Chronic and acute regulation of Na+/Cl--dependent neurotransmitter transporters: Drugs, substrates, presynaptic receptors, and signaling systems

Pharmacology and Therapeutics

Volumn 92, Issue 1, 2001, Pages 21-55

  Zahniser, Nancy R ^a   Doolen, Suzanne ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Chronic drug; Presynaptic receptors; Signaling mechanisms; Substrates; Trafficking; Transporter regulation

Indexed keywords

ALCOHOL; ALPHA 2 ADRENERGIC RECEPTOR; AMPHETAMINE; ARACHIDONIC ACID; CARRIER PROTEIN; CLONIDINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DESIPRAMINE; DEXAMPHETAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; GAMMA AMINOBUTYRIC ACID TRANSPORTER 1; IPRONIAZID; NEUROTRANSMITTER; NITRIC OXIDE; NORADRENALIN TRANSPORTER; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PRESYNAPTIC RECEPTOR; PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; RESERPINE; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CELL INTERACTION; CELL SURFACE; CONCENTRATION (PARAMETERS); CYTOSKELETON; ENZYME ANALYSIS; EXPOSURE; HUMAN; IN VITRO STUDY; MEMBRANE POTENTIAL; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; OLIGOMERIZATION; PHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR AFFINITY; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

EID: 0035673504     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(01)00158-9     Document Type: Review

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214. Is there a functional linkage between neurotransmitter uptake mechanisms and presynaptic receptors?
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221. Astrocytic processes compensate for the apparent lack of GABA transporters in the axon terminals of cerebellar Purkinje cells
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266. Cloning of the cocaine-sensitive bovine dopamine transporter
267. Distinct functions of the two isoforms of dopamine D2 receptors
268. The vesicular monoamine transporter is not regulated by dopaminergic drug treatments
269. Signaling by distinct classes of phosphoinositide 3-kinases
270. Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes
271. Serotonin transporter production and degradation rates: Studies with RTI-76
272. Dopamine transporter cysteine mutants: Second extracellular loop cysteines are required for transporter expression
273. Effects of ethanol on striatal dopamine overflow and clearance: An in vivo electrochemical study
274. Identification of PKC-isoform-specific biological actions using pharmacological approaches
275. Intrastriatal infusion of (+/-)-S-nitroso-N-acetylpenicillamine releases vesicular dopamine via an ionotropic glutamate receptor-mediated mechanism: An in vivo microdialysis study in chloral hydrate-anesthetized rats
276. Endogenous nitric oxide facilitates striatal dopamine and glutamate efflux in vivo: Role of ionotropic glutamate receptor-dependent mechanisms
277. Synaptic regulation of mesocorticolimbic dopamine neurons
278. Chronic L-deprenyl-induced up-regulation of the dopamine uptake carrier
279. 3H-GBR 12,935 are differentially regulated by chronic cocaine self-administration
280. Striatal dopamine nerve terminal markers in human, chronic methamphetamine users
281. Striatal dopamine, dopamine transporter, and vesicular monoamine transporter in chronic cocaine users
282. Potential new insights into the molecular mechanisms of methamphetamine-induced neurodegeneration
283. Acute administration of α-methyl-para-tyrosine alters levels of norepinephrine transporter mRNA in the rat brainstem
284. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants
285. Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations
286. Role of phosphatidylinositol 3-kinase in angiotensin II regulation of norepinephrine neuromodulation in brain neurons of the spontaneously hypertensive rat
287. Effects of arachidonic acid on glutamate and γ-aminobutyric acid uptake in primary cultures of rat cerebral cortical astrocytes and neurons
288. Arachidonic acid inhibits uptake of glutamate and glutamine but not of GABA in cultured cerebellar granule cells
289. Acute depletion of serotonin down-regulates serotonin transporter mRNA in raphe neurons
290. 3H]5-hydroxytryptamine uptake in rat cortex
291. Arachidonic acid inhibits glycine transport in cultured glial cells
292. Glycine transporters are differentially expressed among CNS cells
293. Chronic cocaine action on the dopamine transporter
294. Epidermal growth factor receptor agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on phosphatidylinositol 3-kinase and transcription factor NF-kappaB
295. Regulation of the functional activity of the human dopamine transporter by the arachidonic acid pathway
296. Regulation of the functional activity of the human transporter in a neuronal cell line
297. Serotonin transporters are located on the axons beyond the synaptic junctions: Anatomical and functional evidence
298. Down-regulation of norepinephrine transporters on PC12 cells by transporter inhibitors
299. Down-regulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine
300. Persistent membrane retention of desipramine causes lasting inhibition of norepinephrine transporter function
301. Regulation of the human norepinephrine transporter by cocaine and amphetamine
302. Activation of protein kinase C inhibits uptake, currents and binding associated with the human dopamine transporter expressed in Xenopus oocytes
303. Effect of nitroprusside (nitric oxide) on endogenous dopamine release from rat striatal slices
304. Hyperactivity and impaired response habituation in hyperdopaminergic mice
305. Volume transmission in the CNS and its relevance for neuropsychopharmacology