETTE SMOKING; ENDOTHELIUM LESION; HUMAN; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; THROMBOSIS;

EID: 0031193869     PISSN: 00917435     EISSN: None     Source Type: Journal    
DOI: 10.1006/pmed.1997.0175     Document Type: Article

References (45)

1. Beeman J A, Hunter W C. Fatal nicotine poisoning: a report of twenty-four cases. Arch Pathol. 24:1937;481-485.
2. Benowitz N L. Pharmacology of nicotine: addiction and therapeutics. Annu Rev Pharmacol Toxicol. 36:1996;597-613.
3. Department of Health and Human Services PHS, 1988, The health consequences of smoking: nicotine addiction. A report of the Surgeon General, Govt. Printing Office, Washington.
4. Green M S, Jucha E, Luz Y. Blood pressure in smokers and nonsmokers: epidemiologic findings. Am Heart J. 111:1986;932-940.
5. Isles C, Brown J J, Cummings A M. Excess smoking in malignant-phase hypertension. Br Med J. 1:1979;579-581.
6. Totti N III, McCusker K T, Campbell E J, Griffin G L, Senior R M. Nicotine is chemotactic for neutrophils and enhances neutrophil responsiveness to chemotactic peptides. Science. 223:1984;169-173.
7. Hecht S S, Hoffmann D. The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surv. 8:1989;273-294.
8. Tricker A R, Preussmann R. Exposure to nicotine-derivedN. Effects of nicotine on biological systems. 1991;Birkhauser, Basel. p. 109-113.
9. Benowitz N L. Pharmacologic aspects of cigarette smoking and nicotine addiction. N Engl J Med. 319:1988;1318-1330.
10. Benowitz N L, Kuyt F, Jacob P III. Influence of nicotine on cardiovascular and hormonal effects of cigarette smoking. Clin Pharmacol Ther. 36:1984;74-81.
11. Strohschneider T, Oberhoff M, Hanke H, Hannekum A, Karsch K R. Effect of chronic nicotine delivery on the proliferation rate of endothelial and smooth muscle cells in experimentally induced vascular wall plaques. Clin Invest. 72:1994;908-912.
12. 3. J Pharmacol Exp Ther. 260:1992;1-8.
13. Cluette-Brown J, Mulligan J, Doyle K, Hagan S, Osmolski T, Hojnacki J. Oral nicotine induces an atherogenic lipoprotein profile. Proc Soc Exp Biol Med. 182:1986;409-413.
14. Craig W Y, Palomaki G E, Haddow J E. Cigarette smoking and serum lipid and lipoprotein concentrations: an analysis of published data. Br Med J. 298:1989;784-788.
15. Harats D, Ben-Naim M, Dabach Y, Hollander G, Stein O, Stein Y. Cigarette smoking renders LDL susceptible to peroxidatives modification and enhanced metabolism by macrophages. Atherosclerosis. 79:1989;245-252.
16. Hellerstein M K, Benowitz N L, Neese R A, Schwartz J, Hoh R, Jacob P III. Effects of cigarette smoking and its cessation on lipid metabolism and energy expenditure in heavy smokers. J Clin Invest. 93:1994;265-272.
17. Quensel M, Agardh C-D, Nilsson-Ehle P. Nicotine does not affect plasma lipoprotein concentrations in healthy men. Scand J Clin Lab Invest. 49:1989;149-153.
18. Thomas G AO, Davies S V, Rhodes J, Russell M AH, Feyerabend C, Säwe U. Is transdermal nicotine associated with cardiovascular risk? J R Coll Physicians London. 29:1995;392-396.
19. Benowitz N L, Porchet H, Sheiner L, Jacob P III. Nicotine absorption and cardiovascular effects with smokeless tobacco use: comparison with cigarettes and nicotine gum. Clin Pharmacol Ther. 44:1988;23-28.
20. Cellina G U, Honour A J, Littler W A. Direct arterial pressure, heart rate, and electrocardiogram during cigarette smoking in unrestricted patients. Am Heart J. 89:1975;18-25.
21. Pickering T, Schwartz J E, James G D. Ambulatory blood pressure monitoring for evaluating the relationships between lifestyle, hypertension and cardiovascular risk. Clin Exp Pharmacol Physiol. 22:1995;226-231.
22. Thyberg J. Effects of nicotine on phenotypic modulation and initiation of DNA synthesis in cultured arterial smooth muscle cells. Virchows Archiv. 52:1986;25-32.
23. Lin S J, Hong C Y, Chang M S, Chiang B N, Chien S. Long-term nicotine exposure increases aortic endothelial cell death and enhances transendothelial macromolecular transport in rats. Arterioscler Thromb. 12:1992;1305-1312.
24. Davis J W, Shelton L, Eigenberg D A, Hignite C E, Watanabe I S. Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets. Clin Pharmacol Ther. 37:1985;529-533.
25. Folts J D, Bonebrake F C. The effects of cigarette smoke and nicotine on platelet thrombus formation in stenosed dog coronary arteries: inhibition with phenotolamine. Circulation. 65:1982;465-469.
26. Pfueller S L, Burns P, Mak K, Firkin B G. Effects of nicotine on platelet function. Haemostasis. 18:1988;163-169.
27. 2. Circulation. 83:1991;1698-1704.
28. Benowitz N L, Fitzgerald G A, Wilson M, Zhang Q. Nicotine effects on eicosanoid formation and hemostatic function: comparison of transdermal nicotine and cigarette smoking. J Am Coll Cardiol. 22:1993;1159-1167.
29. McBride P E. The health consequences of smoking: cardiovascular diseases. Med Clin N Am. 76:1992;333-353.
30. Grines C L, Topol E J, O'Neill W W, George B S, Kereiakes D, Phillips H R. Effect of cigarette smoking on outcome after thrombolytic therapy for myocardial infarction. Circulation. 91:1995;298-303.
31. Rivers J T, White H D, Cross D B, Williams B F, Norris R M. Reinfarction after thrombolytic therapy for acute myocardial infarction followed by conservative management: incidence and effect of smoking. J Am Coll Cardiol. 16:1990;340-348.
32. Galan K M, Deligonul U, Kern M J, Chaitman B R, Vandormael M G. Increased frequency of restenosis in patients continuing to smoke cigarettes after percutaneous transluminal coronary angioplasty. Am J Cardiol. 61:1988;260-263.
33. Woodman O L. Coronary vascular responses to nicotine in the anaesthetized dog. Naunyn Schmiedebergs Arch Pharmacol. 343:1991;65-69.
34. Myers M G, Benowitz N L, Dubbin J D, Haynes R B, Sole M J. Cardiovascular effects of smoking in patients with ischemic heart disease. Chest. 93:1988;14-19.
35. Wald N J, Idle M, Boreham J, Bailey A, Van Vunakis H. Serum cotinine levels in pipe smokers: evidence against nicotine as cause of coronary heart disease. Lancet. 2:1981;775-777.
36. Huhtasaari F, Asplund K, Lundberg V, Stegmayr B, Wester P O. Tobacco and myocardial infarction: is snuff less dangerous than cigarettes? Br Med J. 305:1992;1252-1256.
37. Bolinder G, Alfredsson L, Englund A, deFaire U. Smokeless tobacco use and increased cardiovascular mortality among Swedish construction workers. Am J Public Health. 84:1994;399-404.
38. Arch Intern Med. 154:1994;989-995.
39. Joseph A M, Norman S M, Ferry L H, Prochazka A V, Westman E C, Steele B G. The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. N Engl J Med. 335:1996;1792-1798.
40. J, J, Mahmarian, L, A, Moye, G, A, Nasser, S, F, Nagueh, M, F, Bloom, N, L, Benowitz, et al. A strategy of smoking cessation combined with nicotine patch therapy reduces the extent of exercise-induced myocardial ischemia, J Am Coll Cardiol.
41. Henningfield J E, Stapleton J M, Benowitz N L, Grayson R F, London E D. Higher levels of nicotine in arterial than in venous blood after cigarette smoking. Drug Alcohol Depend. 33:1993;23-29.
42. Benowitz N L, Jacob P III. Intravenous nicotine replacement suppresses nicotine intake from cigarette smoking. J Pharmacol Exp Ther. 254:1990;1000-1005.
43. Willett W C, Green A, Stampfer M J, Speizer F E, Colditz G A, Rosner B. Relative and absolute excess risks of coronary heart disease among women who smoke cigarettes. N Engl J Med. 317:1987;1303-1309.
44. Newcomb P A, Carbone P P. The health consequences of smoking: cancer. Med Clin North Am. 76:1992;305.
45. Benowitz N L. Nicotine and coronary heart diseases. Trends Cardiovasc Med. 1:1991;315-321.